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Entry version 132 (08 May 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Unconventional myosin-VIIb

Gene

Myo7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli.By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi158 – 165ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
Biological processDifferentiation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-VIIb
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo7b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107709 Myo7b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003290471 – 2113Unconventional myosin-VIIbAdd BLAST2113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei904PhosphoserineCombined sources1
Modified residuei1339PhosphothreonineCombined sources1
Modified residuei1368PhosphoserineCombined sources1
Modified residuei1642PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99MZ6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99MZ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99MZ6

PeptideAtlas

More...
PeptideAtlasi
Q99MZ6

PRoteomics IDEntifications database

More...
PRIDEi
Q99MZ6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99MZ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99MZ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed primarily in kidney and intestine. Detected in proximal tubule cells of the kidney and enterocytes of the intestine, specifically the distal tips of apical microvilli on these transporting epithelial cells (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in intestinal enterocytes at embryonic day 17.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024388 Expressed in 115 organ(s), highest expression level in intestinal villus

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99MZ6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5.

Interacts with CDHR2.

Interacts with CDHR5.

Interacts with USH1C (By similarity).

Interacts with ANKS4B; requires initial interaction with USH1C (Probable).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q99MZ6, 3 interactors

Molecular INTeraction database

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MINTi
Q99MZ6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000118046

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99MZ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 760Myosin motorPROSITE-ProRule annotationAdd BLAST696
Domaini745 – 765IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini763 – 792IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini786 – 815IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini809 – 838IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini832 – 861IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini855 – 884IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini989 – 1189MyTH4 1PROSITE-ProRule annotationAdd BLAST201
Domaini1194 – 1503FERM 1PROSITE-ProRule annotationAdd BLAST310
Domaini1498 – 1564SH3PROSITE-ProRule annotationAdd BLAST67
Domaini1641 – 1790MyTH4 2PROSITE-ProRule annotationAdd BLAST150
Domaini1790 – 1896MyTH4 3PROSITE-ProRule annotationAdd BLAST107
Domaini1796 – 2099FERM 2PROSITE-ProRule annotationAdd BLAST304

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni637 – 659Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni962 – 1578Mediates interaction with ANKS4B1 PublicationAdd BLAST617
Regioni1497 – 2113Mediates interaction with CDHR2, CDHR5 and USH1CBy similarityAdd BLAST617

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4229 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157247

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007836

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99MZ6

KEGG Orthology (KO)

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KOi
K21868

Identification of Orthologs from Complete Genome Data

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OMAi
FMAAVFE

Database of Orthologous Groups

More...
OrthoDBi
527681at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99MZ6

TreeFam database of animal gene trees

More...
TreeFami
TF335306

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 2 hits
cd13198 FERM_C1_MyoVII, 1 hit
cd13199 FERM_C2_MyoVII, 1 hit
cd01381 MYSc_Myo7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 2 hits
1.25.40.530, 2 hits
2.30.29.30, 2 hits
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR008989 Myosin_S1_N
IPR041793 MyoVII_FERM_C1
IPR041794 MyoVII_FERM_C2
IPR036106 MYSc_Myo7
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 2 hits
SM00015 IQ, 4 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 2 hits
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 2 hits
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 2 hits
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99MZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVFRLGDHV WLDPPSSSKT GVAIGGIVKE TKLGKTLIED DEGKEHWVHA
60 70 80 90 100
EDLSTLRPMH PNSAQGVDDM IRLGDLNEAG VVHNLLIRYQ QHKIYTYTGS
110 120 130 140 150
ILVAVNPFQM LPLYTLEQVQ IYYSRHMGEL PPHIFAIANS CYFNMKKNKR
160 170 180 190 200
DQCCIISGES GAGKTETTKL ILQFLATVSG QHSWIEQQVL EANPILEAFG
210 220 230 240 250
NAKTIRNDNS SRFGKYIDIH FNSSGVIEGA SIEHFLLEKS RVCRQAPEER
260 270 280 290 300
NYHIFYCMLM GMSPEEKQML SLGMPSEYHY LTMGSCTSSE GLSDAKDYAH
310 320 330 340 350
VRSAMKILQF SDSENWDISK LLAAILHLGN VGFMAAVFEN LDSSDVMETP
360 370 380 390 400
AFPLAMKLLE VQHQALRDCL IKHTIPVLGE FVSRPVNIAQ ATDRRDAFVK
410 420 430 440 450
GIYGRLFQWI VKKINAAIFT PQAQDPQNVR RAIGLLDIFG FENFQNNSFE
460 470 480 490 500
QLCINFANEH LQQFFVKHVF TMEQEEYLSE NITWNYIHYT DNQPILDMLA
510 520 530 540 550
LKPMSIISLL DEESRFPQGT DVTMLQKLNS IHANNKSFLS PRSIHDTRFG
560 570 580 590 600
IAHFAGDVYY QAEGFLEKNR DVLSTDILIL IHSSKNKFLK EIFNVDSSQT
610 620 630 640 650
KLGHGTICQV KAGSQLFKSS DSIKRPVTLA SQFKQSLDQL MRILTNCQPY
660 670 680 690 700
FVRCIKPNEY KKPLLFDREL CIQQLRYSGM METVHIRKSG FPIRYTFDEF
710 720 730 740 750
SQRFRVLLPS PERMQFQNKP RQMTLHIADL CLGTDKDWKV GKTKIFLKDH
760 770 780 790 800
QDTVLEIRRS QALDGAAIRI QRVLRGHKYR KEFLRQRRAA VTLQAGWRGY
810 820 830 840 850
SQRKNFKLIL VGFERLQAIA RSHLLMRQFQ AMRQRIVQLQ ARCRGYLVRQ
860 870 880 890 900
QVQAKRRAVV IIQAHARGMV VRKSYWQQKS TGPQVILAKE PKAQVAVHER
910 920 930 940 950
KRKSIYDTVT DTAMVEKVFG FLPAMIGGQE GPAPTRFEDL EVKTQKLHEV
960 970 980 990 1000
DLDTVPMMAM PEEEVDSLAE YTFPKFAVTY FQKSASHTHI QKPLRYPLLY
1010 1020 1030 1040 1050
HENDTDHSAA LDVWIIILRF MGDLPEPVVY GRNSLTGSSV MRQIHDKLGK
1060 1070 1080 1090 1100
DSVTQHNRSS QVASQLNFGE EAFKFDGPIS DRPMSNLEKV HFIVGYAIMR
1110 1120 1130 1140 1150
PGLRDEIYCQ ICKQLSENYK TSSRARGWIL LSLCLGCFPP SERFMKYLLN
1160 1170 1180 1190 1200
FISQGPPSYG PFCAERLQRT FANGVRAEPP TWLELQAVKS KKHIPIQVIL
1210 1220 1230 1240 1250
ATGRSLTISV DSASTSREIC QHVAQKQGLR DNLGFSLQVA VYDKFWSLGS
1260 1270 1280 1290 1300
GCDHLMDAVA QCEQLARERG ESQRQAPWRI YFRKEFFTPW HDSQEDPVST
1310 1320 1330 1340 1350
ELIYHQVLRG VWSGEYNFEK EEELVELLAR HCYVQLGATV KSNAVQELLP
1360 1370 1380 1390 1400
SCVPSKLYRT KSPEKWASLV TAAHAKAQYT QSKATPLAVR EQTVEAARLL
1410 1420 1430 1440 1450
WPLLFSRLFE VTTLSGPRLP KTQLVLAINW KGMYFLDQKE RTLLGLSFAE
1460 1470 1480 1490 1500
VMGLVANRDA PGGKKLLLAT LQEEYEFVSP SSVAIAEMVA LFLGGLKERS
1510 1520 1530 1540 1550
VFAMALQDRR ATDDITLLPF KKGDLLILTK KQGLLASENW ALGQNDRTGK
1560 1570 1580 1590 1600
TGLVPTACLY TIPSVTKPST QLLSLLAMSP EKRKLAAQEV RALEPPLEDQ
1610 1620 1630 1640 1650
LTESPYTLEE FSYQFFRAPE KETISRAAMP MARSRGHLWA YSPEPLRQPL
1660 1670 1680 1690 1700
LKSVHDKAKL RDAACQIFLA ILKYTGDYPS RQSWHSLELT DQMFSLALQD
1710 1720 1730 1740 1750
PALQDELYCQ ILKQLTHNSI RFSEERAWQL LWLCTGLFPP GKTLLPHAQK
1760 1770 1780 1790 1800
FIDSRKKKPL ALDCSRRLHR VLRVGPRKQP PHDVEVKAAE QNVSKLHHEV
1810 1820 1830 1840 1850
YLPNDTSKSM EVGSSSRVRD LCEGIGTRLQ LASWDGCSLF IKITDKVISL
1860 1870 1880 1890 1900
KEGDFFFDSL RQVSDWVKKN RPQKEGASVT LPYQVFFMRK LWLNVTPGKD
1910 1920 1930 1940 1950
VNADTILHYH QELPKYLRGF HKCSREDAIH LGGLICKIQF GSDSSQLASV
1960 1970 1980 1990 2000
SKVLKELVPQ NLTRLMSSEE WKKSLLLECD KNKRKTVAEA KVEFLKYMYR
2010 2020 2030 2040 2050
WPTFGSAFFE VKQTSEPSYP DILLIAINRH GLLLIHPKTK ELLNTYPFTK
2060 2070 2080 2090 2100
ISSWSSGNTY FHMALGSLGQ GSRLLCETSL GYKMDDLLTS YVQQLLNTVN
2110
KQRGFRAPAP ANP
Length:2,113
Mass (Da):240,859
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7116B047D1B08AA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti227 – 228IE → LA in AAK28339 (PubMed:11401444).Curated2
Sequence conflicti2033L → V in AAK28339 (PubMed:11401444).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF242411 mRNA Translation: AAK28339.1
BC138338 mRNA Translation: AAI38339.1
BC138341 mRNA Translation: AAI38342.1
BC026416 mRNA Translation: AAH26416.1
AK220152 mRNA Translation: BAD90338.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50244.1

NCBI Reference Sequences

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RefSeqi
NP_115770.2, NM_032394.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000134663; ENSMUSP00000118046; ENSMUSG00000024388

Database of genes from NCBI RefSeq genomes

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GeneIDi
17922

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17922

UCSC genome browser

More...
UCSCi
uc008eix.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242411 mRNA Translation: AAK28339.1
BC138338 mRNA Translation: AAI38339.1
BC138341 mRNA Translation: AAI38342.1
BC026416 mRNA Translation: AAH26416.1
AK220152 mRNA Translation: BAD90338.1
CCDSiCCDS50244.1
RefSeqiNP_115770.2, NM_032394.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F3YX-ray3.41A962-1578[»]
SMRiQ99MZ6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ99MZ6, 3 interactors
MINTiQ99MZ6
STRINGi10090.ENSMUSP00000118046

PTM databases

iPTMnetiQ99MZ6
PhosphoSitePlusiQ99MZ6

Proteomic databases

jPOSTiQ99MZ6
MaxQBiQ99MZ6
PaxDbiQ99MZ6
PeptideAtlasiQ99MZ6
PRIDEiQ99MZ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000134663; ENSMUSP00000118046; ENSMUSG00000024388
GeneIDi17922
KEGGimmu:17922
UCSCiuc008eix.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4648
MGIiMGI:107709 Myo7b

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000157247
HOGENOMiHOG000007836
InParanoidiQ99MZ6
KOiK21868
OMAiFMAAVFE
OrthoDBi527681at2759
PhylomeDBiQ99MZ6
TreeFamiTF335306

Miscellaneous databases

Protein Ontology

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PROi
PR:Q99MZ6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024388 Expressed in 115 organ(s), highest expression level in intestinal villus
GenevisibleiQ99MZ6 MM

Family and domain databases

CDDicd14473 FERM_B-lobe, 2 hits
cd13198 FERM_C1_MyoVII, 1 hit
cd13199 FERM_C2_MyoVII, 1 hit
cd01381 MYSc_Myo7, 1 hit
Gene3Di1.20.80.10, 2 hits
1.25.40.530, 2 hits
2.30.29.30, 2 hits
2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR008989 Myosin_S1_N
IPR041793 MyoVII_FERM_C1
IPR041794 MyoVII_FERM_C2
IPR036106 MYSc_Myo7
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 2 hits
SM00015 IQ, 4 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47031 SSF47031, 2 hits
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 2 hits
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 2 hits
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO7B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MZ6
Secondary accession number(s): B9EHR5, Q571N7, Q8R0U3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 27, 2011
Last modified: May 8, 2019
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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