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Protein

Kinesin-like protein KIF17

Gene

Kif17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi91 – 98ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • anterograde dendritic transport of neurotransmitter receptor complex Source: SynGO
  • cell projection organization Source: GO_Central
  • intraciliary transport Source: MGI
  • microtubule-based process Source: MGI
  • neurogenesis Source: GO_Central
  • protein-containing complex localization Source: MGI
  • protein transport Source: UniProtKB-KW
  • vesicle-mediated transport Source: MGI

Keywordsi

Molecular functionMotor protein
Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF17
Short name:
MmKIF17
Gene namesi
Name:Kif17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1098229 Kif17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254511 – 1038Kinesin-like protein KIF17Add BLAST1038

Proteomic databases

MaxQBiQ99PW8
PaxDbiQ99PW8
PRIDEiQ99PW8

PTM databases

iPTMnetiQ99PW8
PhosphoSitePlusiQ99PW8

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

BgeeiENSMUSG00000028758
CleanExiMM_KIF17
ExpressionAtlasiQ99PW8 baseline and differential
GenevisibleiQ99PW8 MM

Interactioni

Subunit structurei

Interacts with LIN-10 PDZ domain. Interacts with PIWIL1. Interacts with TBATA.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200934, 1 interactor
CORUMiQ99PW8
DIPiDIP-36586N
IntActiQ99PW8, 3 interactors
MINTiQ99PW8
STRINGi10090.ENSMUSP00000030539

Structurei

3D structure databases

ProteinModelPortaliQ99PW8
SMRiQ99PW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 335Kinesin motorPROSITE-ProRule annotationAdd BLAST331

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili346 – 470Sequence analysisAdd BLAST125
Coiled coili748 – 855Sequence analysisAdd BLAST108

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000143992
HOGENOMiHOG000116164
HOVERGENiHBG052255
InParanoidiQ99PW8
KOiK20198
OMAiILAQQMG
OrthoDBiEOG091G03RO
PhylomeDBiQ99PW8
TreeFamiTF105223

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99PW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASESVKVVV RCRPMNKRER ELSCQSVVTV DSARGQCFIQ NPGAADEPPK
60 70 80 90 100
QFTFDGAYYI EHFTEQIYNE IAYPLVEGVT EGYNGTIFAY GQTGSGKSFT
110 120 130 140 150
MQGLPDPPCQ RGIIPRAFEH VFESVQCAEN TKFLVRASYL EIYNEDVHDL
160 170 180 190 200
LGADTKQRLE LKEHPEKGVY VKGLSMHTVH NVAQCERVME TGWKNRAVGY
210 220 230 240 250
TLMNKDSSRS HSIFTINIEI YAVDERGKDH LRAGKLNLVD LAGSERQSKT
260 270 280 290 300
GATGERLKEA TKINLSLSAL GNVISALVDG RCKHIPYRDS KLTRLLQDSL
310 320 330 340 350
GGNTKTLMVA CLSPADNNYD ETLSTLRYAN RAKNIKNKPR INEDPKDALL
360 370 380 390 400
REYQEEIKRL KAILAQQMGP GNLSALLSTQ TPPGPVQSEE KLLSPTTVQQ
410 420 430 440 450
DTEAEKQLIR EEYEERLARL KADYEAEQES RVRLQEDITA MRNSYDVKLS
460 470 480 490 500
TLQENLRKEK ETEAILKAEV LCKTEVMSRA ELASGPEYSP PLQYETAVKP
510 520 530 540 550
TILSMPDMPP SGKVTKSQAP LAFEEPHGET SRSEFSFESN ECSTLEDSAT
560 570 580 590 600
SEAFPGPEEF SNMEFSMAAA LTESRYLPEE YLGGQEAAAS PLEAERYVQE
610 620 630 640 650
NEPSLEPLRI LASLQDPFAE VEAKLARLSS TVAMSDSSQT VVPQIPKQPS
660 670 680 690 700
SADLLEPSDT KSEADVAVAD NVVLGTEPDV NLRVAEEVVS EAETGVWMES
710 720 730 740 750
EAQVAHVAQV SEEAQPQPLL AMVSVRRESV GVEVAVLTEE ELQPVDQQQV
760 770 780 790 800
LARLQLLEQQ VVGGEQAKNK DLREKHKRRK RYADERKKQL VAALQNSDED
810 820 830 840 850
GGDWVLLNVY DSIQEEVRAK SKLLEKMQRK LRAAEVEIKD LQSEFQLEKI
860 870 880 890 900
DYLATIRRQE RDSMLFQQLL EQVQPLIRRD CNYSNLEKIR RESSWDEDNG
910 920 930 940 950
FWKIPDPIIL KTSLPVVPTG TQNKPARKTS AVDSGEPHMQ EEDRYKLMLS
960 970 980 990 1000
RSDSENIASN YFRSKRASQI LSTDPMKSLT YHNSPPGLNS SLSNNSALPP
1010 1020 1030
TQTPEMPQPR PFRLESLDIP FSKAKRKKSK NSFGGEPL
Length:1,038
Mass (Da):116,373
Last modified:June 1, 2001 - v1
Checksum:i2BED852A3AFDBD46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008867 mRNA Translation: BAB21099.1
AL807249 Genomic DNA No translation available.
CCDSiCCDS18823.1
RefSeqiNP_034753.1, NM_010623.4
UniGeneiMm.271936

Genome annotation databases

EnsembliENSMUST00000030539; ENSMUSP00000030539; ENSMUSG00000028758
GeneIDi16559
KEGGimmu:16559
UCSCiuc008vkq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKIF17_MOUSE
AccessioniPrimary (citable) accession number: Q99PW8
Secondary accession number(s): A2AM73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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