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Protein

39S ribosomal protein L1, mitochondrial

Gene

Mrpl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L1, mitochondrial
Short name:
L1mt
Short name:
MRP-L1
Gene namesi
Name:Mrpl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2137202 Mrpl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 50MitochondrionSequence analysisAdd BLAST50
ChainiPRO_000025244151 – 33639S ribosomal protein L1, mitochondrialAdd BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99N96
MaxQBiQ99N96
PaxDbiQ99N96
PeptideAtlasiQ99N96
PRIDEiQ99N96

PTM databases

iPTMnetiQ99N96
PhosphoSitePlusiQ99N96

Expressioni

Gene expression databases

BgeeiENSMUSG00000029486 Expressed in 274 organ(s), highest expression level in heart left ventricle
CleanExiMM_MRPL1
ExpressionAtlasiQ99N96 baseline and differential
GenevisibleiQ99N96 MM

Interactioni

Protein-protein interaction databases

BioGridi220433, 1 interactor
IntActiQ99N96, 1 interactor
MINTiQ99N96
STRINGi10090.ENSMUSP00000037046

Structurei

3D structure databases

ProteinModelPortaliQ99N96
SMRiQ99N96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 50Poly-Ala7

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1569 Eukaryota
COG0081 LUCA
GeneTreeiENSGT00390000003587
HOGENOMiHOG000293225
HOVERGENiHBG061212
InParanoidiQ99N96
KOiK02863
OMAiVDNFQRM
OrthoDBiEOG091G0CV1
PhylomeDBiQ99N96

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
IPR005879 Ribosomal_L1_mit
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit
TIGRFAMsiTIGR01170 rplA_mito, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99N96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVRCLRR VLIHHQRHCL CKMASQASLY PCSVNSLLHN RHFAAAAAAA
60 70 80 90 100
TKPARKIKKG AKEKTSDEKP VDDIEKIKSY TYMESDPEDD VYLKRLYPRR
110 120 130 140 150
IYEVEKAIHL LKKFQVLDFT NPKQGVYLDL TLDMALGKKK TVEPFASVIA
160 170 180 190 200
LPHLFSSEVN KVAVFTANAS EIKIAEENGA AFAGGTDLVK KIMDDEVVVD
210 220 230 240 250
FYVAVPEIMG ELNPLRKKLK KRFPKATRNS IGRDIPKMLE LFKTAHEIMV
260 270 280 290 300
DEERQNFLST KIATLDMPSD QIAANLQAVI NEVCKHRPLN LGPFVVRAFL
310 320 330
RSSTSEGLLL KTDSLLPKEA KTTEAETEET QTAEAA
Length:336
Mass (Da):37,597
Last modified:June 16, 2009 - v2
Checksum:i328783081296B824
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D3F3Q9D3F3_MOUSE
39S ribosomal protein L1, mitochond...
Mrpl1
276Annotation score:

Sequence cautioni

The sequence AAH61042 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB26866 differs from that shown. Reason: Frameshift at position 7.Curated
The sequence BAB26866 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB40837 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56K → E in BAB26866 (PubMed:15489334).Curated1
Sequence conflicti94K → R in BAB26866 (PubMed:15489334).Curated1
Sequence conflicti118D → G in BAB26866 (PubMed:15489334).Curated1
Sequence conflicti131T → R in BAB26866 (PubMed:15489334).Curated1
Sequence conflicti140K → R in BAB26866 (PubMed:15489334).Curated1
Sequence conflicti180A → V in BAB26866 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010343 mRNA Translation: BAB26866.1 Sequence problems.
AK142249 mRNA Translation: BAE24994.1
BC028774 mRNA Translation: AAH28774.1
BC061042 mRNA Translation: AAH61042.1 Different initiation.
AB049632 mRNA Translation: BAB40837.1 Different initiation.
CCDSiCCDS19449.1
RefSeqiNP_444388.2, NM_053158.3
XP_006535355.1, XM_006535292.1
UniGeneiMm.295499

Genome annotation databases

EnsembliENSMUST00000036437; ENSMUSP00000037046; ENSMUSG00000029486
ENSMUST00000117766; ENSMUSP00000112977; ENSMUSG00000029486
GeneIDi94061
KEGGimmu:94061
UCSCiuc008yfi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010343 mRNA Translation: BAB26866.1 Sequence problems.
AK142249 mRNA Translation: BAE24994.1
BC028774 mRNA Translation: AAH28774.1
BC061042 mRNA Translation: AAH61042.1 Different initiation.
AB049632 mRNA Translation: BAB40837.1 Different initiation.
CCDSiCCDS19449.1
RefSeqiNP_444388.2, NM_053158.3
XP_006535355.1, XM_006535292.1
UniGeneiMm.295499

3D structure databases

ProteinModelPortaliQ99N96
SMRiQ99N96
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220433, 1 interactor
IntActiQ99N96, 1 interactor
MINTiQ99N96
STRINGi10090.ENSMUSP00000037046

PTM databases

iPTMnetiQ99N96
PhosphoSitePlusiQ99N96

Proteomic databases

EPDiQ99N96
MaxQBiQ99N96
PaxDbiQ99N96
PeptideAtlasiQ99N96
PRIDEiQ99N96

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036437; ENSMUSP00000037046; ENSMUSG00000029486
ENSMUST00000117766; ENSMUSP00000112977; ENSMUSG00000029486
GeneIDi94061
KEGGimmu:94061
UCSCiuc008yfi.2 mouse

Organism-specific databases

CTDi65008
MGIiMGI:2137202 Mrpl1

Phylogenomic databases

eggNOGiKOG1569 Eukaryota
COG0081 LUCA
GeneTreeiENSGT00390000003587
HOGENOMiHOG000293225
HOVERGENiHBG061212
InParanoidiQ99N96
KOiK02863
OMAiVDNFQRM
OrthoDBiEOG091G0CV1
PhylomeDBiQ99N96

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

PROiPR:Q99N96
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029486 Expressed in 274 organ(s), highest expression level in heart left ventricle
CleanExiMM_MRPL1
ExpressionAtlasiQ99N96 baseline and differential
GenevisibleiQ99N96 MM

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
IPR005879 Ribosomal_L1_mit
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit
TIGRFAMsiTIGR01170 rplA_mito, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM01_MOUSE
AccessioniPrimary (citable) accession number: Q99N96
Secondary accession number(s): Q3UQP5, Q8K351, Q9CWW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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