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Protein

Cadherin-23

Gene

Cdh23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Hearing
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-23
Alternative name(s):
Otocadherin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cdh23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1890219 Cdh23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 3064ExtracellularSequence analysisAdd BLAST3041
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3065 – 3085HelicalSequence analysisAdd BLAST21
Topological domaini3086 – 3354CytoplasmicSequence analysisAdd BLAST269

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi26N → I: Strongly reduced affinity for PCDH15. 1 Publication1
Mutagenesisi27R → I: Strongly reduced affinity for PCDH15. 1 Publication1
Mutagenesisi168L → G: Strongly reduced interaction with PCDH15. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000382524 – 3354Cadherin-23Add BLAST3331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi466N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi472N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi694N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi765N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi810N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi827N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi941N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1001N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1018N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1651N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1667N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1818N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1857N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1889N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1902N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2014N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2050N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2357N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2369N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2578N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2616N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2808N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2877N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2896N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2941N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2981N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99PF4

PRoteomics IDEntifications database

More...
PRIDEi
Q99PF4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99PF4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99PF4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In adult animals relatively high levels of expression are found in testis, skeletal muscle, heart, eye and thymus, and lower expression in kidney, lung and brain. Found in the sensory hair cells of the inner ear.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000012819 Expressed in 56 organ(s), highest expression level in internal ear

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99PF4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99PF4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with USH1C and USH1G (By similarity). antiparallel heterodimer with PCDH15. Isoform C1: Interacts with CAMSAP3; leading to inhibit CAMSAP3 ability to induce microtubule bundle formation (PubMed:27349180).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204475, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q99PF4

Database of interacting proteins

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DIPi
DIP-42152N

Protein interaction database and analysis system

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IntActi
Q99PF4, 2 interactors

Molecular INTeraction database

More...
MINTi
Q99PF4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101104

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WBXX-ray1.50A24-124[»]
2WCPX-ray1.98A24-228[»]
2WD0X-ray2.74A/C24-228[»]
2WHVX-ray2.36A24-228[»]
3MVSX-ray1.10A24-233[»]
4APXX-ray1.65A24-228[»]
4AQ8X-ray2.63A/B24-228[»]
4AQAX-ray1.96A24-228[»]
4AQEX-ray2.27A24-228[»]
4AXWX-ray2.23A24-228[»]
4XXWX-ray2.26C/D24-228[»]
5I8DX-ray2.69A1949-2289[»]
5TFKX-ray2.80A1949-2289[»]
5TFLX-ray3.56A/B666-886[»]
5ULUX-ray2.85A1955-2289[»]
5UN2X-ray2.96A1955-2289[»]
5UZ8X-ray1.85A2288-2607[»]
5VH2X-ray2.84A/B/C/D1201-1412[»]
5VT8X-ray2.92A/B/C/D2504-2715[»]
5WJMX-ray2.90A1739-1954[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q99PF4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99PF4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q99PF4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 132Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini133 – 236Cadherin 2PROSITE-ProRule annotationAdd BLAST104
Domaini237 – 348Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini349 – 460Cadherin 4PROSITE-ProRule annotationAdd BLAST112
Domaini461 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST101
Domaini562 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST110
Domaini672 – 784Cadherin 7PROSITE-ProRule annotationAdd BLAST113
Domaini779 – 890Cadherin 8PROSITE-ProRule annotationAdd BLAST112
Domaini891 – 995Cadherin 9PROSITE-ProRule annotationAdd BLAST105
Domaini996 – 1102Cadherin 10PROSITE-ProRule annotationAdd BLAST107
Domaini1103 – 1208Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1210 – 1313Cadherin 12PROSITE-ProRule annotationAdd BLAST104
Domaini1314 – 1418Cadherin 13PROSITE-ProRule annotationAdd BLAST105
Domaini1420 – 1527Cadherin 14PROSITE-ProRule annotationAdd BLAST108
Domaini1529 – 1634Cadherin 15PROSITE-ProRule annotationAdd BLAST106
Domaini1635 – 1744Cadherin 16PROSITE-ProRule annotationAdd BLAST110
Domaini1745 – 1851Cadherin 17PROSITE-ProRule annotationAdd BLAST107
Domaini1852 – 1959Cadherin 18PROSITE-ProRule annotationAdd BLAST108
Domaini1960 – 2069Cadherin 19PROSITE-ProRule annotationAdd BLAST110
Domaini2070 – 2174Cadherin 20PROSITE-ProRule annotationAdd BLAST105
Domaini2175 – 2293Cadherin 21PROSITE-ProRule annotationAdd BLAST119
Domaini2297 – 2402Cadherin 22PROSITE-ProRule annotationAdd BLAST106
Domaini2403 – 2509Cadherin 23PROSITE-ProRule annotationAdd BLAST107
Domaini2510 – 2611Cadherin 24PROSITE-ProRule annotationAdd BLAST102
Domaini2614 – 2722Cadherin 25PROSITE-ProRule annotationAdd BLAST109
Domaini2729 – 2846Cadherin 26PROSITE-ProRule annotationAdd BLAST118
Domaini2847 – 2975Cadherin 27PROSITE-ProRule annotationAdd BLAST129

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with PCDH15.1 Publication

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155245

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000139588

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050768

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99PF4

KEGG Orthology (KO)

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KOi
K06813

Identification of Orthologs from Complete Genome Data

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OMAi
ERAFSIN

Database of Orthologous Groups

More...
OrthoDBi
17702at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316403

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR033030 CDH23

The PANTHER Classification System

More...
PANTHERi
PTHR43956:SF3 PTHR43956:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 25 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 26 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 27 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 17 hits
PS50268 CADHERIN_2, 27 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99PF4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRYSLVTCYA VLWLLMLVPG SWGQVNRLPF FTNHFFDTYL LISEDTPVGS
60 70 80 90 100
SVTQLLARDM DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE
110 120 130 140 150
FTVEFSVSDH QGVITRKVNI QVGDVNDNAP TFHNQPYSVR IPENTPVGTP
160 170 180 190 200
IFIVNATDPD LGAGGSVLYS FQPPSPFFAI DSARGIVTVI QELDYEVTQA
210 220 230 240 250
YQLTVNATDQ DKTRPLSTLA NLAIIITDMQ DMDPIFINLP YSTNIYEHSP
260 270 280 290 300
PGTTVRVITA VDQDKGRPRG IGYTIVSGNT NSIFALDYIS GALTLNGLLD
310 320 330 340 350
RENPLYSHGF ILTVKGTELN DDRTPSDATV TTTFNILVID INDNAPEFNS
360 370 380 390 400
SEYSVAITEL AQVGFALPLF IQVVDKDEDL GLNSMFEVYL VGNNSHHFII
410 420 430 440 450
SPTSVQGKAD IRIRVAIPLD YETVDRYDFD LFANESVPDH VGYAKVKITL
460 470 480 490 500
INENDNRPIF SQPLYNVSLY ENITVGTSVL TVLATDNDVG TFGEVNYFFS
510 520 530 540 550
DDPDRFSLDK DTGLIMLIAR LDYELIQRFT LTVIARDGGG EETTGRVRIN
560 570 580 590 600
VLDVNDNVPT FQKDAYVGAL RENEPSVTQL VRLRATDEDS PPNNLITYSI
610 620 630 640 650
VNASAFGSYF DISIYEGYGV ISVSRPLDYE QIPNGLIYLT VMAKDAGNPP
660 670 680 690 700
LYSTVPVTIE VFDENDNPPT FSKPAYFVSV LENIMAGATV LFLNATDLDR
710 720 730 740 750
SREYGQESII YSLEGSSQFR INARSGEITT TSLLDRETKS EYILIVRAVD
760 770 780 790 800
GGVGHNQKTG IATVNVTLLD INDNHPTWKD APYYINLVEM TPPDSDVTTV
810 820 830 840 850
VAVDPDLGEN GTLVYSIHPP NKFYSLNSTT GKIRTTHVML DRENPDPVEA
860 870 880 890 900
ELMRKIIVSV TDCGRPPLKA TSSATVFVNL LDLNDNDPTF RNLPFVAEIL
910 920 930 940 950
EGTPAGVSVY QVVAIDLDEG LNGLVSYRMQ VGMPRMDFVI NSTSGVVTTT
960 970 980 990 1000
AELDRERIAE YQLRVVASDA GTPTKSSTST LTVRVLDVND ETPTFFPAVY
1010 1020 1030 1040 1050
NVSVSEDVPR EFRVVWLNCT DNDVGLNAEL SYFITAGNVD GKFSVGYRDA
1060 1070 1080 1090 1100
VVRTVVGLDR ETTAAYTLVL EAIDNGPVGK RRTGTATVFV TVLDVNDNRP
1110 1120 1130 1140 1150
IFLQSSYEAS VPEDIPEGHS IVQLKATDAD EGEFGRVWYR ILHGNHGNNF
1160 1170 1180 1190 1200
RIHVGSGLLM RGPRPLDRER NSSHVLMVEA YNHDLGPMRS SVRVIVYVED
1210 1220 1230 1240 1250
VNDEAPVFTQ QQYNRLGLRE TAGIGTSVIV VRATDKDTGD GGLVNYRILS
1260 1270 1280 1290 1300
GAEGKFEIDE STGLIVTVDY LDYETKTSYL MNVSATDGAP PFNQGFCSVY
1310 1320 1330 1340 1350
VTLLNELDEA VQFSNASYEA VIMENLALGT EIVRVQAYSI DNLNQITYRF
1360 1370 1380 1390 1400
DAYTSAQAKA LFKIDAITGV ITVKGLVDRE KGDFYTLTVV ADDGGPKVDS
1410 1420 1430 1440 1450
TVKVYITVLD ENDNSPRFDF TSDSAISVPE DCPVGQRVAT VKARDPDAGS
1460 1470 1480 1490 1500
NGQVVFSLAS GNIAGAFEII TSNDSIGEVF VAKPLDREEL DHYILKVVAS
1510 1520 1530 1540 1550
DRGTPPRKKD HILQVTILDV NDNPPVIESP FGYNVSVNEN VGGGTSVVQV
1560 1570 1580 1590 1600
RATDRDIGIN SVLSYYITEG NEDMTFRMDR ISGEIATRPA PPDRERQNFY
1610 1620 1630 1640 1650
HLVVTVEDEG TPTLSATTHV YVTIVDENDN APVFQQPHYE VVLDEGPDTI
1660 1670 1680 1690 1700
NTSLITVQAL DLDEGPNGTV TYAIVAGNII NTFRINKHTG VITAAKELDY
1710 1720 1730 1740 1750
EISHGRYTLI VTATDQCPIL SHRLTSTTTV LVNVNDINDN VPTFPRDYEG
1760 1770 1780 1790 1800
PFDVTEGQPG PRVWTFLAHD RDSGPNGQVE YSVVDGDPLG EFVISPVEGV
1810 1820 1830 1840 1850
LRVRKDVELD RETIAFYNLT ICARDRGVPP LSSTMLVGIR VLDINDNDPV
1860 1870 1880 1890 1900
LLNLPMNVTI SENSPVSSFV AHVLASDADS GCNALLTFNI TAGNRERAFF
1910 1920 1930 1940 1950
INATTGIVTV NRPLDRERIP EYRLTVSVKD NPENPRIARK DFDLLLVSLA
1960 1970 1980 1990 2000
DENDNHPLFT EGTYQAEVME NSPAGTPLTV LNGPILALDA DEDVYAVVTY
2010 2020 2030 2040 2050
QLLGTHSDLF VIDNSTGVVT VRSGIIIDRE AFSPPFLELL LLAEDIGQLN
2060 2070 2080 2090 2100
GTAHLFITIL DDNDNWPTFS PPTYTVHLLE NCPPGFSVLQ VTATDEDSGL
2110 2120 2130 2140 2150
NGELVYRIEA GAQDRFLIHP VTGVIRVGNA TIDREEQESY RLTVVATDRG
2160 2170 2180 2190 2200
TVPLSGTAIV TILIDDINDS RPEFLNPIQT VSVLESAEPG TIIANVTAID
2210 2220 2230 2240 2250
LDLNPKLEYH IISIVAKDDT DRLVPDQEDA FAVNINTGSV MVKSPLNREL
2260 2270 2280 2290 2300
VATYEVTLSV IDNASDLPEH SVSVPNAKLT VNILDVNDNT PQFKPFGITY
2310 2320 2330 2340 2350
YTERVLEGAT PGTTLIAVAA VDPDKGLNGL ITYTLLDLTP PGYVQLEDSS
2360 2370 2380 2390 2400
AGKVIANRTV DYEEVHWLNF TVRASDNGSP PRAAEIPVYL EIVDINDNNP
2410 2420 2430 2440 2450
IFDQPSYQEA VFEDIAVGTV ILRVTATDAD SGNFALIEYS LVDGEGKFAI
2460 2470 2480 2490 2500
NPNTGDISVL SSLDREKKDH YILTALAKDN PGDVASNRRE NSVQVVIRVL
2510 2520 2530 2540 2550
DVNDCRPQFS KPQFSTSVYE NEPAGTSVIT MLATDQDEGS NSQLTYSLEG
2560 2570 2580 2590 2600
PGMEAFSVDM DSGLVTTQRP LQSYERFNLT VVATDGGEPP LWGTTMLLVE
2610 2620 2630 2640 2650
VIDVNDNRPV FVRPPNGTIL HIKEEIPLRS NVYEVYATDN DEGLNGAVRY
2660 2670 2680 2690 2700
SFLKTTGNRD WEYFTIDPIS GLIQTAQRLD REKQAVYSLI LVASDLGQPV
2710 2720 2730 2740 2750
PYETMQPLQV ALEDIDDNEP LFVRPPKGSP QYQLLTVPEH SPRGTLVGNV
2760 2770 2780 2790 2800
TGAVDADEGP NAIVYYFIAA GDEDKNFHLQ PDGRLLVLRD LDRETEATFS
2810 2820 2830 2840 2850
FIVKASSNRS WTPPRGPSPA LDLLTDLTLQ EVRVVLEDIN DQPPRFTKAE
2860 2870 2880 2890 2900
YTAGVATDAK VGSELIQVLA LDADIGNNSL VFYGILAIHY FRALANDSED
2910 2920 2930 2940 2950
VGQVFTMGSV DGILRTFDLF MAYSPGYFVV DIVARDLAGH NDTAIIGIYI
2960 2970 2980 2990 3000
LRDDQRVKIV INEIPDRVRG FEEEFIRLLS NITGAIVNTD DVQFHVDMKG
3010 3020 3030 3040 3050
RVNFAQTELL IHVVNRDTNR ILDVDRVIQM IDENKEQLRN LFRNYNVLDV
3060 3070 3080 3090 3100
QPAISVQLPD DMSALQMAII VLAILLFLAA MLFVLMNWYY RTIHKRKLKA
3110 3120 3130 3140 3150
IVAGSAGNRG FIDIMDMPNT NKYSFDGSNP VWLDPFCRNL ELAAQAEHED
3160 3170 3180 3190 3200
DLPENLSEIA DLWNSPTRTH GTFGREPAAV KPDDDRYLRA AIQEYDNIAK
3210 3220 3230 3240 3250
LGQIIREGPI KGSLLKVVLE DYLRLKKLFA QRMVQKASSC HSSISELIHT
3260 3270 3280 3290 3300
DLEEEPGDHS PGQGSLRFRH KPPMELKGQD GIHMVHGSTG TLLATDLNSL
3310 3320 3330 3340 3350
PEDDQKGLDR SLETLTASEA TAFERNARTE SAKSTPLHKL RDVIMESPLE

ITEL
Length:3,354
Mass (Da):369,623
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6ADFABF6A5001DC0
GO
Isoform 2 (identifier: Q99PF4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3212-3246: Missing.

Show »
Length:3,319
Mass (Da):365,675
Checksum:i9ECA04DF22B1943F
GO
Isoform C1 (identifier: Q99PF4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3128: MRYSLVTCYA...NTNKYSFDGS → MLLPNYRA
     3247-3247: L → EL

Show »
Length:235
Mass (Da):26,340
Checksum:iA677D16964140D5F
GO
Isoform B2 (identifier: Q99PF4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2240: Missing.
     3212-3246: Missing.

Show »
Length:1,079
Mass (Da):119,695
Checksum:i2A38DE471E7F27CB
GO
Isoform B1 (identifier: Q99PF4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2240: Missing.

Show »
Length:1,114
Mass (Da):123,642
Checksum:i7D0CA1D6A0CCF30C
GO
Isoform C2 (identifier: Q99PF4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3128: MRYSLVTCYA...NTNKYSFDGS → MLLPNYRA
     3212-3246: Missing.

Show »
Length:199
Mass (Da):22,263
Checksum:i3752DE2FAE4B945A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K4DI74K4DI74_MOUSE
Cadherin-23
Cdh23
3,352Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q7M6E9Q7M6_MOUSE
Cadherin-23
Cdh23
3,321Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WIF5F8WIF5_MOUSE
Cadherin-23
Cdh23
3,353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94D → G in AAK07670 (PubMed:11386759).Curated1
Sequence conflicti142 – 143PE → TQ in AAK07670 (PubMed:11386759).Curated2
Sequence conflicti248 – 251HSPP → QLTVNAT in AAK07670 (PubMed:11386759).Curated4
Sequence conflicti379D → N in AAG52817 (PubMed:11138008).Curated1
Sequence conflicti379D → N in AAK07670 (PubMed:11386759).Curated1
Sequence conflicti3128S → A in AAG52817 (PubMed:11138008).Curated1
Sequence conflicti3128S → A in AAK07670 (PubMed:11386759).Curated1
Sequence conflicti3128S → A in AAT72163 (PubMed:15882574).Curated1
Sequence conflicti3128S → A in AAT72164 (PubMed:15882574).Curated1
Sequence conflicti3262G → S in AAG52817 (PubMed:11138008).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti5L → P in strain: CAST/Ei. 1 Publication1
Natural varianti229M → V in strain: CAST/Ei. 1 Publication1
Natural varianti891R → K in strain: CAST/Ei. 1 Publication1
Natural varianti1137V → I in strain: CAST/Ei. 1 Publication1
Natural varianti1236K → R in strain: CAST/Ei. 1 Publication1
Natural varianti2025I → V in strain: CAST/Ei. 1 Publication1
Natural varianti2026I → V in strain: CAST/Ei. 1 Publication1
Natural varianti2217K → T in strain: CAST/Ei. 1 Publication1
Natural varianti2222R → H in strain: CAST/Ei. 1 Publication1
Natural varianti2270H → R in strain: CAST/Ei. 1 Publication1
Natural varianti2617G → A in strain: CAST/Ei. 1 Publication1
Natural varianti2718 – 2720Missing in waltzer. 1 Publication3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0592421 – 3128MRYSL…SFDGS → MLLPNYRA in isoform C1 and isoform C2. Add BLAST3128
Alternative sequenceiVSP_0592431 – 2240Missing in isoform B2 and isoform B1. Add BLAST2240
Alternative sequenceiVSP_0006483212 – 3246Missing in isoform 2, isoform B2 and isoform C2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0592443247L → EL in isoform C1. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF308939 mRNA Translation: AAG52817.1
AY026062 mRNA Translation: AAK07670.1
AY563159 mRNA Translation: AAT72159.1
AY563160 mRNA Translation: AAT72160.1
AY563163 mRNA Translation: AAT72163.1
AY563164 mRNA Translation: AAT72164.1
AK016365 mRNA No translation available.
AC079082 Genomic DNA No translation available.
AC079818 Genomic DNA No translation available.
AC079819 Genomic DNA No translation available.
AC153517 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_075859.2, NM_023370.3
XP_006513665.1, XM_006513602.2
XP_017169418.1, XM_017313929.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.440327

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000105461; ENSMUSP00000101101; ENSMUSG00000012819 [Q99PF4-1]
ENSMUST00000105463; ENSMUSP00000101103; ENSMUSG00000012819 [Q99PF4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22295

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:22295

UCSC genome browser

More...
UCSCi
uc033fpl.1 mouse [Q99PF4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308939 mRNA Translation: AAG52817.1
AY026062 mRNA Translation: AAK07670.1
AY563159 mRNA Translation: AAT72159.1
AY563160 mRNA Translation: AAT72160.1
AY563163 mRNA Translation: AAT72163.1
AY563164 mRNA Translation: AAT72164.1
AK016365 mRNA No translation available.
AC079082 Genomic DNA No translation available.
AC079818 Genomic DNA No translation available.
AC079819 Genomic DNA No translation available.
AC153517 Genomic DNA No translation available.
RefSeqiNP_075859.2, NM_023370.3
XP_006513665.1, XM_006513602.2
XP_017169418.1, XM_017313929.1
UniGeneiMm.440327

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WBXX-ray1.50A24-124[»]
2WCPX-ray1.98A24-228[»]
2WD0X-ray2.74A/C24-228[»]
2WHVX-ray2.36A24-228[»]
3MVSX-ray1.10A24-233[»]
4APXX-ray1.65A24-228[»]
4AQ8X-ray2.63A/B24-228[»]
4AQAX-ray1.96A24-228[»]
4AQEX-ray2.27A24-228[»]
4AXWX-ray2.23A24-228[»]
4XXWX-ray2.26C/D24-228[»]
5I8DX-ray2.69A1949-2289[»]
5TFKX-ray2.80A1949-2289[»]
5TFLX-ray3.56A/B666-886[»]
5ULUX-ray2.85A1955-2289[»]
5UN2X-ray2.96A1955-2289[»]
5UZ8X-ray1.85A2288-2607[»]
5VH2X-ray2.84A/B/C/D1201-1412[»]
5VT8X-ray2.92A/B/C/D2504-2715[»]
5WJMX-ray2.90A1739-1954[»]
ProteinModelPortaliQ99PF4
SMRiQ99PF4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204475, 1 interactor
CORUMiQ99PF4
DIPiDIP-42152N
IntActiQ99PF4, 2 interactors
MINTiQ99PF4
STRINGi10090.ENSMUSP00000101104

PTM databases

iPTMnetiQ99PF4
PhosphoSitePlusiQ99PF4

Proteomic databases

PaxDbiQ99PF4
PRIDEiQ99PF4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105461; ENSMUSP00000101101; ENSMUSG00000012819 [Q99PF4-1]
ENSMUST00000105463; ENSMUSP00000101103; ENSMUSG00000012819 [Q99PF4-2]
GeneIDi22295
KEGGimmu:22295
UCSCiuc033fpl.1 mouse [Q99PF4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64072
MGIiMGI:1890219 Cdh23

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00940000155245
HOGENOMiHOG000139588
HOVERGENiHBG050768
InParanoidiQ99PF4
KOiK06813
OMAiERAFSIN
OrthoDBi17702at2759
TreeFamiTF316403

Miscellaneous databases

EvolutionaryTraceiQ99PF4

Protein Ontology

More...
PROi
PR:Q99PF4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000012819 Expressed in 56 organ(s), highest expression level in internal ear
ExpressionAtlasiQ99PF4 baseline and differential
GenevisibleiQ99PF4 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR033030 CDH23
PANTHERiPTHR43956:SF3 PTHR43956:SF3, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 25 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 26 hits
SUPFAMiSSF49313 SSF49313, 27 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 17 hits
PS50268 CADHERIN_2, 27 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAD23_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99PF4
Secondary accession number(s): E9QP63
, Q5QGS3, Q5QGS4, Q5QGS7, Q5QGS8, Q99NH1, Q9D4N9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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