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Entry version 86 (11 Dec 2019)
Sequence version 1 (01 Jun 2001)
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Protein
Submitted name:

Sialidase

Gene

nanH

Organism
Erysipelothrix rhusiopathiae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM32 Carbohydrate-Binding Module Family 32
CBM40 Carbohydrate-Binding Module Family 40
GH33 Glycoside Hydrolase Family 33

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SialidaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nanHImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiErysipelothrix rhusiopathiaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1648 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesErysipelotrichiaErysipelotrichalesErysipelotrichaceaeErysipelothrix

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 232LAM_G_DOMAINInterPro annotationAdd BLAST179
Domaini368 – 429Cyclic nucleotide-bindingInterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1133 – 1156DisorderedSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108478 Bacteria
COG4409 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000595 cNMP-bd_dom
IPR013320 ConA-like_dom_sf
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR004124 Glyco_hydro_33_N
IPR001791 Laminin_G
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10628 PTHR10628, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13088 BNR_2, 1 hit
PF00754 F5_F8_type_C, 1 hit
PF02973 Sialidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 1 hit
SSF50939 SSF50939, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50025 LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9AJR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRLHLNHPY ITYMRGVFKL KKISNIFVVL LTLVLGISLY PSSIFAMNDL
60 70 80 90 100
NLNDLHLKGE GADISDHLSH IKEFNQGSLT LRFRSESLSS DLTALFSISN
110 120 130 140 150
ANLENNYFAL YYQNSTGKLG IEFRDETGKH IINTSGTSTQ LANANWHTVT
160 170 180 190 200
VLNHGNRVEI YADGILLASQ DNIDFTKIQS LPWNRMKVGG VARLKGENLW
210 220 230 240 250
PFSGKISSLN LTHDILDVDT IKTLHNDTAS TVDPSTSEAI ELYAPGQDGS
260 270 280 290 300
KNYRIPSLLT TQDGTVLAAI DKRITHQADW GNIDIAIRRS QDSGKTWSDT
310 320 330 340 350
EVIIDLKSDP NVSQENVNTN YQSSAFLIDA AMAQDNRNGR IYLLVDMFPE
360 370 380 390 400
SRGFFSVQNE DQDFGQPYVT KEDGTHIVLK GTDGKKYYAK ADGTVFDLNT
410 420 430 440 450
DIITNYRVVL ESEKGMPFND LGDLYEGDTY VGNIYLKKSP LRIRQTAYLW
460 470 480 490 500
LTHSDDDGQT WSSPHDITPQ VKADWMQFIG TGPGVGIQLK NGELAFPIYH
510 520 530 540 550
TNRHGGNSQS TSMIKSADGI TWHKTESLND NRNFNGQVLN SKTLNNGGAL
560 570 580 590 600
VTESQVVQLN NGTLKQFARN VSGKVLVGTS YDNGETWEND LETLPITDVY
610 620 630 640 650
SQMSALHYNH EGKEYILLAN PNGPKRTNGA VKLLQVLEGE RLVLLSNTHM
660 670 680 690 700
QSGNYEYNVV QPLPDGHFGL MYEHKKPENG DNMSMMFKRF SFEDLGVKDT
710 720 730 740 750
SSLSLDIQDT YLEIKSDKAL IPSSNLTLTY NTTQTTKPKR VDTNTLRFNL
760 770 780 790 800
AEPVTILNGF TEGYLETLDG KALNIANKQG LDESLETLKA LDFENLAPSV
810 820 830 840 850
KDAADQLITK AELLSDNPFT IGDFIQQIHA MIGAIDPTYI PNSMFDVTAS
860 870 880 890 900
SQEDEKGNTQ VEGPIGLAFD GDPSTFWHSK WGDKNPPFDV TVSFHHDMVV
910 920 930 940 950
NALTYLPRQD GTLNGVVTEY QILGKLGDAP LHVLNEGTLD TNLTKKIITF
960 970 980 990 1000
EDAHVDTLIF KVVKGLENYG NAAEITLHGK TYRAPLDYSS LNQVLKTLEN
1010 1020 1030 1040 1050
YNQSLYTEAS FKPLLELKEK AYELLDNSET TQEMIDEMVI NLNEFINNLE
1060 1070 1080 1090 1100
LSNYTLDSLR LKIQEVEDYM NTLDLALYTQ TSVQAVYDAL DSAKALLQTP
1110 1120 1130 1140 1150
RFSFRSLFKA STPNEAQIKE AIESLDSAVR GLSKREVETE EPSNPDENIT
1160 1170
PPIVDPLHLT HPKHVYGAVE
Length:1,170
Mass (Da):130,578
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i720953D13BDD15CA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB019122 Genomic DNA Translation: BAB40435.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019122 Genomic DNA Translation: BAB40435.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiCBM32 Carbohydrate-Binding Module Family 32
CBM40 Carbohydrate-Binding Module Family 40
GH33 Glycoside Hydrolase Family 33

Phylogenomic databases

eggNOGiENOG4108478 Bacteria
COG4409 LUCA

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR000595 cNMP-bd_dom
IPR013320 ConA-like_dom_sf
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR004124 Glyco_hydro_33_N
IPR001791 Laminin_G
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
PANTHERiPTHR10628 PTHR10628, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
PF00754 F5_F8_type_C, 1 hit
PF02973 Sialidase, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 1 hit
SSF50939 SSF50939, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50025 LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9AJR8_ERYRH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9AJR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: December 11, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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