Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 140 (18 Sep 2019)
Sequence version 2 (23 Oct 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Ankyrin repeat domain-containing protein 17

Gene

Ankrd17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (PubMed:19619540).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processImmunity, Innate immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 17
Alternative name(s):
Ankyrin repeat domain-containing protein FOE
Gene trap ankyrin repeat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ankrd17
Synonyms:Foe, Gtar, Kiaa0697
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1932101 Ankrd17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deficient mice display embryonic lethality during organogenesis with hemorrhages, impaired vascular smooth muscle cell development, impaired vascular integrity and growth retardation.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003079181 – 2603Ankyrin repeat domain-containing protein 17Add BLAST2603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei15PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei152PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki314Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei799PhosphoserineBy similarity1
Modified residuei1453PhosphoserineBy similarity1
Modified residuei1631PhosphoserineBy similarity1
Modified residuei1692PhosphoserineCombined sources1
Modified residuei1696PhosphoserineCombined sources1
Modified residuei1705PhosphoserineCombined sources1
Modified residuei1870Asymmetric dimethylarginineCombined sources1
Modified residuei2038PhosphoserineBy similarity1
Modified residuei2040PhosphoserineCombined sources1
Modified residuei2041PhosphoserineCombined sources1
Modified residuei2043PhosphoserineCombined sources1
Modified residuei2055PhosphoserineCombined sources1
Modified residuei2063PhosphoserineBy similarity1
Modified residuei2373PhosphoserineBy similarity1
Modified residuei2401PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CDK2.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99NH0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99NH0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99NH0

PeptideAtlas

More...
PeptideAtlasi
Q99NH0

PRoteomics IDEntifications database

More...
PRIDEi
Q99NH0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99NH0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99NH0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99NH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in fetal liver. Detected in adult liver cells, ovarian oocytes, seminiferous tubules of the testes and pelvic region of the kidney. It was not detected in heart, gut, lung, spleen and skeletal muscle. Earliest specific in situ marker of hepatic differentiation during embryogenesis, useful for characterization of inductive events involved in hepatic specification.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at 8.0-8.5 dpc in the foregut endoderm and at 9.5 dpc in cells migrating into the septum transversum. At 10.5 dpc, highly expressed exclusively in the fetal liver. From 10.5 dpc, expressed in the developing liver throughout gestation and in neonates. At 17.5 dpc, detected in the dorsal root ganglia of the peripheral nervous system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000055204 Expressed in 297 organ(s), highest expression level in zygote

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99NH0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99NH0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with NOD2.

Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA.

Interacts with MAVS and IFIH1.

Interacts (via the second ankyrin repeat cluster) with DDX58.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
219887, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q99NH0, 5 interactors

Molecular INTeraction database

More...
MINTi
Q99NH0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000014421

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99NH0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati229 – 258ANK 1Add BLAST30
Repeati262 – 291ANK 2Add BLAST30
Repeati296 – 325ANK 3Add BLAST30
Repeati329 – 358ANK 4Add BLAST30
Repeati362 – 391ANK 5Add BLAST30
Repeati396 – 425ANK 6Add BLAST30
Repeati429 – 458ANK 7Add BLAST30
Repeati462 – 491ANK 8Add BLAST30
Repeati495 – 524ANK 9Add BLAST30
Repeati529 – 558ANK 10Add BLAST30
Repeati559 – 588ANK 11Add BLAST30
Repeati592 – 621ANK 12Add BLAST30
Repeati625 – 654ANK 13Add BLAST30
Repeati659 – 688ANK 14Add BLAST30
Repeati692 – 721ANK 15Add BLAST30
Repeati1078 – 1107ANK 16Add BLAST30
Repeati1111 – 1140ANK 17Add BLAST30
Repeati1145 – 1174ANK 18Add BLAST30
Repeati1178 – 1207ANK 19Add BLAST30
Repeati1213 – 1242ANK 20Add BLAST30
Repeati1247 – 1276ANK 21Add BLAST30
Repeati1280 – 1309ANK 22Add BLAST30
Repeati1315 – 1344ANK 23Add BLAST30
Repeati1348 – 1377ANK 24Add BLAST30
Repeati1381 – 1410ANK 25Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1721 – 1785KHPROSITE-ProRule annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1438 – 1522Sequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 40Ala-richAdd BLAST37
Compositional biasi94 – 106Gly-richAdd BLAST13
Compositional biasi854 – 1004Gln-richAdd BLAST151
Compositional biasi1533 – 1537Poly-Thr5
Compositional biasi1599 – 1696Ser-richAdd BLAST98
Compositional biasi1946 – 2102Ser-richAdd BLAST157

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG4369 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153768

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033942

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99NH0

KEGG Orthology (KO)

More...
KOi
K16726

Database of Orthologous Groups

More...
OrthoDBi
1115202at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99NH0

TreeFam database of animal gene trees

More...
TreeFami
TF328552

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 8 hits
3.30.1370.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 9 hits
PF00013 KH_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 25 hits
SM00322 KH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 3 hits
SSF54791 SSF54791, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50084 KH_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: The N-terminus of another isoform lacking the first 141 amino acids is described in.1 Publication

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99NH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKATVPAAA EGEGSPPAAA AVAAPPAAAA AEVGGGARPA SSPRGMVRVC
60 70 80 90 100
DLLLKKKPPQ QQQQQQPPHH KAKRNRTCRP PSSSESSSDS DNSGGGGGGG
110 120 130 140 150
GGGGGGTSSN NSEEEEDDDD EEEEVSEVES FILDQDDLEN PMLETASKLL
160 170 180 190 200
LSGTADGADL RTVDPETQAR LEALLEAAGI GKLSTADGKA FADPEVLRRL
210 220 230 240 250
TSSVSCALDE AAAALTRMRA ESTANAGQSD NRSLAEACSE GDVNAVRKLL
260 270 280 290 300
IEGRSVNEHT EEGESLLCLA CSAGYYELAQ VLLAMHANVE DRGIKGDITP
310 320 330 340 350
LMAAANGGHV KIVKLLLAHK ADVNAQSSTG NTALTYACAG GYVDVVKVLL
360 370 380 390 400
ESGASIEDHN ENGHTPLMEA GSAGHVEVAR LLLENGAGIN THSNEFKESA
410 420 430 440 450
LTLACYKGHL EMVRFLLEAG ADQEHKTDEM HTALMEACMD GHVEVARLLL
460 470 480 490 500
DSGAQVNMPA DSFESPLTLA ACGGHVELAA LLIERGASLE EVNDEGYTPL
510 520 530 540 550
MEAAREGHEE MVALLLGQGA NINAQTEETQ ETALTLACCG GFLEVADFLI
560 570 580 590 600
KAGADIELGC STPLMEAAQE GHLELVKYLL AAGANVHATT ATGDTALTYA
610 620 630 640 650
CENGHTDVAD VLLQAGADLE HESEGGRTPL MKAARAGHVC TVQFLISKGA
660 670 680 690 700
NVNRTTANND HTVLSLACAG GHLAVVELLL AHGADPTHRL KDGSTMLIEA
710 720 730 740 750
AKGGHTSVVC YLLDYPNNLL AAPPPDVTQL TPPSHDLNRA PRVPVQALPM
760 770 780 790 800
VVPPQEPDKP PANLAATLPV RSKAASKQKS NSHLPANSQD VQGYITNQSP
810 820 830 840 850
ESIVEEAQGK LTELEQRIKE AIEKNAQLQS LELAHADQLT KEKIEELNKT
860 870 880 890 900
REEQIQKKQK ILEELQKVER ELQLKTQQQL KKQYLEVKAQ RIQLQQQQQQ
910 920 930 940 950
SCQHLGLFTS VGVGEQLSEG DYARLQQVDP VLLKDEPQQT AAQMGFAPIQ
960 970 980 990 1000
PLAMPQALPL ATGPLPPGSI ANLTELQGVI VGQPVLGQAQ LAGLGQGILT
1010 1020 1030 1040 1050
ETQQGLMVAS PAQTLNDTLD DIMAAVSGRA SAMSNTPTHS IAASVSQPQT
1060 1070 1080 1090 1100
PTPSPIISPS AMLPIYPAID IDAQTESNHD TALTLACAGG HEELVQTLLE
1110 1120 1130 1140 1150
RGASIEHRDK KGFTPLILAA TAGHVGVVEI LLDNGADIEA QSERTKDTPL
1160 1170 1180 1190 1200
SLACSGGRQE VVELLLARGA NKEHRNVSDY TPLSLAASGG YVNIIKILLN
1210 1220 1230 1240 1250
AGAEINSRTG SKLGISPLML AAMNGHTAAV KLLLDMGSDI NAQIETNRNT
1260 1270 1280 1290 1300
ALTLACFQGR TEVVSLLLDR KANVEHRAKT GLTPLMEAAS GGYAEVGRVL
1310 1320 1330 1340 1350
LDKGADVNAP PVPSSRDTAL TIAADKGHYK FCELLIGKGA HIDVRNKKGN
1360 1370 1380 1390 1400
TPLWLAANGG HLDVVQLLVQ ATADVDAADN RKITPLMAAF RKGHVKVVRY
1410 1420 1430 1440 1450
LVKEVNQFPS DSECMRYIAT ITDKEMLKKC HLCMESIVQA KDRQAAEANK
1460 1470 1480 1490 1500
NASILLEELD LEKLREESRR LALAAKREKR KEKRRKKKEE QRRKLEEIEA
1510 1520 1530 1540 1550
KNKENFELQA AQEKEKLKVE EEPEVLTEPP SATTTTTIGI SATWTTLAGS
1560 1570 1580 1590 1600
HGKRNNTITT TSSKRKNRKN KITPENVQII FDDPLPISYS QPEKVNGESK
1610 1620 1630 1640 1650
SSSTSESGDS DNMRISSCSD ESSNSNSSRK SNNHASAVVT TTMASKKQPS
1660 1670 1680 1690 1700
VLVTFPKEER KSVSGKASIK LSETVNEGTS NSLSTCTKSG PSPLSSPNGK
1710 1720 1730 1740 1750
LTVASPKRGP KREEGWKEVV RRSKKVSVPS TVISRVIGRG GCNINAIREC
1760 1770 1780 1790 1800
TGAHIDIDKQ KDKTGDRIIT IRGGTESTRQ ATQLINALIK DPDKEIDELI
1810 1820 1830 1840 1850
PKNRLKSSTA NSKIGSSAPT TTAANSSLMG IKMTTVALSS TSQTATALTV
1860 1870 1880 1890 1900
PAISSASTHK TIKNPVNNVR PGFPVSLPLA YPPPQFAHAL LAAQTFQQIR
1910 1920 1930 1940 1950
PPRLPMTHFG GTFPPAQSTW GPFPVRPLSP ARATNSPKPH MVPRHSNQNS
1960 1970 1980 1990 2000
SGSQVNSAGS LTSSPTTTAS SSASAVPGTT SNGSPSSPSV RRQLFVTVVK
2010 2020 2030 2040 2050
TSNATTTTVT TTASNNSTAP TNATYPMPTA KEHYPVSSPS SPSPPAQPGG
2060 2070 2080 2090 2100
VSRNSPLDCG SASPNKGASA SEQEASSPPV VEPANSRPPH SSSSSGSSSG
2110 2120 2130 2140 2150
HSTQQQPPGS VPQEPRPPLQ QSQVPSPDVR MTVPPTATSS APVAVPSTAP
2160 2170 2180 2190 2200
VTYPMPQTQM GCSQPPKMEA PAIRPPSHAT AAPHKTPAPV QSSSASVLNV
2210 2220 2230 2240 2250
NHIKRPHSVP SSVQLPSTLS TQSACQNSVH PANKPVAPNF SAPLPFGPFS
2260 2270 2280 2290 2300
TLFENNPTNA HAFWGGPVVS SQSTPESMLS GKSSYLPNSD PLHQSDTSKA
2310 2320 2330 2340 2350
PGFRPPLQRP APSPSGIVNM DTPYGSVTPS STHLGNFASS LSGGQMYGPG
2360 2370 2380 2390 2400
APLGGAPLGG APTAANFNRQ HFSPLSLLTP CSSASNESPA QSVSSGVRAP
2410 2420 2430 2440 2450
SPAPSSVPLG SEKPSSVSQD RKVPVPIGTE RSARIRQTGT SAPSVIGSNL
2460 2470 2480 2490 2500
STSVGHSGIW SFEGIGGNQD KVDWCNPGMG NPMIHRPMSD PGVFSQHQAM
2510 2520 2530 2540 2550
ERDSTGIVTP SGTFHQHVPA GYMDFPKVGS MPFSVYGNAM LPPVAPIADG
2560 2570 2580 2590 2600
AGGPIFNGPH SAEPSWNSLI KMVSSSTENN GPQTVWTGPW APHMNSVHMN

QLG
Length:2,603
Mass (Da):274,213
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i246DAA0E473C3D55
GO
Isoform 2 (identifier: Q99NH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.
     774-1024: Missing.
     1723-2603: Missing.

Note: No experimental confirmation available.
Show »
Length:1,330
Mass (Da):141,475
Checksum:i62113D2B852B4D12
GO
Isoform 3 (identifier: Q99NH0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1024-1024: Missing.
     1597-1600: GESK → VSFL
     1601-2603: Missing.

Note: No experimental confirmation available.
Show »
Length:1,599
Mass (Da):170,377
Checksum:i4F1E675363174B52
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QKG6E9QKG6_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd17
2,352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q804E9Q804_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd17
2,602Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDZ9A0A0G2JDZ9_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd17
2,494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6X1A0A1W2P6X1_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd17
1,600Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH39213 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98003 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti347K → E in AAK07672 (PubMed:11165478).Curated1
Sequence conflicti357E → G in AAK07672 (PubMed:11165478).Curated1
Sequence conflicti908F → L in AAK07672 (PubMed:11165478).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0288661 – 141Missing in isoform 2. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_028867774 – 1024Missing in isoform 2. 1 PublicationAdd BLAST251
Alternative sequenceiVSP_0288681024Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_0288691597 – 1600GESK → VSFL in isoform 3. 1 Publication4
Alternative sequenceiVSP_0288701601 – 2603Missing in isoform 3. 1 PublicationAdd BLAST1003
Alternative sequenceiVSP_0288711723 – 2603Missing in isoform 2. 1 PublicationAdd BLAST881

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF130371 mRNA Translation: AAQ13559.1
AC117578 Genomic DNA No translation available.
AC162171 Genomic DNA No translation available.
AY026253 mRNA Translation: AAK07672.1
AK160263 mRNA Translation: BAE35720.1
AK129193 Transcribed RNA Translation: BAC98003.1 Sequence problems.
BC039213 mRNA Translation: AAH39213.1 Different initiation.
BC057195 mRNA Translation: AAH57195.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57354.1 [Q99NH0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_112148.2, NM_030886.2 [Q99NH0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000014421; ENSMUSP00000014421; ENSMUSG00000055204 [Q99NH0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81702

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:81702

UCSC genome browser

More...
UCSCi
uc008yav.1 mouse [Q99NH0-2]
uc008yay.1 mouse [Q99NH0-3]
uc029vje.1 mouse [Q99NH0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130371 mRNA Translation: AAQ13559.1
AC117578 Genomic DNA No translation available.
AC162171 Genomic DNA No translation available.
AY026253 mRNA Translation: AAK07672.1
AK160263 mRNA Translation: BAE35720.1
AK129193 Transcribed RNA Translation: BAC98003.1 Sequence problems.
BC039213 mRNA Translation: AAH39213.1 Different initiation.
BC057195 mRNA Translation: AAH57195.1
CCDSiCCDS57354.1 [Q99NH0-1]
RefSeqiNP_112148.2, NM_030886.2 [Q99NH0-1]

3D structure databases

SMRiQ99NH0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi219887, 5 interactors
IntActiQ99NH0, 5 interactors
MINTiQ99NH0
STRINGi10090.ENSMUSP00000014421

PTM databases

iPTMnetiQ99NH0
PhosphoSitePlusiQ99NH0
SwissPalmiQ99NH0

Proteomic databases

EPDiQ99NH0
jPOSTiQ99NH0
PaxDbiQ99NH0
PeptideAtlasiQ99NH0
PRIDEiQ99NH0

Genome annotation databases

EnsembliENSMUST00000014421; ENSMUSP00000014421; ENSMUSG00000055204 [Q99NH0-1]
GeneIDi81702
KEGGimmu:81702
UCSCiuc008yav.1 mouse [Q99NH0-2]
uc008yay.1 mouse [Q99NH0-3]
uc029vje.1 mouse [Q99NH0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26057
MGIiMGI:1932101 Ankrd17

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4369 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000153768
HOGENOMiHOG000033942
InParanoidiQ99NH0
KOiK16726
OrthoDBi1115202at2759
PhylomeDBiQ99NH0
TreeFamiTF328552

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ankrd17 mouse

Protein Ontology

More...
PROi
PR:Q99NH0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000055204 Expressed in 297 organ(s), highest expression level in zygote
ExpressionAtlasiQ99NH0 baseline and differential
GenevisibleiQ99NH0 MM

Family and domain databases

Gene3Di1.25.40.20, 8 hits
3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 9 hits
PF00013 KH_1, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 25 hits
SM00322 KH, 1 hit
SUPFAMiSSF48403 SSF48403, 3 hits
SSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50084 KH_TYPE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR17_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99NH0
Secondary accession number(s): Q3TV99
, Q5F4T7, Q6PG69, Q6ZQ66, Q8CHT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 18, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again