Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Resistin-like beta

Gene

Retnlb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable hormone.

GO - Molecular functioni

GO - Biological processi

  • response to bacterium Source: MGI

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Resistin-like beta
Alternative name(s):
Cysteine-rich secreted protein A12-beta
Cysteine-rich secreted protein FIZZ2
RELMbeta
Gene namesi
Name:Retnlb
Synonyms:Fizz2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1888505 Retnlb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25C → A: Fails to homodimerize. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003034624 – 105Resistin-like betaAdd BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25InterchainCombined sources2 Publications
Disulfide bondi49 ↔ 102Combined sources1 Publication
Disulfide bondi61 ↔ 101Combined sources1 Publication
Disulfide bondi70 ↔ 87Combined sources1 Publication
Disulfide bondi72 ↔ 89Combined sources1 Publication
Disulfide bondi76 ↔ 91Combined sources1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ99P86
PRIDEiQ99P86

Expressioni

Tissue specificityi

Strongly expressed in colon, and at lower levels in ileum (PubMed:15834545). In colon, found throughout the crypt and surface epithelium and in goblet cells (at protein level) (PubMed:15834545). Specific to the gastrointestinal tract; not detected in other tissues tested (PubMed:11209052, PubMed:15834545).2 Publications

Inductioni

Up-regulated in colon in response to a high-fat diet. Also up-regulated in obese mice mutant for the leptin receptor LEPR (db/db genotype).1 Publication

Gene expression databases

CleanExiMM_RETNLB

Interactioni

Subunit structurei

Homodimer; disulfide-linked (PubMed:11358969, PubMed:15834545, PubMed:15155948). Heterodimer with RETNLG (PubMed:15834545).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023328

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99P86
SMRiQ99P86
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99P86

Family & Domainsi

Sequence similaritiesi

Belongs to the resistin/FIZZ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J40Z Eukaryota
ENOG410ZE8R LUCA
HOGENOMiHOG000137607
HOVERGENiHBG018297
InParanoidiQ99P86
PhylomeDBiQ99P86
TreeFamiTF337024

Family and domain databases

CDDicd16333 RELM, 1 hit
Gene3Di3.30.1660.20, 1 hit
InterProiView protein in InterPro
IPR009714 Resistin
IPR036262 Resistin-like_sf
PANTHERiPTHR21101 PTHR21101, 1 hit
PfamiView protein in Pfam
PF06954 Resistin, 1 hit
SUPFAMiSSF111423 SSF111423, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99P86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPTLCFLFI LVSLFPLIVP GNAQCSFESL VDQRIKEALS RQEPKTISCT
60 70 80 90 100
SVTSSGRLAS CPAGMVVTGC ACGYGCGSWD IRNGNTCHCQ CSVMDWASAR

CCRMA
Length:105
Mass (Da):11,278
Last modified:June 1, 2001 - v1
Checksum:i2F5FFDA5A28B7141
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J042A0A0R4J042_MOUSE
Resistin-like beta
Retnlb mCG_128612
105Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15F → L in BAB32036 (PubMed:16141072).Curated1
Sequence conflicti105A → V in AAK83103 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323083 mRNA Translation: AAG59826.1
AF290871 mRNA Translation: AAK83103.1
AK020240 mRNA Translation: BAB32036.1
BC022650 mRNA Translation: AAH22650.1
CCDSiCCDS28210.1
RefSeqiNP_076370.3, NM_023881.4
UniGeneiMm.21123

Genome annotation databases

GeneIDi57263
KEGGimmu:57263

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323083 mRNA Translation: AAG59826.1
AF290871 mRNA Translation: AAK83103.1
AK020240 mRNA Translation: BAB32036.1
BC022650 mRNA Translation: AAH22650.1
CCDSiCCDS28210.1
RefSeqiNP_076370.3, NM_023881.4
UniGeneiMm.21123

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RH7X-ray3.11A/B/C/D/E/F25-105[»]
ProteinModelPortaliQ99P86
SMRiQ99P86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023328

Proteomic databases

PaxDbiQ99P86
PRIDEiQ99P86

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi57263
KEGGimmu:57263

Organism-specific databases

CTDi84666
MGIiMGI:1888505 Retnlb

Phylogenomic databases

eggNOGiENOG410J40Z Eukaryota
ENOG410ZE8R LUCA
HOGENOMiHOG000137607
HOVERGENiHBG018297
InParanoidiQ99P86
PhylomeDBiQ99P86
TreeFamiTF337024

Miscellaneous databases

EvolutionaryTraceiQ99P86
PROiPR:Q99P86
SOURCEiSearch...

Gene expression databases

CleanExiMM_RETNLB

Family and domain databases

CDDicd16333 RELM, 1 hit
Gene3Di3.30.1660.20, 1 hit
InterProiView protein in InterPro
IPR009714 Resistin
IPR036262 Resistin-like_sf
PANTHERiPTHR21101 PTHR21101, 1 hit
PfamiView protein in Pfam
PF06954 Resistin, 1 hit
SUPFAMiSSF111423 SSF111423, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRETNB_MOUSE
AccessioniPrimary (citable) accession number: Q99P86
Secondary accession number(s): Q9D286
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again