Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 172 (29 Sep 2021)
Sequence version 2 (09 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Regulating synaptic membrane exocytosis protein 1

Gene

Rims1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab effector involved in exocytosis (PubMed:11797009).

May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (PubMed:11797009).

Plays a role in dendrite formation by melanocytes (By similarity).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi139Zinc 1PROSITE-ProRule annotation1
Metal bindingi142Zinc 1PROSITE-ProRule annotation1
Metal bindingi155Zinc 2PROSITE-ProRule annotation1
Metal bindingi158Zinc 2PROSITE-ProRule annotation1
Metal bindingi163Zinc 1PROSITE-ProRule annotation1
Metal bindingi166Zinc 1PROSITE-ProRule annotation1
Metal bindingi185Zinc 2PROSITE-ProRule annotation1
Metal bindingi188Zinc 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri133 – 193FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Exocytosis, Neurotransmitter transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-181429, Serotonin Neurotransmitter Release Cycle
R-MMU-181430, Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500, Glutamate Neurotransmitter Release Cycle
R-MMU-212676, Dopamine Neurotransmitter Release Cycle
R-MMU-264642, Acetylcholine Neurotransmitter Release Cycle
R-MMU-888590, GABA synthesis, release, reuptake and degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 1
Alternative name(s):
Rab-3-interacting molecule 1
Short name:
RIM 1
Rab-3-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rims1
Synonyms:Kiaa0340, Rab3ip1, Rim1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2152971, Rims1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi33R → G: Abolishes interaction with RAB3A. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001901991 – 1463Regulating synaptic membrane exocytosis protein 1Add BLAST1463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei413PhosphoserineBy similarity1
Modified residuei563PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei716PhosphoserineCombined sources1
Modified residuei812PhosphoserineBy similarity1
Modified residuei866PhosphoserineCombined sources1
Modified residuei1023PhosphoserineCombined sources1
Modified residuei1025PhosphothreonineBy similarity1
Modified residuei1027PhosphoserineCombined sources1
Modified residuei1079PhosphoserineBy similarity1
Modified residuei1081PhosphoserineBy similarity1
Modified residuei1082PhosphoserineBy similarity1
Modified residuei1110PhosphoserineCombined sources1
Modified residuei1111PhosphoserineCombined sources1
Modified residuei1113PhosphoserineCombined sources1
Modified residuei1187PhosphoserineBy similarity1
Modified residuei1448PhosphoserineCombined sources1
Modified residuei1451PhosphoserineCombined sources1
Modified residuei1454PhosphoserineBy similarity1
Modified residuei1463PhosphoserineBy similarity1
Isoform 7 (identifier: Q99NE5-7)
Modified residuei413PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by BRSK1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q99NE5

PRoteomics IDEntifications database

More...
PRIDEi
Q99NE5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
255141 [Q99NE5-1]
255142 [Q99NE5-2]
255143 [Q99NE5-3]
255144 [Q99NE5-4]
255145 [Q99NE5-5]
255146 [Q99NE5-6]
255147 [Q99NE5-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99NE5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99NE5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions.

Interacts with TSPOAP1 and RIMBP2; interacts with PPFIA3 and PPFIA4.

Interacts with ERC1 (By similarity).

Interacts with RAB3A, RAB3B and RAB3D that have been activated by GTP-binding.

Interacts with RAB3C, RAB10, RAB26 AND RAB37. Binds UNC13A.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
228025, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q99NE5, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000095420

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99NE5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99NE5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 205RabBDPROSITE-ProRule annotationAdd BLAST184
Domaini440 – 526PDZPROSITE-ProRule annotationAdd BLAST87
Domaini577 – 700C2 1PROSITE-ProRule annotationAdd BLAST124
Domaini1309 – 1427C2 2PROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni205 – 393DisorderedSequence analysisAdd BLAST189
Regioni533 – 567DisorderedSequence analysisAdd BLAST35
Regioni705 – 856DisorderedSequence analysisAdd BLAST152
Regioni874 – 1049DisorderedSequence analysisAdd BLAST176
Regioni1104 – 1161DisorderedSequence analysisAdd BLAST58
Regioni1216 – 1266DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi205 – 222Polar residuesSequence analysisAdd BLAST18
Compositional biasi239 – 259Polar residuesSequence analysisAdd BLAST21
Compositional biasi284 – 299Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi306 – 376Basic and acidic residuesSequence analysisAdd BLAST71
Compositional biasi539 – 565Polar residuesSequence analysisAdd BLAST27
Compositional biasi724 – 745Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi780 – 800Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi828 – 848Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi878 – 895Polar residuesSequence analysisAdd BLAST18
Compositional biasi896 – 910Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi926 – 943Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1014 – 1039Polar residuesSequence analysisAdd BLAST26
Compositional biasi1104 – 1146Polar residuesSequence analysisAdd BLAST43
Compositional biasi1216 – 1231Polar residuesSequence analysisAdd BLAST16

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri133 – 193FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2060, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99NE5

Identification of Orthologs from Complete Genome Data

More...
OMAi
NRGRWSP

Database of Orthologous Groups

More...
OrthoDBi
109268at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99NE5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR001478, PDZ
IPR036034, PDZ_sf
IPR010911, Rab_BD
IPR039032, Rim-like
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD

The PANTHER Classification System

More...
PANTHERi
PTHR12157, PTHR12157, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 2 hits
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49562, SSF49562, 2 hits
SSF50156, SSF50156, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 2 hits
PS50106, PDZ, 1 hit
PS50916, RABBD, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced.

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99NE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE
60 70 80 90 100
EAMLKCVVRD MAKPAACKTP RNAESQPHQP PLNIFRCVCV PRKPSSEEGG
110 120 130 140 150
PDRNWRLHQQ FESYKEQVRK IGEEARRYQG EHKDDAPTCG ICHKTKFADG
160 170 180 190 200
CGHLCSYCRT KFCARCGGRV SLRSNNEDKV VMWVCNLCRK QQEILTKSGA
210 220 230 240 250
WFFGSGPQQP SQDGTLSDTA TGAGSEVPRE KKARLQERSR SQTPLSTAAV
260 270 280 290 300
SSQDTASHGA PLDRNKGAEP SQQALGPEQK QASRSRSEPP RERKKAPGLS
310 320 330 340 350
EQNGKGGQKS ERKRVPKSVV QPGEGTADER ERKERRETRR LEKGRSQDYP
360 370 380 390 400
DRLEKREDGR VAEDEKQRKE EEGVSTPEYT SCEDVELESE SVSEKGDLDY
410 420 430 440 450
WLDPATWHSR ETSPISSHPV TWQPSKEGDR LIGRVILNKR TTMPKESGAL
460 470 480 490 500
LGLKVVGGKM TDLGRLGAFI TKVKKGSLAD VVGHLRAGDE VLEWNGKPLP
510 520 530 540 550
GATNEEVYNI ILESKSEPQV EIIVSRPIGD IPRIPESSHP PLESSSSSFE
560 570 580 590 600
SQKMERPSIS VISPTSPGAL KDAPQVLPGQ LSVKLWYDKV GHQLIVNVLQ
610 620 630 640 650
ATDLPPRVDG RPRNPYVKMY FLPDRSDKSK RRTKTVKKLL EPKWNQTFVY
660 670 680 690 700
SHVHRRDFRE RMLEITVWDQ PRVQDEESEF LGEILIELET ALLDDEPHWY
710 720 730 740 750
KLQTHDESSL PLPQPSPFMP RRHIHGESSS KKLQRSQRIS DSDISDYEVD
760 770 780 790 800
DGIGVVPPVG YRASARESKA TTLTVPEQQR TTHHRSRSVS PHRGDDQGRP
810 820 830 840 850
RSRLPNVPLQ RSLDEIHPTR RSRSPTRHHD ASRSLADHRS RHAESQYSSE
860 870 880 890 900
PDSELLMLPR AKRGRSAECL HMTSELQPSL DRARSASTNC LRPDTSLHSP
910 920 930 940 950
ERERGRWSPS LARRRPASPR IQIQHASPEN DRHSRKSERS SIQKQSRKGT
960 970 980 990 1000
ASDADRVLPP CLSRRGYAIP RATDQPVIRG KHTTRSRSSE HSSIRTLCSM
1010 1020 1030 1040 1050
HHLAPGGSAP PSPLLTRTHR QGSPTQSPPA DTSFGSRRGR QLPQVPVRSG
1060 1070 1080 1090 1100
SIEQASLVVE ERTRQMKMKV HRFKQTTGSG SSQELDHEQY SKYNIHKDQY
1110 1120 1130 1140 1150
RSCDNASAKS SDSDVSDVSA ISRASSTSRL SSTSFMSEQS ERPRGRISSF
1160 1170 1180 1190 1200
TPKMQGRRMG TSGRAIIKST SVSGEIYTLE HNDGSQSDTA VGTVGAGGKK
1210 1220 1230 1240 1250
RRSSLSAKVV AIVSRRSRST SQLSQTESGH KKLKSTIQRS TETGMAAEMR
1260 1270 1280 1290 1300
KMVRQPSRES TDGSINSYSS EGNLIFPGVR VGPDSQFSDF LDGLGPAQLV
1310 1320 1330 1340 1350
GRQTLATPAM GDIQIGMEDK KGQLEVEVIR ARSLTQKPGS KSTPAPYVKV
1360 1370 1380 1390 1400
YLLENGACIA KKKTRIARKT LDPLYQQSLV FDESPQGKVL QVIVWGDYGR
1410 1420 1430 1440 1450
MDHKCFMGVA QILLEELDLS SMVIGWYKLF PPSSLVDPTL TPLTRRASQS
1460
SLESSSGPPC IRS
Length:1,463
Mass (Da):163,161
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E0BE5D522924738
GO
Isoform 2 (identifier: Q99NE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-388: GVSTPEYTSCEDVELE → YQTRYRSDPNLARYPV
     389-1463: Missing.

Show »
Length:388
Mass (Da):43,845
Checksum:iD928680A7C9516D9
GO
Isoform 3 (identifier: Q99NE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     904-931: Missing.

Show »
Length:1,435
Mass (Da):159,940
Checksum:i1FC9923B9DB475D0
GO
Isoform 4 (identifier: Q99NE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     904-931: Missing.
     956-1016: Missing.

Show »
Length:1,374
Mass (Da):153,345
Checksum:i6C99725DAB7FFE0D
GO
Isoform 5 (identifier: Q99NE5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     904-1016: Missing.

Show »
Length:1,350
Mass (Da):150,647
Checksum:i1DAECF1761B05766
GO
Isoform 6 (identifier: Q99NE5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     853-1016: Missing.

Show »
Length:1,299
Mass (Da):144,930
Checksum:i0D0D326E71A9C39A
GO
Isoform 7 (identifier: Q99NE5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-369: K → KEEEYQTRYR...KRRQMSVSSS
     853-1016: Missing.
     1150-1170: FTPKMQGRRMGTSGRAIIKST → LTLVLLMMALPYKFVQKSRLF
     1171-1463: Missing.

Show »
Length:1,184
Mass (Da):132,994
Checksum:i40271B0A3D3ACD08
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VBV0F6VBV0_MOUSE
Regulating synaptic membrane exocyt...
Rims1
1,666Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TZK4F6TZK4_MOUSE
Regulating synaptic membrane exocyt...
Rims1
1,477Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Y0S3F6Y0S3_MOUSE
Regulating synaptic membrane exocyt...
Rims1
1,613Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PWP6E9PWP6_MOUSE
Regulating synaptic membrane exocyt...
Rims1
1,641Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7TPL9Q7TPL9_MOUSE
Regulating synaptic membrane exocyt...
Rims1
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A668KL79A0A668KL79_MOUSE
Regulating synaptic membrane exocyt...
Rims1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022230369K → KEEEYQTRYRSDPNLARYPV KAPLEEQQMRMHARVSRARH ERRHSDVALPHTEAAAAVSA ETTAGKRAQTTARVSPPESP RARAPAAQPPAEHGPPPPRP APGPAEPPEPRVPEPLRKQG RLDPGSAVLLRKAKREKAES MLRNDSLSSDQSESVRPSPP KPHRPKRGGKRRQMSVSSS in isoform 7. 1 Publication1
Alternative sequenceiVSP_022231373 – 388GVSTP…DVELE → YQTRYRSDPNLARYPV in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_022232389 – 1463Missing in isoform 2. 1 PublicationAdd BLAST1075
Alternative sequenceiVSP_022233853 – 1016Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST164
Alternative sequenceiVSP_022234904 – 1016Missing in isoform 5. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_022235904 – 931Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_022236956 – 1016Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_0222371150 – 1170FTPKM…IIKST → LTLVLLMMALPYKFVQKSRL F in isoform 7. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0222381171 – 1463Missing in isoform 7. 1 PublicationAdd BLAST293

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ310531 mRNA Translation: CAC32041.1
AY356534 mRNA Translation: AAR14797.1
AY356535 mRNA Translation: AAR14798.1
AY356536 mRNA Translation: AAR14799.1
AY356537 mRNA Translation: AAR14800.1
AY356538 mRNA Translation: AAR14801.1
AK220335 mRNA Translation: BAD90402.1

NCBI Reference Sequences

More...
RefSeqi
NP_001012641.1, NM_001012623.1
NP_001012642.1, NM_001012624.1
NP_001012643.1, NM_001012625.1
NP_444500.1, NM_053270.1
NP_898839.2, NM_183018.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116837

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:116837

UCSC genome browser

More...
UCSCi
uc029qni.1, mouse [Q99NE5-1]
uc029qnj.1, mouse [Q99NE5-3]
uc029qnk.1, mouse [Q99NE5-4]
uc029qnm.1, mouse [Q99NE5-6]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310531 mRNA Translation: CAC32041.1
AY356534 mRNA Translation: AAR14797.1
AY356535 mRNA Translation: AAR14798.1
AY356536 mRNA Translation: AAR14799.1
AY356537 mRNA Translation: AAR14800.1
AY356538 mRNA Translation: AAR14801.1
AK220335 mRNA Translation: BAD90402.1
RefSeqiNP_001012641.1, NM_001012623.1
NP_001012642.1, NM_001012624.1
NP_001012643.1, NM_001012625.1
NP_444500.1, NM_053270.1
NP_898839.2, NM_183018.2

3D structure databases

SMRiQ99NE5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi228025, 11 interactors
IntActiQ99NE5, 4 interactors
STRINGi10090.ENSMUSP00000095420

PTM databases

iPTMnetiQ99NE5
PhosphoSitePlusiQ99NE5

Proteomic databases

PeptideAtlasiQ99NE5
PRIDEiQ99NE5
ProteomicsDBi255141 [Q99NE5-1]
255142 [Q99NE5-2]
255143 [Q99NE5-3]
255144 [Q99NE5-4]
255145 [Q99NE5-5]
255146 [Q99NE5-6]
255147 [Q99NE5-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
116837

Genome annotation databases

GeneIDi116837
KEGGimmu:116837
UCSCiuc029qni.1, mouse [Q99NE5-1]
uc029qnj.1, mouse [Q99NE5-3]
uc029qnk.1, mouse [Q99NE5-4]
uc029qnm.1, mouse [Q99NE5-6]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22999
MGIiMGI:2152971, Rims1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG2060, Eukaryota
InParanoidiQ99NE5
OMAiNRGRWSP
OrthoDBi109268at2759
PhylomeDBiQ99NE5

Enzyme and pathway databases

ReactomeiR-MMU-181429, Serotonin Neurotransmitter Release Cycle
R-MMU-181430, Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500, Glutamate Neurotransmitter Release Cycle
R-MMU-212676, Dopamine Neurotransmitter Release Cycle
R-MMU-264642, Acetylcholine Neurotransmitter Release Cycle
R-MMU-888590, GABA synthesis, release, reuptake and degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
116837, 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rims1, mouse

Protein Ontology

More...
PROi
PR:Q99NE5
RNActiQ99NE5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di2.30.42.10, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR001478, PDZ
IPR036034, PDZ_sf
IPR010911, Rab_BD
IPR039032, Rim-like
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
PANTHERiPTHR12157, PTHR12157, 2 hits
PfamiView protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00239, C2, 2 hits
SM00228, PDZ, 1 hit
SUPFAMiSSF49562, SSF49562, 2 hits
SSF50156, SSF50156, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50106, PDZ, 1 hit
PS50916, RABBD, 1 hit
PS50178, ZF_FYVE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIMS1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99NE5
Secondary accession number(s): Q5DU35
, Q5J8K0, Q5J8K1, Q5J8K2, Q5J8K3, Q5J8K4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 9, 2007
Last modified: September 29, 2021
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again