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Protein

Guanine nucleotide exchange factor for Rab-3A

Gene

Rab3il1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activates RAB8A and RAB8B (By similarity).By similarity1 Publication

GO - Molecular functioni

  • kinase binding Source: RGD
  • Rab guanyl-nucleotide exchange factor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor for Rab-3A
Alternative name(s):
Rab-3A-interacting-like protein 1
Short name:
Rab3A-interacting-like protein 1
Rabin3-like 1
Gene namesi
Name:Rab3il1
Synonyms:Grab
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619764 Rab3il1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052971 – 377Guanine nucleotide exchange factor for Rab-3AAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei169PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99NH3
PRIDEiQ99NH3

PTM databases

iPTMnetiQ99NH3
PhosphoSitePlusiQ99NH3

Expressioni

Tissue specificityi

Selectively localized to the brain (at protein level).1 Publication

Developmental stagei

Negligible levels at embryonic stages E9 and E15. RAB3IL1 levels increase progressively at postnatal ages P3, P7 and P13 with maximal levels in adult brain.1 Publication

Interactioni

Subunit structurei

Interacts with RAB3A and IHPK1 through the coiled-coil domain. This interaction is competitive. IHPK1 kinase activity is not required for this interaction.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027611

Structurei

3D structure databases

SMRiQ99NH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 128Sequence analysisAdd BLAST52

Sequence similaritiesi

Belongs to the SEC2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4324 Eukaryota
ENOG410XPSY LUCA
HOGENOMiHOG000220814
HOVERGENiHBG057034
InParanoidiQ99NH3
KOiK16779
PhylomeDBiQ99NH3

Family and domain databases

InterProiView protein in InterPro
IPR009449 Sec2_N
PfamiView protein in Pfam
PF06428 Sec2p, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99NH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWSGPPQQDE GLPVGLSAIS VPWKNLGPSK GNRKSPGGLV EASASWEEAG
60 70 80 90 100
GEEHPAAAPL DVSRLRSSSM EIREKGSEFL KEELYKAQKE LKLKDEECER
110 120 130 140 150
LCKVRAQLEQ ELEELTASLF EEAHKMVREA NMKQAASEKQ LKEAWGKIDM
160 170 180 190 200
LQAEVTALKT LVITSTPASP NRELHPQLLS PTKAGPRKGH SRQKSTSSLC
210 220 230 240 250
PVVCPTAGHI PTPDKEGKEV DTTLFAEFQA WRASPTLDKN CPFLERVYRE
260 270 280 290 300
DVGPCLDFTV QELSALVRTA VEDNTLTIEP VASQTLPNVE CNNTNTCALS
310 320 330 340 350
GLARTCHHRI RLGDSDGHYY ISPSSRARIT AVCNFFTYVR YIQQGLVRQD
360 370
AEPMFWEIMR LRKGMSLAKL GFFPQEA
Length:377
Mass (Da):41,908
Last modified:June 1, 2001 - v1
Checksum:i0F76A1D1AB095B62
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LPG6F1LPG6_RAT
Guanine nucleotide exchange factor ...
Rab3il1
376Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026049 mRNA Translation: AAK07668.1
RefSeqiNP_599238.1, NM_134411.1
UniGeneiRn.162492

Genome annotation databases

GeneIDi171452
KEGGirno:171452
UCSCiRGD:619764 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026049 mRNA Translation: AAK07668.1
RefSeqiNP_599238.1, NM_134411.1
UniGeneiRn.162492

3D structure databases

SMRiQ99NH3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027611

PTM databases

iPTMnetiQ99NH3
PhosphoSitePlusiQ99NH3

Proteomic databases

PaxDbiQ99NH3
PRIDEiQ99NH3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171452
KEGGirno:171452
UCSCiRGD:619764 rat

Organism-specific databases

CTDi5866
RGDi619764 Rab3il1

Phylogenomic databases

eggNOGiKOG4324 Eukaryota
ENOG410XPSY LUCA
HOGENOMiHOG000220814
HOVERGENiHBG057034
InParanoidiQ99NH3
KOiK16779
PhylomeDBiQ99NH3

Miscellaneous databases

PROiPR:Q99NH3

Family and domain databases

InterProiView protein in InterPro
IPR009449 Sec2_N
PfamiView protein in Pfam
PF06428 Sec2p, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiR3GEF_RAT
AccessioniPrimary (citable) accession number: Q99NH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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