UniProtKB - Q9BFY9 (Q9BFY9_SYLFL)
Beta-2 adrenergic receptor
ADRB2
Functioni
GO - Molecular functioni
- beta2-adrenergic receptor activity Source: InterPro
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: InterPro
- regulation of blood vessel diameter Source: InterPro
- regulation of smooth muscle contraction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-2 adrenergic receptorARBA annotationAlternative name(s): Beta-2 adrenoreceptorARBA annotation |
Gene namesi | Name:ADRB2Imported |
Organismi | Sylvilagus floridanus (Cottontail rabbit)Imported |
Taxonomic identifieri | 9988 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Sylvilagus |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 19 – 45 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 57 – 78 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 99 – 118 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 147 – 168 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 226 – 246 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneInteractioni
Subunit structurei
Binds SLC9A3R1 and GPRASP1.
Interacts with ARRB1 and ARRB2.
Interacts with SRC, USP20 and USP33.
Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation.
Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination.
Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane.
Interacts with CNIH4.
Interacts with ARRDC3.
ARBA annotationChemistry databases
BindingDBi | Q9BFY9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 277 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 277 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationFamily and domain databases
InterProi | View protein in InterPro IPR000332, ADRB2_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF21, PTHR24248:SF21, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00562, ADRENRGCB2AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
10 20 30 40 50
VLVITAIAKF ERLQTVTNYF ITSLACADLV MGLAVVPFGA SHILMKMWTF
60 70 80 90 100
GNFWCEFWTS IDVLCVTASI ETLCVIAVDR YFAITSPFKY QSLLTKNKAR
110 120 130 140 150
VVILMVWIVS GLTSFLPIQM HWYRATHQEA INCYAKETCC DFFTNQAYAI
160 170 180 190 200
ASSIVSFYLP LVVMVFVYSR VFQVAKKQLQ KIDKSEGRFH AQNLSQVEQD
210 220 230 240 250
GRSGHGHGLR RSSKFCLKEH KALKTLGIIM GTFTLCWLPF FIVNIVHVIR
260 270
DNLIPKEVYI LLNWVGYVNS AFNPLIY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 277 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY011282 Genomic DNA Translation: AAG35442.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY011282 Genomic DNA Translation: AAG35442.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
BindingDBi | Q9BFY9 |
Protein family/group databases
GPCRDBi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR000332, ADRB2_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF21, PTHR24248:SF21, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00562, ADRENRGCB2AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9BFY9_SYLFL | |
Accessioni | Q9BFY9Primary (citable) accession number: Q9BFY9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |