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Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Gene

Srd5a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.By similarity

Catalytic activityi

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta4-steroid + NADPH.By similarity

GO - Molecular functioni

  • 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: MGI
  • amide binding Source: MGI
  • cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
  • oxidoreductase activity Source: GO_Central
  • sterol 5-alpha reductase activity Source: MGI
  • testosterone dehydrogenase [NAD(P)] activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDifferentiation, Sexual differentiation
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-193048 Androgen biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC:1.3.1.22By similarity)
Alternative name(s):
5 alpha-SR2
SR type 2
Steroid 5-alpha-reductase 2
Short name:
S5AR 2
Gene namesi
Name:Srd5a2
Synonyms:5art2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2150380 Srd5a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136781 – 2543-oxo-5-alpha-steroid 4-dehydrogenase 2Add BLAST254

Proteomic databases

PaxDbiQ99N99
PRIDEiQ99N99

PTM databases

PhosphoSitePlusiQ99N99

Expressioni

Gene expression databases

BgeeiENSMUSG00000038541 Expressed in 72 organ(s), highest expression level in adrenal gland
CleanExiMM_SRD5A2
GenevisibleiQ99N99 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048862

Structurei

3D structure databases

ProteinModelPortaliQ99N99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1638 Eukaryota
ENOG410XS6P LUCA
GeneTreeiENSGT00510000046634
HOGENOMiHOG000050133
HOVERGENiHBG003402
InParanoidiQ99N99
KOiK12344
OMAiTNIAADR
OrthoDBiEOG091G0KU4
PhylomeDBiQ99N99
TreeFamiTF314668

Family and domain databases

InterProiView protein in InterPro
IPR016636 3-oxo-5-alpha-steroid_4-DH
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039357 SRD5A/TECR
PANTHERiPTHR10556 PTHR10556, 1 hit
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PIRSFiPIRSF015596 5_alpha-SR2, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q99N99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIVCHQVPV LAGSATLATM GTLILCFGKP ASYGKHSESV SSGVPLLPAR
60 70 80 90 100
IAWFLQELPS FVVSVGMLAW QPRSLFGPPG NVLLGLFSAH YFHRTFIYSL
110 120 130 140 150
LTRGRPLSAV IFLKATAFCI GNGLLQAYYL VYCAEYPEEW YTDMRFSVGV
160 170 180 190 200
FFFILGMGIN IHSDCMLRQL RKPGEVIYRI PQGGLFTYVS GANFLGEIIE
210 220 230 240 250
WMGYALATWS VPAFAFAFFT LCFLGMQAFY HHRFYLKMFK DYPKSRKALI

PFIF
Length:254
Mass (Da):28,619
Last modified:June 1, 2001 - v1
Checksum:i8D25019E8DC4DF47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049456 mRNA Translation: BAB40179.1
AK138946 mRNA Translation: BAE23830.1
BC125510 mRNA Translation: AAI25511.1
CCDSiCCDS28968.1
RefSeqiNP_444418.1, NM_053188.2
UniGeneiMm.38933

Genome annotation databases

EnsembliENSMUST00000043458; ENSMUSP00000048862; ENSMUSG00000038541
GeneIDi94224
KEGGimmu:94224
UCSCiuc008dnt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049456 mRNA Translation: BAB40179.1
AK138946 mRNA Translation: BAE23830.1
BC125510 mRNA Translation: AAI25511.1
CCDSiCCDS28968.1
RefSeqiNP_444418.1, NM_053188.2
UniGeneiMm.38933

3D structure databases

ProteinModelPortaliQ99N99
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048862

PTM databases

PhosphoSitePlusiQ99N99

Proteomic databases

PaxDbiQ99N99
PRIDEiQ99N99

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043458; ENSMUSP00000048862; ENSMUSG00000038541
GeneIDi94224
KEGGimmu:94224
UCSCiuc008dnt.1 mouse

Organism-specific databases

CTDi6716
MGIiMGI:2150380 Srd5a2

Phylogenomic databases

eggNOGiKOG1638 Eukaryota
ENOG410XS6P LUCA
GeneTreeiENSGT00510000046634
HOGENOMiHOG000050133
HOVERGENiHBG003402
InParanoidiQ99N99
KOiK12344
OMAiTNIAADR
OrthoDBiEOG091G0KU4
PhylomeDBiQ99N99
TreeFamiTF314668

Enzyme and pathway databases

ReactomeiR-MMU-193048 Androgen biosynthesis

Miscellaneous databases

PROiPR:Q99N99
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038541 Expressed in 72 organ(s), highest expression level in adrenal gland
CleanExiMM_SRD5A2
GenevisibleiQ99N99 MM

Family and domain databases

InterProiView protein in InterPro
IPR016636 3-oxo-5-alpha-steroid_4-DH
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039357 SRD5A/TECR
PANTHERiPTHR10556 PTHR10556, 1 hit
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PIRSFiPIRSF015596 5_alpha-SR2, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS5A2_MOUSE
AccessioniPrimary (citable) accession number: Q99N99
Secondary accession number(s): Q3UTZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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