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UniProtKB - Q99ND3 (Q99ND3_RAT)
Protein
Submitted name:
Peroxisome proliferator activated receptor delta, isoform CRA_b
Gene
Ppard
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor binding Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- fatty acid binding Source: RGD
- linoleic acid binding Source: RGD
- lipid binding Source: RGD
- NF-kappaB binding Source: RGD
- nuclear receptor activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
- transcription coactivator binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- adipose tissue development Source: RGD
- apoptotic process Source: RGD
- apoptotic signaling pathway Source: RGD
- axon ensheathment Source: RGD
- cell differentiation Source: RGD
- cell-substrate adhesion Source: RGD
- cellular response to hypoxia Source: RGD
- cellular response to lipopolysaccharide Source: RGD
- decidualization Source: RGD
- embryo implantation Source: RGD
- fatty acid beta-oxidation Source: RGD
- fatty acid metabolic process Source: GO_Central
- fatty acid oxidation Source: RGD
- fatty acid transport Source: RGD
- heart development Source: RGD
- hormone-mediated signaling pathway Source: GO_Central
- keratinocyte migration Source: RGD
- keratinocyte proliferation Source: RGD
- lipid metabolic process Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of cell growth Source: RGD
- negative regulation of cholesterol storage Source: GO_Central
- negative regulation of collagen biosynthetic process Source: RGD
- negative regulation of epithelial cell proliferation Source: RGD
- negative regulation of inflammatory response Source: RGD
- negative regulation of miRNA transcription Source: RGD
- negative regulation of myoblast differentiation Source: RGD
- negative regulation of smooth muscle cell migration Source: RGD
- negative regulation of smooth muscle cell proliferation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- phospholipid biosynthetic process Source: RGD
- placenta development Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of epidermis development Source: RGD
- positive regulation of fatty acid metabolic process Source: GO_Central
- positive regulation of fatty acid oxidation Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
- positive regulation of myoblast proliferation Source: RGD
- positive regulation of phosphatidylinositol 3-kinase signaling Source: RGD
- positive regulation of skeletal muscle tissue regeneration Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- proteoglycan metabolic process Source: RGD
- regulation of cell population proliferation Source: RGD
- regulation of fat cell differentiation Source: RGD
- regulation of lipid metabolic process Source: GO_Central
- regulation of skeletal muscle satellite cell proliferation Source: RGD
- response to activity Source: RGD
- response to glucose Source: RGD
- response to lipid Source: GO_Central
- response to organic substance Source: RGD
- response to vitamin A Source: RGD
- vasodilation Source: RGD
- vitamin A metabolic process Source: RGD
- wound healing Source: RGD
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-200425, Carnitine metabolism R-RNO-204174, Regulation of pyruvate dehydrogenase (PDH) complex R-RNO-383280, Nuclear Receptor transcription pathway R-RNO-5362517, Signaling by Retinoic Acid |
Names & Taxonomyi
Protein namesi | Submitted name: Peroxisome proliferator activated receptor delta, isoform CRA_bImportedSubmitted name: Peroxisome proliferator-activated receptor betaImportedSubmitted name: Peroxisome proliferator-activated receptor delta |
Gene namesi | ORF Names:rCG_60581Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3370, Ppard |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000000503, Expressed in pancreas and 21 other tissues |
Interactioni
GO - Molecular functioni
- DNA-binding transcription factor binding Source: RGD
- NF-kappaB binding Source: RGD
- transcription coactivator binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000045974 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 70 – 144 | Nuclear receptorInterPro annotationAdd BLAST | 75 | |
Domaini | 210 – 438 | NR LBDInterPro annotationAdd BLAST | 229 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 53 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 22 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 33 – 53 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156676 |
HOGENOMi | CLU_007368_4_1_1 |
OMAi | RVNGYCE |
OrthoDBi | 1240230at2759 |
TreeFami | TF316304 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR003075, 1Cnucl_rcpt_B IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01290, PROXISOMPABR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q99ND3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQPQEETPE AREEEKEEVA TGDGAPELNG GPEHTLPSSS CTDLSQNSSP
60 70 80 90 100
SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT
110 120 130 140 150
IRMKLKYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA
160 170 180 190 200
EKRKLVAGLT ASEGCQQNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL
210 220 230 240 250
TGKSSHNAPF IIHDIETLWQ AEKGLVWKQL VNGPPPYNEI SVHVFYRCQS
260 270 280 290 300
TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD
310 320 330 340 350
GLLVANGSGF VTHEFLRSIR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF
360 370 380 390 400
IAAIILCGDR PGLMNVPQVE AIQDTILQAL EFHLQVNHPD SQYLFPKLLQ
410 420 430 440
KMADLRQLVT EHAQMMQWLK KTESETLLHP LLQEIYKDMY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JVK6 | A0A0G2JVK6_RAT | Peroxisome proliferator-activated r... | Ppard | 342 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306400 mRNA Translation: CAC29088.1 CH473988 Genomic DNA Translation: EDL96915.1 |
RefSeqi | NP_037273.2, NM_013141.2 XP_006256228.1, XM_006256166.3 XP_006256229.1, XM_006256167.3 XP_006256230.1, XM_006256168.3 |
Genome annotation databases
Ensembli | ENSRNOT00000042539.6; ENSRNOP00000045974.3; ENSRNOG00000000503.8 |
GeneIDi | 25682 |
KEGGi | rno:25682 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306400 mRNA Translation: CAC29088.1 CH473988 Genomic DNA Translation: EDL96915.1 |
RefSeqi | NP_037273.2, NM_013141.2 XP_006256228.1, XM_006256166.3 XP_006256229.1, XM_006256167.3 XP_006256230.1, XM_006256168.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000045974 |
Genome annotation databases
Ensembli | ENSRNOT00000042539.6; ENSRNOP00000045974.3; ENSRNOG00000000503.8 |
GeneIDi | 25682 |
KEGGi | rno:25682 |
Organism-specific databases
CTDi | 5467 |
RGDi | 3370, Ppard |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156676 |
HOGENOMi | CLU_007368_4_1_1 |
OMAi | RVNGYCE |
OrthoDBi | 1240230at2759 |
TreeFami | TF316304 |
Enzyme and pathway databases
Reactomei | R-RNO-200425, Carnitine metabolism R-RNO-204174, Regulation of pyruvate dehydrogenase (PDH) complex R-RNO-383280, Nuclear Receptor transcription pathway R-RNO-5362517, Signaling by Retinoic Acid |
Gene expression databases
Bgeei | ENSRNOG00000000503, Expressed in pancreas and 21 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR003075, 1Cnucl_rcpt_B IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01290, PROXISOMPABR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q99ND3_RAT | |
Accessioni | Q99ND3Primary (citable) accession number: Q99ND3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |