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Protein

E3 ubiquitin-protein ligase TRIM11

Gene

Trim11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.3 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri87 – 127B box-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • protein domain specific binding Source: MGI
  • transcription factor binding Source: UniProtKB
  • ubiquitin protein ligase activity Source: MGI
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAntiviral defense, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM11 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM11Curated
Tripartite motif-containing protein 11
Gene namesi
Name:Trim11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2137355 Trim11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562161 – 467E3 ubiquitin-protein ligase TRIM11Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99PQ2
PaxDbiQ99PQ2
PRIDEiQ99PQ2

PTM databases

iPTMnetiQ99PQ2
PhosphoSitePlusiQ99PQ2

Expressioni

Tissue specificityi

Expressed in embryonic central nervous system (CNS), kidney, thymus and gut.

Inductioni

By PAX6.1 Publication

Gene expression databases

BgeeiENSMUSG00000020455 Expressed in 264 organ(s), highest expression level in secondary oocyte
CleanExiMM_TRIM11
ExpressionAtlasiQ99PQ2 baseline and differential
GenevisibleiQ99PQ2 MM

Interactioni

Subunit structurei

Binds cytoplasmic tail of integrin alpha-1 (By similarity). Interacts with MED15/ARC105; this interaction leads to MED15 ubiquitination and proteasomal degradation (By similarity). Interacts with the HN peptide. Interacts with PHOX2B. Interacts with PAX6.By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220446, 3 interactors
STRINGi10090.ENSMUSP00000090749

Structurei

3D structure databases

ProteinModelPortaliQ99PQ2
SMRiQ99PQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 460B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili128 – 207Sequence analysisAdd BLAST80

Domaini

The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6. They are also involved in MED15-binding.By similarity
The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.1 Publication

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri87 – 127B box-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiQ99PQ2
KOiK10650
OMAiFAGNGFW
OrthoDBiEOG091G05W2
PhylomeDBiQ99PQ2
TreeFamiTF338674

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99PQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP
60 70 80 90 100
YACPECRELS AQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCAAHREPLT
110 120 130 140 150
TFCGDDLSLL CPICERSEHW THRVRPLQEA ADDLKGRLEK SLEHLRKQME
160 170 180 190 200
DAMLFQAQAE ETCALWQKMV ESQRQNVLGE FERLRRLLAE EEQQLLQKLE
210 220 230 240 250
EEELEVLPRL REGAARLGQQ STQLAALISE LESRCQLPAL GLLQDIKDAL
260 270 280 290 300
CRVQDVKLQP PAVVPMELRT VCRVPGLVET LRRFRGDITL DPDTANPELV
310 320 330 340 350
LSEDRRSVQR GEQRQALPDN PERFDPGPCV LGQERITSGR HYWEVEVGDQ
360 370 380 390 400
TSWALGVCKE TANRKEKGEL SAGNGFWILV FLGSFYNSNE PAFSPLRDPP
410 420 430 440 450
KRVGIFLDYE AGHLSFYSAT DGSLLFIFPE TLFSGTLRPL FSPLSSSPTP
460
MTICRLIGVS GDTLGPQ
Length:467
Mass (Da):52,580
Last modified:June 1, 2001 - v1
Checksum:i82B7CF68807E9DA8
GO
Isoform 2 (identifier: Q99PQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-244: Q → QLCIECCALEREASIAK

Note: No experimental confirmation available.
Show »
Length:483
Mass (Da):54,314
Checksum:i51BDFFCD514046FC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AB83A2AB83_MOUSE
E3 ubiquitin-protein ligase TRIM11
Trim11
253Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012059244Q → QLCIECCALEREASIAK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220124 mRNA Translation: AAG53497.1
AK139477 mRNA Translation: BAE24028.1
AK170656 mRNA Translation: BAE41941.1
AL607108 Genomic DNA Translation: CAM24055.1
AL662809 Genomic DNA Translation: CAM24489.1
CH466628 Genomic DNA Translation: EDL07693.1
BC020102 mRNA Translation: AAH20102.1
CCDSiCCDS36168.1 [Q99PQ2-1]
CCDS70195.1 [Q99PQ2-2]
RefSeqiNP_001277917.1, NM_001290988.1 [Q99PQ2-2]
NP_444398.1, NM_053168.2 [Q99PQ2-1]
UniGeneiMm.248049

Genome annotation databases

EnsembliENSMUST00000093061; ENSMUSP00000090749; ENSMUSG00000020455 [Q99PQ2-1]
ENSMUST00000108810; ENSMUSP00000104438; ENSMUSG00000020455 [Q99PQ2-2]
GeneIDi94091
KEGGimmu:94091
UCSCiuc007jcy.2 mouse [Q99PQ2-1]
uc011xvj.2 mouse [Q99PQ2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220124 mRNA Translation: AAG53497.1
AK139477 mRNA Translation: BAE24028.1
AK170656 mRNA Translation: BAE41941.1
AL607108 Genomic DNA Translation: CAM24055.1
AL662809 Genomic DNA Translation: CAM24489.1
CH466628 Genomic DNA Translation: EDL07693.1
BC020102 mRNA Translation: AAH20102.1
CCDSiCCDS36168.1 [Q99PQ2-1]
CCDS70195.1 [Q99PQ2-2]
RefSeqiNP_001277917.1, NM_001290988.1 [Q99PQ2-2]
NP_444398.1, NM_053168.2 [Q99PQ2-1]
UniGeneiMm.248049

3D structure databases

ProteinModelPortaliQ99PQ2
SMRiQ99PQ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220446, 3 interactors
STRINGi10090.ENSMUSP00000090749

PTM databases

iPTMnetiQ99PQ2
PhosphoSitePlusiQ99PQ2

Proteomic databases

EPDiQ99PQ2
PaxDbiQ99PQ2
PRIDEiQ99PQ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093061; ENSMUSP00000090749; ENSMUSG00000020455 [Q99PQ2-1]
ENSMUST00000108810; ENSMUSP00000104438; ENSMUSG00000020455 [Q99PQ2-2]
GeneIDi94091
KEGGimmu:94091
UCSCiuc007jcy.2 mouse [Q99PQ2-1]
uc011xvj.2 mouse [Q99PQ2-2]

Organism-specific databases

CTDi81559
MGIiMGI:2137355 Trim11

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiQ99PQ2
KOiK10650
OMAiFAGNGFW
OrthoDBiEOG091G05W2
PhylomeDBiQ99PQ2
TreeFamiTF338674

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q99PQ2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020455 Expressed in 264 organ(s), highest expression level in secondary oocyte
CleanExiMM_TRIM11
ExpressionAtlasiQ99PQ2 baseline and differential
GenevisibleiQ99PQ2 MM

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI11_MOUSE
AccessioniPrimary (citable) accession number: Q99PQ2
Secondary accession number(s): A2A868
, A2AB84, Q3TCL5, Q8VDX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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