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UniProtKB - Q99P72 (RTN4_MOUSE)

Entry version 183 (25 May 2022)
Sequence version 2 (02 May 2006)
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Protein

Reticulon-4

Gene

Rtn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities.

By similarity

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system (PubMed:20573699).

Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (By similarity).

Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (PubMed:20573699).

Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (PubMed:23625008).

By similarity2 Publications

Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells (PubMed:15034570).

Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P) (PubMed:26301690).

Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair (PubMed:19805174).

Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation (PubMed:21183689).

Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes (PubMed:25917084).

Also involved in immune response to LPS (PubMed:26174362).

Plays a role in liver regeneration through the modulation of hepatocytes proliferation (PubMed:23299899).

Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (By similarity).

By similarityCurated7 Publications

Regulates cardiomyocyte apoptosis upon hypoxic conditions (PubMed:27763637).

With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-193634, Axonal growth inhibition (RHOA activation)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reticulon-4Curated
Alternative name(s):
Neurite outgrowth inhibitor
Short name:
Nogo protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rtn4Imported
Synonyms:Kiaa0886, Nogo1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1915835, Rtn4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000020458

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 988CytoplasmicSequence analysisAdd BLAST988
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei989 – 1009HelicalSequence analysisAdd BLAST21
Topological domaini1010 – 1078LumenalSequence analysisAdd BLAST69
Transmembranei1079 – 1099HelicalSequence analysisAdd BLAST21
Topological domaini1100 – 1162CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Isoform A mutant embryos show defects in the development of fore- and hindlimb innervation. Increased fasciculation and decreased branching of nerves innervating fore- and hindlimbs seen. Disturbances of the radial migration pattern of neuronal precursor cells seen in embryonic cortex (PubMed:20093372, PubMed:20573699). Isoform A mutants show increased density of blood vessels in postnatal brain, which is lost in adult brain (PubMed:23625008). Knockout mice for isoforms A and B are markedly hypotensive compared to control mice, with no significant increase of heart rate. They have mesenteric arteries thinner than controls (PubMed:26301690). Upon vascular injury mutants show markedly enhanced neointima formation and, in some cases, complete occlusion of the femoral artery (PubMed:15034570). Mutants for isoforms A and B show a marked reduction in neutrophil and monocyte recruitment to sites of inflammation (PubMed:21183689). Mutants for isoforms A and B are insensitive to stimulation with TLR9, TLR3 and TLR7 ligands (PubMed:25917084). Mutant mice for isoform C display improved cardiac function, smaller infarct area and less apoptotic cells after myocardial infarction (PubMed:27763637). Knockout mice show impaired responses to tissue injury (PubMed:19805174).9 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001681661 – 1162Reticulon-4Add BLAST1162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei7PhosphoserineBy similarity1
Modified residuei16PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei329PhosphoserineBy similarity1
Modified residuei344PhosphoserineCombined sources1
Modified residuei348PhosphothreonineCombined sources1
Modified residuei426PhosphoserineBy similarity1
Modified residuei430PhosphothreonineBy similarity1
Modified residuei489PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei727PhosphoserineCombined sources1
Modified residuei768PhosphoserineCombined sources1
Modified residuei832PhosphoserineBy similarity1
Modified residuei834PhosphothreonineBy similarity1
Modified residuei857PhosphoserineCombined sources1
Modified residuei961PhosphoserineBy similarity1
Modified residuei1074N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99P72

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99P72

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99P72

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99P72

PeptideAtlas

More...PeptideAtlasi		Q99P72

PRoteomics IDEntifications database

More...PRIDEi		Q99P72

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		256639 [Q99P72-2]
256640 [Q99P72-3]
256641 [Q99P72-1]
331244
343118

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99P72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99P72

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q99P72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cardiomyocytes (at protein level) (PubMed:32075961). Highly expressed in brain but not deteceted in aorta, femoral and carotid arteries (PubMed:15034570). Main isoform expressed in neurons (PubMed:23625008, PubMed:27786289).4 Publications
Expressed in cardiomyocytes (at protein level) (PubMed:32075961). Expressed in splenocytes, T-cells, B-cells, bone marrow derived dendritic cells and macrophages (at protein level) (PubMed:19805174, PubMed:25917084). Expressed in neurons (PubMed:23625008, PubMed:27786289). Highly expressed in endothelial cells and vascular smooth muscle cells, including blood vessels and mesenteric arteries (PubMed:15034570, PubMed:26301690). Expressed in bronchial and alveolar epithelial cells as well as vascular endothelial cells of lungs (PubMed:26174362).8 Publications
Expressed in B-cells, bone marrow dendritic cells and macrophages (at protein level).1 Publication
Expressed in cardiomyocytes.1 Publication
Expressed at very low levels in neurons.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in radial glial cells, migrating postmitotic as well as postmigratory neurons of the embryonic cortex (PubMed:20093372). Expression is down-regulated in the ganglion cell layer and in the plexiform layer of the retina at P8 (PubMed:20093372). Isoform B: expression increases in regenirating liver (PubMed:23299899).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform C: expression is induced by hypoxic treatments or myocardial infarction (PubMed:27763637). Isoform C: is negatively regulated by the microRNA miR-182 (PubMed:27763637). Isoform B: expression is down-regulated by LPS in alveolar epithelium (PubMed:26174362). Isoform B: induced during tissue ischemia (PubMed:19805174). Isoform B2: induced during tissue ischemia (PubMed:19805174).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000020458, Expressed in piriform cortex and 343 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99P72, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to RTN4R (By similarity).

Interacts with ATL1 (By similarity).

Interacts with TMEM170A (By similarity).

Interacts with RTN4IP1 (PubMed:12067236).

By similarity1 Publication

Interacts in trans with CNTNAP1 (By similarity).

Interacts with REEP5 (PubMed:32075961).

By similarity1 Publication

Homodimer (By similarity).

Interacts with BAD/Bcl-xl and BCL2. Interact with RTN3 (By similarity).

Interacts with NGBR (By similarity).

Interacts with SPTLC1 (PubMed:26301690).

Interacts with GRAMD4 (PubMed:25917084).

Interacts with CDH5 (By similarity).

Interacts with BACE1 and BACE2 (By similarity).

Interacts with REEP5 (PubMed:32075961).

By similarity3 Publications

Interacts with BACE1 and BACE2 (By similarity).

Interacts with TMEM33 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		212938, 11 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q99P72

Database of interacting proteins

More...DIPi		DIP-41976N

Protein interaction database and analysis system

More...IntActi		Q99P72, 5 interactors

Molecular INTeraction database

More...MINTi		Q99P72

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000099907

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99P72, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q99P72

Biological Magnetic Resonance Data Bank

More...BMRBi		Q99P72

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99P72

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q99P72

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini975 – 1162ReticulonPROSITE-ProRule annotationAdd BLAST188

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 183DisorderedSequence analysisAdd BLAST183
Regioni406 – 432DisorderedSequence analysisAdd BLAST27
Regioni711 – 730DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi31 – 53Acidic residuesSequence analysisAdd BLAST23
Compositional biasi86 – 100Pro residuesSequence analysisAdd BLAST15
Compositional biasi135 – 157Pro residuesSequence analysisAdd BLAST23
Compositional biasi406 – 423Basic and acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).By similarity
N-terminal part, called Am-Nogo-B(1-200), is the functional domain for RTN4B-mediated signaling in endothelial and vascular smooth muscle cells.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1792, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156568

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048580_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99P72

Identification of Orthologs from Complete Genome Data

More...OMAi		FEVVDYH

Database of Orthologous Groups

More...OrthoDBi		212372at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99P72

TreeFam database of animal gene trees

More...TreeFami		TF105431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003388, Reticulon

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02453, Reticulon, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50845, RETICULON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q99P72-2) [UniParc]FASTAAdd to basket
Also known as: RTN4A2 Publications, Nogo-A2 Publications, RTN-xLBy similarity

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDIDQSSLV SSSADSPPRP PPAFKYQFVT EPEDEEDEED EEEEEDDEDL 
        60         70         80         90        100
EELEVLERKP AAGLSAAPVP PAAAPLLDFS SDSVPPAPRG PLPAAPPTAP 
       110        120        130        140        150
ERQPSWERSP AASAPSLPPA AAVLPSKLPE DDEPPARPPA PAGASPLAEP 
       160        170        180        190        200
AAPPSTPAAP KRRGSGSVDE TLFALPAASE PVIPSSAEKI MDLKEQPGNT 
       210        220        230        240        250
VSSGQEDFPS VLFETAASLP SLSPLSTVSF KEHGYLGNLS AVASTEGTIE 
       260        270        280        290        300
ETLNEASREL PERATNPFVN RESAEFSVLE YSEMGSSFNG SPKGESAMLV 
       310        320        330        340        350
ENTKEEVIVR SKDKEDLVCS AALHNPQESP ATLTKVVKED GVMSPEKTMD 
       360        370        380        390        400
IFNEMKMSVV APVREEYADF KPFEQAWEVK DTYEGSRDVL AARANMESKV 
       410        420        430        440        450
DKKCFEDSLE QKGHGKDSES RNENASFPRT PELVKDGSRA YITCDSFSSA 
       460        470        480        490        500
TESTAANIFP VLEDHTSENK TDEKKIEERK AQIITEKTSP KTSNPFLVAI 
       510        520        530        540        550
HDSEADYVTT DNLSKVTEAV VATMPEGLTP DLVQEACESE LNEATGTKIA 
       560        570        580        590        600
YETKVDLVQT SEAIQESIYP TAQLCPSFEE AEATPSPVLP DIVMEAPLNS 
       610        620        630        640        650
LLPSTGASVA QPSASPLEVP SPVSYDGIKL EPENPPPYEE AMSVALKTSD 
       660        670        680        690        700
SKEEIKEPES FNAAAQEAEA PYISIACDLI KETKLSTEPS PEFSNYSEIA 
       710        720        730        740        750
KFEKSVPDHC ELVDDSSPES EPVDLFSDDS IPEVPQTQEE AVMLMKESLT 
       760        770        780        790        800
EVSETVTQHK HKERLSASPQ EVGKPYLESF QPNLHITKDA ASNEIPTLTK 
       810        820        830        840        850
KETISLQMEE FNTAIYSNDD LLSSKEDKMK ESETFSDSSP IEIIDEFPTF 
       860        870        880        890        900
VSAKDDSPKE YTDLEVSNKS EIANVQSGAN SLPCSELPCD LSFKNTYPKD 
       910        920        930        940        950
EAHVSDEFSK SRSSVSKVPL LLPNVSALES QIEMGNIVKP KVLTKEAEEK 
       960        970        980        990       1000
LPSDTEKEDR SLTAVLSAEL NKTSVVDLLY WRDIKKTGVV FGASLFLLLS 
      1010       1020       1030       1040       1050
LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE 
      1060       1070       1080       1090       1100
VAISEELVQK YSNSALGHVN STIKELRRLF LVDDLVDSLK FAVLMWVFTY 
      1110       1120       1130       1140       1150
VGALFNGLTL LILALISLFS IPVIYERHQA QIDHYLGLAN KSVKDAMAKI 
      1160 
QAKIPGLKRK AE
Length:1,162
Mass (Da):126,613
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i855697FBEE11781F
GO
Isoform D (identifier: Q99P72-3) [UniParc]FASTAAdd to basket
Also known as: RTN4D2 Publications, Nogo-D2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-169: LPPAAAVLPS...PKRRGSGSVD → MAPPLAGGGQ...RSSRLSAARN

Show »
Length:1,046
Mass (Da):114,222
Checksum:i8CE2E2238ED51222
GO
Isoform C (identifier: Q99P72-1) [UniParc]FASTAAdd to basket
Also known as: RTN4C2 Publications, Nogo-C2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     1-963: Missing.
     964-974: AVLSAELNKTS → MDDQKKRWKDK

Show »
Length:199
Mass (Da):22,466
Checksum:i07BE5D580059ED9C
GO
Isoform B2 (identifier: Q99P72-4) [UniParc]FASTAAdd to basket
Also known as: RTN4B21 Publication, Nogo-B21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     188-974: Missing.

Show »
Length:375
Mass (Da):40,301
Checksum:i23D9EB19BE671AE6
GO
Isoform B (identifier: Q99P72-5) [UniParc]FASTAAdd to basket
Also known as: RTN4B1 Publication, Nogo-B1 Publication, RTN4B11 Publication, Nogo-B11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     167-974: SVDETLFALP...VLSAELNKTS → SV

Show »
Length:356
Mass (Da):38,404
Checksum:i4366C03BA9630B56
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32192 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BC056373 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4I → V in BAD90301 (Ref. 4) Curated1
Sequence conflicti16S → R in BAD90301 (Ref. 4) Curated1
Sequence conflicti21P → L in BAD90301 (Ref. 4) Curated1
Sequence conflicti67A → V in AAM77068 (Ref. 3) Curated1
Sequence conflicti413G → S in AAM77068 (Ref. 3) Curated1
Sequence conflicti413G → S in BAD90301 (Ref. 4) Curated1
Sequence conflicti429R → S in AAM77068 (Ref. 3) Curated1
Sequence conflicti429R → S in BAD90301 (Ref. 4) Curated1
Sequence conflicti448S → T in AAM77068 (Ref. 3) Curated1
Sequence conflicti448S → T in BAD90301 (Ref. 4) Curated1
Sequence conflicti487 – 490KTSP → HASA in AAH32192 (PubMed:15489334).Curated4
Sequence conflicti651S → A in AAM77068 (Ref. 3) Curated1
Sequence conflicti651S → A in AAH32192 (PubMed:15489334).Curated1
Sequence conflicti651S → A in BAD90301 (Ref. 4) Curated1
Sequence conflicti665A → V in BAD90301 (Ref. 4) Curated1
Sequence conflicti692E → G in AAM77068 (Ref. 3) Curated1
Sequence conflicti692E → G in BAC75974 (Ref. 8) Curated1
Sequence conflicti733E → D in BAD90301 (Ref. 4) Curated1
Sequence conflicti772V → L in BAD90301 (Ref. 4) Curated1
Sequence conflicti916S → F in BAC75974 (Ref. 8) Curated1
Sequence conflicti990V → VY in AAM77068 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0180881 – 963Missing in isoform C. 2 PublicationsAdd BLAST963
Alternative sequenceiVSP_0180891 – 116Missing in isoform D. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_018090117 – 169LPPAA…SGSVD → MAPPLAGGGQKGGAASEAWV PSLFVGVSGSTCTAAKSLVP IPARSSRLSAARN in isoform D. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_060062167 – 974SVDET…LNKTS → SV in isoform B. 1 PublicationAdd BLAST808
Alternative sequenceiVSP_060063188 – 974Missing in isoform B2. 1 PublicationAdd BLAST787
Alternative sequenceiVSP_018091964 – 974AVLSAELNKTS → MDDQKKRWKDK in isoform C. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY102280 mRNA Translation: AAM73502.1
AY102281 mRNA Translation: AAM73503.1
AY102282 mRNA Translation: AAM73504.1
AY102283 mRNA Translation: AAM73505.1
AY102284 mRNA Translation: AAM73506.1
AY102286 Genomic DNA Translation: AAM73507.1
AY102286 Genomic DNA Translation: AAM73508.1
AY102286 Genomic DNA Translation: AAM73509.1
AY102286 Genomic DNA Translation: AAM73510.1
AY102286 Genomic DNA Translation: AAM73511.1
AF326337 mRNA Translation: AAK08076.1
AY114152 mRNA Translation: AAM77068.1
AK220511 mRNA Translation: BAD90301.1
CH466604 Genomic DNA Translation: EDL23794.1
AL929371 Genomic DNA No translation available.
BC032192 mRNA Translation: AAH32192.1 Different initiation.
BC056373 mRNA No translation available.
AB073672 mRNA Translation: BAC75974.1
AK003859 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS24499.1 [Q99P72-5]
CCDS24500.1 [Q99P72-4]
CCDS24501.1 [Q99P72-2]
CCDS24502.1 [Q99P72-3]
CCDS24503.1 [Q99P72-1]

NCBI Reference Sequences

More...RefSeqi		NP_077188.1, NM_024226.4 [Q99P72-1]
NP_918940.1, NM_194051.3 [Q99P72-3]
NP_918941.1, NM_194052.3 [Q99P72-5]
NP_918942.1, NM_194053.3 [Q99P72-4]
NP_918943.1, NM_194054.3 [Q99P72-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000060992; ENSMUSP00000053754; ENSMUSG00000020458 [Q99P72-1]
ENSMUST00000078830; ENSMUSP00000077875; ENSMUSG00000020458 [Q99P72-5]
ENSMUST00000102841; ENSMUSP00000099905; ENSMUSG00000020458 [Q99P72-3]
ENSMUST00000102842; ENSMUSP00000099906; ENSMUSG00000020458 [Q99P72-4]
ENSMUST00000102843; ENSMUSP00000099907; ENSMUSG00000020458 [Q99P72-2]
ENSMUST00000170731; ENSMUSP00000126413; ENSMUSG00000020458 [Q99P72-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		68585

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:68585

UCSC genome browser

More...UCSCi		uc007ihk.2, mouse [Q99P72-2]
uc007ihl.2, mouse
uc007ihm.2, mouse
uc007ihn.2, mouse [Q99P72-3]
uc007iho.2, mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Nerve regrowth: nipped by a no-go - Issue 69 of April 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY102280 mRNA Translation: AAM73502.1
AY102281 mRNA Translation: AAM73503.1
AY102282 mRNA Translation: AAM73504.1
AY102283 mRNA Translation: AAM73505.1
AY102284 mRNA Translation: AAM73506.1
AY102286 Genomic DNA Translation: AAM73507.1
AY102286 Genomic DNA Translation: AAM73508.1
AY102286 Genomic DNA Translation: AAM73509.1
AY102286 Genomic DNA Translation: AAM73510.1
AY102286 Genomic DNA Translation: AAM73511.1
AF326337 mRNA Translation: AAK08076.1
AY114152 mRNA Translation: AAM77068.1
AK220511 mRNA Translation: BAD90301.1
CH466604 Genomic DNA Translation: EDL23794.1
AL929371 Genomic DNA No translation available.
BC032192 mRNA Translation: AAH32192.1 Different initiation.
BC056373 mRNA No translation available.
AB073672 mRNA Translation: BAC75974.1
AK003859 mRNA No translation available.
CCDSiCCDS24499.1 [Q99P72-5]
CCDS24500.1 [Q99P72-4]
CCDS24501.1 [Q99P72-2]
CCDS24502.1 [Q99P72-3]
CCDS24503.1 [Q99P72-1]
RefSeqiNP_077188.1, NM_024226.4 [Q99P72-1]
NP_918940.1, NM_194051.3 [Q99P72-3]
NP_918941.1, NM_194052.3 [Q99P72-5]
NP_918942.1, NM_194053.3 [Q99P72-4]
NP_918943.1, NM_194054.3 [Q99P72-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KO2NMR-A1025-1090[»]
AlphaFoldDBiQ99P72
BMRBiQ99P72
SMRiQ99P72
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi212938, 11 interactors
CORUMiQ99P72
DIPiDIP-41976N
IntActiQ99P72, 5 interactors
MINTiQ99P72
STRINGi10090.ENSMUSP00000099907

PTM databases

iPTMnetiQ99P72
PhosphoSitePlusiQ99P72
SwissPalmiQ99P72

Proteomic databases

EPDiQ99P72
jPOSTiQ99P72
MaxQBiQ99P72
PaxDbiQ99P72
PeptideAtlasiQ99P72
PRIDEiQ99P72
ProteomicsDBi256639 [Q99P72-2]
256640 [Q99P72-3]
256641 [Q99P72-1]
331244
343118

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3949, 542 antibodies from 44 providers

The DNASU plasmid repository

More...DNASUi		68585

Genome annotation databases

EnsembliENSMUST00000060992; ENSMUSP00000053754; ENSMUSG00000020458 [Q99P72-1]
ENSMUST00000078830; ENSMUSP00000077875; ENSMUSG00000020458 [Q99P72-5]
ENSMUST00000102841; ENSMUSP00000099905; ENSMUSG00000020458 [Q99P72-3]
ENSMUST00000102842; ENSMUSP00000099906; ENSMUSG00000020458 [Q99P72-4]
ENSMUST00000102843; ENSMUSP00000099907; ENSMUSG00000020458 [Q99P72-2]
ENSMUST00000170731; ENSMUSP00000126413; ENSMUSG00000020458 [Q99P72-5]
GeneIDi68585
KEGGimmu:68585
UCSCiuc007ihk.2, mouse [Q99P72-2]
uc007ihl.2, mouse
uc007ihm.2, mouse
uc007ihn.2, mouse [Q99P72-3]
uc007iho.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57142
MGIiMGI:1915835, Rtn4
VEuPathDBiHostDB:ENSMUSG00000020458

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG1792, Eukaryota
GeneTreeiENSGT00940000156568
HOGENOMiCLU_048580_0_0_1
InParanoidiQ99P72
OMAiFEVVDYH
OrthoDBi212372at2759
PhylomeDBiQ99P72
TreeFamiTF105431

Enzyme and pathway databases

ReactomeiR-MMU-193634, Axonal growth inhibition (RHOA activation)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		68585, 3 hits in 68 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Rtn4, mouse
EvolutionaryTraceiQ99P72

Protein Ontology

More...PROi		PR:Q99P72
RNActiQ99P72, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000020458, Expressed in piriform cortex and 343 other tissues
GenevisibleiQ99P72, MM

Family and domain databases

InterProiView protein in InterPro
IPR003388, Reticulon
PfamiView protein in Pfam
PF02453, Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845, RETICULON, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTN4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99P72
Secondary accession number(s): Q5DTK9
, Q78NS1, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8BH78, Q8BHF5, Q8K290, Q8K3G8, Q9CTE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 2, 2006
Last modified: May 25, 2022
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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