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Protein

ATP-dependent RNA helicase DHX30

Gene

Dhx30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent helicase (PubMed:25219788). Plays an important role in the assembly of the mitochondrial large ribosomal subunit (By similarity). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (By similarity). Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD (PubMed:25219788).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi480 – 487ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent RNA helicase DHX30Curated (EC:3.6.4.131 Publication)
Alternative name(s):
DEAH box protein 30
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dhx30
Synonyms:Helg1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920081 Dhx30

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Mitochondrion nucleoid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002455391 – 1217ATP-dependent RNA helicase DHX30Add BLAST1217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei403PhosphoserineBy similarity1
Isoform 3 (identifier: Q99PU8-3)
Modified residuei15PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 3: Phosphorylated on Ser-15.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99PU8

PeptideAtlas

More...
PeptideAtlasi
Q99PU8

PRoteomics IDEntifications database

More...
PRIDEi
Q99PU8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99PU8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99PU8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99PU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney, and testis. Expression is strongest in the testis and brain, while the lowest levels of expression are found in the spleen and lung.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at low levels of expression at 3.5 and 6.5 days post coitum (dpc). At 7.5 dpc, it is detected in the ectoderm, mesoderm, and ectoplacental cone. By 8.5 dpc, expression is increased, specifically in the central nervous system, neural plate, and neural tube, which remains constant until 10.5 dpc where it decreases. By 11.5 to 15.5 dpc, expression is reduced further in the central nervous system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032480 Expressed in 298 organ(s), highest expression level in substantia nigra

CleanEx database of gene expression profiles

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CleanExi
MM_DHX30

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99PU8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99PU8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a complex with TFAM and SSBP1. Interacts (via N-terminus) with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Found in a complex with GRSF1, DDX28, FASTKD2 and FASTKD5.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
215593, 2 interactors

Protein interaction database and analysis system

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IntActi
Q99PU8, 2 interactors

Molecular INTeraction database

More...
MINTi
Q99PU8

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000062622

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q99PU8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99PU8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 144DRBMAdd BLAST69
Domaini467 – 635Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini677 – 850Helicase C-terminalPROSITE-ProRule annotationAdd BLAST174

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi582 – 585DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi211 – 222Poly-GluAdd BLAST12
Compositional biasi1033 – 1036Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0920 Eukaryota
COG1643 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112212

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG081437

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99PU8

KEGG Orthology (KO)

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KOi
K13185

Database of Orthologous Groups

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OrthoDBi
278674at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99PU8

TreeFam database of animal gene trees

More...
TreeFami
TF352030

Family and domain databases

Conserved Domains Database

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CDDi
cd00079 HELICc, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99PU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVTPVCNSST WQPKDSSFLS WPEMFSLDSF RKDRTQHRQR QCKLPPPRLP
60 70 80 90 100
PMCVNPAPGG TITRASRDLL KEFPQPKNLL NSVIGRALGI SHAKDKLVYV
110 120 130 140 150
HTNGPKKKKV TLHIKWPKSV EVEGYGSKKI DAERQAAAAA CQLFKGWGLL
160 170 180 190 200
GPRNELFDAA KYRVLADRFG SPADSWWRPE PTMPPTSWRQ LNPENIRPGG
210 220 230 240 250
PAGLSRSLGR EEEEDEEEEL EEGTIDVTEF LSMTQQDSHN PLRDSRGGSF
260 270 280 290 300
EMTDDDSAIR ALTQFPLPKN LLAKVIQIAT SSSTAKNLMQ FHTVGTKTKL
310 320 330 340 350
ATLTLLWPCP MTFVAKGRRK AEAENKAAAL ACKKLKSLGL VDRNNEPLTH
360 370 380 390 400
AMYNLASLRE LGETQRRPCT IQVPEPILRK IEAFLSHYPV DSSWISPELR
410 420 430 440 450
LQSDDILPLG KDSGPLSDPI TGKPYMPLSE AEEVRLSQSL LELWRRRGPI
460 470 480 490 500
WQEAPQLPVD PHRDTILSAI EQHPVVVISG DTGCGKTTRI PQLLLERYVT
510 520 530 540 550
EGRGARCNVI ITQPRRISAV SVAQRVSHEL GPSLRRNVGF QVRLESKPPA
560 570 580 590 600
RGGALLFCTV GILLRKLQSN PSLEGVSHVI VDEVHERDVN TDFLLILLKG
610 620 630 640 650
LQRLNPALRL VLMSATGDNE RFSRYFGGCP VIKVPGFMYP VKEHYLEDIL
660 670 680 690 700
AKLGKHQYPH RHRHHESEDE CALDLDLVTD LVLHIDARGE PGGILCFLPG
710 720 730 740 750
WQEIKGVQQR LQEALGMHES KYLILPVHSN IPMMDQKAIF QQPPLGVRKI
760 770 780 790 800
VLATNIAETS ITVNDIVHVV DSGLHKEERY DLKTKVSCLE TVWVSRANVI
810 820 830 840 850
QRRGRAGRCQ SGFAYHLFPR SRLEKMVPFQ VPEILRTPLE NLVLQAKIHM
860 870 880 890 900
PEKTAVEFLS KAVDSPNIKA VDEAVILLQE IGVLDQREYL TTLGQRLAHI
910 920 930 940 950
STDPRLAKAI VLAAIFRCLH PLLVVVSCLT RDPFSSSLQN RAEVDKVKAL
960 970 980 990 1000
LSHDSGSDHL AFVRAVAGWE EVLRWQDRTS RENYLEENLL YAPSLRFIHG
1010 1020 1030 1040 1050
LIKQFSENIY EAFLVGKPSD CTLPSAQCNE YSEEEELVKG VLMAGLYPNL
1060 1070 1080 1090 1100
IQVRQGKVTR QGKFKPNSVT YRTKSGNILL HKSTINREAT RLRSRWLTYF
1110 1120 1130 1140 1150
MAVKSNGSVF VRDSSQVHPL AVLLLTDGDV HIRDDGRRAT ISLSDSDLLR
1160 1170 1180 1190 1200
LEGDSRTVRL LREFRRALGR MVERSLRSEL AALPLSVQQE HGQLLALLAE
1210
LLRGPCGSFD MRKTADD
Length:1,217
Mass (Da):136,668
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6157413C98A1200
GO
Isoform 2 (identifier: Q99PU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.
Show »
Length:1,194
Mass (Da):134,059
Checksum:iCC8CAA05C68C1CF8
GO
Isoform 3 (identifier: Q99PU8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: MVTPVCNSST...NPAPGGTITR → MAAARRLMAL...PGEGDGSMVN

Show »
Length:1,223
Mass (Da):136,487
Checksum:i2DB769E729F6D469
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGL8A0A0G2JGL8_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
1,186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGD9A0A0G2JGD9_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFR1A0A0G2JFR1_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JE53A0A0G2JE53_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGY7A0A0G2JGY7_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEN0A0A0G2JEN0_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGU3A0A0G2JGU3_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEN9A0A0G2JEN9_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGL1A0A0G2JGL1_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEY7A0A0G2JEY7_MOUSE
ATP-dependent RNA helicase DHX30
Dhx30
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45P → H in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti83V → G in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti142Q → E in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti168R → C in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti180E → D in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti272L → M in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti342D → G in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti663R → W in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti663R → W in BAE32286 (PubMed:16141072).Curated1
Sequence conflicti783K → R in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti822R → Q in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti991Y → H in BAE27081 (PubMed:16141072).Curated1
Sequence conflicti1211M → V in AAH16202 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0197461 – 64MVTPV…GTITR → MAAARRLMALAAGVSPRLRP PDPLVASGRQGCSRGFSSSF VRSDGTQEAAEVESEVAPSE PGEGDGSMVN in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_0197471 – 23Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB047557 mRNA Translation: BAB32789.1
AK146326 mRNA Translation: BAE27081.1
AK148778 mRNA Translation: BAE28661.1
AK153969 mRNA Translation: BAE32286.1
BC004082 mRNA Translation: AAH04082.1
BC016202 mRNA Translation: AAH16202.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS23560.1 [Q99PU8-1]
CCDS57705.1 [Q99PU8-3]
CCDS57706.1 [Q99PU8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001239611.1, NM_001252682.1 [Q99PU8-2]
NP_001239612.1, NM_001252683.1 [Q99PU8-3]
NP_579925.1, NM_133347.2 [Q99PU8-1]
XP_006512361.1, XM_006512298.3 [Q99PU8-1]
XP_006512362.1, XM_006512299.1 [Q99PU8-1]
XP_006512363.1, XM_006512300.1 [Q99PU8-1]
XP_006512364.1, XM_006512301.3 [Q99PU8-1]
XP_006512366.1, XM_006512303.1 [Q99PU8-2]
XP_006512367.1, XM_006512304.1 [Q99PU8-2]
XP_006512368.1, XM_006512305.3 [Q99PU8-2]
XP_011241331.1, XM_011243029.2 [Q99PU8-1]
XP_017169102.1, XM_017313613.1 [Q99PU8-1]
XP_017169103.1, XM_017313614.1 [Q99PU8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.276305

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000062368; ENSMUSP00000062622; ENSMUSG00000032480 [Q99PU8-3]
ENSMUST00000111991; ENSMUSP00000107622; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000165596; ENSMUSP00000129174; ENSMUSG00000032480 [Q99PU8-1]
ENSMUST00000197928; ENSMUSP00000142549; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000198425; ENSMUSP00000142659; ENSMUSG00000032480 [Q99PU8-1]
ENSMUST00000199529; ENSMUSP00000142489; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000200066; ENSMUSP00000143371; ENSMUSG00000032480 [Q99PU8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
72831

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:72831

UCSC genome browser

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UCSCi
uc009rtg.2 mouse [Q99PU8-3]
uc009rth.2 mouse [Q99PU8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047557 mRNA Translation: BAB32789.1
AK146326 mRNA Translation: BAE27081.1
AK148778 mRNA Translation: BAE28661.1
AK153969 mRNA Translation: BAE32286.1
BC004082 mRNA Translation: AAH04082.1
BC016202 mRNA Translation: AAH16202.1
CCDSiCCDS23560.1 [Q99PU8-1]
CCDS57705.1 [Q99PU8-3]
CCDS57706.1 [Q99PU8-2]
RefSeqiNP_001239611.1, NM_001252682.1 [Q99PU8-2]
NP_001239612.1, NM_001252683.1 [Q99PU8-3]
NP_579925.1, NM_133347.2 [Q99PU8-1]
XP_006512361.1, XM_006512298.3 [Q99PU8-1]
XP_006512362.1, XM_006512299.1 [Q99PU8-1]
XP_006512363.1, XM_006512300.1 [Q99PU8-1]
XP_006512364.1, XM_006512301.3 [Q99PU8-1]
XP_006512366.1, XM_006512303.1 [Q99PU8-2]
XP_006512367.1, XM_006512304.1 [Q99PU8-2]
XP_006512368.1, XM_006512305.3 [Q99PU8-2]
XP_011241331.1, XM_011243029.2 [Q99PU8-1]
XP_017169102.1, XM_017313613.1 [Q99PU8-1]
XP_017169103.1, XM_017313614.1 [Q99PU8-1]
UniGeneiMm.276305

3D structure databases

ProteinModelPortaliQ99PU8
SMRiQ99PU8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215593, 2 interactors
IntActiQ99PU8, 2 interactors
MINTiQ99PU8
STRINGi10090.ENSMUSP00000062622

PTM databases

iPTMnetiQ99PU8
PhosphoSitePlusiQ99PU8
SwissPalmiQ99PU8

Proteomic databases

PaxDbiQ99PU8
PeptideAtlasiQ99PU8
PRIDEiQ99PU8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062368; ENSMUSP00000062622; ENSMUSG00000032480 [Q99PU8-3]
ENSMUST00000111991; ENSMUSP00000107622; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000165596; ENSMUSP00000129174; ENSMUSG00000032480 [Q99PU8-1]
ENSMUST00000197928; ENSMUSP00000142549; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000198425; ENSMUSP00000142659; ENSMUSG00000032480 [Q99PU8-1]
ENSMUST00000199529; ENSMUSP00000142489; ENSMUSG00000032480 [Q99PU8-2]
ENSMUST00000200066; ENSMUSP00000143371; ENSMUSG00000032480 [Q99PU8-2]
GeneIDi72831
KEGGimmu:72831
UCSCiuc009rtg.2 mouse [Q99PU8-3]
uc009rth.2 mouse [Q99PU8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22907
MGIiMGI:1920081 Dhx30

Phylogenomic databases

eggNOGiKOG0920 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00940000158279
HOGENOMiHOG000112212
HOVERGENiHBG081437
InParanoidiQ99PU8
KOiK13185
OrthoDBi278674at2759
PhylomeDBiQ99PU8
TreeFamiTF352030

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dhx30 mouse

Protein Ontology

More...
PROi
PR:Q99PU8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032480 Expressed in 298 organ(s), highest expression level in substantia nigra
CleanExiMM_DHX30
ExpressionAtlasiQ99PU8 baseline and differential
GenevisibleiQ99PU8 MM

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHX30_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99PU8
Secondary accession number(s): Q3U4Z4
, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2001
Last modified: January 16, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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