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Entry version 117 (13 Nov 2019)
Sequence version 1 (01 Jun 2001)
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Protein

NMDA receptor synaptonuclear signaling and neuronal migration factor

Gene

Nsmf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.1 Publication

Miscellaneous

Transport from dendrites to the nucleus is induced by NMDA receptor activation and results in a rapid stripping of synaptic contacts and a reduction of dendritic complexity (By similarity). KIF5C associates to its 3'-UTR mRNA in granules along dendritic shafts, suggesting that this protein may regulate its dendritic trafficking and local translation at postsynaptic sites.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NMDA receptor synaptonuclear signaling and neuronal migration factor
Alternative name(s):
Juxtasynaptic attractor of caldendrin on dendritic boutons protein
Short name:
Jacob protein
Nasal embryonic luteinizing hormone-releasing hormone factor
Short name:
Nasal embryonic LHRH factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nsmf
Synonyms:Jac, Nelf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1861755 Nsmf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus, Synapse, Synaptosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967792 – 532NMDA receptor synaptonuclear signaling and neuronal migration factorAdd BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei206PhosphoserineCombined sources1
Modified residuei292PhosphoserineBy similarity1
Modified residuei294PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically processed after NMDA receptor activation. Cleaved in a calcium-dependent and calpain-sensitive manner. Calpain cleavage is essential for the translocation process from dendrites to the nucleus (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99NF2

PRoteomics IDEntifications database

More...
PRIDEi
Q99NF2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99NF2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99NF2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in immature migratory, in comparison to postmigrating, gonadotropin-releasing hormone (GnRH) neuronal cell lines (at protein level). Expressed in adult brain and liver. In the brain, expressed in the primary pituitary gland, cortex, hippocampus, olfactory bulb and thalamus.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 14.5 dpc embryo found at high levels within the forebrain, olfactory epithelium and olfactory pit. At 12.5 dpc embryo detected on olfactory axons including olfactory pathway on which the LHRH neurons move. From 11.5 dpc to 17.5 dpc embryos expressed in LHRH (luteinizing hormone-releasing hormone) neurons as they migrate from the olfactory pit into the developing forebrain.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by gonadotropin releasing hormone (GnRH).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000006476 Expressed in 276 organ(s), highest expression level in telencephalon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99NF2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99NF2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KPNA1; the interaction occurs in a calcium-independent manner after synaptic NMDA receptor stimulation and is required for nuclear import of NSMF but is competed by CABP1.

Interacts (via the central NLS-containing motif region) with CABP1 (via EF-hands 1 and 2); the interaction occurs in a calcium-dependent manner after synaptic NMDA receptor stimulation and prevents the nuclear import of NSMF. Cannot be competed by calmodulin (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
O88751-12EBI-15688721,EBI-15688755From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q99NF2, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097908

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99NF2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 235Necessary and sufficient to elicit dendritic processes and synaptic contactsBy similarityAdd BLAST234

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi249 – 252Nuclear localization signalBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NSMF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGJD Eukaryota
ENOG410YVK8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000459

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99NF2

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQGSREC

Database of Orthologous Groups

More...
OrthoDBi
611342at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99NF2

TreeFam database of animal gene trees

More...
TreeFami
TF331286

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033374 NSMF

The PANTHER Classification System

More...
PANTHERi
PTHR32061 PTHR32061, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99NF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAAASRRRA LRSEAMSSVA AKVRAARAFG EYLSQSHPEN RNGADHLLAD
60 70 80 90 100
AYSGHDGSPE MQPAPQNKRR LSLVSNGRYE GSISDEAVSG KPAIEGPQPH
110 120 130 140 150
VYTISREPAL LPGSEAEAIE LAVVKGRRQR ERHPHHHSQP LRASPGSSRE
160 170 180 190 200
DISRPCQSWA GSRQGSKECP GCAQLVPGPS SRAFGLEQPP LPEAPGRHKK
210 220 230 240 250
LERMYSVDGV SDDVPIRTWF PKENLFSFQT ATTTMQAISV FRGYAERKRR
260 270 280 290 300
KRENDSASVI QRNFRKHLRM VGSRRVKAQT FAERRERSFS RSWSDPTPMK
310 320 330 340 350
ADTSHDSRDS SDLQSSHCTL DEACEDLDWD TEKGLEAMAC NTEGFLPPKV
360 370 380 390 400
MLISSKVPKA EYIPTIIRRD DPSIIPILYD HEHATFEDIL EEIEKKLNIY
410 420 430 440 450
HKGAKIWKML IFCQGGPGHL YLLKNKVATF AKVEKEEDMI HFWKRLSRLM
460 470 480 490 500
SKVNPEPNVI HIMGCYILGN PNGEKLFQNL RTLMTPYKVT FESPLELSAQ
510 520 530
GKQMIETYFD FRLYRLWKSR QHSKLLDFDD VL
Length:532
Mass (Da):60,293
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE83212A82B90987
GO
Isoform 2 (identifier: Q99NF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-239: Missing.

Show »
Length:530
Mass (Da):60,093
Checksum:i7E23CEF852FBD7C3
GO
Isoform 3 (identifier: Q99NF2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-262: Missing.

Show »
Length:509
Mass (Da):57,489
Checksum:i0AFA15AE1F3EE049
GO
Isoform 4 (identifier: Q99NF2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGAPVTM
     238-239: Missing.
     280-309: Missing.

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):57,267
Checksum:iB004C1941F83193B
GO
Isoform 5 (identifier: Q99NF2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-226: DDVPIRTWFPKENLF → GEGLIFGPGQIPAGL
     227-532: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):24,144
Checksum:i6596EBEFB9CA483C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJ96A2AJ96_MOUSE
NMDA receptor synaptonuclear-signal...
Nsmf Nelf
500Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AJ92A2AJ92_MOUSE
NMDA receptor synaptonuclear-signal...
Nsmf Nelf
507Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AJ95A2AJ95_MOUSE
NMDA receptor synaptonuclear-signal...
Nsmf Nelf
479Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TKU5F6TKU5_MOUSE
NMDA receptor synaptonuclear-signal...
Nsmf Nelf
509Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWK2A0A0A6YWK2_MOUSE
NMDA receptor synaptonuclear-signal...
Nsmf
328Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AJ91A2AJ91_MOUSE
NMDA receptor synaptonuclear-signal...
Nsmf Nelf
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YW62A0A0A6YW62_MOUSE
NMDA receptor synaptonuclear-signal...
Nsmf
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AJ90A2AJ90_MOUSE
NMDA receptor synaptonuclear-signal...
Nsmf Nelf
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VTS9F6VTS9_MOUSE
NMDA receptor synaptonuclear-signal...
Nsmf Nelf
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti248K → N in BAC35375 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0147641M → MRGAPVTM in isoform 4. 1 Publication1
Alternative sequenceiVSP_014765212 – 226DDVPI…KENLF → GEGLIFGPGQIPAGL in isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_014766227 – 532Missing in isoform 5. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_014767238 – 239Missing in isoform 2 and isoform 4. 2 Publications2
Alternative sequenceiVSP_014768240 – 262Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_014769280 – 309Missing in isoform 4. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF266508 mRNA Translation: AAF74501.2
AJ278902 mRNA Translation: CAC27332.1
AK004986 mRNA Translation: BAB23721.1
AK019560 mRNA Translation: BAC25597.1
AK041478 mRNA Translation: BAC30955.1
AK045384 mRNA Translation: BAC32338.1
AK053402 mRNA Translation: BAC35375.1
AL732585 Genomic DNA No translation available.
BC006642 mRNA Translation: AAH06642.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS15745.1 [Q99NF2-1]
CCDS15746.1 [Q99NF2-2]
CCDS15747.1 [Q99NF2-3]

NCBI Reference Sequences

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RefSeqi
NP_001034475.1, NM_001039386.1 [Q99NF2-1]
NP_001034476.1, NM_001039387.1 [Q99NF2-2]
NP_001171125.1, NM_001177654.1
NP_001171126.1, NM_001177655.1
NP_064672.2, NM_020276.3 [Q99NF2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000006646; ENSMUSP00000006646; ENSMUSG00000006476 [Q99NF2-2]
ENSMUST00000100334; ENSMUSP00000097908; ENSMUSG00000006476 [Q99NF2-1]
ENSMUST00000102931; ENSMUSP00000099995; ENSMUSG00000006476 [Q99NF2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56876

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:56876

UCSC genome browser

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UCSCi
uc008iqa.1 mouse [Q99NF2-5]
uc008iqb.1 mouse [Q99NF2-1]
uc008iqc.1 mouse [Q99NF2-2]
uc008iqd.1 mouse [Q99NF2-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266508 mRNA Translation: AAF74501.2
AJ278902 mRNA Translation: CAC27332.1
AK004986 mRNA Translation: BAB23721.1
AK019560 mRNA Translation: BAC25597.1
AK041478 mRNA Translation: BAC30955.1
AK045384 mRNA Translation: BAC32338.1
AK053402 mRNA Translation: BAC35375.1
AL732585 Genomic DNA No translation available.
BC006642 mRNA Translation: AAH06642.1
CCDSiCCDS15745.1 [Q99NF2-1]
CCDS15746.1 [Q99NF2-2]
CCDS15747.1 [Q99NF2-3]
RefSeqiNP_001034475.1, NM_001039386.1 [Q99NF2-1]
NP_001034476.1, NM_001039387.1 [Q99NF2-2]
NP_001171125.1, NM_001177654.1
NP_001171126.1, NM_001177655.1
NP_064672.2, NM_020276.3 [Q99NF2-3]

3D structure databases

SMRiQ99NF2
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ99NF2, 3 interactors
STRINGi10090.ENSMUSP00000097908

PTM databases

iPTMnetiQ99NF2
PhosphoSitePlusiQ99NF2

Proteomic databases

PaxDbiQ99NF2
PRIDEiQ99NF2

Genome annotation databases

EnsembliENSMUST00000006646; ENSMUSP00000006646; ENSMUSG00000006476 [Q99NF2-2]
ENSMUST00000100334; ENSMUSP00000097908; ENSMUSG00000006476 [Q99NF2-1]
ENSMUST00000102931; ENSMUSP00000099995; ENSMUSG00000006476 [Q99NF2-3]
GeneIDi56876
KEGGimmu:56876
UCSCiuc008iqa.1 mouse [Q99NF2-5]
uc008iqb.1 mouse [Q99NF2-1]
uc008iqc.1 mouse [Q99NF2-2]
uc008iqd.1 mouse [Q99NF2-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26012
MGIiMGI:1861755 Nsmf

Phylogenomic databases

eggNOGiENOG410IGJD Eukaryota
ENOG410YVK8 LUCA
GeneTreeiENSGT00390000000459
InParanoidiQ99NF2
OMAiRQGSREC
OrthoDBi611342at2759
PhylomeDBiQ99NF2
TreeFamiTF331286

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nsmf mouse

Protein Ontology

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PROi
PR:Q99NF2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000006476 Expressed in 276 organ(s), highest expression level in telencephalon
ExpressionAtlasiQ99NF2 baseline and differential
GenevisibleiQ99NF2 MM

Family and domain databases

InterProiView protein in InterPro
IPR033374 NSMF
PANTHERiPTHR32061 PTHR32061, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSMF_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99NF2
Secondary accession number(s): A2AJ93
, A2AJ94, Q8BPT0, Q8C9R5, Q9DBF4, Q9ERZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: November 13, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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