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Entry version 123 (18 Sep 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Helicase ARIP4

Gene

Rad54l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro. Acts as an AR-coregulator in Sertoli cells.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Enzyme activity is enhanced by dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA).1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=40 nM for DNA1 Publication
  2. KM=25 µM for ATP1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi304 – 311ATPCurated8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDNA-binding, Helicase, Hydrolase
    LigandATP-binding, Nucleotide-binding

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Helicase ARIP4 (EC:3.6.4.12)
    Alternative name(s):
    Androgen receptor-interacting protein 4
    RAD54-like protein 2
    Steroid receptor-interacting SNF2 domain-containing protein-like
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Rad54l2
    Synonyms:Arip4, Srisnf2l
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:1933196 Rad54l2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Death by 11.5 dpc. At 9.5 dpc and 10.5 dpc, almost all major tissues are proportionally smaller, and the neural tube is shrunk in some embryos. Dramatically reduced cell proliferation and increased apoptosis are observed in 9.5 dpc and 10.5 dpc embryos. Embryonic fibroblasts stop to grow after 2 or 3 passages and exhibit increased apoptosis and decreased DNA synthesis compared with wild-type.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi310K → A: Abolishes ATP-binding. 1 Publication1
    Mutagenesisi361K → E: Decreased sumoylation; when associated with E-573; E-664; E-935; E-961 and E-1013. 1 Publication1
    Mutagenesisi462 – 463DE → AA: Abolishes ATPase activity. 1 Publication2
    Mutagenesisi573K → E: Decreased sumoylation; when associated with E-361; E-664; E-935; E-961 and E-1013. 1 Publication1
    Mutagenesisi664K → E: Decreased sumoylation; when associated with E-361; E-573; E-935; E-961 and E-1013. 1 Publication1
    Mutagenesisi935K → E: Decreased sumoylation; when associated with E-361; E-573; E-664; E-961 and E-1013. 1 Publication1
    Mutagenesisi961K → E: Decreased sumoylation; when associated with E-361; E-573; E-664; E-935 and E-1013. 1 Publication1
    Mutagenesisi1013K → E: Decreased sumoylation; when associated with E-361; E-573; E-664; E-935 and E-961. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003157821 – 1466Helicase ARIP4Add BLAST1466

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
    Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
    Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
    Cross-linki664Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
    Cross-linki681Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
    Cross-linki758Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
    Cross-linki900Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
    Cross-linki1013Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
    Cross-linki1017Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1168PhosphoserineCombined sources1
    Modified residuei1171PhosphoserineCombined sources1
    Modified residuei1259PhosphothreonineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Sumoylated.1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q99NG0

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q99NG0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q99NG0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q99NG0

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q99NG0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q99NG0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed at relatively low level, with highest expression in testis, liver and kidney. In brain, it is expressed in hippocampal and cerebellar neurons. In testis, it is present at high level in Sertoli cell nuclei. Also present in Leydig cell (at protein level).2 Publications

    <p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Mainly expressed in the neural tube and limb buds during early embryonic development. Also present in testis: at the onset of spermatogenesis, it is expressed in spermatogonia, pachytene, and diplotene spermatocytes. In Sertoli cells it is expressed in a stage-dependent manner, with high expression levels at stages II-VI and VII-VIII.2 Publications

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with AR via its N-terminus.

    Interacts with DYRK1A. Binds DNA and mononucleosomes, but does not seem to form large multiprotein complexes.

    3 Publications

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    219861, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    Q99NG0, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000045454

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini291 – 511Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST221
    Domaini727 – 895Helicase C-terminalPROSITE-ProRule annotationAdd BLAST169

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi462 – 465DEAH box4
    Motifi550 – 554LXXLL motif 15
    Motifi1328 – 1332LXXLL motif 25

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 42Glu-richAdd BLAST25
    Compositional biasi222 – 228Poly-Glu7

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors.By similarity

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the SNF2/RAD54 helicase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1015 Eukaryota
    COG0553 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000168429

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q99NG0

    KEGG Orthology (KO)

    More...
    KOi
    K10876

    Database of Orthologous Groups

    More...
    OrthoDBi
    815681at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q99NG0

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR014001 Helicase_ATP-bd
    IPR001650 Helicase_C
    IPR027417 P-loop_NTPase
    IPR000330 SNF2_N

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00271 Helicase_C, 1 hit
    PF00176 SNF2_N, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00487 DEXDc, 1 hit
    SM00490 HELICc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540 SSF52540, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51192 HELICASE_ATP_BIND_1, 1 hit
    PS51194 HELICASE_CTER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    Q99NG0-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSDESASGSD PDLDPDVELE DEEEEEEEEE VAVEEHDRDD EEGLLDDTSL
    60 70 80 90 100
    EGMCGTEHAQ LGEDGQRPPR CTSTTSSQSE PSEQLRHQGK ILASEDPKKK
    110 120 130 140 150
    RAQKPSHMRR NIRKLLREDQ LEPVTKAAQQ EELERRKRLE QQRKEYAAPI
    160 170 180 190 200
    PTVPLEFLPE EIVLRASDGP QLPPRVLAQE VICLDSSSGS EDEKSSRDEV
    210 220 230 240 250
    IELSSGEEDT LHIVDSSESV SEEDEEEEKG GTHVNDALNQ HDALGRVLVN
    260 270 280 290 300
    LNHPPEEENV FLAPQLARAV KPHQIGGIRF LYDNLVESLE RFKTSSGFGC
    310 320 330 340 350
    ILAHSMGLGK TLQVISFIDV LFRHTPAKTV LAIVPVNTLQ NWLAEFNMWL
    360 370 380 390 400
    PAPEALPADS KPEEVQPRFF KVHILNDEHK TVASRAKVTA DWVSEGGVLL
    410 420 430 440 450
    MGYEMYRLLT LKKSLATSRP KKTKKRSHPV IIDLDEEDRQ QEFRREFEKA
    460 470 480 490 500
    LCRPGPDVVI CDEGHRIKNC QASTSQALKN IRSRRRVVLT GYPLQNNLIE
    510 520 530 540 550
    YWCMVDFVRP DFLGTRQEFS NMFERPILNG QCIDSTPQDV RLMRYRSHVL
    560 570 580 590 600
    HSLLEGFVQR RGHTVLKIHL PAKEENVILV RLSQIQRDLY TQFMDRFRDC
    610 620 630 640 650
    GTSGWLGLNP LKAFCVCCKI WNHPDVLYEA LQKENLANEQ DLDVEELGSA
    660 670 680 690 700
    GTSARCPPHG TKVKGEDSAL PSSMGEATNS KFLQGVGFNP FQERGNNIVT
    710 720 730 740 750
    YEWAKELLTN YQTGVLENSP KMVLLFHLIE ESVKLGDKIL VFSQSLSTLA
    760 770 780 790 800
    LIEEFLGKRD MPCLPGAEGQ GTQKWVRNVS YFRLDGSTPA FERERLINQF
    810 820 830 840 850
    NDPSNLTTWL FLLSTRAGCL GVNLIGANRV VVFDASWNPC HDAQAVCRVY
    860 870 880 890 900
    RYGQKKPCHI YRLVADYTLE KKIYDRQISK QGMSDRVVDD LNPMLNFTRK
    910 920 930 940 950
    EVENLLHFVE KEPAPQTSLD IKGIKESVLQ LACLKYPHLI TKEPFEHESL
    960 970 980 990 1000
    LLNRKDHKLT KAEKKAAKKS YEEDKRTSVP YTRPSYAQYY PASDQSLTSI
    1010 1020 1030 1040 1050
    PAFSQRNWQP TLKGDEKPVA SVRPVQSTPI PMMPRHVPLS GGVSSASSTN
    1060 1070 1080 1090 1100
    TSMNFPINYL QRAGVLVQKV VTTTDIVIPG LNSSTDVQAR INAGESIHII
    1110 1120 1130 1140 1150
    RGTKGTYIRT SDGRIFAVRA TGKPKAPEDG RMAASGSQGP SLASTSNGRH
    1160 1170 1180 1190 1200
    SASSPKAPDP EGLARPVSPD SPEIISELQQ YADVAAARES RQSSPSISAA
    1210 1220 1230 1240 1250
    LPGPPGQLMD NSTIPGTALG TEPCLGGHCL NSSLLVTGQP SGGRHPVLDL
    1260 1270 1280 1290 1300
    RGHKRKLATP SVTQESIRRR SRKGHLPAPV QPYEHGYPVS GGFAMPPVSL
    1310 1320 1330 1340 1350
    NHNLTTPFTS QAGENSLFMG SNPSYYQLSN LLADARLVFP VTTDPLVPAG
    1360 1370 1380 1390 1400
    PVSSSSTATS VTASNPSFML NPSVPGMLPS YSLPFSQPLL SEPRMFAPFP
    1410 1420 1430 1440 1450
    SPGLPSNLSR GVSVYPGYMS PHAGYPAGGL LRSQVPPFDS HEVAEVGFSS
    1460
    NDDEDKDDDV IEVTGK
    Length:1,466
    Mass (Da):162,540
    Last modified:June 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5945AD802B03D12
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9QKL0E9QKL0_MOUSE
    Helicase ARIP4
    Rad54l2
    1,467Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WP96A0A087WP96_MOUSE
    Helicase ARIP4
    Rad54l2
    56Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WPJ6A0A087WPJ6_MOUSE
    Helicase ARIP4
    Rad54l2
    190Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1197I → V in BAE25404 (PubMed:16141072).Curated1
    Sequence conflicti1267I → V in BAE25404 (PubMed:16141072).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ132389 mRNA Translation: CAC24703.1
    BC133714 mRNA Translation: AAI33715.1
    AK143506 mRNA Translation: BAE25404.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_109655.2, NM_030730.2

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    81000

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:81000

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ132389 mRNA Translation: CAC24703.1
    BC133714 mRNA Translation: AAI33715.1
    AK143506 mRNA Translation: BAE25404.1
    RefSeqiNP_109655.2, NM_030730.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi219861, 1 interactor
    IntActiQ99NG0, 1 interactor
    STRINGi10090.ENSMUSP00000045454

    PTM databases

    iPTMnetiQ99NG0
    PhosphoSitePlusiQ99NG0

    Proteomic databases

    EPDiQ99NG0
    MaxQBiQ99NG0
    PaxDbiQ99NG0
    PRIDEiQ99NG0

    Genome annotation databases

    GeneIDi81000
    KEGGimmu:81000

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    23132
    MGIiMGI:1933196 Rad54l2

    Phylogenomic databases

    eggNOGiKOG1015 Eukaryota
    COG0553 LUCA
    HOGENOMiHOG000168429
    InParanoidiQ99NG0
    KOiK10876
    OrthoDBi815681at2759
    PhylomeDBiQ99NG0

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Rad54l2 mouse

    Protein Ontology

    More...
    PROi
    PR:Q99NG0

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Family and domain databases

    InterProiView protein in InterPro
    IPR014001 Helicase_ATP-bd
    IPR001650 Helicase_C
    IPR027417 P-loop_NTPase
    IPR000330 SNF2_N
    PfamiView protein in Pfam
    PF00271 Helicase_C, 1 hit
    PF00176 SNF2_N, 1 hit
    SMARTiView protein in SMART
    SM00487 DEXDc, 1 hit
    SM00490 HELICc, 1 hit
    SUPFAMiSSF52540 SSF52540, 2 hits
    PROSITEiView protein in PROSITE
    PS51192 HELICASE_ATP_BIND_1, 1 hit
    PS51194 HELICASE_CTER, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARIP4_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99NG0
    Secondary accession number(s): Q3UPJ1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 1, 2001
    Last modified: September 18, 2019
    This is version 123 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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