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Protein
Submitted name:

Transient receptor potential Ca2+ channel 6A

Gene

Trpc6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelSAAS annotation, ReceptorImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-114508 Effects of PIP2 hydrolysis
R-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-3295583 TRP channels

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential Ca2+ channel 6AImported
Submitted name:
Transient receptor potential cation channel, subfamily C, member 6Imported
Submitted name:
Transient receptor potential cation channel, subfamily C, member 6, isoform CRA_bImported
Gene namesi
Name:Trpc6Imported
Synonyms:trp6AImported
ORF Names:rCG_31778Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi619788 Trpc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei403 – 422HelicalSequence analysisAdd BLAST20
Transmembranei442 – 461HelicalSequence analysisAdd BLAST20
Transmembranei489 – 507HelicalSequence analysisAdd BLAST19
Transmembranei527 – 546HelicalSequence analysisAdd BLAST20
Transmembranei633 – 655HelicalSequence analysisAdd BLAST23
Transmembranei702 – 723HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000006324 Expressed in 8 organ(s), highest expression level in brain
ExpressionAtlasiQ99N78 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008905

Structurei

3D structure databases

SMRiQ99N78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 154ANK_REP_REGIONInterPro annotationAdd BLAST51
Domaini217 – 249ANK_REP_REGIONInterPro annotationAdd BLAST33
Repeati217 – 249ANKPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili883 – 918Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020590
HOVERGENiHBG068337
KOiK04969
OMAiNRGPAYM
OrthoDBiEOG091G01FB
TreeFamiTF313147

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005462 TRPC6_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF7 PTHR10117:SF7, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01647 TRPCHANNEL6
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99N78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQSPGFVTR RGGSPKAAPG AGARRNESQD YLLMDELGDD GYPQLQQPPY
60 70 80 90 100
GYYPSFRGNE NRLTHRRQTV LREKGRRLAN RGPAYMFNDH STSLSIEEER
110 120 130 140 150
FLDAAEYGNI PVVRKMLEEC LSLNVNCVDY MGQNALQLAV ANEHLEITEL
160 170 180 190 200
LLKKENLSRV GDALLLAISK GYVRIVEAIL NHPAFAEGKR LATSPSQSEL
210 220 230 240 250
QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK GARIERPHDY
260 270 280 290 300
FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS
310 320 330 340 350
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE
360 370 380 390 400
TRQPGDLARP NLSRLKLAIK YEVKKFVAHP NCQQQLLSIW YENLSGLRQQ
410 420 430 440 450
TMAVKFLVVL AVAIGLPFLA LIYWCAPCSK MGKILRGPFM KFVAHAASFT
460 470 480 490 500
IFLGLLVMNA ADRFEGTKLL PNETSTDNAR QLFRMKTSCF SWMEMLIISW
510 520 530 540 550
VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF IARFMAFWHA
560 570 580 590 600
SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI
610 620 630 640 650
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG
660 670 680 690 700
MFNLYSYYIG AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE
710 720 730 740 750
NIGYVLYGVY NVTMVIVLLN MLIAMINSSF QEIEDDADVE WKFARAKLWF
760 770 780 790 800
SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK KWMSELIQGH KKGFQEDAEM
810 820 830 840 850
NKRNEEKKFG ILGSHEDLSK FSLDRNQLAH NKQSSTRSSE DFHLNSFSNP
860 870 880 890 900
PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE
910 920 930
KSQNTEDLAE LIRKLGERLS LESKQEESRR
Length:930
Mass (Da):106,560
Last modified:June 1, 2001 - v1
Checksum:iF3F333C23A0EB2CA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MAN2F1MAN2_RAT
Transient receptor potential cation...
Trpc6
777Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069064 Genomic DNA No translation available.
AABR07069065 Genomic DNA No translation available.
AABR07069066 Genomic DNA No translation available.
AB051212 Genomic DNA Translation: BAB41215.1
CH473993 Genomic DNA Translation: EDL78511.1
RefSeqiNP_446011.1, NM_053559.1
UniGeneiRn.105986

Genome annotation databases

EnsembliENSRNOT00000008905; ENSRNOP00000008905; ENSRNOG00000006324
GeneIDi89823
KEGGirno:89823
UCSCiRGD:619788 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069064 Genomic DNA No translation available.
AABR07069065 Genomic DNA No translation available.
AABR07069066 Genomic DNA No translation available.
AB051212 Genomic DNA Translation: BAB41215.1
CH473993 Genomic DNA Translation: EDL78511.1
RefSeqiNP_446011.1, NM_053559.1
UniGeneiRn.105986

3D structure databases

SMRiQ99N78
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008905

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008905; ENSRNOP00000008905; ENSRNOG00000006324
GeneIDi89823
KEGGirno:89823
UCSCiRGD:619788 rat

Organism-specific databases

CTDi7225
RGDi619788 Trpc6

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020590
HOVERGENiHBG068337
KOiK04969
OMAiNRGPAYM
OrthoDBiEOG091G01FB
TreeFamiTF313147

Enzyme and pathway databases

ReactomeiR-RNO-114508 Effects of PIP2 hydrolysis
R-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-3295583 TRP channels

Miscellaneous databases

ChiTaRSiTrpc6 rat

Gene expression databases

BgeeiENSRNOG00000006324 Expressed in 8 organ(s), highest expression level in brain
ExpressionAtlasiQ99N78 baseline and differential

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005462 TRPC6_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF7 PTHR10117:SF7, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01647 TRPCHANNEL6
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ99N78_RAT
AccessioniPrimary (citable) accession number: Q99N78
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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