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Entry version 138 (07 Apr 2021)
Sequence version 2 (24 May 2004)
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Protein

Phosphatidate phosphatase LPIN2

Gene

Lpin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane (PubMed:17158099). Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-ethylmaleimide.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processFatty acid metabolism, Lipid metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1483191, Synthesis of PC
R-MMU-1483213, Synthesis of PE
R-MMU-4419969, Depolymerisation of the Nuclear Lamina
R-MMU-75109, Triglyceride biosynthesis

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000602

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidate phosphatase LPIN2Curated (EC:3.1.3.41 Publication)
Alternative name(s):
Lipin-21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lpin2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891341, Lpin2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi731S → D: Abolishes phosphatidate phosphatase activity but does not prevent membrane association. 1 Publication1
Mutagenesisi731S → L: Abolishes phosphatidate phosphatase activity but does not prevent membrane association nor coactivator activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002098821 – 893Phosphatidate phosphatase LPIN2Add BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei106Phosphoserine1 Publication1
Modified residuei174PhosphoserineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei243PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Modified residuei563PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99PI5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99PI5

PRoteomics IDEntifications database

More...
PRIDEi
Q99PI5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
291962 [Q99PI5-1]
291963 [Q99PI5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99PI5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99PI5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high level in liver and to some extend in lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. Expressed also in circulating red blood cells and site of lymphopoiesis.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By fasting in hepatocytes. Up-regulated in fld/fld (defect in LPIN1) mice. Up-regulated at protein level but not at transcript level in ob/ob and db/db mice, two obese mice models.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024052, Expressed in primary oocyte and 296 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99PI5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99PI5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
211110, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000118610

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99PI5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99PI5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 108N-LIPAdd BLAST108
Regioni632 – 834C-LIPAdd BLAST203

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi153 – 158Nuclear localization signalSequence analysis6
Motifi686 – 690DXDXT motif5
Motifi697 – 701LXXIL motif5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lipin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2116, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156313

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_595744_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99PI5

Identification of Orthologs from Complete Genome Data

More...
OMAi
NFCTEHI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036412, HAD-like_sf
IPR026058, LIPIN
IPR031703, Lipin_mid
IPR007651, Lipin_N
IPR013209, LNS2
IPR031315, LNS2/PITP

The PANTHER Classification System

More...
PANTHERi
PTHR12181, PTHR12181, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16876, Lipin_mid, 1 hit
PF04571, Lipin_N, 1 hit
PF08235, LNS2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00775, LNS2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99PI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNYVGQLAGQ VLVTVKELYK GINQATLSGC IDVVVVRQQD GSYQCSPFHV
60 70 80 90 100
RFGKLGVLRS KEKVIDIEIN GSAVDLHMKL GDNGEAFFVE ETEEEYEKLP
110 120 130 140 150
AYLATSPIPT EDQFFKHIET PLVKSSGNER PAQSSDVSHT LESEAVFTQS
160 170 180 190 200
SVKKKKRRRK KCKQDNRKEE QAASPVAEDV GDVGVSSDDE KRAQAARGSS
210 220 230 240 250
NASLKEEDYK EPSLFHSGDN YPLSDGDWSP LETTYPQAVC PKSDSELEVK
260 270 280 290 300
PSESLLRSEP HMEWTWGGFP ESTKVTKRER YDYHPRTATI TPSENTHFRV
310 320 330 340 350
IPSEDSLIRE VEKDATVEDT TCTIVKPKPR ALCKQLSDAA STELPESPLE
360 370 380 390 400
APQISSLLDA DPVPSPSAEA PSEPKPAAKD SPTKKKGVHK RSQHQGPDDI
410 420 430 440 450
YLDDLKALEP EVAALYFPKS DTDPGSRQWP ESDTFSGSQS PQSVGSAAAD
460 470 480 490 500
SGTECLSDSA MDLPDVTLSL CGGLSENGEI SKEKFMEHII TYHEFAENPG
510 520 530 540 550
LIDNPNLVIR IYNRYYNWAL AAPMILSLQV FQKSLPKATV ESWVKDKMPK
560 570 580 590 600
KSGRWWFWRK KESMIKQLPE TKEGKSEVPP ANDLPSNAEE PTSARPAEND
610 620 630 640 650
TSSDEGSQEL EESIKVDPIT VETLSHCGTA SYKKSLRLSS DQIAKLKLHD
660 670 680 690 700
GPNDVVFSIT TQYQGTCRCA GTIYLWNWND KVIISDIDGT ITKSDALGQI
710 720 730 740 750
LPQLGKDWTH QGIARLYHSI NENGYKFLYC SARAIGMADM TRGYLHWVND
760 770 780 790 800
KGTILPRGPL MLSPSSLFSA FHREVIEKKP EKFKIECLND IKNLFAPSRQ
810 820 830 840 850
PFYAAFGNRP NDVYAYTQVG VPDCRIFTVN PKGELIQERT KGNKSSYHRL
860 870 880 890
SELVEHVFPL LSKEQNSAFP CPEFSSFCYW RDPIPDLDLD DLA
Length:893
Mass (Da):99,613
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C7FD7881946F8EA
GO
Isoform 2 (identifier: Q99PI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     388-459: VHKRSQHQGP...DSGTECLSDS → LVWLKNNCLL...PKMNRNKNTF
     460-893: Missing.

Show »
Length:459
Mass (Da):50,997
Checksum:i69F763FB79AA0742
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWN0E9PWN0_MOUSE
Phosphatidate phosphatase
Lpin2
931Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RH34D6RH34_MOUSE
Phosphatidate phosphatase LPIN2
Lpin2
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VTY5F6VTY5_MOUSE
Phosphatidate phosphatase LPIN2
Lpin2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti839R → S in BAC34088 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010387388 – 459VHKRS…CLSDS → LVWLKNNCLLGDRCISGYDH GCVSRGPTWQLMTDSSARGP NALFWPLWAPGTQPYIRQNM HIPKMNRNKNTF in isoform 2. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_010388460 – 893Missing in isoform 2. 1 PublicationAdd BLAST434

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF286723 mRNA Translation: AAG52761.1
AK033662 mRNA Translation: BAC28415.1
AK050138 mRNA Translation: BAC34088.1
AK086834 mRNA Translation: BAC39754.1
BC039698 mRNA Translation: AAH39698.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28956.1 [Q99PI5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_075020.2, NM_022882.4 [Q99PI5-1]
XP_006524850.1, XM_006524787.3
XP_006524851.1, XM_006524788.2 [Q99PI5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000129635; ENSMUSP00000119282; ENSMUSG00000024052 [Q99PI5-1]
ENSMUST00000156570; ENSMUSP00000120634; ENSMUSG00000024052 [Q99PI5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:64898

UCSC genome browser

More...
UCSCi
uc008dmc.1, mouse [Q99PI5-2]
uc012awp.1, mouse [Q99PI5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286723 mRNA Translation: AAG52761.1
AK033662 mRNA Translation: BAC28415.1
AK050138 mRNA Translation: BAC34088.1
AK086834 mRNA Translation: BAC39754.1
BC039698 mRNA Translation: AAH39698.1
CCDSiCCDS28956.1 [Q99PI5-1]
RefSeqiNP_075020.2, NM_022882.4 [Q99PI5-1]
XP_006524850.1, XM_006524787.3
XP_006524851.1, XM_006524788.2 [Q99PI5-1]

3D structure databases

SMRiQ99PI5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi211110, 3 interactors
STRINGi10090.ENSMUSP00000118610

Chemistry databases

SwissLipidsiSLP:000000602

PTM databases

iPTMnetiQ99PI5
PhosphoSitePlusiQ99PI5

Proteomic databases

jPOSTiQ99PI5
PaxDbiQ99PI5
PRIDEiQ99PI5
ProteomicsDBi291962 [Q99PI5-1]
291963 [Q99PI5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2826, 189 antibodies

Genome annotation databases

EnsembliENSMUST00000129635; ENSMUSP00000119282; ENSMUSG00000024052 [Q99PI5-1]
ENSMUST00000156570; ENSMUSP00000120634; ENSMUSG00000024052 [Q99PI5-2]
GeneIDi64898
KEGGimmu:64898
UCSCiuc008dmc.1, mouse [Q99PI5-2]
uc012awp.1, mouse [Q99PI5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9663
MGIiMGI:1891341, Lpin2

Phylogenomic databases

eggNOGiKOG2116, Eukaryota
GeneTreeiENSGT00940000156313
HOGENOMiCLU_595744_0_0_1
InParanoidiQ99PI5
OMAiNFCTEHI

Enzyme and pathway databases

ReactomeiR-MMU-1483191, Synthesis of PC
R-MMU-1483213, Synthesis of PE
R-MMU-4419969, Depolymerisation of the Nuclear Lamina
R-MMU-75109, Triglyceride biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
64898, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Lpin2, mouse

Protein Ontology

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PROi
PR:Q99PI5
RNActiQ99PI5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024052, Expressed in primary oocyte and 296 other tissues
ExpressionAtlasiQ99PI5, baseline and differential
GenevisibleiQ99PI5, MM

Family and domain databases

InterProiView protein in InterPro
IPR036412, HAD-like_sf
IPR026058, LIPIN
IPR031703, Lipin_mid
IPR007651, Lipin_N
IPR013209, LNS2
IPR031315, LNS2/PITP
PANTHERiPTHR12181, PTHR12181, 1 hit
PfamiView protein in Pfam
PF16876, Lipin_mid, 1 hit
PF04571, Lipin_N, 1 hit
PF08235, LNS2, 1 hit
SMARTiView protein in SMART
SM00775, LNS2, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPIN2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99PI5
Secondary accession number(s): Q8C357
, Q8C7I8, Q8CC85, Q8CHR7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 24, 2004
Last modified: April 7, 2021
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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