Pomt1

Functionⁱ

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.By similarity

Catalytic activityⁱ

Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.By similarity

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functionⁱ

dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ER-associated misfolded protein catabolic process Source: GO_Central
extracellular matrix organization Source: Ensembl
positive regulation of protein O-linked glycosylation
Source: RGD
Inferred from direct assayⁱ
- 16704966

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase

Molecular function

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAⁱ	2.4.1.109 5301
Reactomeⁱ	R-RNO-5173105 O-linked glycosylation
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT39 Glycosyltransferase Family 39

CAZyⁱ

GT39 Glycosyltransferase Family 39

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein O-mannosyl-transferase 1 (EC:2.4.1.109) Alternative name(s): Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Gene namesⁱ	Name:Pomt1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

Rat genome database More...RGDⁱ	620078 Pomt1

RGDⁱ

620078 Pomt1

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	30 – 50	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	90 – 110	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	121 – 141	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	176 – 196	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	205 – 225	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	228 – 248	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	267 – 287	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	597 – 617	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	636 – 656	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	660 – 680	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000121486	1 – 747	Protein O-mannosyl-transferase 1Add BLAST		747

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	435	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	471	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	539	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q99PR0
PRIDEⁱ	Q99PR0

PTM databases

UniCarbKBⁱ	Q99PR0

UniCarbKBⁱ

Q99PR0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000010477
ExpressionAtlasⁱ	Q99PR0 baseline and differential
Genevisibleⁱ	Q99PR0 RN

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000015214

STRINGⁱ

10116.ENSRNOP00000015214

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99PR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	318 – 381	MIR 1PROSITE-ProRule annotationAdd BLAST	64
Domainⁱ	392 – 449	MIR 2PROSITE-ProRule annotationAdd BLAST	58
Domainⁱ	453 – 513	MIR 3PROSITE-ProRule annotationAdd BLAST	61

Sequence similaritiesⁱ

Belongs to the glycosyltransferase 39 family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3359 Eukaryota COG1928 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144161
HOGENOMⁱ	HOG000157526
HOVERGENⁱ	HBG053637
InParanoidⁱ	Q99PR0
KEGG Orthology (KO) More...KOⁱ	K00728
OMAⁱ	WWIVKDP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02QX
PhylomeDBⁱ	Q99PR0
TreeFamⁱ	TF300552

Family and domain databases

InterProⁱ	View protein in InterPro IPR027005 GlyclTrfase_39-like IPR003342 Glyco_trans_39/83 IPR036300 MIR_dom_sf IPR016093 MIR_motif IPR032421 PMT_4TMC
PANTHERⁱ	PTHR10050 PTHR10050, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02815 MIR, 1 hit PF02366 PMT, 1 hit PF16192 PMT_4TMC, 1 hit
SMARTⁱ	View protein in SMART SM00472 MIR, 3 hits
SUPFAMⁱ	SSF82109 SSF82109, 1 hit
PROSITEⁱ	View protein in PROSITE PS50919 MIR, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99PR0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNRSMGRED TLGVLPSLLF CKMLRFLKRP LVVTIDINLN LVALTVLGLL 
        60         70         80         90        100
TRLWQLSYPR AVVFDEVYYG QYISFYMKRV FFLDDSGPPF GHMLLALGGW 
       110        120        130        140        150
LGGFDGNFLW NRIGAEYSSN VPVWSLRLLP ALAGALSVPM AYQIVLELHF 
       160        170        180        190        200
SHCTAMGAAL LMLIENALIT QSRLMLLESI LIFFNLLAVL SYLKFFNSQT 
       210        220        230        240        250
HSPFSVHWWL WLMLTGVSCS CAVGIKYMGI FTYLLVLSIA AVHAWHLIGD 
       260        270        280        290        300
QTLSNICVLS HLLARAVALL VVPVFLYLLF FYVHLMLLYR SGPHDQIMSS 
       310        320        330        340        350
AFQASLEGGL ARITQGQPLE VAFGSQVTLK SVSGKPLPCW LHSHKNTYPM 
       360        370        380        390        400
IYENGRGSSH QQQVTCYPFK DINNWWIVKD PGRHQLVVNN PPRPVRHGDI 
       410        420        430        440        450
VQLVHGMTTR LLNTHDVAAP LSPHSQEVSC YIDYNISMPA QNLWKLDIVN 
       460        470        480        490        500
RESNQDTWKT ILSEVRFVHV NTSAILKLSG AHLPDWGFRQ LEVVGEKLSL 
       510        520        530        540        550
GPHESMVWNV EEHRYGRGHE QKERELELHS PTQHDISRNL SFMARFSELQ 
       560        570        580        590        600
WKMLTLKNED LEHQYSSTPL EWLTLDTNIA YWLHPRTSAQ IHLLGNIVIW 
       610        620        630        640        650
TSASLATVAY TLLFFWYLLR RRRNICDLPE DAWSHWVLAG ALCIGGWALN 
       660        670        680        690        700
YLPFFLMERM LFLYHYLPAL TFQILLLPIV MQHASDHLCR SQLQRNVFSA 
       710        720        730        740 
LVVAWYSSAC HVSNMLRPLT YGDTSLSPGE LRALRWKDSW DILIRKY

Length:747

Mass (Da):85,496

Last modified:June 1, 2001 - v1

Checksum:ⁱ7ECE8F752E7FFA89

GO

Sequence cautionⁱ

The sequence AAH70912 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF192388 mRNA Translation: AAG53461.1 BC070912 mRNA Translation: AAH70912.1 Sequence problems.
NCBI Reference Sequences More...RefSeqⁱ	NP_445858.1, NM_053406.2
UniGeneⁱ	Rn.162659

Genome annotation databases

Ensemblⁱ	ENSRNOT00000015214; ENSRNOP00000015214; ENSRNOG00000010477
GeneIDⁱ	84430
KEGGⁱ	rno:84430
UCSC genome browser More...UCSCⁱ	RGD:620078 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q99PR0	Protein O-mannosyl-transferase 1		MOUSE		746
Uncharacterized protein		NEOLE		755
UPI0004E472E2		RAT		608
UPI00077DC302		PERMB		747
UPI000A313C8B		MUSPA		747
+15

Protein	Similar proteins		Species	Score	Length
Q99PR0	Protein O-mannosyl-transferase 1		HUMAN		747
Protein O-mannosyltransferase 1		COLAP		757
Protein O-mannosyltransferase 1		MACMU		747
POMT1 isoform 5		PANTR		747
UPI0002745944		PANPA		747
+524

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF192388 mRNA Translation: AAG53461.1 BC070912 mRNA Translation: AAH70912.1 Sequence problems.
NCBI Reference Sequences More...RefSeqⁱ	NP_445858.1, NM_053406.2
UniGeneⁱ	Rn.162659

3D structure databases

ProteinModelPortalⁱ	Q99PR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000015214

STRINGⁱ

10116.ENSRNOP00000015214

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT39 Glycosyltransferase Family 39

CAZyⁱ

GT39 Glycosyltransferase Family 39

PTM databases

UniCarbKBⁱ	Q99PR0

UniCarbKBⁱ

Q99PR0

Proteomic databases

PaxDbⁱ	Q99PR0
PRIDEⁱ	Q99PR0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000015214; ENSRNOP00000015214; ENSRNOG00000010477
GeneIDⁱ	84430
KEGGⁱ	rno:84430
UCSC genome browser More...UCSCⁱ	RGD:620078 rat

Organism-specific databases

CTDⁱ	10585
Rat genome database More...RGDⁱ	620078 Pomt1

Phylogenomic databases

eggNOGⁱ	KOG3359 Eukaryota COG1928 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144161
HOGENOMⁱ	HOG000157526
HOVERGENⁱ	HBG053637
InParanoidⁱ	Q99PR0
KEGG Orthology (KO) More...KOⁱ	K00728
OMAⁱ	WWIVKDP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02QX
PhylomeDBⁱ	Q99PR0
TreeFamⁱ	TF300552

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
BRENDAⁱ	2.4.1.109 5301
Reactomeⁱ	R-RNO-5173105 O-linked glycosylation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q99PR0

PROⁱ

PR:Q99PR0

Gene expression databases

Bgeeⁱ	ENSRNOG00000010477
ExpressionAtlasⁱ	Q99PR0 baseline and differential
Genevisibleⁱ	Q99PR0 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR027005 GlyclTrfase_39-like IPR003342 Glyco_trans_39/83 IPR036300 MIR_dom_sf IPR016093 MIR_motif IPR032421 PMT_4TMC
PANTHERⁱ	PTHR10050 PTHR10050, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02815 MIR, 1 hit PF02366 PMT, 1 hit PF16192 PMT_4TMC, 1 hit
SMARTⁱ	View protein in SMART SM00472 MIR, 3 hits
SUPFAMⁱ	SSF82109 SSF82109, 1 hit
PROSITEⁱ	View protein in PROSITE PS50919 MIR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	POMT1_RAT
Accessionⁱ	Q99PR0Primary (citable) accession number: Q99PR0 Secondary accession number(s): Q6IRI2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
	Last sequence update:	June 1, 2001
	Last modified:	May 23, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - Q99PR0 (POMT1_RAT)

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Protein O-mannosyl-transferase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ