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Protein

Neurotrimin

Gene

Ntm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neural cell adhesion molecule.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrimin
Gene namesi
Name:Ntm
Synonyms:Hnt, Nt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2446259 Ntm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001511234 – 321NeurotriminAdd BLAST288
PropeptideiPRO_0000015113322 – 344Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 201PROSITE-ProRule annotation
Disulfide bondi243 ↔ 295PROSITE-ProRule annotation
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi321GPI-anchor amidated asparagine; alternateSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagine; alternateSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ99PJ0
PaxDbiQ99PJ0
PeptideAtlasiQ99PJ0
PRIDEiQ99PJ0

PTM databases

iPTMnetiQ99PJ0
PhosphoSitePlusiQ99PJ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000059974 Expressed in 286 organ(s), highest expression level in visual cortex
CleanExiMM_HNT
ExpressionAtlasiQ99PJ0 baseline and differential
GenevisibleiQ99PJ0 MM

Interactioni

Protein-protein interaction databases

IntActiQ99PJ0, 3 interactors
MINTiQ99PJ0
STRINGi10090.ENSMUSP00000074578

Structurei

3D structure databases

ProteinModelPortaliQ99PJ0
SMRiQ99PJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 126Ig-like C2-type 1Add BLAST88
Domaini136 – 218Ig-like C2-type 2Add BLAST83
Domaini222 – 309Ig-like C2-type 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJF Eukaryota
ENOG4111SM8 LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ99PJ0
OMAiSIIDNMT
OrthoDBiEOG091G0B5D
PhylomeDBiQ99PJ0

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q99PJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID NRVTRVAWLN RSTILYAGND KWCLDPRVVL LSNTQTQYSI
110 120 130 140 150
EIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVSPKIVE ISSDISINEG
160 170 180 190 200
NNISLTCIAT GRPEPTVTWR HISPKAVGFV SEDEYLEIQG ITREQSGEYE
210 220 230 240 250
CSASNDVAAP VVRRVKVTVN YPPYISEAKG TGVPVGQKGT LQCEASAVPS
260 270 280 290 300
AEFQWFKDDK RLVEGKKGVK VENRPFLSKL TFFNVSEHDY GNYTCVASNK
310 320 330 340
LGHTNASIML FGPGAVSEVN NGTSRRAGCI WLLPLLVLHL LLKF
Length:344
Mass (Da):37,984
Last modified:December 13, 2002 - v2
Checksum:iC885BBA52C148554
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BG33Q8BG33_MOUSE
Neurotrimin
Ntm Hnt
344Annotation score:
D3Z396D3Z396_MOUSE
Neurotrimin
Ntm
316Annotation score:
F6RQ26F6RQ26_MOUSE
Neurotrimin
Ntm
191Annotation score:
F6Z2M6F6Z2M6_MOUSE
Neurotrimin
Ntm
179Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75L → P in AAK00276 (Ref. 1) Curated1
Sequence conflicti92S → G in AAK00276 (Ref. 1) Curated1
Sequence conflicti119T → I in AAK00276 (Ref. 1) Curated1
Sequence conflicti187E → Q in AAK00276 (Ref. 1) Curated1
Sequence conflicti213R → P in AAK00276 (Ref. 1) Curated1
Sequence conflicti225I → F in AAK00276 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282980 mRNA Translation: AAK00276.1
BC023307 mRNA Translation: AAH23307.1
UniGeneiMm.283138

Genome annotation databases

EnsembliENSMUST00000115237; ENSMUSP00000110892; ENSMUSG00000059974
UCSCiuc009oqt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282980 mRNA Translation: AAK00276.1
BC023307 mRNA Translation: AAH23307.1
UniGeneiMm.283138

3D structure databases

ProteinModelPortaliQ99PJ0
SMRiQ99PJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99PJ0, 3 interactors
MINTiQ99PJ0
STRINGi10090.ENSMUSP00000074578

PTM databases

iPTMnetiQ99PJ0
PhosphoSitePlusiQ99PJ0

Proteomic databases

MaxQBiQ99PJ0
PaxDbiQ99PJ0
PeptideAtlasiQ99PJ0
PRIDEiQ99PJ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115237; ENSMUSP00000110892; ENSMUSG00000059974
UCSCiuc009oqt.1 mouse

Organism-specific databases

MGIiMGI:2446259 Ntm

Phylogenomic databases

eggNOGiENOG410IQJF Eukaryota
ENOG4111SM8 LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ99PJ0
OMAiSIIDNMT
OrthoDBiEOG091G0B5D
PhylomeDBiQ99PJ0

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiNtm mouse
PROiPR:Q99PJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059974 Expressed in 286 organ(s), highest expression level in visual cortex
CleanExiMM_HNT
ExpressionAtlasiQ99PJ0 baseline and differential
GenevisibleiQ99PJ0 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNTRI_MOUSE
AccessioniPrimary (citable) accession number: Q99PJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 13, 2002
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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