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Protein

Regulator of G-protein signaling 18

Gene

Rgs18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 18
Short name:
RGS18
Gene namesi
Name:Rgs18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1927498 Rgs18

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042281 – 235Regulator of G-protein signaling 18Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1
Modified residuei216PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99PG4
PaxDbiQ99PG4
PRIDEiQ99PG4

PTM databases

iPTMnetiQ99PG4
PhosphoSitePlusiQ99PG4

Expressioni

Tissue specificityi

Expressed in bone marrow, spleen, fetal liver and lung. At very low levels expressed in heart.

Gene expression databases

BgeeiENSMUSG00000026357 Expressed in 89 organ(s), highest expression level in blood
CleanExiMM_RGS18
ExpressionAtlasiQ99PG4 baseline and differential
GenevisibleiQ99PG4 MM

Interactioni

Protein-protein interaction databases

BioGridi211040, 2 interactors
STRINGi10090.ENSMUSP00000027603

Structurei

3D structure databases

ProteinModelPortaliQ99PG4
SMRiQ99PG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 202RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ99PG4
KOiK16449
OMAiLNMCESK
OrthoDBiEOG091G0BDG
PhylomeDBiQ99PG4
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034950 RGS18
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF155 PTHR10845:SF155, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q99PG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMSLVFFSQ LNMCESKEKT FFKLMHGSGK EETSIEAKIR AKEKRNRLSL
60 70 80 90 100
LLQRPDFHGE TQASRSALLA KETRVSPEEA VKWAESFDKL LSHRDGVDAF
110 120 130 140 150
TRFLKTEFSE ENIEFWVACE DFKKCKEPQQ IILKAKAIYE KFIQNDAPKE
160 170 180 190 200
VNIDFHTKEV IAKSIAQPTL HSFDTAQSRV YQLMEHDSYK RFLKSETYLH
210 220 230
LIEGRPQRPT NLRRRSRSFT YNDFQDVKSD VAIWL
Length:235
Mass (Da):27,610
Last modified:June 1, 2001 - v1
Checksum:i6433435AC1CBCFD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302685 mRNA Translation: AAG53657.1
AB042807 mRNA Translation: BAB60723.1
CCDSiCCDS15350.1
RefSeqiNP_075019.1, NM_022881.4
UniGeneiMm.253927

Genome annotation databases

EnsembliENSMUST00000027603; ENSMUSP00000027603; ENSMUSG00000026357
GeneIDi64214
KEGGimmu:64214
UCSCiuc007cxl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302685 mRNA Translation: AAG53657.1
AB042807 mRNA Translation: BAB60723.1
CCDSiCCDS15350.1
RefSeqiNP_075019.1, NM_022881.4
UniGeneiMm.253927

3D structure databases

ProteinModelPortaliQ99PG4
SMRiQ99PG4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211040, 2 interactors
STRINGi10090.ENSMUSP00000027603

PTM databases

iPTMnetiQ99PG4
PhosphoSitePlusiQ99PG4

Proteomic databases

MaxQBiQ99PG4
PaxDbiQ99PG4
PRIDEiQ99PG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027603; ENSMUSP00000027603; ENSMUSG00000026357
GeneIDi64214
KEGGimmu:64214
UCSCiuc007cxl.1 mouse

Organism-specific databases

CTDi64407
MGIiMGI:1927498 Rgs18

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ99PG4
KOiK16449
OMAiLNMCESK
OrthoDBiEOG091G0BDG
PhylomeDBiQ99PG4
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

ChiTaRSiRgs18 mouse
PROiPR:Q99PG4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026357 Expressed in 89 organ(s), highest expression level in blood
CleanExiMM_RGS18
ExpressionAtlasiQ99PG4 baseline and differential
GenevisibleiQ99PG4 MM

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034950 RGS18
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF155 PTHR10845:SF155, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS18_MOUSE
AccessioniPrimary (citable) accession number: Q99PG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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