UniProtKB - Q99N96 (RM01_MOUSE)
Protein
39S ribosomal protein L1, mitochondrial
Gene
Mrpl1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: GO_Central
- structural constituent of ribosome Source: MGI
GO - Biological processi
- maturation of LSU-rRNA Source: GO_Central
- translation Source: MGI
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-MMU-5389840, Mitochondrial translation elongation R-MMU-5419276, Mitochondrial translation termination |
Names & Taxonomyi
Protein namesi | Recommended name: 39S ribosomal protein L1, mitochondrialShort name: L1mt Short name: MRP-L1 |
Gene namesi | Name:Mrpl1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2137202, Mrpl1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Cytosol
- cytosolic large ribosomal subunit Source: GO_Central
Mitochondrion
- mitochondrial large ribosomal subunit Source: MGI
- mitochondrion Source: MGI
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 50 | MitochondrionSequence analysisAdd BLAST | 50 | |
ChainiPRO_0000252441 | 51 – 336 | 39S ribosomal protein L1, mitochondrialAdd BLAST | 286 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 85 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99N96 |
jPOSTi | Q99N96 |
MaxQBi | Q99N96 |
PaxDbi | Q99N96 |
PeptideAtlasi | Q99N96 |
PRIDEi | Q99N96 |
PTM databases
iPTMneti | Q99N96 |
PhosphoSitePlusi | Q99N96 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029486, Expressed in heart left ventricle and 289 other tissues |
Genevisiblei | Q99N96, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 220433, 26 interactors |
ComplexPortali | CPX-5302, 39S mitochondrial large ribosomal subunit |
IntActi | Q99N96, 1 interactor |
MINTi | Q99N96 |
STRINGi | 10090.ENSMUSP00000112451 |
Miscellaneous databases
RNActi | Q99N96, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 44 – 50 | Poly-Ala | 7 |
Sequence similaritiesi
Belongs to the universal ribosomal protein uL1 family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1569, Eukaryota |
GeneTreei | ENSGT00940000162168 |
HOGENOMi | CLU_074129_0_0_1 |
InParanoidi | Q99N96 |
OMAi | VDNFQRM |
OrthoDBi | 1432931at2759 |
PhylomeDBi | Q99N96 |
Family and domain databases
CDDi | cd00403, Ribosomal_L1, 1 hit |
Gene3Di | 3.40.50.790, 1 hit |
InterProi | View protein in InterPro IPR023674, Ribosomal_L1-like IPR028364, Ribosomal_L1/biogenesis IPR016095, Ribosomal_L1_3-a/b-sand IPR005879, Ribosomal_L1_mit |
Pfami | View protein in Pfam PF00687, Ribosomal_L1, 1 hit |
SUPFAMi | SSF56808, SSF56808, 1 hit |
TIGRFAMsi | TIGR01170, rplA_mito, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q99N96-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAVRCLRR VLIHHQRHCL CKMASQASLY PCSVNSLLHN RHFAAAAAAA
60 70 80 90 100
TKPARKIKKG AKEKTSDEKP VDDIEKIKSY TYMESDPEDD VYLKRLYPRR
110 120 130 140 150
IYEVEKAIHL LKKFQVLDFT NPKQGVYLDL TLDMALGKKK TVEPFASVIA
160 170 180 190 200
LPHLFSSEVN KVAVFTANAS EIKIAEENGA AFAGGTDLVK KIMDDEVVVD
210 220 230 240 250
FYVAVPEIMG ELNPLRKKLK KRFPKATRNS IGRDIPKMLE LFKTAHEIMV
260 270 280 290 300
DEERQNFLST KIATLDMPSD QIAANLQAVI NEVCKHRPLN LGPFVVRAFL
310 320 330
RSSTSEGLLL KTDSLLPKEA KTTEAETEET QTAEAA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ9D3F3 | Q9D3F3_MOUSE | 39S ribosomal protein L1, mitochond... | Mrpl1 | 276 | Annotation score: |
Sequence cautioni
The sequence AAH61042 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB26866 differs from that shown. Reason: Frameshift.Curated
The sequence BAB26866 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB40837 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 | K → E in BAB26866 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 94 | K → R in BAB26866 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 118 | D → G in BAB26866 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 131 | T → R in BAB26866 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 140 | K → R in BAB26866 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 180 | A → V in BAB26866 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010343 mRNA Translation: BAB26866.1 Sequence problems. AK142249 mRNA Translation: BAE24994.1 BC028774 mRNA Translation: AAH28774.1 BC061042 mRNA Translation: AAH61042.1 Different initiation. AB049632 mRNA Translation: BAB40837.1 Different initiation. |
CCDSi | CCDS19449.1 |
RefSeqi | NP_444388.2, NM_053158.3 XP_006535355.1, XM_006535292.1 |
Genome annotation databases
Ensembli | ENSMUST00000036437; ENSMUSP00000037046; ENSMUSG00000029486 ENSMUST00000117766; ENSMUSP00000112977; ENSMUSG00000029486 |
GeneIDi | 94061 |
KEGGi | mmu:94061 |
UCSCi | uc008yfi.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010343 mRNA Translation: BAB26866.1 Sequence problems. AK142249 mRNA Translation: BAE24994.1 BC028774 mRNA Translation: AAH28774.1 BC061042 mRNA Translation: AAH61042.1 Different initiation. AB049632 mRNA Translation: BAB40837.1 Different initiation. |
CCDSi | CCDS19449.1 |
RefSeqi | NP_444388.2, NM_053158.3 XP_006535355.1, XM_006535292.1 |
3D structure databases
SMRi | Q99N96 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 220433, 26 interactors |
ComplexPortali | CPX-5302, 39S mitochondrial large ribosomal subunit |
IntActi | Q99N96, 1 interactor |
MINTi | Q99N96 |
STRINGi | 10090.ENSMUSP00000112451 |
PTM databases
iPTMneti | Q99N96 |
PhosphoSitePlusi | Q99N96 |
Proteomic databases
EPDi | Q99N96 |
jPOSTi | Q99N96 |
MaxQBi | Q99N96 |
PaxDbi | Q99N96 |
PeptideAtlasi | Q99N96 |
PRIDEi | Q99N96 |
Protocols and materials databases
Antibodypediai | 24877, 199 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000036437; ENSMUSP00000037046; ENSMUSG00000029486 ENSMUST00000117766; ENSMUSP00000112977; ENSMUSG00000029486 |
GeneIDi | 94061 |
KEGGi | mmu:94061 |
UCSCi | uc008yfi.2, mouse |
Organism-specific databases
CTDi | 65008 |
MGIi | MGI:2137202, Mrpl1 |
Phylogenomic databases
eggNOGi | KOG1569, Eukaryota |
GeneTreei | ENSGT00940000162168 |
HOGENOMi | CLU_074129_0_0_1 |
InParanoidi | Q99N96 |
OMAi | VDNFQRM |
OrthoDBi | 1432931at2759 |
PhylomeDBi | Q99N96 |
Enzyme and pathway databases
Reactomei | R-MMU-5389840, Mitochondrial translation elongation R-MMU-5419276, Mitochondrial translation termination |
Miscellaneous databases
BioGRID-ORCSi | 94061, 0 hits in 17 CRISPR screens |
ChiTaRSi | Mrpl1, mouse |
PROi | PR:Q99N96 |
RNActi | Q99N96, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029486, Expressed in heart left ventricle and 289 other tissues |
Genevisiblei | Q99N96, MM |
Family and domain databases
CDDi | cd00403, Ribosomal_L1, 1 hit |
Gene3Di | 3.40.50.790, 1 hit |
InterProi | View protein in InterPro IPR023674, Ribosomal_L1-like IPR028364, Ribosomal_L1/biogenesis IPR016095, Ribosomal_L1_3-a/b-sand IPR005879, Ribosomal_L1_mit |
Pfami | View protein in Pfam PF00687, Ribosomal_L1, 1 hit |
SUPFAMi | SSF56808, SSF56808, 1 hit |
TIGRFAMsi | TIGR01170, rplA_mito, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RM01_MOUSE | |
Accessioni | Q99N96Primary (citable) accession number: Q99N96 Secondary accession number(s): Q3UQP5, Q8K351, Q9CWW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | June 16, 2009 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries