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UniProtKB - Q99MZ3 (MLXPL_MOUSE)

Entry version 166 (23 Feb 2022)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Carbohydrate-responsive element-binding protein

Gene

Mlxipl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-163358, PKA-mediated phosphorylation of key metabolic factors
R-MMU-163765, ChREBP activates metabolic gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carbohydrate-responsive element-binding protein
Short name:
ChREBP
Alternative name(s):
MLX interactor
MLX-interacting protein-like
Williams-Beuren syndrome chromosomal region 14 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mlxipl
Synonyms:Mio, Wbscr14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1927999, Mlxipl

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000005373

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001275051 – 864Carbohydrate-responsive element-binding proteinAdd BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei27PhosphothreonineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei566Phosphoserine; by AMPKBy similarity1
Modified residuei614PhosphoserineBy similarity1
Modified residuei626PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-566 by AMPK inactivates the DNA-binding activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99MZ3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99MZ3

PeptideAtlas

More...PeptideAtlasi		Q99MZ3

PRoteomics IDEntifications database

More...PRIDEi		Q99MZ3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		290086 [Q99MZ3-1]
290087 [Q99MZ3-2]
290088 [Q99MZ3-3]
290089 [Q99MZ3-4]
290090 [Q99MZ3-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99MZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99MZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the ventricular and intermediate zones of the developing spinal cord of 12.5 dpc embryos. In later embryos expressed in a variety of tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000005373, Expressed in islet of Langerhans and 173 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99MZ3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a heterodimer with TCFL4/MLX.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		208443, 6 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000005507

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99MZ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1864
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99MZ3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini661 – 715bHLHPROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 41DisorderedSequence analysisAdd BLAST27
Regioni53 – 77DisorderedSequence analysisAdd BLAST25
Regioni332 – 397DisorderedSequence analysisAdd BLAST66
Regioni449 – 468DisorderedSequence analysisAdd BLAST20
Regioni489 – 533DisorderedSequence analysisAdd BLAST45
Regioni547 – 570DisorderedSequence analysisAdd BLAST24
Regioni583 – 602DisorderedSequence analysisAdd BLAST20
Regioni715 – 736Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi339 – 373Polar residuesSequence analysisAdd BLAST35
Compositional biasi498 – 533Polar residuesSequence analysisAdd BLAST36
Compositional biasi583 – 601Pro residuesSequence analysisAdd BLAST19

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3582, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007471_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99MZ3

Identification of Orthologs from Complete Genome Data

More...OMAi		NTAINLC

Database of Orthologous Groups

More...OrthoDBi		388166at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99MZ3

TreeFam database of animal gene trees

More...TreeFami		TF324749

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00010, HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00353, HLH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99MZ3-1) [UniParc]FASTAAdd to basket
Also known as: Zeta

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARALADLSV NLQVPRVVPS PDSDSDTDLE DPSPRRSAGG LHRSQVIHSG 
        60         70         80         90        100
HFMVSSPHSD SLTRRRDQEG PVGLADFGPR SIDPTLTHLF ECLSLAYSGK 
       110        120        130        140        150
LVSPKWKNFK GLKLLCRDKI RLNNAIWRAW YIQYVQRRKS PVCGFVTPLQ 
       160        170        180        190        200
GSEADEHRKP EAVILEGNYW KRRIEVVMRE YHKWRIYYKK RLRKSSREGD 
       210        220        230        240        250
FLAPKQVEGG WPPPERWCEQ LFSSVVPVLL GGSEEEPGGR QLLDLDCFLS 
       260        270        280        290        300
DISDTLFTMT QPSPSSLQLP PEDAYVGNAD MIQPDLTPLQ PSLDDFMEIS 
       310        320        330        340        350
DFFTNYRPPQ TPTSSNYIES PSFGPMADSL FSSGILAPEM PSPASSSSSS 
       360        370        380        390        400
GMTPHSGNTR LQARNSCSGP LDPNPFLSSE FLLPEDPKTK IPPAPGPTPL 
       410        420        430        440        450
LPFPTPVKVH GLEPCTPSPF PTMAPPPSLL PEESLLSARF PFTSAPPAPG 
       460        470        480        490        500
VSTLPAPTTF VPTPQPGPGP VPFSVDHLPH GYLEPVFGPH FTVPQGMQPR 
       510        520        530        540        550
CKPSSPSPGG QKASPPTLAS ATASPTATAT ARDNNPCLTQ LLRAAKPEQA 
       560        570        580        590        600
LEPPTMPGTL LRPPESPQDT VSEIPRARAF FPPIPAPTPP RPPPGPATLA 
       610        620        630        640        650
PPRSLVVPKA ERLSPPASSG SERRLSGDLN SIQPSGALSV HLSPPQTVLS 
       660        670        680        690        700
RGRVDNNKME NRRITHISAE QKRRFNIKLG FDTLHGLVST LSAQPSLKVS 
       710        720        730        740        750
KATTLQKTAE YILMLQQERA AMQEEAQQLR DEIEELNAAI NLCQQQLPAT 
       760        770        780        790        800
GVPITHQRFD QMRDMFDDYV RTRTLHNWKF WVFSILIRPL FESFNGMVST 
       810        820        830        840        850
ASLHSLRQTS LAWLEQYCSL PALRPTVLNS LRQLSTSTSI LTDPSLVPEQ 
       860 
ATRAVTEGTL GRPL
Length:864
Mass (Da):94,875
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E6AFFB04C71B327
GO
Isoform 2 (identifier: Q99MZ3-2) [UniParc]FASTAAdd to basket
Also known as: Theta

The sequence of this isoform differs from the canonical sequence as follows:
     58-79: Missing.

Show »
Length:842
Mass (Da):92,482
Checksum:i14BFA5F3820AFF74
GO
Isoform 3 (identifier: Q99MZ3-3) [UniParc]FASTAAdd to basket
Also known as: Iota

The sequence of this isoform differs from the canonical sequence as follows:
     699-744: VSKATTLQKT...ELNAAINLCQ → GLPTQRPTLV...YAGGGAAAAG
     745-864: Missing.

Show »
Length:744
Mass (Da):80,170
Checksum:iF052B12D7CE0259B
GO
Isoform 4 (identifier: Q99MZ3-4) [UniParc]FASTAAdd to basket
Also known as: Kappa

The sequence of this isoform differs from the canonical sequence as follows:
     699-714: VSKATTLQKTAEYILM → LPGLANTEAHIGGARR
     715-864: Missing.

Show »
Length:714
Mass (Da):77,556
Checksum:i4BAD0BE936A72292
GO
Isoform 5 (identifier: Q99MZ3-5) [UniParc]FASTAAdd to basket
Also known as: Eta

The sequence of this isoform differs from the canonical sequence as follows:
     545-556: AKPEQALEPPTM → VVLIVLPVPSQA
     557-864: Missing.

Show »
Length:556
Mass (Da):60,602
Checksum:iBF8BA1D9BEA7E942
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q3B6F6Q3B6_MOUSE
Carbohydrate-responsive element-bin...
Mlxipl
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q4B6F6Q4B6_MOUSE
Carbohydrate-responsive element-bin...
Mlxipl
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUT0A0A0J9YUT0_MOUSE
Carbohydrate-responsive element-bin...
Mlxipl
545Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUR1A0A0J9YUR1_MOUSE
Carbohydrate-responsive element-bin...
Mlxipl
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67D → Y in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti107K → N in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti128R → I in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti138 – 139RK → TR in AAF68175 (PubMed:10780788).Curated2
Sequence conflicti155D → H in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti175E → D in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti183K → V in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti727 – 728QQ → HE in AAF68175 (PubMed:10780788).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00217458 – 79Missing in isoform 2. CuratedAdd BLAST22
Alternative sequenceiVSP_002175545 – 556AKPEQ…EPPTM → VVLIVLPVPSQA in isoform 5. CuratedAdd BLAST12
Alternative sequenceiVSP_002176557 – 864Missing in isoform 5. CuratedAdd BLAST308
Alternative sequenceiVSP_002177699 – 744VSKAT…INLCQ → GLPTQRPTLVALAGEQSNHA SEDSGVHPDAAAGTGSYAGG GAAAAG in isoform 3. CuratedAdd BLAST46
Alternative sequenceiVSP_002179699 – 714VSKAT…EYILM → LPGLANTEAHIGGARR in isoform 4. CuratedAdd BLAST16
Alternative sequenceiVSP_002180715 – 864Missing in isoform 4. CuratedAdd BLAST150
Alternative sequenceiVSP_002178745 – 864Missing in isoform 3. CuratedAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF245475 mRNA Translation: AAK20940.1
AF245476 mRNA Translation: AAK20941.1
AF245477 mRNA Translation: AAK20942.1
AF245478 mRNA Translation: AAK20943.1
AF245479 mRNA Translation: AAK20944.1
AF156604 mRNA Translation: AAF68175.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS39316.1 [Q99MZ3-1]

NCBI Reference Sequences

More...RefSeqi		NP_067430.2, NM_021455.4 [Q99MZ3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000005507; ENSMUSP00000005507; ENSMUSG00000005373 [Q99MZ3-1]
ENSMUST00000128691; ENSMUSP00000121348; ENSMUSG00000005373 [Q99MZ3-4]
ENSMUST00000129008; ENSMUSP00000114933; ENSMUSG00000005373 [Q99MZ3-5]
ENSMUST00000153519; ENSMUSP00000122198; ENSMUSG00000005373 [Q99MZ3-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		58805

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:58805

UCSC genome browser

More...UCSCi		uc008zxt.2, mouse [Q99MZ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245475 mRNA Translation: AAK20940.1
AF245476 mRNA Translation: AAK20941.1
AF245477 mRNA Translation: AAK20942.1
AF245478 mRNA Translation: AAK20943.1
AF245479 mRNA Translation: AAK20944.1
AF156604 mRNA Translation: AAF68175.1
CCDSiCCDS39316.1 [Q99MZ3-1]
RefSeqiNP_067430.2, NM_021455.4 [Q99MZ3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GNTX-ray2.41B117-137[»]
SMRiQ99MZ3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi208443, 6 interactors
STRINGi10090.ENSMUSP00000005507

PTM databases

iPTMnetiQ99MZ3
PhosphoSitePlusiQ99MZ3

Proteomic databases

MaxQBiQ99MZ3
PaxDbiQ99MZ3
PeptideAtlasiQ99MZ3
PRIDEiQ99MZ3
ProteomicsDBi290086 [Q99MZ3-1]
290087 [Q99MZ3-2]
290088 [Q99MZ3-3]
290089 [Q99MZ3-4]
290090 [Q99MZ3-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14346, 353 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		58805

Genome annotation databases

EnsembliENSMUST00000005507; ENSMUSP00000005507; ENSMUSG00000005373 [Q99MZ3-1]
ENSMUST00000128691; ENSMUSP00000121348; ENSMUSG00000005373 [Q99MZ3-4]
ENSMUST00000129008; ENSMUSP00000114933; ENSMUSG00000005373 [Q99MZ3-5]
ENSMUST00000153519; ENSMUSP00000122198; ENSMUSG00000005373 [Q99MZ3-3]
GeneIDi58805
KEGGimmu:58805
UCSCiuc008zxt.2, mouse [Q99MZ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51085
MGIiMGI:1927999, Mlxipl
VEuPathDBiHostDB:ENSMUSG00000005373

Phylogenomic databases

eggNOGiKOG3582, Eukaryota
GeneTreeiENSGT00940000159210
HOGENOMiCLU_007471_1_0_1
InParanoidiQ99MZ3
OMAiNTAINLC
OrthoDBi388166at2759
PhylomeDBiQ99MZ3
TreeFamiTF324749

Enzyme and pathway databases

ReactomeiR-MMU-163358, PKA-mediated phosphorylation of key metabolic factors
R-MMU-163765, ChREBP activates metabolic gene expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		58805, 4 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Mlxipl, mouse

Protein Ontology

More...PROi		PR:Q99MZ3
RNActiQ99MZ3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000005373, Expressed in islet of Langerhans and 173 other tissues
GenevisibleiQ99MZ3, MM

Family and domain databases

Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010, HLH, 1 hit
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLXPL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MZ3
Secondary accession number(s): Q99MY9
, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: February 23, 2022
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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