UniProtKB - Q99PE2 (ANRA2_MOUSE)
Ankyrin repeat family A protein 2
Ankra2
Functioni
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (By similarity).
May also regulate LRP2/megalin (PubMed:11095640).
By similarity1 PublicationGO - Molecular functioni
- histone deacetylase binding Source: MGI
- low-density lipoprotein particle receptor binding Source: MGI
- protein kinase binding Source: MGI
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- regulation of gene expression Source: GO_Central
- regulation of protein-containing complex assembly Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat family A protein 2Alternative name(s): RFXANK-like protein 2 |
Gene namesi | Name:Ankra2 Synonyms:Ankra |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915808, Ankra2 |
VEuPathDBi | HostDB:ENSMUSG00000021661 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- Membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: MGI
Other locations
- 3M complex Source: Ensembl
- cytoplasm Source: MGI
- membrane Source: MGI
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066896 | 1 – 312 | Ankyrin repeat family A protein 2Add BLAST | 312 |
Proteomic databases
PaxDbi | Q99PE2 |
PRIDEi | Q99PE2 |
ProteomicsDBi | 281884 |
PTM databases
iPTMneti | Q99PE2 |
PhosphoSitePlusi | Q99PE2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021661, Expressed in embryo and 281 other tissues |
Genevisiblei | Q99PE2, MM |
Interactioni
Subunit structurei
Interacts (via ANK repeats) with CCDC8 (via PxLPxI/L motif); mediates the interaction with the 3M complex which is composed of CCDC8, CUL7 and OBSL1.
Interacts (via ANK repeats) with HDAC4 (via PxLPxI/L motif).
Interacts (via ANK repeats) with HDAC5 (via PxLPxI/L motif) (By similarity).
Interacts (via ANK repeats) with LRP2/megalin (via PxLPxI/L motif) (PubMed:11095640).
Interacts (via ANK repeats) with RFX7 (via PxLPxI/L motif) (By similarity).
Interacts with AHRR (PubMed:17949687).
Interacts with NEK6 (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- histone deacetylase binding Source: MGI
- low-density lipoprotein particle receptor binding Source: MGI
- protein kinase binding Source: MGI
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 212926, 2 interactors |
ELMi | Q99PE2 |
IntActi | Q99PE2, 1 interactor |
STRINGi | 10090.ENSMUSP00000022164 |
Miscellaneous databases
RNActi | Q99PE2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 147 – 179 | ANK 1Add BLAST | 33 | |
Repeati | 180 – 212 | ANK 2Add BLAST | 33 | |
Repeati | 213 – 245 | ANK 3Add BLAST | 33 | |
Repeati | 246 – 278 | ANK 4Add BLAST | 33 | |
Repeati | 279 – 312 | ANK 5Add BLAST | 34 |
Domaini
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0502, Eukaryota |
GeneTreei | ENSGT00940000157156 |
HOGENOMi | CLU_078123_0_0_1 |
InParanoidi | Q99PE2 |
OrthoDBi | 1348558at2759 |
PhylomeDBi | Q99PE2 |
TreeFami | TF333112 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MATSANLDIG AQLIVEECPS SYISGMPDIK LEHQLDPNPD EGAAQGVAMG
60 70 80 90 100
MKFILPNRFD MNVCSRFVKS LNEEDSKNIQ DQVNSDLEVA SVLFKAECNI
110 120 130 140 150
HTSPSPGIQV RHVYTPSTTK HFSPIKQSTT LTNKHRGNEV STTPLLANSL
160 170 180 190 200
SAHQLAAQGE MLYLATRIEQ ENVINHTDEE GFTPLMWAAA HGQIAVVEFL
210 220 230 240 250
LQNGADPQLL GKGRESALSL ACSKGYTDIV KMLLDCGVDV NEYDWNGGTP
260 270 280 290 300
LLYAVHGNHV KCVKMLLENG ADPTIETDSG YNSMDLAVAL GYRGVQQAIE
310
SHLLKLLQNI RE
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6AXE4 | Q6AXE4_MOUSE | Ankra2 protein | Ankra2 | 309 | Annotation score: | ||
D3Z4I1 | D3Z4I1_MOUSE | Ankyrin repeat family A protein 2 | Ankra2 | 154 | Annotation score: | ||
Q6NZJ1 | Q6NZJ1_MOUSE | Ankra2 protein | Ankra2 | 304 | Annotation score: | ||
Q8C4M9 | Q8C4M9_MOUSE | Ankyrin repeat family A protein 2 | Ankra2 | 144 | Annotation score: | ||
A0A286YDH7 | A0A286YDH7_MOUSE | Ankyrin repeat family A protein 2 | Ankra2 | 152 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF314031 mRNA Translation: AAK01620.1 |
CCDSi | CCDS26713.1 |
RefSeqi | NP_075961.1, NM_023472.2 |
Genome annotation databases
Ensembli | ENSMUST00000022164; ENSMUSP00000022164; ENSMUSG00000021661 |
GeneIDi | 68558 |
KEGGi | mmu:68558 |
UCSCi | uc007ror.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF314031 mRNA Translation: AAK01620.1 |
CCDSi | CCDS26713.1 |
RefSeqi | NP_075961.1, NM_023472.2 |
3D structure databases
SMRi | Q99PE2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212926, 2 interactors |
ELMi | Q99PE2 |
IntActi | Q99PE2, 1 interactor |
STRINGi | 10090.ENSMUSP00000022164 |
PTM databases
iPTMneti | Q99PE2 |
PhosphoSitePlusi | Q99PE2 |
Proteomic databases
PaxDbi | Q99PE2 |
PRIDEi | Q99PE2 |
ProteomicsDBi | 281884 |
Protocols and materials databases
Antibodypediai | 24269, 186 antibodies from 22 providers |
DNASUi | 68558 |
Genome annotation databases
Ensembli | ENSMUST00000022164; ENSMUSP00000022164; ENSMUSG00000021661 |
GeneIDi | 68558 |
KEGGi | mmu:68558 |
UCSCi | uc007ror.2, mouse |
Organism-specific databases
CTDi | 57763 |
MGIi | MGI:1915808, Ankra2 |
VEuPathDBi | HostDB:ENSMUSG00000021661 |
Phylogenomic databases
eggNOGi | KOG0502, Eukaryota |
GeneTreei | ENSGT00940000157156 |
HOGENOMi | CLU_078123_0_0_1 |
InParanoidi | Q99PE2 |
OrthoDBi | 1348558at2759 |
PhylomeDBi | Q99PE2 |
TreeFami | TF333112 |
Miscellaneous databases
BioGRID-ORCSi | 68558, 1 hit in 65 CRISPR screens |
ChiTaRSi | Ankra2, mouse |
PROi | PR:Q99PE2 |
RNActi | Q99PE2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021661, Expressed in embryo and 281 other tissues |
Genevisiblei | Q99PE2, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ANRA2_MOUSE | |
Accessioni | Q99PE2Primary (citable) accession number: Q99PE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot