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Entry version 81 (18 Sep 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Xanthan lyase

Gene

xly

Organism
Bacillus sp. (strain GL1)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in xanthan depolymerization pathway by cleaving the linkage between the terminal mannosyl and glucuronyl residues of the side chain of xanthan to liberate pyruvylated mannose.3 Publications

Miscellaneous

The 99 kDa precursor is converted to a mature form (77 kDa) through the removal of a C-terminal (22 kDa) fragment without any loss in activity.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Highly specific for pyruvylated xanthan but not effective with hyaluronate, chondroitin A, gellan, heparin or pectin. Affinity for pyruvylated mannose is 400-fold stronger in comparison with mannose. Activated by Co2+ at 1 mM. Completely inhibited by Hg2+ but not affected by other divalent cations. Intensely inhibited by NaCl and KCl at 150 mM, in particular by the Na+ and K+ ions but not the Cl- ions. Partially inhibited by iodoacetamide and N-ethylmaleimide at 1 mM but not by dithiothreitol, reduced glutathione or 2-mercaptoethanol.3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.25 mM for xanthan2 Publications

    pH dependencei

    Optimum pH is 5.5 (in the presence of sodium acetate). Active between pH 6.5 and 9.2 Publications

    Temperature dependencei

    Optimum temperature is 50 degrees Celsius. Stable at 4 degrees Celsius at pH 6.5 - 9. 60% loss of activity when incubated at 45 degrees Celsius and pH 7.0 for 10 minutes.2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei148Carbohydrate1 Publication1
    Binding sitei148Substrate 12 Publications1
    Binding sitei246Substrate 21 Publication1
    Binding sitei255Carbohydrate1 Publication1
    Binding sitei255Substrate 12 Publications1
    Binding sitei309Carbohydrate1 Publication1
    Binding sitei309Substrate 1 and 22 Publications1
    Binding sitei313Carbohydrate1 Publication1
    Binding sitei424Substrate 21 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi515Calcium2 Publications1
    Metal bindingi516Calcium2 Publications1
    Metal bindingi517Calcium2 Publications1
    Binding sitei612Substrate 1 and 22 Publications1
    Metal bindingi676Calcium2 Publications1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • calcium ion binding Source: UniProtKB
    • mannose binding Source: UniProtKB
    • xanthan lyase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    LigandCalcium, Metal-binding

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    PL8 Polysaccharide Lyase Family 8

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Xanthan lyaseImported (EC:4.2.2.121 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:xlyImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus sp. (strain GL1)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri84635 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    • Secreted 1 Publication

    GO - Cellular componenti

    Keywords - Cellular componenti

    Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi194N → A: Loss of activity by 60%. 1 Publication1
    Mutagenesisi246H → A: Loss of activity by 60%. 1 Publication1
    Mutagenesisi255Y → F: Loss of activity by 50%. 1 Publication1
    Mutagenesisi313R → A: Reduced catalytic activity. 1 Publication1
    Mutagenesisi315Y → F: Negligible change in catalytic activity. 1 Publication1
    Mutagenesisi612R → A: Increased catalysis rate but decreased affinity with substrate. 1 Publication1

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB04386 4,6-O-(1-Carboxyethylidene)-Beta-D-Glucose
    DB04597 4,6-O-(1-CARBOXYETHYLIDENE)-BETA-D-MANNOSE
    DB04596 4-O-{4,6-O-[(1S)-1-Carboxyethylidene]-Beta-D-mannopyranosyl}-D-glucopyranuronic acid

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041793326 – 930Xanthan lyaseSequence analysisAdd BLAST905

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9AQS0

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    4 Publications

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1930
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9AQS0

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9AQS0

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni146 – 148Substrate binding1 Publication3
    Regioni313 – 315Substrate binding2 Publications3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the polysaccharide lyase 8 family.Sequence analysis

    Keywords - Domaini

    Signal

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd14488 CBM6-CBM35-CBM36_like_2, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.50.10.100, 1 hit
    2.60.220.10, 1 hit
    2.70.98.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR033803 CBM6/CBM35/CBM36-like_2
    IPR008929 Chondroitin_lyas
    IPR011013 Gal_mutarotase_sf_dom
    IPR014718 GH-type_carb-bd
    IPR038970 Lyase_8
    IPR011071 Lyase_8-like_C
    IPR012970 Lyase_8_alpha_N
    IPR004103 Lyase_8_C
    IPR003159 Lyase_8_central_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR38481 PTHR38481, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02278 Lyase_8, 1 hit
    PF02884 Lyase_8_C, 1 hit
    PF08124 Lyase_8_N, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48230 SSF48230, 1 hit
    SSF49863 SSF49863, 1 hit
    SSF74650 SSF74650, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9AQS0-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLSGILIAAL LMTLWGGWQP DIAHASDEFD ALRIKWATLL TGGPALDPAD
    60 70 80 90 100
    SDIAARTDKL AQDANDYWED MDLSSSRTYI WYALRGNGTS DNVNAVYERL
    110 120 130 140 150
    RTMALAATTV GSSLYGNADL KEDILDALDW LYVNSYNSTR SRSAYNWWHW
    160 170 180 190 200
    QLGIPMSLND IAVLLYDDIS AARMATYMDT IDYFTPSIGL TGANRAWQAI
    210 220 230 240 250
    VVGVRAVIVK DAVKLAAARN GLSGTGIFPY ATGGDGFYAD GSFVQHTTFA
    260 270 280 290 300
    YTGGYGSSVL ETTANLMYLL SGSTWSVSDP NQSNVWQWIY EAYRPLLYKG
    310 320 330 340 350
    AMMDMVRGRE ISRSYAQDHA VGHGIVASIV RLAQFAPAPH AAAFKQIAKR
    360 370 380 390 400
    VIQEDTFSSF YGDVSTDTIR LAKAIVDDPS IAPAAAPNLY KQYAAMDRAV
    410 420 430 440 450
    LQRPGFALGL ALYSTRISSY ESINSENGRG WYTGAGATYL YNQDLAQYSE
    460 470 480 490 500
    DYWPTVDAYR IPGTTVASGT PIASGTGTSS WTGGVSLAGQ YGASGMDLSY
    510 520 530 540 550
    GAYNLSARKS WFMFDDEIVA LGSGISSTAG IPIETVVDNR KLNGAGDNAW
    560 570 580 590 600
    TANGAALSTG LGVAQTLTGV NWVHLAGNTA DGSDIGYYFP GGATLQTKRE
    610 620 630 640 650
    ARTGTWKQIN NRPATPSTAV TRNYETMWID HGTNPSGASY GYVLLPNKTS
    660 670 680 690 700
    AQVGAYAADP AIEIVVNTSG VQSVKEKTLG LVGANFWTDT TQTADLITSN
    710 720 730 740 750
    KKASVMTREI ADERLEASVS DPTQANNGTI AIELARSAEG YSADPGITVT
    760 770 780 790 800
    QLAPTIKFTV NVNGAKGKSF HASFQLGEDT SGPVDPGEPE LPSVIVDNAD
    810 820 830 840 850
    SAGVTRTGTW KTASTQTDRY GANYLHDDNA GKGTKSVTFT PNLPIAGSYE
    860 870 880 890 900
    VYLMWPAHFN REDAVQVDVG HASGTTRTAV DQRSGGGVWH SIGTYEFLAG
    910 920 930
    SGGSVTIRND ALGSPDGYVV ADAVKFVAVG
    Length:930
    Mass (Da):99,313
    Last modified:June 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E8B69D3E94019C4
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB037178 Genomic DNA Translation: BAB21059.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB037178 Genomic DNA Translation: BAB21059.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1J0MX-ray2.30A26-777[»]
    1J0NX-ray2.40A26-777[»]
    1X1HX-ray2.30A26-777[»]
    1X1IX-ray1.80A26-777[»]
    1X1JX-ray2.10A26-777[»]
    2E22X-ray2.40A26-777[»]
    2E24X-ray2.15A26-777[»]
    SMRiQ9AQS0
    ModBaseiSearch...
    PDBe-KBiSearch...

    Chemistry databases

    DrugBankiDB04386 4,6-O-(1-Carboxyethylidene)-Beta-D-Glucose
    DB04597 4,6-O-(1-CARBOXYETHYLIDENE)-BETA-D-MANNOSE
    DB04596 4-O-{4,6-O-[(1S)-1-Carboxyethylidene]-Beta-D-mannopyranosyl}-D-glucopyranuronic acid

    Protein family/group databases

    CAZyiPL8 Polysaccharide Lyase Family 8

    Proteomic databases

    PRIDEiQ9AQS0

    Miscellaneous databases

    EvolutionaryTraceiQ9AQS0

    Family and domain databases

    CDDicd14488 CBM6-CBM35-CBM36_like_2, 1 hit
    Gene3Di1.50.10.100, 1 hit
    2.60.220.10, 1 hit
    2.70.98.10, 1 hit
    InterProiView protein in InterPro
    IPR033803 CBM6/CBM35/CBM36-like_2
    IPR008929 Chondroitin_lyas
    IPR011013 Gal_mutarotase_sf_dom
    IPR014718 GH-type_carb-bd
    IPR038970 Lyase_8
    IPR011071 Lyase_8-like_C
    IPR012970 Lyase_8_alpha_N
    IPR004103 Lyase_8_C
    IPR003159 Lyase_8_central_dom
    PANTHERiPTHR38481 PTHR38481, 1 hit
    PfamiView protein in Pfam
    PF02278 Lyase_8, 1 hit
    PF02884 Lyase_8_C, 1 hit
    PF08124 Lyase_8_N, 1 hit
    SUPFAMiSSF48230 SSF48230, 1 hit
    SSF49863 SSF49863, 1 hit
    SSF74650 SSF74650, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXANLY_BACGL
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9AQS0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
    Last sequence update: June 1, 2001
    Last modified: September 18, 2019
    This is version 81 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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