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Entry version 134 (16 Oct 2019)
Sequence version 2 (01 Mar 2002)
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Protein

Ribosome-binding protein 1

Gene

Rrbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosome-binding protein 1
Alternative name(s):
Ribosome receptor protein
Short name:
RRp
Short name:
mRRp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rrbp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1932395 Rrbp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7LumenalSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 1605CytoplasmicSequence analysisAdd BLAST1577

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000974421 – 1605Ribosome-binding protein 1Add BLAST1605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei111PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei159PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei786PhosphoserineBy similarity1
Modified residuei818PhosphoserineBy similarity1
Cross-linki823Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei1135N6-acetyllysineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1178PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99PL5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99PL5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99PL5

PeptideAtlas

More...
PeptideAtlasi
Q99PL5

PRoteomics IDEntifications database

More...
PRIDEi
Q99PL5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99PL5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99PL5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99PL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027422 Expressed in 296 organ(s), highest expression level in pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99PL5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99PL5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
219905, 222 interactors

Protein interaction database and analysis system

More...
IntActi
Q99PL5, 226 interactors

Molecular INTeraction database

More...
MINTi
Q99PL5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000016072

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99PL5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati196 – 205110
Repeati206 – 215210
Repeati216 – 225310
Repeati226 – 235410
Repeati236 – 245510
Repeati246 – 255610
Repeati256 – 265710
Repeati266 – 275810
Repeati276 – 285910
Repeati286 – 2951010
Repeati296 – 3051110
Repeati306 – 3151210
Repeati316 – 3251310
Repeati326 – 3351410
Repeati336 – 3451510
Repeati346 – 3551610
Repeati356 – 3651710
Repeati366 – 3751810
Repeati376 – 3851910
Repeati386 – 3952010
Repeati396 – 4052110
Repeati406 – 4152210
Repeati416 – 4252310
Repeati426 – 4352410
Repeati436 – 4452510
Repeati446 – 4552610
Repeati456 – 4652710
Repeati466 – 4752810
Repeati476 – 4852910
Repeati486 – 4953010
Repeati496 – 5053110
Repeati506 – 5153210
Repeati516 – 5253310
Repeati527 – 5363410
Repeati537 – 5463510
Repeati547 – 5563610
Repeati557 – 5663710
Repeati567 – 5763810
Repeati577 – 5863910
Repeati587 – 5964010
Repeati597 – 6064110
Repeati607 – 6164210
Repeati617 – 6264310
Repeati628 – 6374410
Repeati638 – 6474510
Repeati648 – 6574610
Repeati658 – 6674710
Repeati668 – 6774810
Repeati678 – 6874910
Repeati688 – 6975010
Repeati698 – 7075110
Repeati708 – 7175210
Repeati718 – 7275310
Repeati729 – 7385410
Repeati739 – 7485510
Repeati749 – 7585610
Repeati759 – 7685710
Repeati769 – 7785810
Repeati779 – 7885910
Repeati789 – 7986010
Repeati799 – 8086110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni196 – 80861 X 10 AA tandem repeats of [NSQ]-[NKQVGA]-[GSAQKRT]-[ASGDTK]-[KGTQSAV]-[KGAED]-[EQVGIPTDMA]-[EGVAS]-[AGVPETNS]-[AQNGPTVS]Add BLAST613

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFNK Eukaryota
ENOG410XY8H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158015

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99PL5

KEGG Orthology (KO)

More...
KOi
K14000

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDDERAC

Database of Orthologous Groups

More...
OrthoDBi
327650at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99PL5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007794 Rib_rcpt_KP
IPR040248 RRBP1

The PANTHER Classification System

More...
PANTHERi
PTHR18939 PTHR18939, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05104 Rib_recp_KP_reg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 12 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 3 (identifier: Q99PL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIYDTQTLG VVVFGGFMVV SAIGIFLVST FSMKETSYEE ALANQRKEMA
60 70 80 90 100
KTHHQKGEKK KKEKTVEKKG KTKKKEEKPN GKIPEHDLDP NVTIILKEPV
110 120 130 140 150
RVSAVAVAPT SVHSSVGHTP IATVPAMPQE KLASSPKDRK KKEKKVAKVE
160 170 180 190 200
PAVSSIVNSI QVLASKSAIL EATPKEVPMV AVPPVGSKAS SPATSSQGKK
210 220 230 240 250
GQGAQNQAKK GEGAQNQGKK GEGAQNQAKK GEGAQNQAKK GEGAQNQGKK
260 270 280 290 300
GEGAQNQAKK GEGGQNQAKK GEGAQNQGKK GEGAQNQGKK GEGAQNQAKK
310 320 330 340 350
GEGAQNQAKK GEGAQNQGKK GEGAQNQSKK GEGAQNQAKK GEGGQNQAKK
360 370 380 390 400
GEGAQNQAKK GEGAQNQAKK GEGVQNQAKK GVEGAQNQGK KGEANQNQAK
410 420 430 440 450
KGEGGQNQTK KGEGPQNQGK KGEAAQKQDK KIEGAQNQGK KPEGTSNQGK
460 470 480 490 500
KGEGAQNQGK KGEGAQNQSK KGEGAQNQAK KGEGGQNQAK KGEGAQNQAK
510 520 530 540 550
KGEGAQNQAK KGEGVQNQAK KGVEGAQNQG KKGEANQNQA KKGEGGQNQT
560 570 580 590 600
KKGEGPQNQG KKGEAAQKQD KKIEGAQNQG KKPEGTSNQG KKGEGAQNQG
610 620 630 640 650
KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG
660 670 680 690 700
KKGEGAQNQG KKGEGPQNQA KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG
710 720 730 740 750
KKAEGVQSQS KKGEGTQNQG KKGDGNPNQG KKGEGASNQN RKTDTVANQG
760 770 780 790 800
TKQEGVSNQV KKSEGSPNQG KKAEGAPNQG KKKDGSPSQA KKVDAAANQG
810 820 830 840 850
KKSEMAPAQG QKASMVQSQE APKQDAPAKK KSGSRKKGEP GPPDCDGPLF
860 870 880 890 900
LPYKTLVSTV GSMVFSEGEA QRLIEILSEK TGVIQDTWHK ATQKGDPVAI
910 920 930 940 950
LKRQLQEKEK LLATEQEDAA VAKSKLRELN KEMASEKAKA AAGEAKVKKQ
960 970 980 990 1000
LVAREQEIAA VQARMQASYR DHVKEVQQLQ GKIRTLQEQL ENGPNTQLAR
1010 1020 1030 1040 1050
LQQENSILRD ALNQATSQVE SKQNTELAKL RQELSKVNKE LVEKSEASRQ
1060 1070 1080 1090 1100
EEQQRKALEA KAATFEKQVL QLQASHKESE EALQKRLEEV TRELCRAQTS
1110 1120 1130 1140 1150
HANLRADAEK AQEQQQRVAE LHSKLQSSEV EVKSKCEELS SLHGQLKEAR
1160 1170 1180 1190 1200
AENSQLTERI RSIEALLEAG QAQDTQASHA EANQQQTRLK ELESQVSCLE
1210 1220 1230 1240 1250
KETSELKEAM EQQKGKNNDL REKNWKAMEA LALAERACEE KLRSLTQAKE
1260 1270 1280 1290 1300
ESEKQLHLAE AQTKETLLAL LPGLSISAHQ NYAEWLQEFK EKGSELLKKP
1310 1320 1330 1340 1350
PTLEPSMDIV LKLREAEETQ NSLQAECDQY RTILAETEGM LKDLQKSVEE
1360 1370 1380 1390 1400
EERVWKAKVG AAEEELHKSR VTVKHLEDIV EKLKGELESS DQVREHTSHL
1410 1420 1430 1440 1450
EAELEKHMAA ASAECQNYAK EVAGLRQLLL ESQSQLDEAK SEAQKQSDEL
1460 1470 1480 1490 1500
ALVRQQLSDM RSHVEDGDVA GSPAVPPAEQ DPMKLKTQLE RTEATLEAEQ
1510 1520 1530 1540 1550
TRRQKLTAEF EEAQRTACRI QEELEKLRAA GPLESSGKEE ITQLKERLEK
1560 1570 1580 1590 1600
EKRLTSDLGR AAIKLQELLK TTQEQLTKEK DTVKKLQEQL GKAEDGSSSK

EGTSV
Note: No experimental confirmation available.
Length:1,605
Mass (Da):172,879
Last modified:March 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BE08088BF10C665
GO
Isoform RRp61 (identifier: Q99PL5-2) [UniParc]FASTAAdd to basket
Also known as: p180

The sequence of this isoform differs from the canonical sequence as follows:
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:842
Mass (Da):86,953
Checksum:iDAD1C053D4904BAC
GO
Isoform RRp47 (identifier: Q99PL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-449: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:701
Mass (Da):72,468
Checksum:i63D57896FC079133
GO
Isoform RRp41 (identifier: Q99PL5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-666: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:641
Mass (Da):66,454
Checksum:i0509DA8AF7772544
GO
Isoform RRp16.8 (identifier: Q99PL5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-626: Missing.
     717-738: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:398
Mass (Da):41,731
Checksum:i4C72BD0F051EC91F
GO
Isoform RRp15a (identifier: Q99PL5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-730: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:380
Mass (Da):39,877
Checksum:i212A3D6A950A28BA
GO
Isoform RRp15b (identifier: Q99PL5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-666: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:380
Mass (Da):39,908
Checksum:i3599ED50A5A46A28
GO
Isoform RRp10 (identifier: Q99PL5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-720: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:330
Mass (Da):34,843
Checksum:i0F543600AD81F64F
GO
Isoform RRp5.4 (identifier: Q99PL5-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-766: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:284
Mass (Da):30,074
Checksum:i52547E6ED669C411
GO
Isoform RRp2 (identifier: Q99PL5-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     196-787: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:250
Mass (Da):26,672
Checksum:i8F29ACC4CEC3502A
GO
Isoform RRp1.8 (identifier: Q99PL5-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-789: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:229
Mass (Da):24,693
Checksum:i4B3A6F26525DD903
GO
Isoform RRp0 (identifier: Q99PL5-12) [UniParc]FASTAAdd to basket
Also known as: ES130

The sequence of this isoform differs from the canonical sequence as follows:
     177-809: Missing.
     841-842: GP → VC
     843-1605: Missing.

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Length:209
Mass (Da):22,667
Checksum:i1885DB27662C7343
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AVJ7A2AVJ7_MOUSE
Ribosome-binding protein 1
Rrbp1
1,464Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti670A → G in AAK11965 (PubMed:11167022).Curated1
Sequence conflicti700G → S in AAK11967 (PubMed:11167022).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003952177 – 809Missing in isoform RRp0. 1 PublicationAdd BLAST633
Alternative sequenceiVSP_003951177 – 789Missing in isoform RRp1.8. 1 PublicationAdd BLAST613
Alternative sequenceiVSP_003953196 – 787Missing in isoform RRp2. 1 PublicationAdd BLAST592
Alternative sequenceiVSP_003955205 – 666Missing in isoform RRp15b. 1 PublicationAdd BLAST462
Alternative sequenceiVSP_003954205 – 626Missing in isoform RRp16.8. 1 PublicationAdd BLAST422
Alternative sequenceiVSP_003957209 – 766Missing in isoform RRp5.4. 1 PublicationAdd BLAST558
Alternative sequenceiVSP_003956209 – 720Missing in isoform RRp10. 1 PublicationAdd BLAST512
Alternative sequenceiVSP_003958269 – 730Missing in isoform RRp15a. 1 PublicationAdd BLAST462
Alternative sequenceiVSP_003959309 – 449Missing in isoform RRp47. 2 PublicationsAdd BLAST141
Alternative sequenceiVSP_003961466 – 666Missing in isoform RRp41. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_003962717 – 738Missing in isoform RRp16.8. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_003963841 – 842GP → VC in isoform RRp61, isoform RRp1.8, isoform RRp0, isoform RRp2, isoform RRp16.8, isoform RRp15b, isoform RRp10, isoform RRp5.4, isoform RRp15a, isoform RRp47 and isoform RRp41. 2 Publications2
Alternative sequenceiVSP_003964843 – 1605Missing in isoform RRp61, isoform RRp1.8, isoform RRp0, isoform RRp2, isoform RRp16.8, isoform RRp15b, isoform RRp10, isoform RRp5.4, isoform RRp15a, isoform RRp47 and isoform RRp41. 2 PublicationsAdd BLAST763

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF273683 mRNA Translation: AAK11963.1
AF273684 mRNA Translation: AAK11964.1
AF273685 mRNA Translation: AAK11965.1
AF273686 mRNA Translation: AAK11966.1
AF273687 mRNA Translation: AAK11967.1
AF273688 mRNA Translation: AAK11968.1
AF273689 mRNA Translation: AAK11969.1
AF273690 mRNA Translation: AAK11970.1
AF273691 mRNA Translation: AAK11971.1
AF273692 mRNA Translation: AAK11972.1
AF273693 mRNA Translation: AAK11973.1
AL929550 Genomic DNA No translation available.
BC031452 mRNA Translation: AAH31452.1
AK019964 mRNA Translation: BAB31939.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38253.1 [Q99PL5-3]

NCBI Reference Sequences

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RefSeqi
NP_077243.2, NM_024281.2
NP_598329.1, NM_133626.2 [Q99PL5-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000037875; ENSMUSP00000040560; ENSMUSG00000027422 [Q99PL5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81910

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:81910

UCSC genome browser

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UCSCi
uc008mqk.1 mouse [Q99PL5-3]
uc008mql.1 mouse [Q99PL5-12]
uc008mqm.1 mouse [Q99PL5-11]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273683 mRNA Translation: AAK11963.1
AF273684 mRNA Translation: AAK11964.1
AF273685 mRNA Translation: AAK11965.1
AF273686 mRNA Translation: AAK11966.1
AF273687 mRNA Translation: AAK11967.1
AF273688 mRNA Translation: AAK11968.1
AF273689 mRNA Translation: AAK11969.1
AF273690 mRNA Translation: AAK11970.1
AF273691 mRNA Translation: AAK11971.1
AF273692 mRNA Translation: AAK11972.1
AF273693 mRNA Translation: AAK11973.1
AL929550 Genomic DNA No translation available.
BC031452 mRNA Translation: AAH31452.1
AK019964 mRNA Translation: BAB31939.1
CCDSiCCDS38253.1 [Q99PL5-3]
RefSeqiNP_077243.2, NM_024281.2
NP_598329.1, NM_133626.2 [Q99PL5-3]

3D structure databases

SMRiQ99PL5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi219905, 222 interactors
IntActiQ99PL5, 226 interactors
MINTiQ99PL5
STRINGi10090.ENSMUSP00000016072

PTM databases

iPTMnetiQ99PL5
PhosphoSitePlusiQ99PL5
SwissPalmiQ99PL5

Proteomic databases

EPDiQ99PL5
jPOSTiQ99PL5
PaxDbiQ99PL5
PeptideAtlasiQ99PL5
PRIDEiQ99PL5

Genome annotation databases

EnsembliENSMUST00000037875; ENSMUSP00000040560; ENSMUSG00000027422 [Q99PL5-3]
GeneIDi81910
KEGGimmu:81910
UCSCiuc008mqk.1 mouse [Q99PL5-3]
uc008mql.1 mouse [Q99PL5-12]
uc008mqm.1 mouse [Q99PL5-11]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6238
MGIiMGI:1932395 Rrbp1

Phylogenomic databases

eggNOGiENOG410IFNK Eukaryota
ENOG410XY8H LUCA
GeneTreeiENSGT00940000158015
InParanoidiQ99PL5
KOiK14000
OMAiCDDERAC
OrthoDBi327650at2759
PhylomeDBiQ99PL5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rrbp1 mouse

Protein Ontology

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PROi
PR:Q99PL5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027422 Expressed in 296 organ(s), highest expression level in pancreas
ExpressionAtlasiQ99PL5 baseline and differential
GenevisibleiQ99PL5 MM

Family and domain databases

InterProiView protein in InterPro
IPR007794 Rib_rcpt_KP
IPR040248 RRBP1
PANTHERiPTHR18939 PTHR18939, 2 hits
PfamiView protein in Pfam
PF05104 Rib_recp_KP_reg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRRBP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99PL5
Secondary accession number(s): A2AVJ8
, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: October 16, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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