Mrpl1

Functionⁱ

GO - Molecular functionⁱ

RNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
structural constituent of ribosome Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

maturation of LSU-rRNA
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
translation Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5389840 Mitochondrial translation elongation R-MMU-5419276 Mitochondrial translation termination

Reactomeⁱ

R-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 39S ribosomal protein L1, mitochondrial Short name: L1mt Short name: MRP-L1
Gene namesⁱ	Name:Mrpl1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:2137202 Mrpl1

Keywords - Cellular componentⁱ

Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 50	MitochondrionSequence analysisAdd BLAST		50
ChainⁱPRO_0000252441	51 – 336	39S ribosomal protein L1, mitochondrialAdd BLAST		286

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	85	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q99N96
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99N96
PaxDbⁱ	Q99N96
PeptideAtlas More...PeptideAtlasⁱ	Q99N96
PRIDEⁱ	Q99N96

PTM databases

iPTMnetⁱ	Q99N96
PhosphoSitePlusⁱ	Q99N96

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029486 Expressed in 274 organ(s), highest expression level in heart left ventricle
CleanExⁱ	MM_MRPL1
ExpressionAtlasⁱ	Q99N96 baseline and differential
Genevisibleⁱ	Q99N96 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	220433, 1 interactor
IntActⁱ	Q99N96, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q99N96
STRINGⁱ	10090.ENSMUSP00000037046

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99N96
SMRⁱ	Q99N96
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	44 – 50	Poly-Ala		7

Sequence similaritiesⁱ

Belongs to the universal ribosomal protein uL1 family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1569 Eukaryota COG0081 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003587
HOGENOMⁱ	HOG000293225
HOVERGENⁱ	HBG061212
InParanoidⁱ	Q99N96
KEGG Orthology (KO) More...KOⁱ	K02863
OMAⁱ	VDNFQRM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CV1
PhylomeDBⁱ	Q99N96

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00403 Ribosomal_L1, 1 hit
Gene3Dⁱ	3.40.50.790, 1 hit
InterProⁱ	View protein in InterPro IPR023674 Ribosomal_L1-like IPR028364 Ribosomal_L1/biogenesis IPR016095 Ribosomal_L1_3-a/b-sand IPR005879 Ribosomal_L1_mit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00687 Ribosomal_L1, 1 hit
SUPFAMⁱ	SSF56808 SSF56808, 1 hit
TIGRFAMsⁱ	TIGR01170 rplA_mito, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q99N96-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAAVRCLRR VLIHHQRHCL CKMASQASLY PCSVNSLLHN RHFAAAAAAA 
        60         70         80         90        100
TKPARKIKKG AKEKTSDEKP VDDIEKIKSY TYMESDPEDD VYLKRLYPRR 
       110        120        130        140        150
IYEVEKAIHL LKKFQVLDFT NPKQGVYLDL TLDMALGKKK TVEPFASVIA 
       160        170        180        190        200
LPHLFSSEVN KVAVFTANAS EIKIAEENGA AFAGGTDLVK KIMDDEVVVD 
       210        220        230        240        250
FYVAVPEIMG ELNPLRKKLK KRFPKATRNS IGRDIPKMLE LFKTAHEIMV 
       260        270        280        290        300
DEERQNFLST KIATLDMPSD QIAANLQAVI NEVCKHRPLN LGPFVVRAFL 
       310        320        330 
RSSTSEGLLL KTDSLLPKEA KTTEAETEET QTAEAA

Length:336

Mass (Da):37,597

Last modified:June 16, 2009 - v2

Checksum:ⁱ328783081296B824

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q9D3F3	Q9D3F3_MOUSE		39S ribosomal protein L1, mitochond... 39S ribosomal protein L1, mitochondrial	Mrpl1	276	Annotation score:

Sequence cautionⁱ

The sequence AAH61042 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB26866 differs from that shown. Reason: Frameshift at position 7.Curated

The sequence BAB26866 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB40837 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	56	K → E in BAB26866 (PubMed:15489334).Curated	1
Sequence conflictⁱ	94	K → R in BAB26866 (PubMed:15489334).Curated	1
Sequence conflictⁱ	118	D → G in BAB26866 (PubMed:15489334).Curated	1
Sequence conflictⁱ	131	T → R in BAB26866 (PubMed:15489334).Curated	1
Sequence conflictⁱ	140	K → R in BAB26866 (PubMed:15489334).Curated	1
Sequence conflictⁱ	180	A → V in BAB26866 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK010343 mRNA Translation: BAB26866.1 Sequence problems. AK142249 mRNA Translation: BAE24994.1 BC028774 mRNA Translation: AAH28774.1 BC061042 mRNA Translation: AAH61042.1 Different initiation. AB049632 mRNA Translation: BAB40837.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19449.1
NCBI Reference Sequences More...RefSeqⁱ	NP_444388.2, NM_053158.3 XP_006535355.1, XM_006535292.1
UniGeneⁱ	Mm.295499

Genome annotation databases

Ensemblⁱ	ENSMUST00000036437; ENSMUSP00000037046; ENSMUSG00000029486 ENSMUST00000117766; ENSMUSP00000112977; ENSMUSG00000029486
GeneIDⁱ	94061
KEGGⁱ	mmu:94061
UCSC genome browser More...UCSCⁱ	uc008yfi.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99N96	Uncharacterized protein (Fragment)		MOUSE		194	UniRef100_Q99N96
UPI0005ABB2D4		MOUSE		254

Protein	Similar proteins		Species	Score	Length	Source
Q99N96	Uncharacterized protein (Fragment)		MOUSE		194	UniRef90_Q99N96
Mitochondrial ribosomal protein L1-like		RAT		328
UPI000A3124A3		MUSPA		336
UPI000A31826C		MUSCR		333
Mitochondrial ribosomal protein L1		RAT		323
+5

Protein	Similar proteins		Species	Score	Length	Source
Q99N96	39S ribosomal protein L1, mitochondrial		HUMAN		325	UniRef50_Q9BYD6
39S ribosomal protein L1, mitochondrial	)	BOVIN		325
Mitochondrial ribosomal protein L1		PANTR		325
Uncharacterized protein		NOMLE		331
Mitochondrial ribosomal protein L1		PONAB		325
+208

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK010343 mRNA Translation: BAB26866.1 Sequence problems. AK142249 mRNA Translation: BAE24994.1 BC028774 mRNA Translation: AAH28774.1 BC061042 mRNA Translation: AAH61042.1 Different initiation. AB049632 mRNA Translation: BAB40837.1 Different initiation.
CCDSⁱ	CCDS19449.1
RefSeqⁱ	NP_444388.2, NM_053158.3 XP_006535355.1, XM_006535292.1
UniGeneⁱ	Mm.295499

3D structure databases

ProteinModelPortalⁱ	Q99N96
SMRⁱ	Q99N96
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	220433, 1 interactor
IntActⁱ	Q99N96, 1 interactor
MINTⁱ	Q99N96
STRINGⁱ	10090.ENSMUSP00000037046

PTM databases

iPTMnetⁱ	Q99N96
PhosphoSitePlusⁱ	Q99N96

Proteomic databases

EPDⁱ	Q99N96
MaxQBⁱ	Q99N96
PaxDbⁱ	Q99N96
PeptideAtlasⁱ	Q99N96
PRIDEⁱ	Q99N96

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000036437; ENSMUSP00000037046; ENSMUSG00000029486 ENSMUST00000117766; ENSMUSP00000112977; ENSMUSG00000029486
GeneIDⁱ	94061
KEGGⁱ	mmu:94061
UCSCⁱ	uc008yfi.2 mouse

Organism-specific databases

CTDⁱ	65008
MGIⁱ	MGI:2137202 Mrpl1

Phylogenomic databases

eggNOGⁱ	KOG1569 Eukaryota COG0081 LUCA
GeneTreeⁱ	ENSGT00390000003587
HOGENOMⁱ	HOG000293225
HOVERGENⁱ	HBG061212
InParanoidⁱ	Q99N96
KOⁱ	K02863
OMAⁱ	VDNFQRM
OrthoDBⁱ	EOG091G0CV1
PhylomeDBⁱ	Q99N96

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5389840 Mitochondrial translation elongation R-MMU-5419276 Mitochondrial translation termination

Reactomeⁱ

R-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q99N96
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029486 Expressed in 274 organ(s), highest expression level in heart left ventricle
CleanExⁱ	MM_MRPL1
ExpressionAtlasⁱ	Q99N96 baseline and differential
Genevisibleⁱ	Q99N96 MM

Family and domain databases

CDDⁱ	cd00403 Ribosomal_L1, 1 hit
Gene3Dⁱ	3.40.50.790, 1 hit
InterProⁱ	View protein in InterPro IPR023674 Ribosomal_L1-like IPR028364 Ribosomal_L1/biogenesis IPR016095 Ribosomal_L1_3-a/b-sand IPR005879 Ribosomal_L1_mit
Pfamⁱ	View protein in Pfam PF00687 Ribosomal_L1, 1 hit
SUPFAMⁱ	SSF56808 SSF56808, 1 hit
TIGRFAMsⁱ	TIGR01170 rplA_mito, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RM01_MOUSE
Accessionⁱ	Q99N96Primary (citable) accession number: Q99N96 Secondary accession number(s): Q3UQP5, Q8K351, Q9CWW4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	June 16, 2009
	Last modified:	November 7, 2018
	This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Ribosomal proteins
Ribosomal proteins families and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99N96 (RM01_MOUSE)

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39S ribosomal protein L1, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ