Peroxisome proliferator activated receptor delta, isoform CRA_b

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 12573457
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• drug binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• fatty acid binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12600885
• linoleic acid binding Source: Ensembl
• lipid binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• NF-kappaB binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 15728586
• nuclear receptor activity Source: RGDTraceable author statementⁱ
  • 12573457
• nuclear receptor transcription coactivator activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• protein heterodimerization activity Source: Ensembl
• proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• RNA polymerase II repressing transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• signaling receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• steroid hormone receptor activity Source: InterPro
• transcription coactivator activity Source: RGDInferred from direct assayⁱ
  • 19965574
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• transcription regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• adipose tissue development Source: Ensembl
• apoptotic signaling pathway Source: Ensembl
• axon ensheathment Source: Ensembl
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cell-substrate adhesion Source: Ensembl
• cellular response to hypoxia Source: Ensembl
• cellular response to lipopolysaccharide Source: RGDInferred from direct assayⁱ
  • 15728586
• decidualization Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 12773104
• embryo implantation Source: RGDInferred from expression patternⁱ
  • 12773104
• fatty acid beta-oxidation Source: Ensembl
• fatty acid metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• fatty acid oxidation Source: RGDInferred from direct assayⁱ
  • 12600885
• fatty acid transport Source: Ensembl
• heart development Source: RGDInferred from expression patternⁱ
  • 15754086
• hormone-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• keratinocyte migration Source: Ensembl
• keratinocyte proliferation Source: Ensembl
• lipid metabolic process Source: RGDInferred from direct assayⁱ
  • 20338185
• mRNA transcription Source: RGDInferred from direct assayⁱ
  • 19965574
• multicellular organism development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of apoptotic process Source: RGDInferred from direct assayⁱ
  • 16337160
• negative regulation of cell growth Source: RGDInferred from direct assayⁱ
  • 18293166
• negative regulation of cholesterol storage Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of collagen biosynthetic process Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17346664
• negative regulation of epithelial cell proliferation Source: Ensembl
• negative regulation of inflammatory response Source: RGDInferred from direct assayⁱ
  • 17461989
• negative regulation of myoblast differentiation Source: Ensembl
• negative regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• negative regulation of smooth muscle cell migration Source: RGDInferred from direct assayⁱ
  • 18585719
• negative regulation of smooth muscle cell proliferation Source: RGDInferred from direct assayⁱ
  • 18585719
• negative regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• phospholipid biosynthetic process Source: RGDInferred from direct assayⁱ
  • 17148578
• positive regulation of blood vessel diameter Source: RGDInferred from direct assayⁱ
  • 19906781
• positive regulation of epidermis development Source: RGDInferred from direct assayⁱ
  • 19675577
• positive regulation of insulin secretion Source: RGDInferred from direct assayⁱ
  • 19965574
• positive regulation of myoblast proliferation Source: Ensembl
• positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• positive regulation of skeletal muscle tissue regeneration Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• proteoglycan metabolic process Source: RGDInferred from direct assayⁱ
  • 17140817
• regulation of fat cell differentiation Source: Ensembl
• regulation of lipid metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of skeletal muscle satellite cell proliferation Source: Ensembl
• response to activity Source: RGDInferred from expression patternⁱ
  • 20233940
• response to glucose Source: RGDInferred from expression patternⁱ
  • 18573863
• response to lipid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to organic substance Source: RGDInferred from expression patternⁱ
  • 18338635
  • 18843091
• response to vitamin A Source: RGDInferred from expression patternⁱ
  • 19342198
• vitamin A metabolic process Source: RGDInferred from mutant phenotypeⁱ
  • 12576510
• wound healing Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• NF-kappaB binding Source: RGDInferred from physical interactionⁱ
  • 15728586
• protein heterodimerization activity Source: Ensembl
• RNA polymerase II repressing transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEQPQEETPE AREEEKEEVA TGDGAPELNG GPEHTLPSSS CTDLSQNSSP 
        60         70         80         90        100
SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT 
       110        120        130        140        150
IRMKLKYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA 
       160        170        180        190        200
EKRKLVAGLT ASEGCQQNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL 
       210        220        230        240        250
TGKSSHNAPF IIHDIETLWQ AEKGLVWKQL VNGPPPYNEI SVHVFYRCQS 
       260        270        280        290        300
TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD 
       310        320        330        340        350
GLLVANGSGF VTHEFLRSIR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF 
       360        370        380        390        400
IAAIILCGDR PGLMNVPQVE AIQDTILQAL EFHLQVNHPD SQYLFPKLLQ 
       410        420        430        440
KMADLRQLVT EHAQMMQWLK KTESETLLHP LLQEIYKDMY            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ