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Protein

Transcription cofactor vestigial-like protein 1

Gene

Vgll1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: MGI

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 1
Short name:
Vgl-1
Alternative name(s):
Vestigial-related factor
Gene namesi
Name:Vgll1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2655768 Vgll1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913481 – 307Transcription cofactor vestigial-like protein 1Add BLAST307

Proteomic databases

PaxDbiQ99NC0
PRIDEiQ99NC0

PTM databases

PhosphoSitePlusiQ99NC0

Expressioni

Gene expression databases

BgeeiENSMUSG00000031131 Expressed in 13 organ(s), highest expression level in placenta
CleanExiMM_VGLL1
ExpressionAtlasiQ99NC0 baseline and differential
GenevisibleiQ99NC0 MM

Interactioni

Subunit structurei

Interacts with TEFs.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Tead4Q62296-14EBI-15985690,EBI-15985676

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59848N
IntActiQ99NC0, 1 interactor
STRINGi10090.ENSMUSP00000033465

Structurei

Secondary structure

1307
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99NC0
SMRiQ99NC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiENOG410IZ27 Eukaryota
ENOG410YSUV LUCA
GeneTreeiENSGT00730000111322
HOGENOMiHOG000231385
HOVERGENiHBG055872
InParanoidiQ99NC0
OMAiWENCNSA
OrthoDBiEOG091G0GKN
PhylomeDBiQ99NC0
TreeFamiTF326340

Family and domain databases

InterProiView protein in InterPro
IPR011520 Vg_fam
PANTHERiPTHR15950 PTHR15950, 2 hits
PfamiView protein in Pfam
PF07545 Vg_Tdu, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99NC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEMKKNGVW IPESSQKPVK TEWNAGSVIF TYFEGDINSM VDEHFSRALR
60 70 80 90 100
NLKRPHKCSS SSHSDNLTLK NGVNKTRTDT SHTDRERKVE SSQTENSGEL
110 120 130 140 150
KDVPVEEKGT NKSMPPNQRH LSSWTIAQPA ASPENGARSS SLDEYGLKAM
160 170 180 190 200
DQHSLSMPKT PSALPLEPWH FSSLARPGFI APAYFPVFPD RHLTPEVYRV
210 220 230 240 250
FPDRHLTPEV YHVFPDRHLT PEVYPDGRCG PLQHLVQQDR YQNHPLEPAA
260 270 280 290 300
RENCSPAKIA GSTGSLMNLP PYPVHYKKKI CARGAASASL DDERSPSPKR

RRDAYYY
Length:307
Mass (Da):34,691
Last modified:June 1, 2001 - v1
Checksum:i1AC4714CF93C27E9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AFK0A2AFK0_MOUSE
Transcription cofactor vestigial-li...
Vgll1
150Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036708 mRNA Translation: BAB40534.1
AL672128 Genomic DNA No translation available.
CCDSiCCDS30151.1
RefSeqiNP_001300692.1, NM_001313763.1
NP_573514.1, NM_133251.2
UniGeneiMm.190616

Genome annotation databases

EnsembliENSMUST00000033465; ENSMUSP00000033465; ENSMUSG00000031131
ENSMUST00000114745; ENSMUSP00000110393; ENSMUSG00000031131
ENSMUST00000114746; ENSMUSP00000110394; ENSMUSG00000031131
GeneIDi170828
KEGGimmu:170828
UCSCiuc009tgz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036708 mRNA Translation: BAB40534.1
AL672128 Genomic DNA No translation available.
CCDSiCCDS30151.1
RefSeqiNP_001300692.1, NM_001313763.1
NP_573514.1, NM_133251.2
UniGeneiMm.190616

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z2QX-ray2.74C/D20-51[»]
ProteinModelPortaliQ99NC0
SMRiQ99NC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59848N
IntActiQ99NC0, 1 interactor
STRINGi10090.ENSMUSP00000033465

PTM databases

PhosphoSitePlusiQ99NC0

Proteomic databases

PaxDbiQ99NC0
PRIDEiQ99NC0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033465; ENSMUSP00000033465; ENSMUSG00000031131
ENSMUST00000114745; ENSMUSP00000110393; ENSMUSG00000031131
ENSMUST00000114746; ENSMUSP00000110394; ENSMUSG00000031131
GeneIDi170828
KEGGimmu:170828
UCSCiuc009tgz.1 mouse

Organism-specific databases

CTDi51442
MGIiMGI:2655768 Vgll1

Phylogenomic databases

eggNOGiENOG410IZ27 Eukaryota
ENOG410YSUV LUCA
GeneTreeiENSGT00730000111322
HOGENOMiHOG000231385
HOVERGENiHBG055872
InParanoidiQ99NC0
OMAiWENCNSA
OrthoDBiEOG091G0GKN
PhylomeDBiQ99NC0
TreeFamiTF326340

Miscellaneous databases

PROiPR:Q99NC0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031131 Expressed in 13 organ(s), highest expression level in placenta
CleanExiMM_VGLL1
ExpressionAtlasiQ99NC0 baseline and differential
GenevisibleiQ99NC0 MM

Family and domain databases

InterProiView protein in InterPro
IPR011520 Vg_fam
PANTHERiPTHR15950 PTHR15950, 2 hits
PfamiView protein in Pfam
PF07545 Vg_Tdu, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVGLL1_MOUSE
AccessioniPrimary (citable) accession number: Q99NC0
Secondary accession number(s): A2AFJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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