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Protein

ADP-ribosylation factor-like protein 4D

Gene

Arl4d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35GTPBy similarity8
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4D
Alternative name(s):
ADP-ribosylation factor-like protein 4L
ADP-ribosylation factor-like protein 5
Gene namesi
Name:Arl4d
Synonyms:Arf4l, Arl5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1933155 Arl4d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074652 – 201ADP-ribosylation factor-like protein 4DAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ99PE9
PRIDEiQ99PE9

PTM databases

PhosphoSitePlusiQ99PE9

Expressioni

Gene expression databases

BgeeiENSMUSG00000034936 Expressed in 251 organ(s), highest expression level in decidua
CleanExiMM_ARL4D
GenevisibleiQ99PE9 MM

Interactioni

Subunit structurei

Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D (By similarity).By similarity

Protein-protein interaction databases

BioGridi219856, 3 interactors
MINTiQ99PE9
STRINGi10090.ENSMUSP00000035918

Structurei

3D structure databases

ProteinModelPortaliQ99PE9
SMRiQ99PE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ99PE9
KOiK07945
OMAiSITFQVW
OrthoDBiEOG091G0LK5
TreeFamiTF105464

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV
60 70 80 90 100
PTKGFNTEKI RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV
110 120 130 140 150
VDSAETERLE EARMELHRIS KASDNQGVPV LVLANKQDQP GALSAAEVEK
160 170 180 190 200
RLAVRELAAA TLTHVQGCSA VDGLGLQPGL EHLYEMILKR KKAPRSSKKR

R
Length:201
Mass (Da):22,270
Last modified:October 3, 2012 - v2
Checksum:iA6462A22B3AD451A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7E → D in AAG53667 (PubMed:12414990).Curated1
Sequence conflicti106T → I in AAG53667 (PubMed:12414990).Curated1
Sequence conflicti113 – 114RM → KV in AAG53667 (PubMed:12414990).Curated2
Sequence conflicti167G → A in AAG53667 (PubMed:12414990).Curated1
Sequence conflicti178P → Q in AAG53667 (PubMed:12414990).Curated1
Sequence conflicti182H → R in AAG53667 (PubMed:12414990).Curated1
Sequence conflicti196S → G in AAG53667 (PubMed:12414990).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312686 mRNA Translation: AAG53667.1
AK004126 mRNA Translation: BAB23183.1
AK013320 mRNA Translation: BAB28789.1
AL590994 Genomic DNA Translation: CAM22640.1
CH466558 Genomic DNA Translation: EDL34064.1
BC016113 mRNA Translation: AAH16113.1
CCDSiCCDS36336.1
RefSeqiNP_079680.1, NM_025404.3
UniGeneiMm.266840

Genome annotation databases

EnsembliENSMUST00000039388; ENSMUSP00000035918; ENSMUSG00000034936
GeneIDi80981
KEGGimmu:80981
UCSCiuc007lpq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312686 mRNA Translation: AAG53667.1
AK004126 mRNA Translation: BAB23183.1
AK013320 mRNA Translation: BAB28789.1
AL590994 Genomic DNA Translation: CAM22640.1
CH466558 Genomic DNA Translation: EDL34064.1
BC016113 mRNA Translation: AAH16113.1
CCDSiCCDS36336.1
RefSeqiNP_079680.1, NM_025404.3
UniGeneiMm.266840

3D structure databases

ProteinModelPortaliQ99PE9
SMRiQ99PE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219856, 3 interactors
MINTiQ99PE9
STRINGi10090.ENSMUSP00000035918

PTM databases

PhosphoSitePlusiQ99PE9

Proteomic databases

PaxDbiQ99PE9
PRIDEiQ99PE9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039388; ENSMUSP00000035918; ENSMUSG00000034936
GeneIDi80981
KEGGimmu:80981
UCSCiuc007lpq.2 mouse

Organism-specific databases

CTDi379
MGIiMGI:1933155 Arl4d

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ99PE9
KOiK07945
OMAiSITFQVW
OrthoDBiEOG091G0LK5
TreeFamiTF105464

Miscellaneous databases

PROiPR:Q99PE9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034936 Expressed in 251 organ(s), highest expression level in decidua
CleanExiMM_ARL4D
GenevisibleiQ99PE9 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARL4D_MOUSE
AccessioniPrimary (citable) accession number: Q99PE9
Secondary accession number(s): Q9CQB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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