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Protein

Breast cancer metastasis-suppressor 1 homolog

Gene

Brms1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity).By similarity

GO - Molecular functioni

  • histone deacetylase binding Source: GO_Central
  • NF-kappaB binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer metastasis-suppressor 1 homolog
Gene namesi
Name:Brms1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2388804 Brms1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649891 – 246Breast cancer metastasis-suppressor 1 homologAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ99N20
MaxQBiQ99N20
PaxDbiQ99N20
PRIDEiQ99N20

PTM databases

iPTMnetiQ99N20
PhosphoSitePlusiQ99N20

Expressioni

Gene expression databases

BgeeiENSMUSG00000080268 Expressed in 174 organ(s), highest expression level in testis
CleanExiMM_BRMS1
ExpressionAtlasiQ99N20 baseline and differential
GenevisibleiQ99N20 MM

Interactioni

Subunit structurei

Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223258, 2 interactors
ComplexPortaliCPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443 SIN3A histone deacetylase complex
CPX-3444 SIN3B histone deacetylase complex
IntActiQ99N20, 2 interactors
MINTiQ99N20
STRINGi10090.ENSMUSP00000112266

Structurei

3D structure databases

ProteinModelPortaliQ99N20
SMRiQ99N20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili51 – 98By similarityAdd BLAST48

Domaini

Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.By similarity

Sequence similaritiesi

Belongs to the BRMS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4466 Eukaryota
ENOG410Y9N9 LUCA
GeneTreeiENSGT00910000144178
HOGENOMiHOG000007483
HOVERGENiHBG050734
InParanoidiQ99N20
KOiK19196
OMAiEEANECD
OrthoDBiEOG091G0UCP
PhylomeDBiQ99N20
TreeFamiTF323740

Family and domain databases

InterProiView protein in InterPro
IPR013907 Sds3
PANTHERiPTHR21964 PTHR21964, 1 hit
PfamiView protein in Pfam
PF08598 Sds3, 1 hit
SMARTiView protein in SMART
SM01401 Sds3, 1 hit

Sequencei

Sequence statusi: Complete.

Q99N20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIQPSGKET EEMEAEGDSA AEMNGEADES EEERSGSQTE SEEESSEMDD
60 70 80 90 100
EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE
110 120 130 140 150
YTEPLGGLQQ SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKM
160 170 180 190 200
LLYDTLLGEL QERIQRLEED RQSLDISSEW WDDKLHSRSS SKAGDAMPPS
210 220 230 240
KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKADGP
Length:246
Mass (Da):28,210
Last modified:June 1, 2001 - v1
Checksum:i3825F0B5CB84E575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233580 mRNA Translation: AAK15007.1
AF368292 Genomic DNA Translation: AAK51553.1
BC016108 mRNA Translation: AAH16108.1
CCDSiCCDS50355.1
RefSeqiNP_598916.1, NM_134155.1
UniGeneiMm.29628

Genome annotation databases

EnsembliENSMUST00000116567; ENSMUSP00000112266; ENSMUSG00000080268
GeneIDi107392
KEGGimmu:107392
UCSCiuc008gbz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233580 mRNA Translation: AAK15007.1
AF368292 Genomic DNA Translation: AAK51553.1
BC016108 mRNA Translation: AAH16108.1
CCDSiCCDS50355.1
RefSeqiNP_598916.1, NM_134155.1
UniGeneiMm.29628

3D structure databases

ProteinModelPortaliQ99N20
SMRiQ99N20
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223258, 2 interactors
ComplexPortaliCPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443 SIN3A histone deacetylase complex
CPX-3444 SIN3B histone deacetylase complex
IntActiQ99N20, 2 interactors
MINTiQ99N20
STRINGi10090.ENSMUSP00000112266

PTM databases

iPTMnetiQ99N20
PhosphoSitePlusiQ99N20

Proteomic databases

EPDiQ99N20
MaxQBiQ99N20
PaxDbiQ99N20
PRIDEiQ99N20

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000116567; ENSMUSP00000112266; ENSMUSG00000080268
GeneIDi107392
KEGGimmu:107392
UCSCiuc008gbz.1 mouse

Organism-specific databases

CTDi25855
MGIiMGI:2388804 Brms1

Phylogenomic databases

eggNOGiKOG4466 Eukaryota
ENOG410Y9N9 LUCA
GeneTreeiENSGT00910000144178
HOGENOMiHOG000007483
HOVERGENiHBG050734
InParanoidiQ99N20
KOiK19196
OMAiEEANECD
OrthoDBiEOG091G0UCP
PhylomeDBiQ99N20
TreeFamiTF323740

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones

Miscellaneous databases

PROiPR:Q99N20
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000080268 Expressed in 174 organ(s), highest expression level in testis
CleanExiMM_BRMS1
ExpressionAtlasiQ99N20 baseline and differential
GenevisibleiQ99N20 MM

Family and domain databases

InterProiView protein in InterPro
IPR013907 Sds3
PANTHERiPTHR21964 PTHR21964, 1 hit
PfamiView protein in Pfam
PF08598 Sds3, 1 hit
SMARTiView protein in SMART
SM01401 Sds3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBRMS1_MOUSE
AccessioniPrimary (citable) accession number: Q99N20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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