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Protein

Carbohydrate-responsive element-binding protein

Gene

Mlxipl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-163358 PKA-mediated phosphorylation of key metabolic factors
R-MMU-163765 ChREBP activates metabolic gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carbohydrate-responsive element-binding protein
Short name:
ChREBP
Alternative name(s):
MLX interactor
MLX-interacting protein-like
Williams-Beuren syndrome chromosomal region 14 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mlxipl
Synonyms:Mio, Wbscr14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1927999 Mlxipl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001275051 – 864Carbohydrate-responsive element-binding proteinAdd BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei27PhosphothreonineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei566Phosphoserine; by AMPKBy similarity1
Modified residuei614PhosphoserineBy similarity1
Modified residuei626PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-566 by AMPK inactivates the DNA-binding activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99MZ3

PeptideAtlas

More...
PeptideAtlasi
Q99MZ3

PRoteomics IDEntifications database

More...
PRIDEi
Q99MZ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99MZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99MZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the ventricular and intermediate zones of the developing spinal cord of E12.5 embryos. In later embryos expressed in a variety of tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005373 Expressed in 131 organ(s), highest expression level in brown adipose tissue

CleanEx database of gene expression profiles

More...
CleanExi
MM_MLXIPL

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99MZ3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99MZ3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a heterodimer with TCFL4/MLX.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
208443, 6 interactors

Protein interaction database and analysis system

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IntActi
Q99MZ3, 1 interactor

Molecular INTeraction database

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MINTi
Q99MZ3

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000005507

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1864
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GNTX-ray2.41B117-137[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q99MZ3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99MZ3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini661 – 715bHLHPROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni715 – 736Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi345 – 350Poly-Ser6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3582 Eukaryota
ENOG410XTA5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113606

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG073589

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99MZ3

KEGG Orthology (KO)

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KOi
K09113

Identification of Orthologs from Complete Genome Data

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OMAi
WQPPERW

Database of Orthologous Groups

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OrthoDBi
388166at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99MZ3

TreeFam database of animal gene trees

More...
TreeFami
TF324749

Family and domain databases

Conserved Domains Database

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CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99MZ3-1) [UniParc]FASTAAdd to basket
Also known as: Zeta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARALADLSV NLQVPRVVPS PDSDSDTDLE DPSPRRSAGG LHRSQVIHSG
60 70 80 90 100
HFMVSSPHSD SLTRRRDQEG PVGLADFGPR SIDPTLTHLF ECLSLAYSGK
110 120 130 140 150
LVSPKWKNFK GLKLLCRDKI RLNNAIWRAW YIQYVQRRKS PVCGFVTPLQ
160 170 180 190 200
GSEADEHRKP EAVILEGNYW KRRIEVVMRE YHKWRIYYKK RLRKSSREGD
210 220 230 240 250
FLAPKQVEGG WPPPERWCEQ LFSSVVPVLL GGSEEEPGGR QLLDLDCFLS
260 270 280 290 300
DISDTLFTMT QPSPSSLQLP PEDAYVGNAD MIQPDLTPLQ PSLDDFMEIS
310 320 330 340 350
DFFTNYRPPQ TPTSSNYIES PSFGPMADSL FSSGILAPEM PSPASSSSSS
360 370 380 390 400
GMTPHSGNTR LQARNSCSGP LDPNPFLSSE FLLPEDPKTK IPPAPGPTPL
410 420 430 440 450
LPFPTPVKVH GLEPCTPSPF PTMAPPPSLL PEESLLSARF PFTSAPPAPG
460 470 480 490 500
VSTLPAPTTF VPTPQPGPGP VPFSVDHLPH GYLEPVFGPH FTVPQGMQPR
510 520 530 540 550
CKPSSPSPGG QKASPPTLAS ATASPTATAT ARDNNPCLTQ LLRAAKPEQA
560 570 580 590 600
LEPPTMPGTL LRPPESPQDT VSEIPRARAF FPPIPAPTPP RPPPGPATLA
610 620 630 640 650
PPRSLVVPKA ERLSPPASSG SERRLSGDLN SIQPSGALSV HLSPPQTVLS
660 670 680 690 700
RGRVDNNKME NRRITHISAE QKRRFNIKLG FDTLHGLVST LSAQPSLKVS
710 720 730 740 750
KATTLQKTAE YILMLQQERA AMQEEAQQLR DEIEELNAAI NLCQQQLPAT
760 770 780 790 800
GVPITHQRFD QMRDMFDDYV RTRTLHNWKF WVFSILIRPL FESFNGMVST
810 820 830 840 850
ASLHSLRQTS LAWLEQYCSL PALRPTVLNS LRQLSTSTSI LTDPSLVPEQ
860
ATRAVTEGTL GRPL
Length:864
Mass (Da):94,875
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E6AFFB04C71B327
GO
Isoform 2 (identifier: Q99MZ3-2) [UniParc]FASTAAdd to basket
Also known as: Theta

The sequence of this isoform differs from the canonical sequence as follows:
     58-79: Missing.

Show »
Length:842
Mass (Da):92,482
Checksum:i14BFA5F3820AFF74
GO
Isoform 3 (identifier: Q99MZ3-3) [UniParc]FASTAAdd to basket
Also known as: Iota

The sequence of this isoform differs from the canonical sequence as follows:
     699-744: VSKATTLQKT...ELNAAINLCQ → GLPTQRPTLV...YAGGGAAAAG
     745-864: Missing.

Show »
Length:744
Mass (Da):80,170
Checksum:iF052B12D7CE0259B
GO
Isoform 4 (identifier: Q99MZ3-4) [UniParc]FASTAAdd to basket
Also known as: Kappa

The sequence of this isoform differs from the canonical sequence as follows:
     699-714: VSKATTLQKTAEYILM → LPGLANTEAHIGGARR
     715-864: Missing.

Show »
Length:714
Mass (Da):77,556
Checksum:i4BAD0BE936A72292
GO
Isoform 5 (identifier: Q99MZ3-5) [UniParc]FASTAAdd to basket
Also known as: Eta

The sequence of this isoform differs from the canonical sequence as follows:
     545-556: AKPEQALEPPTM → VVLIVLPVPSQA
     557-864: Missing.

Show »
Length:556
Mass (Da):60,602
Checksum:iBF8BA1D9BEA7E942
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q4B6F6Q4B6_MOUSE
Carbohydrate-responsive element-bin...
Mlxipl
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q3B6F6Q3B6_MOUSE
Carbohydrate-responsive element-bin...
Mlxipl
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUR1A0A0J9YUR1_MOUSE
Carbohydrate-responsive element-bin...
Mlxipl
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUT0A0A0J9YUT0_MOUSE
Carbohydrate-responsive element-bin...
Mlxipl
545Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67D → Y in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti107K → N in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti128R → I in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti138 – 139RK → TR in AAF68175 (PubMed:10780788).Curated2
Sequence conflicti155D → H in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti175E → D in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti183K → V in AAF68175 (PubMed:10780788).Curated1
Sequence conflicti727 – 728QQ → HE in AAF68175 (PubMed:10780788).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00217458 – 79Missing in isoform 2. CuratedAdd BLAST22
Alternative sequenceiVSP_002175545 – 556AKPEQ…EPPTM → VVLIVLPVPSQA in isoform 5. CuratedAdd BLAST12
Alternative sequenceiVSP_002176557 – 864Missing in isoform 5. CuratedAdd BLAST308
Alternative sequenceiVSP_002177699 – 744VSKAT…INLCQ → GLPTQRPTLVALAGEQSNHA SEDSGVHPDAAAGTGSYAGG GAAAAG in isoform 3. CuratedAdd BLAST46
Alternative sequenceiVSP_002179699 – 714VSKAT…EYILM → LPGLANTEAHIGGARR in isoform 4. CuratedAdd BLAST16
Alternative sequenceiVSP_002180715 – 864Missing in isoform 4. CuratedAdd BLAST150
Alternative sequenceiVSP_002178745 – 864Missing in isoform 3. CuratedAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF245475 mRNA Translation: AAK20940.1
AF245476 mRNA Translation: AAK20941.1
AF245477 mRNA Translation: AAK20942.1
AF245478 mRNA Translation: AAK20943.1
AF245479 mRNA Translation: AAK20944.1
AF156604 mRNA Translation: AAF68175.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS39316.1 [Q99MZ3-1]

NCBI Reference Sequences

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RefSeqi
NP_067430.2, NM_021455.4 [Q99MZ3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.34213

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000005507; ENSMUSP00000005507; ENSMUSG00000005373 [Q99MZ3-1]
ENSMUST00000128691; ENSMUSP00000121348; ENSMUSG00000005373 [Q99MZ3-4]
ENSMUST00000129008; ENSMUSP00000114933; ENSMUSG00000005373 [Q99MZ3-5]
ENSMUST00000153519; ENSMUSP00000122198; ENSMUSG00000005373 [Q99MZ3-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
58805

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:58805

UCSC genome browser

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UCSCi
uc008zxt.2 mouse [Q99MZ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245475 mRNA Translation: AAK20940.1
AF245476 mRNA Translation: AAK20941.1
AF245477 mRNA Translation: AAK20942.1
AF245478 mRNA Translation: AAK20943.1
AF245479 mRNA Translation: AAK20944.1
AF156604 mRNA Translation: AAF68175.1
CCDSiCCDS39316.1 [Q99MZ3-1]
RefSeqiNP_067430.2, NM_021455.4 [Q99MZ3-1]
UniGeneiMm.34213

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GNTX-ray2.41B117-137[»]
ProteinModelPortaliQ99MZ3
SMRiQ99MZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208443, 6 interactors
IntActiQ99MZ3, 1 interactor
MINTiQ99MZ3
STRINGi10090.ENSMUSP00000005507

PTM databases

iPTMnetiQ99MZ3
PhosphoSitePlusiQ99MZ3

Proteomic databases

PaxDbiQ99MZ3
PeptideAtlasiQ99MZ3
PRIDEiQ99MZ3

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
58805
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005507; ENSMUSP00000005507; ENSMUSG00000005373 [Q99MZ3-1]
ENSMUST00000128691; ENSMUSP00000121348; ENSMUSG00000005373 [Q99MZ3-4]
ENSMUST00000129008; ENSMUSP00000114933; ENSMUSG00000005373 [Q99MZ3-5]
ENSMUST00000153519; ENSMUSP00000122198; ENSMUSG00000005373 [Q99MZ3-3]
GeneIDi58805
KEGGimmu:58805
UCSCiuc008zxt.2 mouse [Q99MZ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51085
MGIiMGI:1927999 Mlxipl

Phylogenomic databases

eggNOGiKOG3582 Eukaryota
ENOG410XTA5 LUCA
GeneTreeiENSGT00940000159210
HOGENOMiHOG000113606
HOVERGENiHBG073589
InParanoidiQ99MZ3
KOiK09113
OMAiWQPPERW
OrthoDBi388166at2759
PhylomeDBiQ99MZ3
TreeFamiTF324749

Enzyme and pathway databases

ReactomeiR-MMU-163358 PKA-mediated phosphorylation of key metabolic factors
R-MMU-163765 ChREBP activates metabolic gene expression

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q99MZ3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005373 Expressed in 131 organ(s), highest expression level in brown adipose tissue
CleanExiMM_MLXIPL
ExpressionAtlasiQ99MZ3 baseline and differential
GenevisibleiQ99MZ3 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLXPL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MZ3
Secondary accession number(s): Q99MY9
, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: January 16, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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