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Protein

Sex-determining region Y protein

Gene

SRY

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi60 – 128HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Calmodulin-binding, DNA-binding, Repressor
Biological processDifferentiation, Sexual differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y protein
Alternative name(s):
Testis-determining factor
Gene namesi
Name:SRY
Synonyms:TDF
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000486781 – 204Sex-determining region Y proteinAdd BLAST204

Post-translational modificationi

Acetylation of Lys-136 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9BG90

Interactioni

Subunit structurei

Interacts with CALM, EP300, HDAC3, KPNB1, KRAB-O/ZFP748, PARP1, SLC9A3R2 and WT1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9BG90
SMRiQ9BG90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRY family.Curated

Phylogenomic databases

HOVERGENiHBG008712
InParanoidiQ9BG90
KOiK09266

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017253 SRY
PANTHERiPTHR10270:SF199 PTHR10270:SF199, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF037653 SRY, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BG90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSYASAMLS VFNTDGYSPA AQQNIPALRR SSSFICTESC SSKYQCEAGE
60 70 80 90 100
NSKGSVQDKV KRPMNAFIVW SRDQKRKMAL ENPKMRNSEI SKQLGYQWKM
110 120 130 140 150
LTEADKWPFF QEAQKLQAMH REKYPNYKYR PRRKAKMLQN SCSLLPADPS
160 170 180 190 200
SVPCREVQLD NRLYRDDCTK ATHSRMQHQL GHLPPINTAS SPQQRDRYSH

STKL
Length:204
Mass (Da):23,618
Last modified:June 1, 2001 - v1
Checksum:i774EFEC92B3A0B40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322901 mRNA Translation: AAK01652.1
RefSeqiNP_001028008.1, NM_001032836.1
UniGeneiMmu.3544

Genome annotation databases

GeneIDi574155
KEGGimcc:574155

Similar proteinsi

Entry informationi

Entry nameiSRY_MACMU
AccessioniPrimary (citable) accession number: Q9BG90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

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