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UniProtKB - Q99N42 (TYPH_MOUSE)
Protein
Thymidine phosphorylase
Gene
Tymp
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).
By similarityCatalytic activityi
- EC:2.4.2.4
: dTMP biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine. This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 102 | SubstrateBy similarity | 1 | |
Binding sitei | 188 | SubstrateBy similarity | 1 | |
Binding sitei | 203 | SubstrateBy similarity | 1 | |
Binding sitei | 207 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- 1,4-alpha-oligoglucan phosphorylase activity Source: MGI
- protein homodimerization activity Source: MGI
- pyrimidine-nucleoside phosphorylase activity Source: InterPro
- thymidine phosphorylase activity Source: MGI
GO - Biological processi
- animal organ morphogenesis Source: MGI
- chemotaxis Source: MGI
- dTMP catabolic process Source: MGI
- mitochondrial genome maintenance Source: MGI
- pyrimidine nucleobase metabolic process Source: InterPro
- pyrimidine nucleoside metabolic process Source: MGI
- regulation of gastric motility Source: MGI
- regulation of myelination Source: MGI
- regulation of transmission of nerve impulse Source: MGI
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.4.2.4, 3474 |
Reactomei | R-MMU-73614, Pyrimidine salvage R-MMU-73621, Pyrimidine catabolism |
SABIO-RKi | Q99N42 |
UniPathwayi | UPA00578;UER00638 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Tymp Synonyms:Ecgf1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920212, Tymp |
VEuPathDBi | HostDB:ENSMUSG00000022615 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059047 | 1 – 471 | Thymidine phosphorylaseAdd BLAST | 471 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 6 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q99N42 |
MaxQBi | Q99N42 |
PaxDbi | Q99N42 |
PeptideAtlasi | Q99N42 |
PRIDEi | Q99N42 |
ProteomicsDBi | 298078 |
PTM databases
iPTMneti | Q99N42 |
PhosphoSitePlusi | Q99N42 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022615, Expressed in multi-cellular organism and 91 other tissues |
Genevisiblei | Q99N42, MM |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000023285 |
Chemistry databases
BindingDBi | Q99N42 |
Miscellaneous databases
RNActi | Q99N42, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QPRY, Eukaryota |
GeneTreei | ENSGT00390000009250 |
HOGENOMi | CLU_025040_0_2_1 |
InParanoidi | Q99N42 |
OMAi | DVWRRMI |
OrthoDBi | 1214417at2759 |
PhylomeDBi | Q99N42 |
TreeFami | TF332198 |
Family and domain databases
Gene3Di | 3.40.1030.10, 1 hit 3.90.1170.30, 1 hit |
InterProi | View protein in InterPro IPR000312, Glycosyl_Trfase_fam3 IPR017459, Glycosyl_Trfase_fam3_N_dom IPR036320, Glycosyl_Trfase_fam3_N_dom)sf IPR035902, Nuc_phospho_transferase IPR036566, PYNP-like_C_sf IPR013102, PYNP_C IPR018090, Pyrmidine_PPas_bac/euk IPR000053, Thymidine/pyrmidine_PPase |
PANTHERi | PTHR10515, PTHR10515, 1 hit |
Pfami | View protein in Pfam PF02885, Glycos_trans_3N, 1 hit PF00591, Glycos_transf_3, 1 hit PF07831, PYNP_C, 1 hit |
PIRSFi | PIRSF000478, TP_PyNP, 1 hit |
SMARTi | View protein in SMART SM00941, PYNP_C, 1 hit |
SUPFAMi | SSF47648, SSF47648, 1 hit SSF52418, SSF52418, 1 hit SSF54680, SSF54680, 1 hit |
TIGRFAMsi | TIGR02644, Y_phosphoryl, 1 hit |
i Sequence
Sequence statusi: Complete.
Q99N42-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPGTPPPS ASGGGGGEPR QLPELIRLKR DGGHLREADI RNFVHAVIDG
60 70 80 90 100
RAQDTQIGAM LMAIRLQGMN LEETSVLTRA LAESGQQLEW PKAWHQQLVD
110 120 130 140 150
KHSTGGVGDK VSLVLAPALA ACGCKVPMIS GRSLGHTGGT LDKLESIPGF
160 170 180 190 200
GVTQSPEQML HILEEVGCCI VGQSAKLVPA DGILYAARDV TATVDSVPLI
210 220 230 240 250
TASILSKKAV EGLSTLVVDV KFGGAAVFPD QEKARELAKM LVRVGVSLGL
260 270 280 290 300
KVAAALTAMD NPLGRSVGHT LEVEEALLCL DGAGPPDLRD LVIRLGGAIL
310 320 330 340 350
WISGQAETQD QGAARVAAAL DDGSARRRFQ LMLSAQGVDP GLAKALCSGS
360 370 380 390 400
PTQRRQLLPH AREQEELLAP ADGIVECVRA LPLARVLHDL GAGRSRAGQP
410 420 430 440 450
IRPGVGAEVL VDVGQCLSRG TPWLRVHLDG PALSSQQRRT LQGALVLSDR
460 470
APFKVPSPFA ELVLPPTIAQ P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB060274 mRNA Translation: BAB41208.1 |
CCDSi | CCDS27747.1 |
RefSeqi | NP_612175.1, NM_138302.1 |
Genome annotation databases
Ensembli | ENSMUST00000023285; ENSMUSP00000023285; ENSMUSG00000022615 |
GeneIDi | 72962 |
KEGGi | mmu:72962 |
UCSCi | uc007xgl.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB060274 mRNA Translation: BAB41208.1 |
CCDSi | CCDS27747.1 |
RefSeqi | NP_612175.1, NM_138302.1 |
3D structure databases
SMRi | Q99N42 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000023285 |
Chemistry databases
BindingDBi | Q99N42 |
ChEMBLi | CHEMBL2606 |
PTM databases
iPTMneti | Q99N42 |
PhosphoSitePlusi | Q99N42 |
Proteomic databases
jPOSTi | Q99N42 |
MaxQBi | Q99N42 |
PaxDbi | Q99N42 |
PeptideAtlasi | Q99N42 |
PRIDEi | Q99N42 |
ProteomicsDBi | 298078 |
Protocols and materials databases
Antibodypediai | 253, 835 antibodies from 36 providers |
DNASUi | 72962 |
Genome annotation databases
Ensembli | ENSMUST00000023285; ENSMUSP00000023285; ENSMUSG00000022615 |
GeneIDi | 72962 |
KEGGi | mmu:72962 |
UCSCi | uc007xgl.2, mouse |
Organism-specific databases
CTDi | 1890 |
MGIi | MGI:1920212, Tymp |
VEuPathDBi | HostDB:ENSMUSG00000022615 |
Phylogenomic databases
eggNOGi | ENOG502QPRY, Eukaryota |
GeneTreei | ENSGT00390000009250 |
HOGENOMi | CLU_025040_0_2_1 |
InParanoidi | Q99N42 |
OMAi | DVWRRMI |
OrthoDBi | 1214417at2759 |
PhylomeDBi | Q99N42 |
TreeFami | TF332198 |
Enzyme and pathway databases
UniPathwayi | UPA00578;UER00638 |
BRENDAi | 2.4.2.4, 3474 |
Reactomei | R-MMU-73614, Pyrimidine salvage R-MMU-73621, Pyrimidine catabolism |
SABIO-RKi | Q99N42 |
Miscellaneous databases
BioGRID-ORCSi | 72962, 1 hit in 50 CRISPR screens |
ChiTaRSi | Tymp, mouse |
PROi | PR:Q99N42 |
RNActi | Q99N42, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022615, Expressed in multi-cellular organism and 91 other tissues |
Genevisiblei | Q99N42, MM |
Family and domain databases
Gene3Di | 3.40.1030.10, 1 hit 3.90.1170.30, 1 hit |
InterProi | View protein in InterPro IPR000312, Glycosyl_Trfase_fam3 IPR017459, Glycosyl_Trfase_fam3_N_dom IPR036320, Glycosyl_Trfase_fam3_N_dom)sf IPR035902, Nuc_phospho_transferase IPR036566, PYNP-like_C_sf IPR013102, PYNP_C IPR018090, Pyrmidine_PPas_bac/euk IPR000053, Thymidine/pyrmidine_PPase |
PANTHERi | PTHR10515, PTHR10515, 1 hit |
Pfami | View protein in Pfam PF02885, Glycos_trans_3N, 1 hit PF00591, Glycos_transf_3, 1 hit PF07831, PYNP_C, 1 hit |
PIRSFi | PIRSF000478, TP_PyNP, 1 hit |
SMARTi | View protein in SMART SM00941, PYNP_C, 1 hit |
SUPFAMi | SSF47648, SSF47648, 1 hit SSF52418, SSF52418, 1 hit SSF54680, SSF54680, 1 hit |
TIGRFAMsi | TIGR02644, Y_phosphoryl, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TYPH_MOUSE | |
Accessioni | Q99N42Primary (citable) accession number: Q99N42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families