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Entry version 164 (29 Sep 2021)
Sequence version 2 (25 Jul 2003)
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Protein

Synaptotagmin-like protein 2

Gene

Sytl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 11 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. Required for cytotoxic granule docking at the immunologic synapse. Isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology. Isoform 1 acts as a positive mediator of mucus secretion by the surface mucus cells of the stomach. Mediates basal mucus secretion by gastric surface cells by promoting the proper granule biognesis and docking of mucus granules with the apical plasma membrane.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-like protein 2
Alternative name(s):
Exophilin-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sytl2
Synonyms:Slp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1933366, Sytl2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000030616

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show a reduced number of mucus granules, a deficiency of granule docking with the apical plasma membrane in the gastric-surface mucus cells and reduction of mucus secretion by gastric primary cells.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi698K → Q: Loss of membrane localization; when associated with Q-699; Q-700; Q-705 and Q-706. 1 Publication1
Mutagenesisi699K → Q: Loss of membrane localization; when associated with Q-698; Q-700; Q-705 and Q-706. 1 Publication1
Mutagenesisi700K → Q: Loss of membrane localization; when associated with Q-698; Q-699; Q-705 and Q-706. 1 Publication1
Mutagenesisi705K → Q: Loss of membrane localization; when associated with Q-698; Q-699; Q-700 and Q-706. 1 Publication1
Mutagenesisi706K → Q: Loss of membrane localization; when associated with Q-698; Q-699; Q-700 and Q-705. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902141 – 950Synaptotagmin-like protein 2Add BLAST950

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A.

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99N50

PeptideAtlas

More...
PeptideAtlasi
Q99N50

PRoteomics IDEntifications database

More...
PRIDEi
Q99N50

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
254745 [Q99N50-1]
254746 [Q99N50-2]
254747 [Q99N50-3]
254748 [Q99N50-4]
254749 [Q99N50-5]
254750 [Q99N50-6]
254751 [Q99N50-7]
254752 [Q99N50-8]
254753 [Q99N50-11]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99N50

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99N50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, lung, kidney, testis and in embryos after day 7. Detected at lower levels in skeletal muscle. Expressed in pancreatic alpha cells. Isoform 6 is highly expressed in brain, but not detectable in the other tissues tested. Isoform 1 is expressed abundantly in the stomach and is predominantly localized at the apical region of gastric-surface mucus cells. Isoform 11 is expressed in cytotoxic T-lymphocytes (CTL).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030616, Expressed in iris and 260 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99N50, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding.

Interacts with RAB27B.

5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
219955, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q99N50, 3 interactors

Molecular INTeraction database

More...
MINTi
Q99N50

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000102829

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99N50, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99N50

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 57RabBDPROSITE-ProRule annotationAdd BLAST57
Domaini644 – 769C2 1PROSITE-ProRule annotationAdd BLAST126
Domaini784 – 913C2 2PROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni78 – 98DisorderedSequence analysisAdd BLAST21
Regioni116 – 289DisorderedSequence analysisAdd BLAST174
Regioni361 – 621DisorderedSequence analysisAdd BLAST261

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi78 – 93Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi130 – 160Polar residuesSequence analysisAdd BLAST31
Compositional biasi195 – 209Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi215 – 229Polar residuesSequence analysisAdd BLAST15
Compositional biasi242 – 258Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi274 – 289Polar residuesSequence analysisAdd BLAST16
Compositional biasi384 – 409Polar residuesSequence analysisAdd BLAST26
Compositional biasi430 – 474Polar residuesSequence analysisAdd BLAST45
Compositional biasi476 – 512Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi530 – 546Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi550 – 564Polar residuesSequence analysisAdd BLAST15
Compositional biasi583 – 597Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi598 – 621Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RabBD domain mediates interaction with RAB27A.By similarity
The C2 1 domain mediates localization to the cell membrane.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1028, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002711_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99N50

Database of Orthologous Groups

More...
OrthoDBi
916843at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99N50

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04020, C2B_SLP_1-2-3-4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010911, Rab_BD
IPR043567, SYTL1-5_C2B
IPR027006, SYTL2

The PANTHER Classification System

More...
PANTHERi
PTHR45716:SF5, PTHR45716:SF5, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49562, SSF49562, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 11 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99N50-1) [UniParc]FASTAAdd to basket
Also known as: Slp2-a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIDLSFLTEE EQDAILKVLQ RDAALKRAEE ERVRHLPEKI KDDQQLKNMS
60 70 80 90 100
GQWFYEAKAK RHRDKIHGAD IIRASMRRKK LPAAAEQNKD TAMRAKESWV
110 120 130 140 150
NNVNKDAVLP PEIAVVEEPE DDTDPAGPSS SLVDPASSVI DMSQESTRTP
160 170 180 190 200
AVSLPKQRKN PFNSPKLPED HSLQQTKPEQ SKTGKAGLFQ ISKEGELSES
210 220 230 240 250
KEKSSIPDMP RQQLEKPKQT VSTEPENASH TKAPIPKARK LIYKSNDLEK
260 270 280 290 300
DDNQSFPRQR RDSLNARGAP RGILKRNSSS SSTDSETLRL NYNLDPKSKI
310 320 330 340 350
LSPGLTIHER ISEKEFSLED DSSTSSLEPL KHVRFSAVKN ELPQSPRPVL
360 370 380 390 400
GQEVGEFTVL ESDQLQNGTE DAGDIEEFQN HPELSHKTPL SHYQLVSSPS
410 420 430 440 450
DSGREREQLM SSGSAPRDEI PCHSDILPTG PQCVESSSVI NGQQEKSSHF
460 470 480 490 500
TKLPSELSKS PSDELTQCGE PEPSQTADHS FRDHRQGSEE EHSPVLKTLE
510 520 530 540 550
RRAARKLPSK SLEDIPSDSS NQAKVDNLPE ELVRSAEDDQ KADQEPDTNE
560 570 580 590 600
CIPGISTVPS LPDNQFSHPD KLKRMSKSVP AFLQDESDDR ETDTASESSY
610 620 630 640 650
QLRRYKKSPS SLTNLSSSSG MTSLSSASGS VMSVYSGDFG NLEVKGSVQF
660 670 680 690 700
ALDYVESLKE LHVFVAQCKD LAAADVKKQR SDPYVKTYLL PDKGKMGKKK
710 720 730 740 750
TLVVKKTLNP VYNEILRYKI ERQFLKTQKL NLSVWHRDTF KRNSFLGEVE
760 770 780 790 800
LDLETWDWDS KQNKQLKWYP LKRKTAPVAL ETENRGEMKL ALQYVPEPSP
810 820 830 840 850
GKKLPTTGEV HIWVKECLDL PLLRGSHLNS FVKCTILPDT SRKSRQKTRA
860 870 880 890 900
VGKTTNPVFN HTMVYDGFRP EDLMEACVEL TVWDHYKLTN QFLGGLRIGF
910 920 930 940 950
GTGKSYGTEV DWMDSTSEEV ALWEKMVNSP NTWVEATLPL RMLLIAKLSK
Length:950
Mass (Da):106,806
Last modified:July 25, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i226B59F5A32FA4A4
GO
Isoform 2 (identifier: Q99N50-2) [UniParc]FASTAAdd to basket
Also known as: Slp2-b

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: MIDLSFLTEE...DHSFRDHRQG → MEKLNFKCMP...NRENGRNTSS

Show »
Length:1,142
Mass (Da):126,918
Checksum:iCC6F5D4889E57472
GO
Isoform 3 (identifier: Q99N50-3) [UniParc]FASTAAdd to basket
Also known as: Slp2-a delta 2S-I

The sequence of this isoform differs from the canonical sequence as follows:
     85-111: Missing.

Show »
Length:923
Mass (Da):103,797
Checksum:i7E19421C7E31200E
GO
Isoform 4 (identifier: Q99N50-4) [UniParc]FASTAAdd to basket
Also known as: Slp2-a delta 2S-II

The sequence of this isoform differs from the canonical sequence as follows:
     539-555: DQKADQEPDTNECIPGI → V

Show »
Length:934
Mass (Da):105,050
Checksum:i1C574A3B6DA0B475
GO
Isoform 5 (identifier: Q99N50-5) [UniParc]FASTAAdd to basket
Also known as: Slp2-a delta 2S-III

The sequence of this isoform differs from the canonical sequence as follows:
     587-626: Missing.

Show »
Length:910
Mass (Da):102,476
Checksum:i9B5E03C56DCBD80E
GO
Isoform 6 (identifier: Q99N50-6) [UniParc]FASTAAdd to basket
Also known as: Slp2-c

The sequence of this isoform differs from the canonical sequence as follows:
     1-574: Missing.

Show »
Length:376
Mass (Da):42,761
Checksum:iB1A35979104F5816
GO
Isoform 7 (identifier: Q99N50-7) [UniParc]FASTAAdd to basket
Also known as: Slp2-d delta 2S-IV

The sequence of this isoform differs from the canonical sequence as follows:
     1-695: Missing.

Show »
Length:255
Mass (Da):29,573
Checksum:iD257677F39ACA7A4
GO
Isoform 8 (identifier: Q99N50-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-574: Missing.
     587-626: Missing.

Show »
Length:336
Mass (Da):38,431
Checksum:i167F9F76C5DF757B
GO
Isoform 9 (identifier: Q99N50-9)
Also known as: Slp2-e
Sequence is not available
Note: Due to intron retention.Curated
Length:
Mass (Da):
Isoform 10 (identifier: Q99N50-10)
Also known as: Slp2-f
Sequence is not available
Note: Due to intron retention.Curated
Length:
Mass (Da):
Isoform 11 (identifier: Q99N50-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-555: DQKADQEPDTNECIPGI → V
     587-626: Missing.

Show »
Length:894
Mass (Da):100,720
Checksum:i3088D38FDF5D0AC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F8MPX2A0A5F8MPX2_MOUSE
Synaptotagmin-like protein 2
Sytl2
2,097Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPH5A0A5F8MPH5_MOUSE
Synaptotagmin-like protein 2
Sytl2
2,153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LHC0A0A140LHC0_MOUSE
Synaptotagmin-like protein 2
Sytl2
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LJF2A0A140LJF2_MOUSE
Synaptotagmin-like protein 2
Sytl2
529Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPI7A0A5F8MPI7_MOUSE
Synaptotagmin-like protein 2
Sytl2
1,280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0078911 – 695Missing in isoform 7. 1 PublicationAdd BLAST695
Alternative sequenceiVSP_0078901 – 574Missing in isoform 6 and isoform 8. 3 PublicationsAdd BLAST574
Alternative sequenceiVSP_0078891 – 487MIDLS…DHRQG → MEKLNFKCMPQEPPDETIFP QKTLSIEPSKENEGKNTEYF GTQVIKKACSEQEIQESIVK TSILPKVSKDTFNDRLQKLL AEATLPASQTSGKEVHEQQA LKVGVSENGKSFAKDEEEVT GLRESPKEPQRRNQQDCSVD KLLKESTRTPLSPLQSPLEA VTTRPISPLKDDLLFEKWMK ENHSPSADQREITAPFPQGV GILAGADLIQKGKHCNTEAM LQLAAEGSPPLAQLPHSFDG VSSSPADMSLSWDAQLPSEN GTLPSQKEISEAIEKVVLPS KPAATDVNAVLQKLLREAGE VDAKLPEREQTAGTPSCPQR VSPLWPAPDPVVPNKDFHSF CTVPDTTHEGRSHLSARMSP SAHATMSPTSTVTQYGQRLL QEVAETVRETVIQPKSQYPE FRAGLEKLLKETLQTSLSKD KKDTMTISPSALTGSCEMSH QLSSEFHLTEIQETVEKAEA PSVTESSFDVGLEKLLKEMS EGPCQLQASGRRDTLEKQPS QVEQAGFMGEIPHHILDGPG ASKMKVSCSGLESQISQCDK QLGGDEAVTGPLIDVQDNKS GFEVPECSQLHEDHKIETNG TIQFVEDKGREKVITGETQA SQEPGFEEAPKEMSVSRNKH SIVLLETKGKAIKTREVKLV LATPYKRQEEEQGPEACSEY EFSDGNTSSNRENGRNTSS in isoform 2. 1 PublicationAdd BLAST487
Alternative sequenceiVSP_00789285 – 111Missing in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_007893539 – 555DQKAD…CIPGI → V in isoform 4 and isoform 11. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_007894587 – 626Missing in isoform 5, isoform 8 and isoform 11. 4 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB057756 mRNA Translation: BAB41084.1
AB050742 mRNA Translation: BAB32652.1
AB057754 mRNA Translation: BAB41082.1
AB057755 mRNA Translation: BAB41083.1
AB057757 mRNA Translation: BAB41085.1
AB057760 mRNA Translation: BAB41088.1
AB057761 mRNA Translation: BAB41089.1
AB057762 mRNA Translation: BAB41090.1
AB057763 mRNA Translation: BAB41091.1
AK027924 mRNA No translation available.
BC138714 mRNA Translation: AAI38715.1
BC145398 mRNA Translation: AAI45399.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40017.1 [Q99N50-5]
CCDS40018.1 [Q99N50-4]
CCDS80750.1 [Q99N50-1]
CCDS80751.1 [Q99N50-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001035174.1, NM_001040085.2 [Q99N50-4]
NP_001035176.1, NM_001040087.2 [Q99N50-6]
NP_001035177.1, NM_001040088.2 [Q99N50-8]
NP_001276512.1, NM_001289583.1 [Q99N50-1]
NP_001276513.1, NM_001289584.1 [Q99N50-3]
NP_001276515.1, NM_001289586.1 [Q99N50-6]
NP_113571.2, NM_031394.3 [Q99N50-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000107210; ENSMUSP00000102828; ENSMUSG00000030616 [Q99N50-5]
ENSMUST00000107211; ENSMUSP00000102829; ENSMUSG00000030616 [Q99N50-4]
ENSMUST00000190731; ENSMUSP00000139865; ENSMUSG00000030616 [Q99N50-1]
ENSMUST00000190837; ENSMUSP00000139450; ENSMUSG00000030616 [Q99N50-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83671

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:83671

UCSC genome browser

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UCSCi
uc009iha.2, mouse [Q99N50-4]
uc009ihb.2, mouse [Q99N50-5]
uc009ihc.2, mouse [Q99N50-1]
uc009ihg.2, mouse [Q99N50-6]
uc009ihh.2, mouse [Q99N50-8]
uc012fow.2, mouse [Q99N50-3]
uc029wmx.2, mouse [Q99N50-7]
uc057aig.1, mouse [Q99N50-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057756 mRNA Translation: BAB41084.1
AB050742 mRNA Translation: BAB32652.1
AB057754 mRNA Translation: BAB41082.1
AB057755 mRNA Translation: BAB41083.1
AB057757 mRNA Translation: BAB41085.1
AB057760 mRNA Translation: BAB41088.1
AB057761 mRNA Translation: BAB41089.1
AB057762 mRNA Translation: BAB41090.1
AB057763 mRNA Translation: BAB41091.1
AK027924 mRNA No translation available.
BC138714 mRNA Translation: AAI38715.1
BC145398 mRNA Translation: AAI45399.1
CCDSiCCDS40017.1 [Q99N50-5]
CCDS40018.1 [Q99N50-4]
CCDS80750.1 [Q99N50-1]
CCDS80751.1 [Q99N50-3]
RefSeqiNP_001035174.1, NM_001040085.2 [Q99N50-4]
NP_001035176.1, NM_001040087.2 [Q99N50-6]
NP_001035177.1, NM_001040088.2 [Q99N50-8]
NP_001276512.1, NM_001289583.1 [Q99N50-1]
NP_001276513.1, NM_001289584.1 [Q99N50-3]
NP_001276515.1, NM_001289586.1 [Q99N50-6]
NP_113571.2, NM_031394.3 [Q99N50-5]

3D structure databases

SMRiQ99N50
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi219955, 3 interactors
IntActiQ99N50, 3 interactors
MINTiQ99N50
STRINGi10090.ENSMUSP00000102829

PTM databases

iPTMnetiQ99N50
PhosphoSitePlusiQ99N50

Proteomic databases

PaxDbiQ99N50
PeptideAtlasiQ99N50
PRIDEiQ99N50
ProteomicsDBi254745 [Q99N50-1]
254746 [Q99N50-2]
254747 [Q99N50-3]
254748 [Q99N50-4]
254749 [Q99N50-5]
254750 [Q99N50-6]
254751 [Q99N50-7]
254752 [Q99N50-8]
254753 [Q99N50-11]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49544, 73 antibodies

The DNASU plasmid repository

More...
DNASUi
83671

Genome annotation databases

EnsembliENSMUST00000107210; ENSMUSP00000102828; ENSMUSG00000030616 [Q99N50-5]
ENSMUST00000107211; ENSMUSP00000102829; ENSMUSG00000030616 [Q99N50-4]
ENSMUST00000190731; ENSMUSP00000139865; ENSMUSG00000030616 [Q99N50-1]
ENSMUST00000190837; ENSMUSP00000139450; ENSMUSG00000030616 [Q99N50-3]
GeneIDi83671
KEGGimmu:83671
UCSCiuc009iha.2, mouse [Q99N50-4]
uc009ihb.2, mouse [Q99N50-5]
uc009ihc.2, mouse [Q99N50-1]
uc009ihg.2, mouse [Q99N50-6]
uc009ihh.2, mouse [Q99N50-8]
uc012fow.2, mouse [Q99N50-3]
uc029wmx.2, mouse [Q99N50-7]
uc057aig.1, mouse [Q99N50-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54843
MGIiMGI:1933366, Sytl2
VEuPathDBiHostDB:ENSMUSG00000030616

Phylogenomic databases

eggNOGiKOG1028, Eukaryota
GeneTreeiENSGT00940000155843
HOGENOMiCLU_002711_2_0_1
InParanoidiQ99N50
OrthoDBi916843at2759
PhylomeDBiQ99N50

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
83671, 0 hits in 60 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sytl2, mouse

Protein Ontology

More...
PROi
PR:Q99N50
RNActiQ99N50, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030616, Expressed in iris and 260 other tissues
GenevisibleiQ99N50, MM

Family and domain databases

CDDicd04020, C2B_SLP_1-2-3-4, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010911, Rab_BD
IPR043567, SYTL1-5_C2B
IPR027006, SYTL2
PANTHERiPTHR45716:SF5, PTHR45716:SF5, 2 hits
PfamiView protein in Pfam
PF00168, C2, 2 hits
SMARTiView protein in SMART
SM00239, C2, 2 hits
SUPFAMiSSF49562, SSF49562, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYTL2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99N50
Secondary accession number(s): B2RS48
, B7ZNS4, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: September 29, 2021
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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