Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cell adhesion molecule 3

Gene

Cadm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: HGNC

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions
R-MMU-420597 Nectin/Necl trans heterodimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 3
Alternative name(s):
Immunoglobulin superfamily member 4B
Short name:
IgSF4B
Nectin-like protein 1
Short name:
NECL-1
Synaptic cell adhesion molecule 3
TSLC1-like protein 1
Gene namesi
Name:Cadm3
Synonyms:Igsf4b, Necl1, Syncam3, Tsll1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2137858 Cadm3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 328ExtracellularSequence analysisAdd BLAST306
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 396CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000004606823 – 396Cell adhesion molecule 3Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 108PROSITE-ProRule annotation
Disulfide bondi150 ↔ 207PROSITE-ProRule annotation
Disulfide bondi252 ↔ 297PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei386PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99N28
PaxDbiQ99N28
PeptideAtlasiQ99N28
PRIDEiQ99N28

PTM databases

iPTMnetiQ99N28
PhosphoSitePlusiQ99N28

Expressioni

Tissue specificityi

Mainly expressed in brain, in neuronal cell bodies of cerebellum, cortex, hippocampus, hypothalamus and spinal cord. In spinal cord predominantly expressed in motor neurons. Expressed in axons, presynaptic nerve terminals, glia cell processes.3 Publications

Developmental stagei

At E14.5 predominantly expressed in the nervous system.1 Publication

Gene expression databases

BgeeiENSMUSG00000005338 Expressed in 223 organ(s), highest expression level in cerebellum
CleanExiMM_CADM3
ExpressionAtlasiQ99N28 baseline and differential
GenevisibleiQ99N28 MM

Interactioni

Subunit structurei

Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, MPP6 and CASK.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220505, 3 interactors
IntActiQ99N28, 3 interactors
MINTiQ99N28
STRINGi10090.ENSMUSP00000106851

Structurei

3D structure databases

ProteinModelPortaliQ99N28
SMRiQ99N28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 124Ig-like V-typeAdd BLAST102
Domaini128 – 226Ig-like C2-type 1Add BLAST99
Domaini231 – 313Ig-like C2-type 2Add BLAST83

Domaini

The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCE Eukaryota
ENOG411017U LUCA
GeneTreeiENSGT00900000140811
HOGENOMiHOG000036057
HOVERGENiHBG057086
InParanoidiQ99N28
KOiK06780
OMAiTTTLNCQ
PhylomeDBiQ99N28
TreeFamiTF326804

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR003585 Neurexin-like
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99N28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAPSALPLL LLLACSWAPG GANLSQDDSQ PWTSDETVVA GGTVVLKCQV
60 70 80 90 100
KDHEDSSLQW SNPAQQTLYF GEKRALRDNR IQLVSSTPHE LSISISNVAL
110 120 130 140 150
ADEGEYTCSI FTMPVRTAKS LVTVLGIPQK PIITGYKSSL REKETATLNC
160 170 180 190 200
QSSGSKPAAQ LTWRKGDQEL HGDQTRIQED PNGKTFTVSS SVSFQVTRED
210 220 230 240 250
DGANIVCSVN HESLKGADRS TSQRIEVLYT PTAMIRPEPA HPREGQKLLL
260 270 280 290 300
HCEGRGNPVP QQYVWVKEGS EPPLKMTQES ALIFPFLNKS DSGTYGCTAT
310 320 330 340 350
SNMGSYTAYF TLNVNDPSPV PSSSSTYHAI IGGIVAFIVF LLLILLIFLG
360 370 380 390
HYLIRHKGTY LTHEAKGSDD APDADTAIIN AEGGQSGGDD KKEYFI
Length:396
Mass (Da):42,964
Last modified:June 1, 2001 - v1
Checksum:iC1ADF8B57D141F3A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K4DI58K4DI58_MOUSE
Cell adhesion molecule 3
Cadm3 Igsf4b, mCG_1205
430Annotation score:

Sequence cautioni

The sequence AAH29659 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059393 mRNA Translation: AAL29691.1
AF195662 mRNA Translation: AAG35584.1
AK030782 mRNA Translation: BAC27137.1
AK038917 mRNA Translation: BAC30168.1
AK053077 mRNA Translation: BAC35258.1
BC029659 mRNA Translation: AAH29659.1 Different initiation.
CCDSiCCDS15528.1
RefSeqiNP_444429.1, NM_053199.3
UniGeneiMm.330524

Genome annotation databases

EnsembliENSMUST00000111220; ENSMUSP00000106851; ENSMUSG00000005338
GeneIDi94332
KEGGimmu:94332
UCSCiuc007drh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059393 mRNA Translation: AAL29691.1
AF195662 mRNA Translation: AAG35584.1
AK030782 mRNA Translation: BAC27137.1
AK038917 mRNA Translation: BAC30168.1
AK053077 mRNA Translation: BAC35258.1
BC029659 mRNA Translation: AAH29659.1 Different initiation.
CCDSiCCDS15528.1
RefSeqiNP_444429.1, NM_053199.3
UniGeneiMm.330524

3D structure databases

ProteinModelPortaliQ99N28
SMRiQ99N28
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220505, 3 interactors
IntActiQ99N28, 3 interactors
MINTiQ99N28
STRINGi10090.ENSMUSP00000106851

PTM databases

iPTMnetiQ99N28
PhosphoSitePlusiQ99N28

Proteomic databases

MaxQBiQ99N28
PaxDbiQ99N28
PeptideAtlasiQ99N28
PRIDEiQ99N28

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111220; ENSMUSP00000106851; ENSMUSG00000005338
GeneIDi94332
KEGGimmu:94332
UCSCiuc007drh.1 mouse

Organism-specific databases

CTDi57863
MGIiMGI:2137858 Cadm3

Phylogenomic databases

eggNOGiENOG410IFCE Eukaryota
ENOG411017U LUCA
GeneTreeiENSGT00900000140811
HOGENOMiHOG000036057
HOVERGENiHBG057086
InParanoidiQ99N28
KOiK06780
OMAiTTTLNCQ
PhylomeDBiQ99N28
TreeFamiTF326804

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions
R-MMU-420597 Nectin/Necl trans heterodimerization

Miscellaneous databases

ChiTaRSiCadm3 mouse
PROiPR:Q99N28
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005338 Expressed in 223 organ(s), highest expression level in cerebellum
CleanExiMM_CADM3
ExpressionAtlasiQ99N28 baseline and differential
GenevisibleiQ99N28 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR003585 Neurexin-like
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADM3_MOUSE
AccessioniPrimary (citable) accession number: Q99N28
Secondary accession number(s): Q8BSQ8, Q8K1H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again