Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q99PU8 (DHX30_MOUSE)

Entry version 142 (25 May 2022)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
Add a publicationFeedback
Protein

ATP-dependent RNA helicase DHX30

Gene

Dhx30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent helicase (PubMed:25219788).

Plays an important role in the assembly of the mitochondrial large ribosomal subunit (By similarity).

Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity).

Associates with mitochondrial DNA (By similarity).

Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD (PubMed:25219788).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi480 – 487ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent RNA helicase DHX30Curated (EC:3.6.4.131 Publication)
Alternative name(s):
DEAH box protein 30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dhx30
Synonyms:Helg1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1920081, Dhx30

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000032480

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Mitochondrion nucleoid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002455391 – 1217ATP-dependent RNA helicase DHX30Add BLAST1217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei403PhosphoserineBy similarity1
Isoform 3 (identifier: Q99PU8-3)
Modified residuei15PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser-15.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99PU8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99PU8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99PU8

PeptideAtlas

More...PeptideAtlasi		Q99PU8

PRoteomics IDEntifications database

More...PRIDEi		Q99PU8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		279650 [Q99PU8-1]
279651 [Q99PU8-2]
279652 [Q99PU8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99PU8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99PU8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q99PU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney, and testis. Expression is strongest in the testis and brain, while the lowest levels of expression are found in the spleen and lung.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at low levels of expression at 3.5 and 6.5 days post coitum (dpc). At 7.5 dpc, it is detected in the ectoderm, mesoderm, and ectoplacental cone. By 8.5 dpc, expression is increased, specifically in the central nervous system, neural plate, and neural tube, which remains constant until 10.5 dpc where it decreases. By 11.5 to 15.5 dpc, expression is reduced further in the central nervous system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000032480, Expressed in substantia nigra and 319 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99PU8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99PU8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a complex with TFAM and SSBP1.

Interacts (via N-terminus) with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner.

Found in a complex with GRSF1, DDX28, FASTKD2 and FASTKD5.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		215593, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q99PU8, 2 interactors

Molecular INTeraction database

More...MINTi		Q99PU8

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000062622

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99PU8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q99PU8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99PU8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 144DRBMAdd BLAST69
Domaini467 – 635Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini677 – 850Helicase C-terminalPROSITE-ProRule annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni176 – 223DisorderedSequence analysisAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi582 – 585DEAH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DEAD box helicase family. DEAH subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0920, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158279

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99PU8

Database of Orthologous Groups

More...OrthoDBi		278674at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99PU8

TreeFam database of animal gene trees

More...TreeFami		TF352030

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR011709, DUF1605
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00270, DEAD, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF07717, OB_NTP_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99PU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVTPVCNSST WQPKDSSFLS WPEMFSLDSF RKDRTQHRQR QCKLPPPRLP 
        60         70         80         90        100
PMCVNPAPGG TITRASRDLL KEFPQPKNLL NSVIGRALGI SHAKDKLVYV 
       110        120        130        140        150
HTNGPKKKKV TLHIKWPKSV EVEGYGSKKI DAERQAAAAA CQLFKGWGLL 
       160        170        180        190        200
GPRNELFDAA KYRVLADRFG SPADSWWRPE PTMPPTSWRQ LNPENIRPGG 
       210        220        230        240        250
PAGLSRSLGR EEEEDEEEEL EEGTIDVTEF LSMTQQDSHN PLRDSRGGSF 
       260        270        280        290        300
EMTDDDSAIR ALTQFPLPKN LLAKVIQIAT SSSTAKNLMQ FHTVGTKTKL 
       310        320        330        340        350
ATLTLLWPCP MTFVAKGRRK AEAENKAAAL ACKKLKSLGL VDRNNEPLTH 
       360        370        380        390        400
AMYNLASLRE LGETQRRPCT IQVPEPILRK IEAFLSHYPV DSSWISPELR 
       410        420        430        440        450
LQSDDILPLG KDSGPLSDPI TGKPYMPLSE AEEVRLSQSL LELWRRRGPI 
       460        470        480        490        500
WQEAPQLPVD PHRDTILSAI EQHPVVVISG DTGCGKTTRI PQLLLERYVT 
       510        520        530        540        550
EGRGARCNVI ITQPRRISAV SVAQRVSHEL GPSLRRNVGF QVRLESKPPA 
       560        570        580        590        600
RGGALLFCTV GILLRKLQSN PSLEGVSHVI VDEVHERDVN TDFLLILLKG 
       610        620        630        640        650
LQRLNPALRL VLMSATGDNE RFSRYFGGCP VIKVPGFMYP VKEHYLEDIL 
       660        670        680        690        700
AKLGKHQYPH RHRHHESEDE CALDLDLVTD LVLHIDARGE PGGILCFLPG 
       710        720        730        740        750
WQEIKGVQQR LQEALGMHES KYLILPVHSN IPMMDQKAIF QQPPLGVRKI 
       760        770        780        790        800
VLATNIAETS ITVNDIVHVV DSGLHKEERY DLKTKVSCLE TVWVSRANVI 
       810        820        830        840        850
QRRGRAGRCQ SGFAYHLFPR SRLEKMVPFQ VPEILRTPLE NLVLQAKIHM 
       860        870        880        890        900
PEKTAVEFLS KAVDSPNIKA VDEAVILLQE IGVLDQREYL TTLGQRLAHI 
       910        920        930        940        950
STDPRLAKAI VLAAIFRCLH PLLVVVSCLT RDPFSSSLQN RAEVDKVKAL 
       960        970        980        990       1000
LSHDSGSDHL AFVRAVAGWE EVLRWQDRTS RENYLEENLL YAPSLRFIHG 
      1010       1020       1030       1040       1050
LIKQFSENIY EAFLVGKPSD CTLPSAQCNE YSEEEELVKG VLMAGLYPNL 
      1060       1070       1080       1090       1100
IQVRQGKVTR QGKFKPNSVT YRTKSGNILL HKSTINREAT RLRSRWLTYF 
      1110       1120       1130       1140       1150
MAVKSNGSVF VRDSSQVHPL AVLLLTDGDV HIRDDGRRAT ISLSDSDLLR 
      1160       1170       1180       1190       1200
LEGDSRTVRL LREFRRALGR MVERSLRSEL AALPLSVQQE HGQLLALLAE 
      1210 
LLRGPCGSFD MRKTADD
Length:1,217
Mass (Da):136,668
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6157413C98A1200
GO
Isoform 2 (identifier: Q99PU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:1,194
Mass (Da):134,059
Checksum:iCC8CAA05C68C1CF8
GO
Isoform 3 (identifier: Q99PU8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: MVTPVCNSST...NPAPGGTITR → MAAARRLMAL...PGEGDGSMVN

Show »
Length:1,223
Mass (Da):136,487
Checksum:i2DB769E729F6D469
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGL8A0A0G2JGL8_MOUSE
RNA helicase
Dhx30
1,186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEN0A0A0G2JEN0_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGU3A0A0G2JGU3_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGY7A0A0G2JGY7_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JE53A0A0G2JE53_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEN9A0A0G2JEN9_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGD9A0A0G2JGD9_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEY7A0A0G2JEY7_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFR1A0A0G2JFR1_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGL1A0A0G2JGL1_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45P → H in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti83V → G in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti142Q → E in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti168R → C in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti180E → D in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti272L → M in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti342D → G in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti663R → W in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti663R → W in BAE32286 (PubMed:16141072).Curated1
Sequence conflicti783K → R in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti822R → Q in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti991Y → H in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti1211M → V in AAH16202 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0197461 – 64MVTPV…GTITR → MAAARRLMALAAGVSPRLRP PDPLVASGRQGCSRGFSSSF VRSDGTQEAAEVESEVAPSE PGEGDGSMVN in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_0197471 – 23Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB047557 mRNA Translation: BAB32789.1
AK146326 mRNA Translation: BAE27081.1
AK148778 mRNA Translation: BAE28661.1
AK153969 mRNA Translation: BAE32286.1
BC004082 mRNA Translation: AAH04082.1
BC016202 mRNA Translation: AAH16202.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS23560.1 [Q99PU8-1]
CCDS57705.1 [Q99PU8-3]
CCDS57706.1 [Q99PU8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001239611.1, NM_001252682.1 [Q99PU8-2]
NP_001239612.1, NM_001252683.1 [Q99PU8-3]
NP_579925.1, NM_133347.2 [Q99PU8-1]
XP_006512361.1, XM_006512298.3 [Q99PU8-1]
XP_006512362.1, XM_006512299.1 [Q99PU8-1]
XP_006512363.1, XM_006512300.1 [Q99PU8-1]
XP_006512364.1, XM_006512301.3 [Q99PU8-1]
XP_006512366.1, XM_006512303.1 [Q99PU8-2]
XP_006512367.1, XM_006512304.1 [Q99PU8-2]
XP_006512368.1, XM_006512305.3 [Q99PU8-2]
XP_011241331.1, XM_011243029.2 [Q99PU8-1]
XP_017169102.1, XM_017313613.1
XP_017169103.1, XM_017313614.1 [Q99PU8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000062368; ENSMUSP00000062622; ENSMUSG00000032480 [Q99PU8-3]
ENSMUST00000111991; ENSMUSP00000107622; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000165596; ENSMUSP00000129174; ENSMUSG00000032480 [Q99PU8-1]
ENSMUST00000197928; ENSMUSP00000142549; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000198425; ENSMUSP00000142659; ENSMUSG00000032480 [Q99PU8-1]
ENSMUST00000199529; ENSMUSP00000142489; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000200066; ENSMUSP00000143371; ENSMUSG00000032480 [Q99PU8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		72831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:72831

UCSC genome browser

More...UCSCi		uc009rtg.2, mouse [Q99PU8-3]
uc009rth.2, mouse [Q99PU8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047557 mRNA Translation: BAB32789.1
AK146326 mRNA Translation: BAE27081.1
AK148778 mRNA Translation: BAE28661.1
AK153969 mRNA Translation: BAE32286.1
BC004082 mRNA Translation: AAH04082.1
BC016202 mRNA Translation: AAH16202.1
CCDSiCCDS23560.1 [Q99PU8-1]
CCDS57705.1 [Q99PU8-3]
CCDS57706.1 [Q99PU8-2]
RefSeqiNP_001239611.1, NM_001252682.1 [Q99PU8-2]
NP_001239612.1, NM_001252683.1 [Q99PU8-3]
NP_579925.1, NM_133347.2 [Q99PU8-1]
XP_006512361.1, XM_006512298.3 [Q99PU8-1]
XP_006512362.1, XM_006512299.1 [Q99PU8-1]
XP_006512363.1, XM_006512300.1 [Q99PU8-1]
XP_006512364.1, XM_006512301.3 [Q99PU8-1]
XP_006512366.1, XM_006512303.1 [Q99PU8-2]
XP_006512367.1, XM_006512304.1 [Q99PU8-2]
XP_006512368.1, XM_006512305.3 [Q99PU8-2]
XP_011241331.1, XM_011243029.2 [Q99PU8-1]
XP_017169102.1, XM_017313613.1
XP_017169103.1, XM_017313614.1 [Q99PU8-1]

3D structure databases

AlphaFoldDBiQ99PU8
SMRiQ99PU8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi215593, 8 interactors
IntActiQ99PU8, 2 interactors
MINTiQ99PU8
STRINGi10090.ENSMUSP00000062622

PTM databases

iPTMnetiQ99PU8
PhosphoSitePlusiQ99PU8
SwissPalmiQ99PU8

Proteomic databases

EPDiQ99PU8
MaxQBiQ99PU8
PaxDbiQ99PU8
PeptideAtlasiQ99PU8
PRIDEiQ99PU8
ProteomicsDBi279650 [Q99PU8-1]
279651 [Q99PU8-2]
279652 [Q99PU8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13009, 163 antibodies from 23 providers

The DNASU plasmid repository

More...DNASUi		72831

Genome annotation databases

EnsembliENSMUST00000062368; ENSMUSP00000062622; ENSMUSG00000032480 [Q99PU8-3]
ENSMUST00000111991; ENSMUSP00000107622; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000165596; ENSMUSP00000129174; ENSMUSG00000032480 [Q99PU8-1]
ENSMUST00000197928; ENSMUSP00000142549; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000198425; ENSMUSP00000142659; ENSMUSG00000032480 [Q99PU8-1]
ENSMUST00000199529; ENSMUSP00000142489; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000200066; ENSMUSP00000143371; ENSMUSG00000032480 [Q99PU8-2]
GeneIDi72831
KEGGimmu:72831
UCSCiuc009rtg.2, mouse [Q99PU8-3]
uc009rth.2, mouse [Q99PU8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22907
MGIiMGI:1920081, Dhx30
VEuPathDBiHostDB:ENSMUSG00000032480

Phylogenomic databases

eggNOGiKOG0920, Eukaryota
GeneTreeiENSGT00940000158279
InParanoidiQ99PU8
OrthoDBi278674at2759
PhylomeDBiQ99PU8
TreeFamiTF352030

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		72831, 17 hits in 73 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Dhx30, mouse

Protein Ontology

More...PROi		PR:Q99PU8
RNActiQ99PU8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000032480, Expressed in substantia nigra and 319 other tissues
ExpressionAtlasiQ99PU8, baseline and differential
GenevisibleiQ99PU8, MM

Family and domain databases

Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR011709, DUF1605
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF07717, OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHX30_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99PU8
Secondary accession number(s): Q3U4Z4
, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2001
Last modified: May 25, 2022
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again