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Protein

Ras-related protein Rab-9A

Gene

Rab9a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans-Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei155GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPBy similarity9
Nucleotide bindingi62 – 66GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-6811440 Retrograde transport at the Trans-Golgi-Network
R-RNO-8873719 RAB geranylgeranylation
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9A
Gene namesi
Name:Rab9a
Synonyms:Rab9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi619740 Rab9a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211412 – 201Ras-related protein Rab-9AAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei179PhosphoserineBy similarity1
Modified residuei187PhosphothreonineBy similarity1
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ99P75
PRIDEiQ99P75

Expressioni

Gene expression databases

BgeeiENSRNOG00000030443 Expressed in 10 organ(s), highest expression level in liver
GenevisibleiQ99P75 RN

Interactioni

Subunit structurei

Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (PubMed:16885419). Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1. Interacts with SGSM2. The GTP-bound form but not the GDP-bound form interacts with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050986

Structurei

3D structure databases

ProteinModelPortaliQ99P75
SMRiQ99P75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394 Eukaryota
ENOG410XNZV LUCA
GeneTreeiENSGT00760000119125
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ99P75
KOiK07899
OMAiRSSCCMP
OrthoDBiEOG091G0JIV
PhylomeDBiQ99P75

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKSSLFKI ILLGDGGVGK SSLMNRYVTN KFDSQLFHTI GVEFLNKDLE
60 70 80 90 100
VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN
110 120 130 140 150
WKKEFIYYAD VKEPESFPFV ILGNKTDIKE RQVSTEEAQA WCKDNGDYPY
160 170 180 190 200
FETSAKDSTN VAAAFEEAVR RILATEDRSD HLIQTDTVNL HRKPKPNSSC

C
Length:201
Mass (Da):22,896
Last modified:April 26, 2005 - v2
Checksum:i43F490EAA67CF7EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29T → A in AAG49586 (PubMed:12051767).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325692 mRNA Translation: AAG49586.1
BC070502 mRNA Translation: AAH70502.1
RefSeqiNP_445910.1, NM_053458.1
UniGeneiRn.35289

Genome annotation databases

EnsembliENSRNOT00000050018; ENSRNOP00000050986; ENSRNOG00000030443
GeneIDi84589
KEGGirno:84589
UCSCiRGD:619740 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325692 mRNA Translation: AAG49586.1
BC070502 mRNA Translation: AAH70502.1
RefSeqiNP_445910.1, NM_053458.1
UniGeneiRn.35289

3D structure databases

ProteinModelPortaliQ99P75
SMRiQ99P75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050986

Proteomic databases

PaxDbiQ99P75
PRIDEiQ99P75

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050018; ENSRNOP00000050986; ENSRNOG00000030443
GeneIDi84589
KEGGirno:84589
UCSCiRGD:619740 rat

Organism-specific databases

CTDi9367
RGDi619740 Rab9a

Phylogenomic databases

eggNOGiKOG0394 Eukaryota
ENOG410XNZV LUCA
GeneTreeiENSGT00760000119125
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ99P75
KOiK07899
OMAiRSSCCMP
OrthoDBiEOG091G0JIV
PhylomeDBiQ99P75

Enzyme and pathway databases

ReactomeiR-RNO-6811440 Retrograde transport at the Trans-Golgi-Network
R-RNO-8873719 RAB geranylgeranylation
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

PROiPR:Q99P75

Gene expression databases

BgeeiENSRNOG00000030443 Expressed in 10 organ(s), highest expression level in liver
GenevisibleiQ99P75 RN

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB9A_RAT
AccessioniPrimary (citable) accession number: Q99P75
Secondary accession number(s): Q6NS34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: April 26, 2005
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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