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Entry version 167 (11 Dec 2019)
Sequence version 2 (25 Nov 2008)
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Protein

Partitioning defective 3 homolog

Gene

Pard3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (PubMed:11839275). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination (PubMed:21949390).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Differentiation
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-MMU-420029 Tight junction interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Partitioning defective 3 homolog
Short name:
PAR-3
Short name:
PARD-3
Alternative name(s):
Atypical PKC isotype-specific-interacting protein
Short name:
ASIP
Ephrin-interacting protein
Short name:
PHIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pard3
Synonyms:Par3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2135608 Pard3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi824 – 826SMS → AMA or EME: Strongly reduces phosphorylation by PRKCZ and abolishes interaction with PKRCI. 1 Publication3
Mutagenesisi831K → A: Inhibits Schwann cell peripheral myelination; when associated with A-848; A-881 and A-1327. 1 Publication1
Mutagenesisi848K → A: Inhibits Schwann cell peripheral myelination; when associated with A-831; A-881 and A-1327. 1 Publication1
Mutagenesisi881K → A: Inhibits Schwann cell peripheral myelination; when associated with A-831; A-848 and A-1327. 1 Publication1
Mutagenesisi1327K → A: Inhibits Schwann cell peripheral myelination; when associated with A-831; A-848 and A-881. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001850701 – 1333Partitioning defective 3 homologAdd BLAST1333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25PhosphoserineCombined sources1
Modified residuei91PhosphothreonineBy similarity1
Modified residuei156PhosphoserineCombined sources1
Modified residuei174PhosphoserineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei489PhosphotyrosineBy similarity1
Modified residuei692PhosphoserineBy similarity1
Modified residuei695PhosphoserineBy similarity1
Modified residuei715PhosphoserineBy similarity1
Modified residuei728PhosphoserineCombined sources1
Modified residuei806PhosphoserineBy similarity1
Modified residuei824PhosphoserineBy similarity1
Modified residuei831N6-acetyllysine1 Publication1
Modified residuei834PhosphoserineBy similarity1
Modified residuei848N6-acetyllysine1 Publication1
Modified residuei849PhosphoserineBy similarity1
Modified residuei869PhosphoserineBy similarity1
Modified residuei881N6-acetyllysine1 Publication1
Modified residuei958Phosphoserine; by AURKABy similarity1
Modified residuei967PhosphoserineBy similarity1
Modified residuei969PhosphoserineBy similarity1
Modified residuei1042PhosphoserineBy similarity1
Modified residuei1327N6-acetyllysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination.1 Publication
Phosphorylation at Ser-824 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1123 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-958 is required for the normal establishment of neuronal polarity (By similarity). Isoform 4 and isoform 5 are phosphorylated during oocyte maturation (Probable).By similarityCurated

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99NH2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99NH2

PeptideAtlas

More...
PeptideAtlasi
Q99NH2

PRoteomics IDEntifications database

More...
PRIDEi
Q99NH2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99NH2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99NH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

All isoforms are expressed in heart, while expression in brain is mainly limited to isoform 1, and to isoform 3 to a weaker level.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At the protein level, isoform 4 expression increases steadily throughout oocyte maturation, whereas isoform 5 expression decreases in the egg as compared to the oocyte. Isoform 1 and isoform 3 are expressed from 9.5 dpc to 14.5 dpc, while isoform 2 is not expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025812 Expressed in 282 organ(s), highest expression level in cornea

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99NH2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99NH2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 2, but not at least isoform 3 interacts with PRKCZ.

Interacts with PRCKI and CDH5.

Interacts (via PDZ 3 domain) with PTEN (via C-terminus).

Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3.

Interacts with LIMK2, AURKA and AURKB.

Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1.

Interacts with ECT2 and FBF1 (By similarity).

Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B.

Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Directly interacts with TIAM1 and TIAM2.

Interacts with SIRT2.

Interacts (via coiled-coil domain) with FRMD4A (PubMed:20080746).

Found in a complex with PARD3, CYTH1 and FRMD4A (PubMed:20080746).

Interacts with SAPCD2 (By similarity).

Interacts with PRKCA (By similarity).

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
220283, 11 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q99NH2

Database of interacting proteins

More...
DIPi
DIP-41727N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q99NH2

Protein interaction database and analysis system

More...
IntActi
Q99NH2, 13 interactors

Molecular INTeraction database

More...
MINTi
Q99NH2

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000125453

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99NH2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99NH2

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q99NH2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini271 – 359PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini461 – 546PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini590 – 677PDZ 3PROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni712 – 936Interaction with PRKCI and PRKCZBy similarityAdd BLAST225
Regioni712 – 932Interaction with PRKCI and PRKCZBy similarityAdd BLAST221
Regioni931 – 1333Interaction with FRMD4A1 PublicationAdd BLAST403

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1046 – 1078Sequence analysisAdd BLAST33
Coiled coili1145 – 1168Sequence analysisAdd BLAST24
Coiled coili1195 – 1218Sequence analysisAdd BLAST24
Coiled coili1274 – 1295Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi980 – 1038Lys-richAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization.By similarity
The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PAR3 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ITAJ Eukaryota
ENOG410ZDVK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000232109

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99NH2

KEGG Orthology (KO)

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KOi
K04237

Database of Orthologous Groups

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OrthoDBi
908238at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR021922 Par3/HAL_N
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF12053 Par3_HAL_N_term, 1 hit
PF00595 PDZ, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156 SSF50156, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99NH2-1) [UniParc]FASTAAdd to basket
Also known as: 180 kDa

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVTVCFGRT RVVVPCGDGR MKVFSLIQQA VTRYRKAVAK DPNYWIQVHR
60 70 80 90 100
LEHGDGGILD LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASFTGTQS
110 120 130 140 150
PEIFGSELGT NNVSAFQPYQ ATSEIEVTPS VLRANMPLHV RRSSDPALTG
160 170 180 190 200
LSTSVSDNNF SSEEPSRKNP TRWSTTAGFL KQNTAGSPKT CDRKKDENYR
210 220 230 240 250
SLPRDPSSWS NQFQRDNARS SLSASHPMVD RWLEKQEQDE EGTEEDSSRV
260 270 280 290 300
EPVGHADTGL ENMPNFSLDD MVKLVQVPND GGPLGIHVVP FSARGGRTLG
310 320 330 340 350
LLVKRLEKGG KAEQENLFHE NDCIVRINDG DLRNRRFEQA QHMFRQAMRA
360 370 380 390 400
RVIWFHVVPA ANKEQYEQLS QREKNNYSPG RFSPDSHCVA NRSVANNAPQ
410 420 430 440 450
ALPRAPRLSQ PPEQLDAHPR LPHSAHASTK PPAAPALAPP SVLSTNVGSV
460 470 480 490 500
YNTKKVGKRL NIQLKKGTEG LGFSITSRDV TIGGSAPIYV KNILPRGAAI
510 520 530 540 550
QDGRLKAGDR LIEVNGVDLA GKSQEEVVSL LRSTKMEGTV SLLVFRQEEA
560 570 580 590 600
FHPREMNAEP SQMQTPKETK AEDEDVVLTP DGTREFLTFE VPLNDSGSAG
610 620 630 640 650
LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL
660 670 680 690 700
LGKANQEAME TLRRSMSTEG NKRGMIQLIV ARRISRCNEL RSPGSPAAPE
710 720 730 740 750
LPIETELDDR ERRISHSLYS GIEGLDESPT RNAALSRIMG KCQLSPTVNM
760 770 780 790 800
PHDDTVMIED DRLPVLPPHL SDQSSSSSHD DVGFIMTEAG TWAKATISDS
810 820 830 840 850
ADCSLSPDVD PVLAFQREGF GRQSMSEKRT KQFSDASQLD FVKTRKSKSM
860 870 880 890 900
DLVADETKLN TVDDQRAGSP SRDVGPSLGL KKSSSLESLQ TAVAEVTLNG
910 920 930 940 950
NIPFHRPRPR IIRGRGCNES FRAAIDKSYD KPMVDDDDEG METLEEDTEE
960 970 980 990 1000
SSRSGRESVS TSSDQPSYSL ERQMNGDPEK RDKTERKKDK AGKDKKKDRE
1010 1020 1030 1040 1050
KEKDKLKAKK GMLKGLGDMF RFGKHRKDDK MEKMGRIKIQ DSFTSEEDRV
1060 1070 1080 1090 1100
RMKEEQERIQ AKTREFRERQ ARERDYAEIQ DFHRTFGCDD ELLYGGMSSY
1110 1120 1130 1140 1150
EGCLALNARP QSPREGHLMD TLYAQVKKPR SSKPGDSNRS TPSNHDRIQR
1160 1170 1180 1190 1200
LRQEFQQAKQ DEDVEDRRRT YSFEQSWSSS RPASQSGRHS VSVEVQVQRQ
1210 1220 1230 1240 1250
RQEERESFQQ AQRQYSSLPR QSRKNASSIS QDSWEQNYAP GEGFQSAKEN
1260 1270 1280 1290 1300
PRYSSYQGSR NGYLGGHGFN ARVMLETQEL LRQEQRRKEQ QLKKQPPADG
1310 1320 1330
VRGPFRQDVP PSPSQVARLN RLQTPEKGRP FYS
Length:1,333
Mass (Da):149,075
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DD680EE824C3837
GO
Isoform 2 (identifier: Q99NH2-2) [UniParc]FASTAAdd to basket
Also known as: 150 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1333: Missing.

Show »
Length:1,029
Mass (Da):113,505
Checksum:i39B0912262E1EFCB
GO
Isoform 3 (identifier: Q99NH2-3) [UniParc]FASTAAdd to basket
Also known as: 100 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     741-744: KCQL → ESGT
     745-1333: Missing.

Show »
Length:744
Mass (Da):81,660
Checksum:i1B857E25F96A6C2B
GO
Isoform 4 (identifier: Q99NH2-4) [UniParc]FASTAAdd to basket
Also known as: PAR-3o1, Partitioning defective 3 oocyte form 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.
     1021-1030: RFGKHRKDDK → SLAKLKPEKR
     1031-1333: Missing.

Show »
Length:895
Mass (Da):98,737
Checksum:i12807D70707852A3
GO
Isoform 5 (identifier: Q99NH2-5) [UniParc]FASTAAdd to basket
Also known as: PAR-3o2, Partitioning defective 3 oocyte form 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.
     741-741: K → T
     742-1333: Missing.

Show »
Length:606
Mass (Da):66,609
Checksum:iEAA4320A1C682CAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A5D6P2A5D6P2_MOUSE
Par-3 (Partitioning defective 3) ho...
Pard3
1,334Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CXL4E0CXL4_MOUSE
Partitioning defective 3 homolog
Pard3
1,289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CZ83E0CZ83_MOUSE
Partitioning defective 3 homolog
Pard3
1,094Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S7Z1F6S7Z1_MOUSE
Partitioning defective 3 homolog
Pard3
1,324Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PYJ2E9PYJ2_MOUSE
Partitioning defective 3 homolog
Pard3
741Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZNY3B7ZNY3_MOUSE
Pard3 protein
Pard3
1,319Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CXR8E0CXR8_MOUSE
Partitioning defective 3 homolog
Pard3
990Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1Y4A0A0R4J1Y4_MOUSE
Partitioning defective 3 homolog
Pard3
896Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CX45E0CX45_MOUSE
Partitioning defective 3 homolog
Pard3
943Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CY24E0CY24_MOUSE
Partitioning defective 3 homolog
Pard3
1,247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti477S → C in BAC29670 (PubMed:16141072).Curated1
Sequence conflicti853V → GI in AAX48909 (PubMed:15766746).Curated1
Sequence conflicti1009K → N in AAK07669 (PubMed:10934475).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0358951 – 135Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_007472741 – 744KCQL → ESGT in isoform 3. 2 Publications4
Alternative sequenceiVSP_035896741K → T in isoform 5. 1 Publication1
Alternative sequenceiVSP_035897742 – 1333Missing in isoform 5. 1 PublicationAdd BLAST592
Alternative sequenceiVSP_007473745 – 1333Missing in isoform 3. 2 PublicationsAdd BLAST589
Alternative sequenceiVSP_0358981021 – 1030RFGKHRKDDK → SLAKLKPEKR in isoform 4. 1 Publication10
Alternative sequenceiVSP_0074741030 – 1333Missing in isoform 2. 1 PublicationAdd BLAST304
Alternative sequenceiVSP_0358991031 – 1333Missing in isoform 4. 1 PublicationAdd BLAST303

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY026057 mRNA Translation: AAK07669.1
AY856081 mRNA Translation: AAX48908.1
AY856082 mRNA Translation: AAX48909.1
AK037015 mRNA Translation: BAC29670.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22788.1 [Q99NH2-1]
CCDS40523.1 [Q99NH2-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001013598.1, NM_001013580.3 [Q99NH2-5]
NP_001013599.1, NM_001013581.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000108752; ENSMUSP00000104383; ENSMUSG00000025812 [Q99NH2-5]
ENSMUST00000160717; ENSMUSP00000125612; ENSMUSG00000025812 [Q99NH2-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
93742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:93742

UCSC genome browser

More...
UCSCi
uc009nzk.2 mouse [Q99NH2-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026057 mRNA Translation: AAK07669.1
AY856081 mRNA Translation: AAX48908.1
AY856082 mRNA Translation: AAX48909.1
AK037015 mRNA Translation: BAC29670.1
CCDSiCCDS22788.1 [Q99NH2-1]
CCDS40523.1 [Q99NH2-5]
RefSeqiNP_001013598.1, NM_001013580.3 [Q99NH2-5]
NP_001013599.1, NM_001013581.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KOHNMR-A581-689[»]
2KOJNMR-A450-558[»]
SMRiQ99NH2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi220283, 11 interactors
CORUMiQ99NH2
DIPiDIP-41727N
ELMiQ99NH2
IntActiQ99NH2, 13 interactors
MINTiQ99NH2
STRINGi10090.ENSMUSP00000125453

PTM databases

iPTMnetiQ99NH2
PhosphoSitePlusiQ99NH2

Proteomic databases

jPOSTiQ99NH2
PaxDbiQ99NH2
PeptideAtlasiQ99NH2
PRIDEiQ99NH2

Genome annotation databases

EnsembliENSMUST00000108752; ENSMUSP00000104383; ENSMUSG00000025812 [Q99NH2-5]
ENSMUST00000160717; ENSMUSP00000125612; ENSMUSG00000025812 [Q99NH2-5]
GeneIDi93742
KEGGimmu:93742
UCSCiuc009nzk.2 mouse [Q99NH2-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56288
MGIiMGI:2135608 Pard3

Phylogenomic databases

eggNOGiENOG410ITAJ Eukaryota
ENOG410ZDVK LUCA
GeneTreeiENSGT00950000183214
HOGENOMiHOG000232109
InParanoidiQ99NH2
KOiK04237
OrthoDBi908238at2759

Enzyme and pathway databases

ReactomeiR-MMU-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-MMU-420029 Tight junction interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pard3 mouse
EvolutionaryTraceiQ99NH2

Protein Ontology

More...
PROi
PR:Q99NH2
RNActiQ99NH2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025812 Expressed in 282 organ(s), highest expression level in cornea
ExpressionAtlasiQ99NH2 baseline and differential
GenevisibleiQ99NH2 MM

Family and domain databases

InterProiView protein in InterPro
IPR021922 Par3/HAL_N
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF12053 Par3_HAL_N_term, 1 hit
PF00595 PDZ, 3 hits
SMARTiView protein in SMART
SM00228 PDZ, 3 hits
SUPFAMiSSF50156 SSF50156, 3 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARD3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99NH2
Secondary accession number(s): Q58T10, Q58T11, Q8CB21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 25, 2008
Last modified: December 11, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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