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Protein

Tachykinin-4

Gene

Tac4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor.8 Publications

GO - Molecular functioni

  • receptor ligand activity Source: UniProtKB
  • signaling receptor binding Source: MGI
  • substance K receptor binding Source: UniProtKB
  • substance P receptor binding Source: UniProtKB

GO - Biological processi

  • cell-cell signaling Source: GO_Central
  • inflammatory response Source: GO_Central
  • mast cell degranulation Source: UniProtKB-KW
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of saliva secretion Source: MGI
  • regulation of blood pressure Source: UniProtKB-KW
  • tachykinin receptor signaling pathway Source: UniProtKB

Keywordsi

Molecular functionHypotensive agent
Biological processMast cell degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-4
Alternative name(s):
Preprotachykinin-C
Short name:
PPT-C
Cleaved into the following chain:
Alternative name(s):
HK1
Hemokinin-1
Hemokinin-I
Short name:
HK-I
Gene namesi
Name:Tac4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1931130 Tac4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000032001417 – 54By similarityAdd BLAST38
PeptideiPRO_000032001556 – 66Hemokinin1 PublicationAdd BLAST11
PropeptideiPRO_000032001669 – 128By similarityAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66Methionine amide1 PublicationSequence analysis1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ99N14
PRIDEiQ99N14

Expressioni

Tissue specificityi

Expressed in hematopoietic cells with highest levels in pre- and pro-B cells but not in later developmental stages. Also detected in uterus, skeletal muscle, brain, spleen, stomach, skin and lactating mammary gland and in cells of myeloid lineage including dendritic and microglial cells and macrophages. In uterus, highest expression is observed in non-pregnant diestrus mice and in day 5 pregnant mice. Compared with mice in diestrus, decreases 2.6-fold in uteri from non-pregnant mice in estrus and 10.2-fold in day 17 pregnant mice. Detected at sites of chronic inflammation such as granulomas.7 Publications

Gene expression databases

BgeeiENSMUSG00000020872
CleanExiMM_TAC4
GenevisibleiQ99N14 MM

Interactioni

GO - Molecular functioni

  • receptor ligand activity Source: UniProtKB
  • signaling receptor binding Source: MGI
  • substance K receptor binding Source: UniProtKB
  • substance P receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021242

Structurei

3D structure databases

SMRiQ99N14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QI Eukaryota
ENOG41113ZV LUCA
GeneTreeiENSGT00390000015220
HOGENOMiHOG000154596
HOVERGENiHBG097570
InParanoidiQ99N14
KOiK05241
OMAiYQLGRIV
OrthoDBiEOG091G0TYJ
PhylomeDBiQ99N14
TreeFamiTF338519

Family and domain databases

InterProiView protein in InterPro
IPR013055 Tachy_Neuro_lke_CS
IPR008216 Tachykinin_fam
PANTHERiPTHR11250 PTHR11250, 1 hit
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99N14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLALLLL IGPSVCTTAG DREELAFGAE AESWVTVNLK GIPVPSIELK
60 70 80 90 100
LQELKRSRTR QFYGLMGKRV GGYQLGRIVQ DLLGTRGLSI EGTCRQAASQ
110 120
QRARPGAVTR ESLQSREEDE APLTTSNV
Length:128
Mass (Da):13,937
Last modified:June 1, 2001 - v1
Checksum:iFED91DCAB39CB444
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235035 mRNA Translation: AAK15025.1
AF515827 mRNA Translation: AAP30873.1
AL627222 Genomic DNA No translation available.
BC119426 mRNA Translation: AAI19427.1
CCDSiCCDS25274.1
RefSeqiNP_444323.1, NM_053093.1
UniGeneiMm.40085

Genome annotation databases

EnsembliENSMUST00000021242; ENSMUSP00000021242; ENSMUSG00000020872
GeneIDi93670
KEGGimmu:93670
UCSCiuc007lac.1 mouse

Entry informationi

Entry nameiTKN4_MOUSE
AccessioniPrimary (citable) accession number: Q99N14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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