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Protein

Heat shock protein beta-2

Gene

Hspb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the kinase DMPK.By similarity

GO - Molecular functioni

GO - Biological processi

  • response to heat Source: MGI
  • somatic muscle development Source: MGI

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-2
Short name:
HspB2
Gene namesi
Name:Hspb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916503 Hspb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259341 – 182Heat shock protein beta-2Add BLAST182

Proteomic databases

PaxDbiQ99PR8
PRIDEiQ99PR8

PTM databases

PhosphoSitePlusiQ99PR8

Expressioni

Gene expression databases

BgeeiENSMUSG00000038086 Expressed in 162 organ(s), highest expression level in soleus muscle
CleanExiMM_HSPB2
GenevisibleiQ99PR8 MM

Interactioni

Subunit structurei

Interacts with DMPK; may enhance its kinase activity.By similarity

Protein-protein interaction databases

BioGridi213316, 70 interactors
IntActiQ99PR8, 2 interactors
MINTiQ99PR8
STRINGi10090.ENSMUSP00000042374

Structurei

3D structure databases

ProteinModelPortaliQ99PR8
SMRiQ99PR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 163sHSPPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233954
HOVERGENiHBG054766
InParanoidiQ99PR8
KOiK09543
OMAiHGYYIRP
OrthoDBiEOG091G0USC
TreeFamiTF105049

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR003090 Alpha-crystallin_N
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00525 Crystallin, 1 hit
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q99PR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGRTVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR
60 70 80 90 100
PRAARAGEGA RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS
110 120 130 140 150
ARHPQRLDRH GFVSREFCRT YVLPADVDPW RVRAALSHDG ILNLEAPRGG
160 170 180
RHLDTEVNEV YISLLPAPPD PEEEEEIARV EP
Length:182
Mass (Da):20,375
Last modified:October 3, 2012 - v2
Checksum:i40E7E69EEB887A39
GO
Isoform 2 (identifier: Q99PR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-125: Missing.

Note: No experimental confirmation available.
Show »
Length:88
Mass (Da):9,810
Checksum:i6251C2B7224B482D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54A → T in AAK13576 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01016032 – 125Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126248 Genomic DNA Translation: AAK13576.1
AK012780 mRNA Translation: BAB28465.1
AC113987 Genomic DNA No translation available.
AC123614 Genomic DNA No translation available.
CCDSiCCDS23171.1 [Q99PR8-1]
RefSeqiNP_001158180.1, NM_001164708.1 [Q99PR8-2]
NP_077761.3, NM_024441.3 [Q99PR8-1]
UniGeneiMm.1980

Genome annotation databases

EnsembliENSMUST00000042790; ENSMUSP00000042374; ENSMUSG00000038086 [Q99PR8-1]
ENSMUST00000217159; ENSMUSP00000148970; ENSMUSG00000038086 [Q99PR8-2]
GeneIDi69253
KEGGimmu:69253
UCSCiuc009pkj.2 mouse [Q99PR8-1]
uc009pkk.2 mouse [Q99PR8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126248 Genomic DNA Translation: AAK13576.1
AK012780 mRNA Translation: BAB28465.1
AC113987 Genomic DNA No translation available.
AC123614 Genomic DNA No translation available.
CCDSiCCDS23171.1 [Q99PR8-1]
RefSeqiNP_001158180.1, NM_001164708.1 [Q99PR8-2]
NP_077761.3, NM_024441.3 [Q99PR8-1]
UniGeneiMm.1980

3D structure databases

ProteinModelPortaliQ99PR8
SMRiQ99PR8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213316, 70 interactors
IntActiQ99PR8, 2 interactors
MINTiQ99PR8
STRINGi10090.ENSMUSP00000042374

PTM databases

PhosphoSitePlusiQ99PR8

Proteomic databases

PaxDbiQ99PR8
PRIDEiQ99PR8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042790; ENSMUSP00000042374; ENSMUSG00000038086 [Q99PR8-1]
ENSMUST00000217159; ENSMUSP00000148970; ENSMUSG00000038086 [Q99PR8-2]
GeneIDi69253
KEGGimmu:69253
UCSCiuc009pkj.2 mouse [Q99PR8-1]
uc009pkk.2 mouse [Q99PR8-2]

Organism-specific databases

CTDi3316
MGIiMGI:1916503 Hspb2

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233954
HOVERGENiHBG054766
InParanoidiQ99PR8
KOiK09543
OMAiHGYYIRP
OrthoDBiEOG091G0USC
TreeFamiTF105049

Miscellaneous databases

PROiPR:Q99PR8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038086 Expressed in 162 organ(s), highest expression level in soleus muscle
CleanExiMM_HSPB2
GenevisibleiQ99PR8 MM

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR003090 Alpha-crystallin_N
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00525 Crystallin, 1 hit
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB2_MOUSE
AccessioniPrimary (citable) accession number: Q99PR8
Secondary accession number(s): E9QKE3, Q9CZC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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