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Protein

28S ribosomal protein S18b, mitochondrial

Gene

Mrps18b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S18b, mitochondrial
Short name:
MRP-S18-b
Short name:
Mrps18-b
Short name:
S18mt-b
Alternative name(s):
28S ribosomal protein S18-2, mitochondrial
Short name:
MRP-S18-2
Gene namesi
Name:Mrps18b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914223 Mrps18b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionBy similarityAdd BLAST33
ChainiPRO_000003062834 – 25428S ribosomal protein S18b, mitochondrialAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99N84
PaxDbiQ99N84
PeptideAtlasiQ99N84
PRIDEiQ99N84

PTM databases

iPTMnetiQ99N84
PhosphoSitePlusiQ99N84

Expressioni

Gene expression databases

BgeeiENSMUSG00000024436 Expressed in 36 organ(s), highest expression level in liver
CleanExiMM_MRPS18B
ExpressionAtlasiQ99N84 baseline and differential
GenevisibleiQ99N84 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025305

Structurei

3D structure databases

ProteinModelPortaliQ99N84
SMRiQ99N84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4021 Eukaryota
ENOG4111KH6 LUCA
GeneTreeiENSGT00390000010554
HOGENOMiHOG000039992
HOVERGENiHBG054347
InParanoidiQ99N84
KOiK16174
OMAiVIFHAPY
OrthoDBiEOG091G0U9G
PhylomeDBiQ99N84
TreeFamiTF315059

Family and domain databases

Gene3Di4.10.640.10, 1 hit
InterProiView protein in InterPro
IPR040054 MRPS18B
IPR001648 Ribosomal_S18
IPR036870 Ribosomal_S18_sf
PANTHERiPTHR13329 PTHR13329, 1 hit
PfamiView protein in Pfam
PF01084 Ribosomal_S18, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002239 Ribosomal_S18, 1 hit
SUPFAMiSSF46911 SSF46911, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99N84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPLRHTLL KLVPTLLRSS YVAQVPLQTL CTRGPPEEDA PSSLPVSPYE
60 70 80 90 100
SEPWKYLDSE EYHNRYGSRP VWADYRRNHK GGVPPQRTRK TCIRNNKVAG
110 120 130 140 150
NPCPICRDHK LHVDFRNVKL LEQFVCAHTG IIFHAPYTGV CMKQHKKLTQ
160 170 180 190 200
AIQKARECGL LSYYVPQVEP RDADFGTVHG AVSVTPPAPT LLSGEPWYPW
210 220 230 240 250
YSWQQPPERE LSRLRRLYQG NLLEESGPPP ESMPEMPTTP PAESSIEQPG

SQSA
Length:254
Mass (Da):28,703
Last modified:June 1, 2001 - v1
Checksum:i2284983FD5848791
GO
Isoform 2 (identifier: Q99N84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-116: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,049
Checksum:i671AEA838DA21FBE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UX79G3UX79_MOUSE
28S ribosomal protein S18b, mitocho...
Mrps18b
188Annotation score:
G3UYQ9G3UYQ9_MOUSE
28S ribosomal protein S18b, mitocho...
Mrps18b
106Annotation score:
G3UYX8G3UYX8_MOUSE
28S ribosomal protein S18b, mitocho...
Mrps18b
111Annotation score:

Sequence cautioni

The sequence AK010250 differs from that shown. Reason: Frameshift at position 19.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00572325 – 116Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049954 mRNA Translation: BAB41007.1
AK002554 mRNA No translation available.
AK010250 mRNA No translation available.
AK166597 mRNA Translation: BAE38883.1
BC021752 mRNA Translation: AAH21752.1
CCDSiCCDS28712.1 [Q99N84-1]
CCDS84307.1 [Q99N84-2]
RefSeqiNP_080154.1, NM_025878.1 [Q99N84-1]
UniGeneiMm.29484
Mm.389267
Mm.440735

Genome annotation databases

EnsembliENSMUST00000025305; ENSMUSP00000025305; ENSMUSG00000024436 [Q99N84-1]
ENSMUST00000113782; ENSMUSP00000109412; ENSMUSG00000024436 [Q99N84-2]
GeneIDi66973
KEGGimmu:66973
UCSCiuc008cjg.1 mouse [Q99N84-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049954 mRNA Translation: BAB41007.1
AK002554 mRNA No translation available.
AK010250 mRNA No translation available.
AK166597 mRNA Translation: BAE38883.1
BC021752 mRNA Translation: AAH21752.1
CCDSiCCDS28712.1 [Q99N84-1]
CCDS84307.1 [Q99N84-2]
RefSeqiNP_080154.1, NM_025878.1 [Q99N84-1]
UniGeneiMm.29484
Mm.389267
Mm.440735

3D structure databases

ProteinModelPortaliQ99N84
SMRiQ99N84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025305

PTM databases

iPTMnetiQ99N84
PhosphoSitePlusiQ99N84

Proteomic databases

EPDiQ99N84
PaxDbiQ99N84
PeptideAtlasiQ99N84
PRIDEiQ99N84

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025305; ENSMUSP00000025305; ENSMUSG00000024436 [Q99N84-1]
ENSMUST00000113782; ENSMUSP00000109412; ENSMUSG00000024436 [Q99N84-2]
GeneIDi66973
KEGGimmu:66973
UCSCiuc008cjg.1 mouse [Q99N84-1]

Organism-specific databases

CTDi28973
MGIiMGI:1914223 Mrps18b

Phylogenomic databases

eggNOGiKOG4021 Eukaryota
ENOG4111KH6 LUCA
GeneTreeiENSGT00390000010554
HOGENOMiHOG000039992
HOVERGENiHBG054347
InParanoidiQ99N84
KOiK16174
OMAiVIFHAPY
OrthoDBiEOG091G0U9G
PhylomeDBiQ99N84
TreeFamiTF315059

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

PROiPR:Q99N84
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024436 Expressed in 36 organ(s), highest expression level in liver
CleanExiMM_MRPS18B
ExpressionAtlasiQ99N84 baseline and differential
GenevisibleiQ99N84 MM

Family and domain databases

Gene3Di4.10.640.10, 1 hit
InterProiView protein in InterPro
IPR040054 MRPS18B
IPR001648 Ribosomal_S18
IPR036870 Ribosomal_S18_sf
PANTHERiPTHR13329 PTHR13329, 1 hit
PfamiView protein in Pfam
PF01084 Ribosomal_S18, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002239 Ribosomal_S18, 1 hit
SUPFAMiSSF46911 SSF46911, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT18B_MOUSE
AccessioniPrimary (citable) accession number: Q99N84
Secondary accession number(s): Q3TLA9, Q9CRK0, Q9DCR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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