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Protein
Submitted name:

Tumor necrosis factor

Gene

tnfa

Organism
Sciurus vulgaris (Red squirrel)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factorImported
Gene namesi
Name:tnfaImported
OrganismiSciurus vulgaris (Red squirrel)Imported
Taxonomic identifieri55149 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciuromorphaSciuridaeSciurinaeSciuriniSciurus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 46HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ99ND1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 215TNF_2InterPro annotationAdd BLAST135

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili86 – 106Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG012516

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002959 TNF_alpha
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF23 PTHR11471:SF23, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01235 TNFALPHA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q99ND1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VELAEEALPK KPWGPQGSSR CLCLSLFSFL LVAAATTLFC LLHFGVIGPQ
60 70 80 90 100
REEFPNNLPL SAQAQMLTLR SSSQNMNDKP VAHVVANQTE EQLQWLSRRA
110 120 130 140 150
NALLANGMEL IDNQLVVPAD GLYLIYSQVL FKGQGCSSYV LLTHTVSRFA
160 170 180 190 200
VSYQDKVNLL SAIKSPCPKE SLEGAEFKPW YEPIYLGGVF ELQKGDRLSA
210
EVNLPSYLDF AESGQ
Length:215
Mass (Da):23,739
Last modified:June 1, 2001 - v1
Checksum:i36441309CA5E9898
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei215Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ286824 Genomic DNA Translation: CAC28540.1

Similar proteinsi

Entry informationi

Entry nameiQ99ND1_SCIVU
AccessioniPrimary (citable) accession number: Q99ND1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: December 20, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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