UniProtKB - Q99P72 (RTN4_MOUSE)
Reticulon-4
Rtn4
Functioni
Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities.
By similarityDevelopmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system (PubMed:20573699).
Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (By similarity).
Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (PubMed:20573699).
Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (PubMed:23625008).
By similarity2 PublicationsMainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells (PubMed:15034570).
Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P) (PubMed:26301690).
Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair (PubMed:19805174).
Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation (PubMed:21183689).
Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes (PubMed:25917084).
Also involved in immune response to LPS (PubMed:26174362).
Plays a role in liver regeneration through the modulation of hepatocytes proliferation (PubMed:23299899).
Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (By similarity).
By similarityCurated7 PublicationsRegulates cardiomyocyte apoptosis upon hypoxic conditions (PubMed:27763637).
With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (By similarity).
By similarity1 PublicationGO - Molecular functioni
- cadherin binding Source: MGI
- protein-containing complex binding Source: MGI
- protein homodimerization activity Source: UniProtKB
- ubiquitin protein ligase binding Source: MGI
GO - Biological processi
- axonal fasciculation Source: UniProtKB
- blastocyst formation Source: MGI
- cardiac epithelial to mesenchymal transition Source: MGI
- cell adhesion involved in sprouting angiogenesis Source: UniProtKB
- cell migration involved in vasculogenesis Source: UniProtKB
- cellular response to hypoxia Source: UniProtKB
- cellular sphingolipid homeostasis Source: UniProtKB
- central nervous system vasculogenesis Source: UniProtKB
- cerebral cortex radial glia-guided migration Source: UniProtKB
- endoplasmic reticulum organization Source: MGI
- endoplasmic reticulum tubular network formation Source: UniProtKB
- endoplasmic reticulum tubular network membrane organization Source: UniProtKB
- endoplasmic reticulum tubular network organization Source: UniProtKB
- leukocyte migration involved in inflammatory response Source: UniProtKB
- negative regulation of amyloid-beta formation Source: UniProtKB
- negative regulation of axon extension Source: UniProtKB
- negative regulation of axonogenesis Source: MGI
- negative regulation of cell growth Source: MGI
- negative regulation of neuron differentiation Source: MGI
- negative regulation of neuron projection development Source: MGI
- negative regulation of neuron projection regeneration Source: MGI
- negative regulation of vasculogenesis Source: UniProtKB
- nervous system development Source: MGI
- nuclear pore complex assembly Source: UniProtKB
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of artery morphogenesis Source: UniProtKB
- positive regulation of dopamine secretion Source: MGI
- positive regulation of epithelial cell migration Source: MGI
- positive regulation of ERBB3 signaling pathway Source: MGI
- positive regulation of glial cell differentiation Source: MGI
- positive regulation of hepatocyte proliferation Source: UniProtKB
- positive regulation of macrophage cytokine production Source: UniProtKB
- positive regulation of macrophage migration Source: UniProtKB
- positive regulation of mammary gland epithelial cell proliferation Source: MGI
- positive regulation of neutrophil migration Source: UniProtKB
- positive regulation of protein kinase B signaling Source: MGI
- positive regulation of protein localization to endoplasmic reticulum Source: MGI
- positive regulation of Rac protein signal transduction Source: UniProtKB
- positive regulation of toll-like receptor 9 signaling pathway Source: UniProtKB
- protein localization to lysosome Source: UniProtKB
- protein stabilization Source: CAFA
- regulation of branching morphogenesis of a nerve Source: UniProtKB
- regulation of cell migration Source: UniProtKB
- regulation of nervous system development Source: UniProtKB
- regulation of sensory perception of pain Source: MGI
Keywordsi
Biological process | Neurogenesis |
Enzyme and pathway databases
Reactomei | R-MMU-193634, Axonal growth inhibition (RHOA activation) |
Names & Taxonomyi
Protein namesi | Recommended name: Reticulon-4CuratedAlternative name(s): Neurite outgrowth inhibitor Short name: Nogo protein1 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915835, Rtn4 |
VEuPathDBi | HostDB:ENSMUSG00000020458 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis; Cytoplasmic side By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Note: Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network. Co-localizes with TMEM33 at the ER sheets.By similarity
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis; Extracellular side By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane 3 Publications; Multi-pass membrane protein Sequence analysis
Other locations
- Cell junction By similarity
Note: Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagement, redistributed toward endothelial junctions where interacts with CDH5 (By similarity).By similarity1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: UniProtKB
- endoplasmic reticulum tubular network Source: MGI
- endoplasmic reticulum tubular network membrane Source: UniProtKB
- integral component of endoplasmic reticulum membrane Source: UniProtKB
Nucleus
- nuclear envelope Source: UniProtKB
Plasma Membrane
- integral component of postsynaptic density membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- cell junction Source: UniProtKB
- cell projection Source: MGI
- cytoplasm Source: MGI
- glutamatergic synapse Source: MGI
- myelin sheath Source: MGI
- neuron projection Source: MGI
- neuronal cell body Source: MGI
- postsynaptic density Source: MGI
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 988 | CytoplasmicSequence analysisAdd BLAST | 988 | |
Transmembranei | 989 – 1009 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1010 – 1078 | LumenalSequence analysisAdd BLAST | 69 | |
Transmembranei | 1079 – 1099 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1100 – 1162 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Endoplasmic reticulum, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168166 | 1 – 1162 | Reticulon-4Add BLAST | 1162 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 105 | PhosphoserineCombined sources | 1 | |
Modified residuei | 145 | PhosphoserineCombined sources | 1 | |
Modified residuei | 165 | PhosphoserineCombined sources | 1 | |
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 329 | PhosphoserineBy similarity | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 | |
Modified residuei | 348 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 426 | PhosphoserineBy similarity | 1 | |
Modified residuei | 430 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 489 | PhosphoserineCombined sources | 1 | |
Modified residuei | 690 | PhosphoserineCombined sources | 1 | |
Modified residuei | 727 | PhosphoserineCombined sources | 1 | |
Modified residuei | 768 | PhosphoserineCombined sources | 1 | |
Modified residuei | 832 | PhosphoserineBy similarity | 1 | |
Modified residuei | 834 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 857 | PhosphoserineCombined sources | 1 | |
Modified residuei | 961 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1074 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q99P72 |
jPOSTi | Q99P72 |
MaxQBi | Q99P72 |
PaxDbi | Q99P72 |
PeptideAtlasi | Q99P72 |
PRIDEi | Q99P72 |
ProteomicsDBi | 256639 [Q99P72-2] 256640 [Q99P72-3] 256641 [Q99P72-1] 331244 343118 |
PTM databases
iPTMneti | Q99P72 |
PhosphoSitePlusi | Q99P72 |
SwissPalmi | Q99P72 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000020458, Expressed in piriform cortex and 343 other tissues |
Genevisiblei | Q99P72, MM |
Interactioni
Subunit structurei
Binds to RTN4R (By similarity).
Interacts with ATL1 (By similarity).
Interacts with TMEM170A (By similarity).
Interacts with RTN4IP1 (PubMed:12067236).
By similarity1 PublicationInteracts in trans with CNTNAP1 (By similarity).
Interacts with REEP5 (PubMed:32075961).
By similarity1 PublicationHomodimer (By similarity).
Interacts with BAD/Bcl-xl and BCL2. Interact with RTN3 (By similarity).
Interacts with NGBR (By similarity).
Interacts with SPTLC1 (PubMed:26301690).
Interacts with GRAMD4 (PubMed:25917084).
Interacts with CDH5 (By similarity).
Interacts with BACE1 and BACE2 (By similarity).
Interacts with REEP5 (PubMed:32075961).
By similarity3 PublicationsInteracts with BACE1 and BACE2 (By similarity).
Interacts with TMEM33 (By similarity).
By similarityBinary interactionsi
GO - Molecular functioni
- cadherin binding Source: MGI
- protein homodimerization activity Source: UniProtKB
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 212938, 11 interactors |
CORUMi | Q99P72 |
DIPi | DIP-41976N |
IntActi | Q99P72, 5 interactors |
MINTi | Q99P72 |
STRINGi | 10090.ENSMUSP00000099907 |
Miscellaneous databases
RNActi | Q99P72, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q99P72 |
BMRBi | Q99P72 |
SMRi | Q99P72 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99P72 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 975 – 1162 | ReticulonPROSITE-ProRule annotationAdd BLAST | 188 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 183 | DisorderedSequence analysisAdd BLAST | 183 | |
Regioni | 406 – 432 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 711 – 730 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 53 | Acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 86 – 100 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 135 – 157 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 406 – 423 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Domaini
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1792, Eukaryota |
GeneTreei | ENSGT00940000156568 |
HOGENOMi | CLU_048580_0_0_1 |
InParanoidi | Q99P72 |
OMAi | FEVVDYH |
OrthoDBi | 212372at2759 |
PhylomeDBi | Q99P72 |
TreeFami | TF105431 |
Family and domain databases
InterProi | View protein in InterPro IPR003388, Reticulon |
Pfami | View protein in Pfam PF02453, Reticulon, 1 hit |
PROSITEi | View protein in PROSITE PS50845, RETICULON, 1 hit |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEDIDQSSLV SSSADSPPRP PPAFKYQFVT EPEDEEDEED EEEEEDDEDL
60 70 80 90 100
EELEVLERKP AAGLSAAPVP PAAAPLLDFS SDSVPPAPRG PLPAAPPTAP
110 120 130 140 150
ERQPSWERSP AASAPSLPPA AAVLPSKLPE DDEPPARPPA PAGASPLAEP
160 170 180 190 200
AAPPSTPAAP KRRGSGSVDE TLFALPAASE PVIPSSAEKI MDLKEQPGNT
210 220 230 240 250
VSSGQEDFPS VLFETAASLP SLSPLSTVSF KEHGYLGNLS AVASTEGTIE
260 270 280 290 300
ETLNEASREL PERATNPFVN RESAEFSVLE YSEMGSSFNG SPKGESAMLV
310 320 330 340 350
ENTKEEVIVR SKDKEDLVCS AALHNPQESP ATLTKVVKED GVMSPEKTMD
360 370 380 390 400
IFNEMKMSVV APVREEYADF KPFEQAWEVK DTYEGSRDVL AARANMESKV
410 420 430 440 450
DKKCFEDSLE QKGHGKDSES RNENASFPRT PELVKDGSRA YITCDSFSSA
460 470 480 490 500
TESTAANIFP VLEDHTSENK TDEKKIEERK AQIITEKTSP KTSNPFLVAI
510 520 530 540 550
HDSEADYVTT DNLSKVTEAV VATMPEGLTP DLVQEACESE LNEATGTKIA
560 570 580 590 600
YETKVDLVQT SEAIQESIYP TAQLCPSFEE AEATPSPVLP DIVMEAPLNS
610 620 630 640 650
LLPSTGASVA QPSASPLEVP SPVSYDGIKL EPENPPPYEE AMSVALKTSD
660 670 680 690 700
SKEEIKEPES FNAAAQEAEA PYISIACDLI KETKLSTEPS PEFSNYSEIA
710 720 730 740 750
KFEKSVPDHC ELVDDSSPES EPVDLFSDDS IPEVPQTQEE AVMLMKESLT
760 770 780 790 800
EVSETVTQHK HKERLSASPQ EVGKPYLESF QPNLHITKDA ASNEIPTLTK
810 820 830 840 850
KETISLQMEE FNTAIYSNDD LLSSKEDKMK ESETFSDSSP IEIIDEFPTF
860 870 880 890 900
VSAKDDSPKE YTDLEVSNKS EIANVQSGAN SLPCSELPCD LSFKNTYPKD
910 920 930 940 950
EAHVSDEFSK SRSSVSKVPL LLPNVSALES QIEMGNIVKP KVLTKEAEEK
960 970 980 990 1000
LPSDTEKEDR SLTAVLSAEL NKTSVVDLLY WRDIKKTGVV FGASLFLLLS
1010 1020 1030 1040 1050
LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
1060 1070 1080 1090 1100
VAISEELVQK YSNSALGHVN STIKELRRLF LVDDLVDSLK FAVLMWVFTY
1110 1120 1130 1140 1150
VGALFNGLTL LILALISLFS IPVIYERHQA QIDHYLGLAN KSVKDAMAKI
1160
QAKIPGLKRK AE
The sequence of this isoform differs from the canonical sequence as follows:
188-974: Missing.
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | I → V in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 16 | S → R in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 21 | P → L in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 67 | A → V in AAM77068 (Ref. 3) Curated | 1 | |
Sequence conflicti | 413 | G → S in AAM77068 (Ref. 3) Curated | 1 | |
Sequence conflicti | 413 | G → S in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 429 | R → S in AAM77068 (Ref. 3) Curated | 1 | |
Sequence conflicti | 429 | R → S in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 448 | S → T in AAM77068 (Ref. 3) Curated | 1 | |
Sequence conflicti | 448 | S → T in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 487 – 490 | KTSP → HASA in AAH32192 (PubMed:15489334).Curated | 4 | |
Sequence conflicti | 651 | S → A in AAM77068 (Ref. 3) Curated | 1 | |
Sequence conflicti | 651 | S → A in AAH32192 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 651 | S → A in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 665 | A → V in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 692 | E → G in AAM77068 (Ref. 3) Curated | 1 | |
Sequence conflicti | 692 | E → G in BAC75974 (Ref. 8) Curated | 1 | |
Sequence conflicti | 733 | E → D in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 772 | V → L in BAD90301 (Ref. 4) Curated | 1 | |
Sequence conflicti | 916 | S → F in BAC75974 (Ref. 8) Curated | 1 | |
Sequence conflicti | 990 | V → VY in AAM77068 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018088 | 1 – 963 | Missing in isoform C. 2 PublicationsAdd BLAST | 963 | |
Alternative sequenceiVSP_018089 | 1 – 116 | Missing in isoform D. 1 PublicationAdd BLAST | 116 | |
Alternative sequenceiVSP_018090 | 117 – 169 | LPPAA…SGSVD → MAPPLAGGGQKGGAASEAWV PSLFVGVSGSTCTAAKSLVP IPARSSRLSAARN in isoform D. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_060062 | 167 – 974 | SVDET…LNKTS → SV in isoform B. 1 PublicationAdd BLAST | 808 | |
Alternative sequenceiVSP_060063 | 188 – 974 | Missing in isoform B2. 1 PublicationAdd BLAST | 787 | |
Alternative sequenceiVSP_018091 | 964 – 974 | AVLSAELNKTS → MDDQKKRWKDK in isoform C. 2 PublicationsAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY102280 mRNA Translation: AAM73502.1 AY102281 mRNA Translation: AAM73503.1 AY102282 mRNA Translation: AAM73504.1 AY102283 mRNA Translation: AAM73505.1 AY102284 mRNA Translation: AAM73506.1 AY102286 Genomic DNA Translation: AAM73507.1 AY102286 Genomic DNA Translation: AAM73508.1 AY102286 Genomic DNA Translation: AAM73509.1 AY102286 Genomic DNA Translation: AAM73510.1 AY102286 Genomic DNA Translation: AAM73511.1 AF326337 mRNA Translation: AAK08076.1 AY114152 mRNA Translation: AAM77068.1 AK220511 mRNA Translation: BAD90301.1 CH466604 Genomic DNA Translation: EDL23794.1 AL929371 Genomic DNA No translation available. BC032192 mRNA Translation: AAH32192.1 Different initiation. BC056373 mRNA No translation available. AB073672 mRNA Translation: BAC75974.1 AK003859 mRNA No translation available. |
CCDSi | CCDS24499.1 [Q99P72-5] CCDS24500.1 [Q99P72-4] CCDS24501.1 [Q99P72-2] CCDS24502.1 [Q99P72-3] CCDS24503.1 [Q99P72-1] |
RefSeqi | NP_077188.1, NM_024226.4 [Q99P72-1] NP_918940.1, NM_194051.3 [Q99P72-3] NP_918941.1, NM_194052.3 [Q99P72-5] NP_918942.1, NM_194053.3 [Q99P72-4] NP_918943.1, NM_194054.3 [Q99P72-2] |
Genome annotation databases
Ensembli | ENSMUST00000060992; ENSMUSP00000053754; ENSMUSG00000020458 [Q99P72-1] ENSMUST00000078830; ENSMUSP00000077875; ENSMUSG00000020458 [Q99P72-5] ENSMUST00000102841; ENSMUSP00000099905; ENSMUSG00000020458 [Q99P72-3] ENSMUST00000102842; ENSMUSP00000099906; ENSMUSG00000020458 [Q99P72-4] ENSMUST00000102843; ENSMUSP00000099907; ENSMUSG00000020458 [Q99P72-2] ENSMUST00000170731; ENSMUSP00000126413; ENSMUSG00000020458 [Q99P72-5] |
GeneIDi | 68585 |
KEGGi | mmu:68585 |
UCSCi | uc007ihk.2, mouse [Q99P72-2] uc007ihl.2, mouse uc007ihm.2, mouse uc007ihn.2, mouse [Q99P72-3] uc007iho.2, mouse |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Nerve regrowth: nipped by a no-go - Issue 69 of April 2006 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY102280 mRNA Translation: AAM73502.1 AY102281 mRNA Translation: AAM73503.1 AY102282 mRNA Translation: AAM73504.1 AY102283 mRNA Translation: AAM73505.1 AY102284 mRNA Translation: AAM73506.1 AY102286 Genomic DNA Translation: AAM73507.1 AY102286 Genomic DNA Translation: AAM73508.1 AY102286 Genomic DNA Translation: AAM73509.1 AY102286 Genomic DNA Translation: AAM73510.1 AY102286 Genomic DNA Translation: AAM73511.1 AF326337 mRNA Translation: AAK08076.1 AY114152 mRNA Translation: AAM77068.1 AK220511 mRNA Translation: BAD90301.1 CH466604 Genomic DNA Translation: EDL23794.1 AL929371 Genomic DNA No translation available. BC032192 mRNA Translation: AAH32192.1 Different initiation. BC056373 mRNA No translation available. AB073672 mRNA Translation: BAC75974.1 AK003859 mRNA No translation available. |
CCDSi | CCDS24499.1 [Q99P72-5] CCDS24500.1 [Q99P72-4] CCDS24501.1 [Q99P72-2] CCDS24502.1 [Q99P72-3] CCDS24503.1 [Q99P72-1] |
RefSeqi | NP_077188.1, NM_024226.4 [Q99P72-1] NP_918940.1, NM_194051.3 [Q99P72-3] NP_918941.1, NM_194052.3 [Q99P72-5] NP_918942.1, NM_194053.3 [Q99P72-4] NP_918943.1, NM_194054.3 [Q99P72-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KO2 | NMR | - | A | 1025-1090 | [»] | |
AlphaFoldDBi | Q99P72 | |||||
BMRBi | Q99P72 | |||||
SMRi | Q99P72 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 212938, 11 interactors |
CORUMi | Q99P72 |
DIPi | DIP-41976N |
IntActi | Q99P72, 5 interactors |
MINTi | Q99P72 |
STRINGi | 10090.ENSMUSP00000099907 |
PTM databases
iPTMneti | Q99P72 |
PhosphoSitePlusi | Q99P72 |
SwissPalmi | Q99P72 |
Proteomic databases
EPDi | Q99P72 |
jPOSTi | Q99P72 |
MaxQBi | Q99P72 |
PaxDbi | Q99P72 |
PeptideAtlasi | Q99P72 |
PRIDEi | Q99P72 |
ProteomicsDBi | 256639 [Q99P72-2] 256640 [Q99P72-3] 256641 [Q99P72-1] 331244 343118 |
Protocols and materials databases
Antibodypediai | 3949, 542 antibodies from 44 providers |
DNASUi | 68585 |
Genome annotation databases
Ensembli | ENSMUST00000060992; ENSMUSP00000053754; ENSMUSG00000020458 [Q99P72-1] ENSMUST00000078830; ENSMUSP00000077875; ENSMUSG00000020458 [Q99P72-5] ENSMUST00000102841; ENSMUSP00000099905; ENSMUSG00000020458 [Q99P72-3] ENSMUST00000102842; ENSMUSP00000099906; ENSMUSG00000020458 [Q99P72-4] ENSMUST00000102843; ENSMUSP00000099907; ENSMUSG00000020458 [Q99P72-2] ENSMUST00000170731; ENSMUSP00000126413; ENSMUSG00000020458 [Q99P72-5] |
GeneIDi | 68585 |
KEGGi | mmu:68585 |
UCSCi | uc007ihk.2, mouse [Q99P72-2] uc007ihl.2, mouse uc007ihm.2, mouse uc007ihn.2, mouse [Q99P72-3] uc007iho.2, mouse |
Organism-specific databases
CTDi | 57142 |
MGIi | MGI:1915835, Rtn4 |
VEuPathDBi | HostDB:ENSMUSG00000020458 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1792, Eukaryota |
GeneTreei | ENSGT00940000156568 |
HOGENOMi | CLU_048580_0_0_1 |
InParanoidi | Q99P72 |
OMAi | FEVVDYH |
OrthoDBi | 212372at2759 |
PhylomeDBi | Q99P72 |
TreeFami | TF105431 |
Enzyme and pathway databases
Reactomei | R-MMU-193634, Axonal growth inhibition (RHOA activation) |
Miscellaneous databases
BioGRID-ORCSi | 68585, 3 hits in 68 CRISPR screens |
ChiTaRSi | Rtn4, mouse |
EvolutionaryTracei | Q99P72 |
PROi | PR:Q99P72 |
RNActi | Q99P72, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020458, Expressed in piriform cortex and 343 other tissues |
Genevisiblei | Q99P72, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003388, Reticulon |
Pfami | View protein in Pfam PF02453, Reticulon, 1 hit |
PROSITEi | View protein in PROSITE PS50845, RETICULON, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RTN4_MOUSE | |
Accessioni | Q99P72Primary (citable) accession number: Q99P72 Secondary accession number(s): Q5DTK9 Q9CTE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | May 2, 2006 | |
Last modified: | May 25, 2022 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries