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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per tetramer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi455MagnesiumUniRule annotation1
Metal bindingi461Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi464MagnesiumUniRule annotation1
Metal bindingi465MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAULO:CC1043-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
Short name:
PheRSUniRule annotation
Gene namesi
Name:pheTUniRule annotation
Ordered Locus Names:CC_1043
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001268631 – 799Phenylalanine--tRNA ligase beta subunitAdd BLAST799

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_1043

Structurei

3D structure databases

ProteinModelPortaliQ9A9E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 148tRNA-bindingUniRule annotationAdd BLAST110
Domaini403 – 477B5UniRule annotationAdd BLAST75
Domaini706 – 798FDX-ACBUniRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6A Bacteria
COG0072 LUCA
COG0073 LUCA
HOGENOMiHOG000292085
KOiK01890
OMAiLTPNRSD

Family and domain databases

CDDicd02796 tRNA_bind_bactPheRS, 1 hit
Gene3Di3.30.70.380, 1 hit
3.50.40.10, 1 hit
HAMAPiMF_00283 Phe_tRNA_synth_beta1, 1 hit
InterProiView protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR005121 Fdx_antiC-bd
IPR036690 Fdx_antiC-bd_sf
IPR012340 NA-bd_OB-fold
IPR004532 Phe-tRNA-ligase_IIc_bsu
IPR020825 Phe-tRNA_synthase_B3/B4
IPR002547 tRNA-bd_dom
IPR033714 tRNA_bind_bactPheRS
IPR005147 tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
PF03147 FDX-ACB, 1 hit
PF01588 tRNA_bind, 1 hit
SMARTiView protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit
SM00896 FDX-ACB, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF50249 SSF50249, 1 hit
SSF54991 SSF54991, 1 hit
TIGRFAMsiTIGR00472 pheT_bact, 1 hit
PROSITEiView protein in PROSITE
PS51483 B5, 1 hit
PS51447 FDX_ACB, 1 hit
PS50886 TRBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A9E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTLSWLKD HLETTATVPE IVAAMTMAGL EVEHVIDPAT KLAPFTVCKI
60 70 80 90 100
VEAARHPNAD RLQVCQVDTV DGRKEIVCGA PNARPGLTTI YAPIGAYVPG
110 120 130 140 150
LDVTLVEKPV RGVVSNGMLC SAAELEYASE SDGIMELEGS LAVGTPAVDA
160 170 180 190 200
LGLEAVIDFE VTPNRPDWLG VAGIARDLAA AGVGTLKDLS IAPIAGTYPS
210 220 230 240 250
PISVTVDGEA CPAFAGRYIR GVKNGPSPKW LQDRLTAIGL RPINALVDVT
260 270 280 290 300
NLISYDRARP LHVYDAHKLS GTQISTRLGR HGEHGDEHLI ALDGKTYELT
310 320 330 340 350
PEMCVIADAN GERPIGLGGV MGGESTGCSE DTVDVFVESA WFEPIRIAQT
360 370 380 390 400
GRTTGIASDA QYRFARTVDT GSLVPGIELA TKLILELCGG EPSEVVYVGE
410 420 430 440 450
VPAAPKGFAF DPDYVGQLSG LAVTPEKTHQ ILAALGFDVV LGSPWTVTPP
460 470 480 490 500
TFRRDVEGKA DLVEEVARIA GYGALPSTPL PEVPRAVGGI LTAKQARARA
510 520 530 540 550
ARRALAAAGY AEAVTFSFTN RKTASLFGGG QDVLVLANPI ASELDCMRPS
560 570 580 590 600
LLPNLIEAAG RNARQGFADA ALFEIGPTFH GDKPADQRTV VSAILAPKAP
610 620 630 640 650
RGWDKAAQGD VFTVKADLLA LLEELGAPVA SLQTAQGSAS SWWHPGRSAR
660 670 680 690 700
LQLGPKAVMA EFGEIHPAVL KALDVAGPVF GFEITLEAIP EPKKKSIKTK
710 720 730 740 750
PAFSPSALMP LTRDFAFLVE KAKAAGDLVK AAAGADKALI TAARVFDVYE
760 770 780 790
GPGVPDGFKS VAIEVVVQPR EATLTDAEIE ALSAKVVAAA EKAGGKLRS
Length:799
Mass (Da):83,872
Last modified:June 1, 2001 - v1
Checksum:i70EA95DEB73B4180
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK23027.1
PIRiG87378
RefSeqiNP_419859.1, NC_002696.2
WP_010918927.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK23027; AAK23027; CC_1043
GeneIDi940568
KEGGiccr:CC_1043
PATRICifig|190650.5.peg.1059

Similar proteinsi

Entry informationi

Entry nameiSYFB_CAUVC
AccessioniPrimary (citable) accession number: Q9A9E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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