UniProtKB - Q99PZ6 (OSPG_SHIFL)
Protein
Protein kinase OspG
Gene
ospG
Organism
Shigella flexneri
Status
Functioni
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is a kinase that is involved in down-regulation of the host innate response induced by invasive bacteria. Prevents or at least delays host phospho-NF-kappa-B inhibitor alpha (NFKBIA) degradation. Does not phosphorylate E2 enzymes.1 Publication
GO - Molecular functioni
- kinase activity Source: UniProtKB
GO - Biological processi
- pathogenesis Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Virulence |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ospG Ordered Locus Names:CP0227 ORF Names:pWR501_0237, SFLP087 |
Encoded oni | Plasmid pCP3011 Publication Plasmid pWR1002 Publications Plasmid pSF51 Publication |
Organismi | Shigella flexneri |
Taxonomic identifieri | 623 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Shigella |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: UniProtKB
Other locations
- host cell Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Disruption phenotypei
Mutant induces a stronger inflammatory reaction upon infection.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 53 | K → A: Lack of autophosphorylation. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395877 | 1 – 196 | Protein kinase OspGAdd BLAST | 196 |
Post-translational modificationi
Autophosphorylated.
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
Binds various host ubiquitinated E2 ubiquitin-conjugating enzymes, including UBE2D2 (UBCH5B).
1 PublicationBinary interactionsi
Hide detailsQ99PZ6
Protein-protein interaction databases
DIPi | DIP-60998N |
IntActi | Q99PZ6, 11 interactors |
MINTi | Q99PZ6 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q99PZ6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the protein kinase superfamily.Curated
Phylogenomic databases
HOGENOMi | CLU_120872_0_0_6 |
OMAi | YTEYYSA |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf |
SUPFAMi | SSF56112, SSF56112, 1 hit |
i Sequence
Sequence statusi: Complete.
Q99PZ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKITSTIIQT PFPFENNNSH AGIVTEPILG KLIGQGSTAE IFEDVNDSSA
60 70 80 90 100
LYKKYDLIGN QYNEILEMAW QESELFNAFY GDEASVVIQY GGDVYLRMLR
110 120 130 140 150
VPGTPLSDID TADIPDNIES LYLQLICKLN ELSIIHYDLN TGNMLYDKES
160 170 180 190
ESLFPIDFRN IYAEYYAATK KDKEIIDRRL QMRTNDFYSL LNRKYL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF386526 Genomic DNA Translation: AAL72314.1 AF348706 Genomic DNA Translation: AAK18547.1 AY879342 Genomic DNA Translation: AAW64846.1 AL391753 Genomic DNA Translation: CAC05855.1 |
RefSeqi | NP_085391.1, NC_002698.1 NP_858360.1, NC_004851.1 WP_000705601.1, NZ_WPGW01000288.1 YP_006960315.1, NC_019197.1 YP_009062537.1, NC_024996.1 |
Genome annotation databases
EnsemblBacteriai | AAL72314; AAL72314; SF_p0227 |
GeneIDi | 1238010 |
KEGGi | sfl:CP0227 |
PATRICi | fig|198214.7.peg.5485 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF386526 Genomic DNA Translation: AAL72314.1 AF348706 Genomic DNA Translation: AAK18547.1 AY879342 Genomic DNA Translation: AAW64846.1 AL391753 Genomic DNA Translation: CAC05855.1 |
RefSeqi | NP_085391.1, NC_002698.1 NP_858360.1, NC_004851.1 WP_000705601.1, NZ_WPGW01000288.1 YP_006960315.1, NC_019197.1 YP_009062537.1, NC_024996.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4BVU | X-ray | 2.70 | A | 1-196 | [»] | |
SMRi | Q99PZ6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-60998N |
IntActi | Q99PZ6, 11 interactors |
MINTi | Q99PZ6 |
Genome annotation databases
EnsemblBacteriai | AAL72314; AAL72314; SF_p0227 |
GeneIDi | 1238010 |
KEGGi | sfl:CP0227 |
PATRICi | fig|198214.7.peg.5485 |
Phylogenomic databases
HOGENOMi | CLU_120872_0_0_6 |
OMAi | YTEYYSA |
Miscellaneous databases
PROi | PR:Q99PZ6 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf |
SUPFAMi | SSF56112, SSF56112, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OSPG_SHIFL | |
Accessioni | Q99PZ6Primary (citable) accession number: Q99PZ6 Secondary accession number(s): Q7BCI9, Q7BEJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 10, 2010 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Plasmid, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families