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Entry version 156 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

B-cell lymphoma/leukemia 11B

Gene

Bcl11b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals (PubMed:12717433). Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes (PubMed:16809611). Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri221 – 251C2H2-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri426 – 453C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri454 – 481C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri786 – 813C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri814 – 843C2H2-type 5PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri844 – 874C2H2-type 6PROSITE-ProRule annotationAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell lymphoma/leukemia 11B
Short name:
BCL-11B
Alternative name(s):
B-cell CLL/lymphoma 11B
COUP-TF-interacting protein 2
Radiation-induced tumor suppressor gene 1 protein
Short name:
mRit1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bcl11b
Synonyms:Ctip2, Rit1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1929913, Bcl11b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000471051 – 884B-cell lymphoma/leukemia 11BAdd BLAST884

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei96PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei128PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei256PhosphoserineBy similarity1
Modified residuei260PhosphothreonineCombined sources1
Modified residuei277PhosphoserineBy similarity1
Modified residuei293Omega-N-methylarginineCombined sources1
Modified residuei322Asymmetric dimethylarginineCombined sources1
Modified residuei358PhosphoserineBy similarity1
Modified residuei376PhosphothreonineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei398PhosphoserineBy similarity1
Modified residuei401PhosphoserineCombined sources1
Modified residuei406PhosphothreonineCombined sources1
Modified residuei416PhosphothreonineCombined sources1
Modified residuei482PhosphoserineBy similarity1
Modified residuei487PhosphoserineBy similarity1
Modified residuei495PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Cross-linki587Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei664PhosphoserineBy similarity1
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki713Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei744PhosphothreonineCombined sources1
Modified residuei755PhosphoserineBy similarity1
Modified residuei762PhosphoserineCombined sources1
Modified residuei841N6-acetyllysineBy similarity1
Cross-linki877Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99PV8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99PV8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99PV8

PeptideAtlas

More...
PeptideAtlasi
Q99PV8

PRoteomics IDEntifications database

More...
PRIDEi
Q99PV8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99PV8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99PV8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and thymus. Expressed in splenic CD4+ T-lymphocytes (PubMed:16809611).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in the developing embryo.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048251, Expressed in thymus and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99PV8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99PV8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TFCOUP1, SIRT1, ARP1 and EAR2 (PubMed:10744719, PubMed:12930829).

Interacts with EP300; the interaction is detected in activated T-lymphocytes, but not under resting conditions (By similarity).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
208391, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q99PV8, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000068258

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99PV8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99PV8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi560 – 647Gly-richAdd BLAST88

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri221 – 251C2H2-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri426 – 453C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri454 – 481C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri786 – 813C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri814 – 843C2H2-type 5PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri844 – 874C2H2-type 6PROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161060

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99PV8

KEGG Orthology (KO)

More...
KOi
K22046

Database of Orthologous Groups

More...
OrthoDBi
224109at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99PV8

TreeFam database of animal gene trees

More...
TreeFami
TF318131

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99PV8-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRKQGNPQ HLSQRELITP EADHVEATIL EEDEGLEIEE PSSLGLMVGG
60 70 80 90 100
PDPDLLTCGQ CQMNFPLGDI LVFIEHKKKQ CGGLGPCYDK VLDKSSPPPS
110 120 130 140 150
SRSELRRVSE PVEIGIQVTP DEDDHLLSPT KGICPKQENI AGPCRPAQLP
160 170 180 190 200
SMAPIAASSS HPPTSVITSP LRALGVLPPC FPLPCCGARP ISGDGTQGEG
210 220 230 240 250
QMEAPFGCQC ELSGKDEPSS YICTTCKQPF NSAWFLLQHA QNTHGFRIYL
260 270 280 290 300
EPGPASTSLT PRLTIPPPLG PETVAQSPLM NFLGDSNPFN LLRMTGPILR
310 320 330 340 350
DHPGFGEGRL PGTPPLFSPP PRHHLDPHRL SAEEMGLVAQ HPSAFDRVMR
360 370 380 390 400
LNPMAIDSPA MDFSRRLREL AGNSSTPPPV SPGRGNPMHR LLNPFQPSPK
410 420 430 440 450
SPFLSTPPLP PMPAGTPPPQ PPAKSKSCEF CGKTFKFQSN LIVHRRSHTG
460 470 480 490 500
EKPYKCQLCD HACSQASKLK RHMKTHMHKA GSLAGRSDDG LSAASSPEPG
510 520 530 540 550
TSELPGDLKA ADGDFRHHES DPSLGPEPED DEDEEEEEEE LLLENESRPE
560 570 580 590 600
SSFSMDSELG RGRENGGGVP PGVAGAGAAA AALADEKALA LGKVMEDAGL
610 620 630 640 650
GALPQYGEKR GAFLKRAGDT GDAGAVGCGD AGAPGAVNGR GGAFAPGAEP
660 670 680 690 700
FPALFPRKPA PLPSPGLGGP ALHAAKRIKV EKDLELPPAA LIPSENVYSQ
710 720 730 740 750
WLVGYAASRH FMKDPFLGFT DARQSPFATS SEHSSENGSL RFSTPPGDLL
760 770 780 790 800
DGGLSGRSGT ASGGSTPHLG GPGPGRPSSK EGRRSDTCEY CGKVFKNCSN
810 820 830 840 850
LTVHRRSHTG ERPYKCELCN YACAQSSKLT RHMKTHGQIG KEVYRCDICQ
860 870 880
MPFSVYSTLE KHMKKWHGEH LLTNDVKIEQ AERS
Length:884
Mass (Da):94,566
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A86B7E34450B2F2
GO
Isoform 2 (identifier: Q99PV8-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     142-213: Missing.

Note: May be due to exon skipping.Curated
Show »
Length:812
Mass (Da):87,336
Checksum:i4924D623215C11AB
GO
Isoform 3 (identifier: Q99PV8-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     21-214: Missing.

Note: May be due to exon skipping.Curated
Show »
Length:690
Mass (Da):74,174
Checksum:iE031A3FD8BD307F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1E1A0A0R4J1E1_MOUSE
B-cell lymphoma/leukemia 11B
Bcl11b
690Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF63683 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20P → R in BAB32730 (PubMed:12565905).Curated1
Sequence conflicti379P → S in AAF63683 (PubMed:10744719).Curated1
Sequence conflicti806 – 807RS → KN in AAF63683 (PubMed:10744719).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti676K → T in gamma induced thymic lymphomas. 1 Publication1
Natural varianti783R → C in gamma induced thymic lymphomas. 1 Publication1
Natural varianti849C → S in gamma induced thymic lymphomas. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00956621 – 214Missing in isoform 3. 1 PublicationAdd BLAST194
Alternative sequenceiVSP_009568142 – 213Missing in isoform 2. 3 PublicationsAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB043551 mRNA Translation: BAB32728.1
AB043553 mRNA Translation: BAB32729.1
AB043583 mRNA Translation: BAB32730.1
AF186019 mRNA Translation: AAF63683.1 Frameshift.
BC019503 mRNA Translation: AAH19503.1
AK088588 mRNA Translation: BAC40438.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36552.1 [Q99PV8-2]
CCDS36553.1 [Q99PV8-1]
CCDS70419.1 [Q99PV8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001073352.1, NM_001079883.1 [Q99PV8-1]
NP_001273272.1, NM_001286343.1
NP_067374.2, NM_021399.2 [Q99PV8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000066060; ENSMUSP00000068258; ENSMUSG00000048251 [Q99PV8-1]
ENSMUST00000109891; ENSMUSP00000105517; ENSMUSG00000048251 [Q99PV8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
58208

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:58208

UCSC genome browser

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UCSCi
uc007ozh.1, mouse [Q99PV8-1]
uc007ozi.1, mouse [Q99PV8-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043551 mRNA Translation: BAB32728.1
AB043553 mRNA Translation: BAB32729.1
AB043583 mRNA Translation: BAB32730.1
AF186019 mRNA Translation: AAF63683.1 Frameshift.
BC019503 mRNA Translation: AAH19503.1
AK088588 mRNA Translation: BAC40438.1
CCDSiCCDS36552.1 [Q99PV8-2]
CCDS36553.1 [Q99PV8-1]
CCDS70419.1 [Q99PV8-3]
RefSeqiNP_001073352.1, NM_001079883.1 [Q99PV8-1]
NP_001273272.1, NM_001286343.1
NP_067374.2, NM_021399.2 [Q99PV8-2]

3D structure databases

SMRiQ99PV8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi208391, 5 interactors
IntActiQ99PV8, 3 interactors
STRINGi10090.ENSMUSP00000068258

PTM databases

iPTMnetiQ99PV8
PhosphoSitePlusiQ99PV8

Proteomic databases

EPDiQ99PV8
jPOSTiQ99PV8
PaxDbiQ99PV8
PeptideAtlasiQ99PV8
PRIDEiQ99PV8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27407, 260 antibodies

Genome annotation databases

EnsembliENSMUST00000066060; ENSMUSP00000068258; ENSMUSG00000048251 [Q99PV8-1]
ENSMUST00000109891; ENSMUSP00000105517; ENSMUSG00000048251 [Q99PV8-2]
GeneIDi58208
KEGGimmu:58208
UCSCiuc007ozh.1, mouse [Q99PV8-1]
uc007ozi.1, mouse [Q99PV8-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64919
MGIiMGI:1929913, Bcl11b

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161060
InParanoidiQ99PV8
KOiK22046
OrthoDBi224109at2759
PhylomeDBiQ99PV8
TreeFamiTF318131

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
58208, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Bcl11b, mouse

Protein Ontology

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PROi
PR:Q99PV8
RNActiQ99PV8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048251, Expressed in thymus and 243 other tissues
ExpressionAtlasiQ99PV8, baseline and differential
GenevisibleiQ99PV8, MM

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 6 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBC11B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99PV8
Secondary accession number(s): Q8C2I1
, Q99PV6, Q99PV7, Q9JLF8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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