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Protein

Histone-lysine N-methyltransferase ASH1L

Gene

Ash1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi885 – 897A.T hook 1Add BLAST13
DNA bindingi1345 – 1357A.T hook 2Add BLAST13
DNA bindingi1843 – 1855A.T hook 3Add BLAST13
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2574 – 2620PHD-typeAdd BLAST47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214841 PKMTs methylate histone lysines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase ASH1L (EC:2.1.1.43)
Alternative name(s):
ASH1-like protein
Absent small and homeotic disks protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ash1l
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2183158 Ash1l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Chromosome, Nucleus, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595171 – 2958Histone-lysine N-methyltransferase ASH1LAdd BLAST2958

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei373N6-acetyllysineBy similarity1
Cross-linki424Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1168PhosphoserineCombined sources1
Modified residuei1218N5-methylglutamineBy similarity1
Modified residuei2307N6-acetyllysineCombined sources1
Modified residuei2309N6-acetyllysineCombined sources1
Modified residuei2313N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated at Gln-1218 by N6AMT1.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99MY8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99MY8

PeptideAtlas

More...
PeptideAtlasi
Q99MY8

PRoteomics IDEntifications database

More...
PRIDEi
Q99MY8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99MY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q99MY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028053 Expressed in 289 organ(s), highest expression level in ciliary body

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99MY8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
228672, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000088451

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q99MY8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99MY8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2081 – 2132AWSPROSITE-ProRule annotationAdd BLAST52
Domaini2135 – 2251SETPROSITE-ProRule annotationAdd BLAST117
Domaini2259 – 2275Post-SETPROSITE-ProRule annotationAdd BLAST17
Domaini2452 – 2522BromoPROSITE-ProRule annotationAdd BLAST71
Domaini2650 – 2787BAHPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2059 – 2278Catalytic domainBy similarityAdd BLAST220

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1378 – 1422Pro-richAdd BLAST45
Compositional biasi1555 – 1787Ser-richAdd BLAST233

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2574 – 2620PHD-typeAdd BLAST47

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1083 Eukaryota
COG2940 LUCA
COG5076 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156698

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080871

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99MY8

KEGG Orthology (KO)

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KOi
K06101

Identification of Orthologs from Complete Genome Data

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OMAi
HSEMTDY

Database of Orthologous Groups

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OrthoDBi
507784at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106416

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR006560 AWS_dom
IPR001025 BAH_dom
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01426 BAH, 1 hit
PF00439 Bromodomain, 1 hit
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00384 AT_hook, 4 hits
SM00570 AWS, 1 hit
SM00439 BAH, 1 hit
SM00297 BROMO, 1 hit
SM00249 PHD, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51215 AWS, 1 hit
PS51038 BAH, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99MY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPRNTAMLG LGSDSEGFSR KSPSTINPGT LASKREAEIE GATEEEDPRK
60 70 80 90 100
RNRERGTEAG KEDGSTDAQQ QFSVKETNFS EGNLKLKIGL QAKRTKKPPK
110 120 130 140 150
NLENYVCRPA IKTTIKHSRK ALKSGKMTDE KNEHCPSKWD SSKLFKKAGD
160 170 180 190 200
ATAIDCQAEE SIHLHSQGES NPLSKKLSPV HSQMADYISA APSLVGSRDP
210 220 230 240 250
DIKDRALLNG GTSVTEKLAQ LIATCPPSKS SKAKPKKLGT GTTVGLVSKD
260 270 280 290 300
LIRKPGVGSI AGIIHKDLIK KPALSTAVGL VTKDPGKKPM FNAAVGLINK
310 320 330 340 350
DSVKKLGTGT TAVFINKDLG KKPGAITTVG LLSKESGKKL GIGIVPGLVN
360 370 380 390 400
KESGKKLGLG TVVGLVNKEL GKKLSSTVGL VAKDVTKKIV ASSAMGLVNK
410 420 430 440 450
DIGKKLLNCP MAGQLGSKDA LNLKSEALLP TQEQLKASCS ANISNHDSQE
460 470 480 490 500
LPESLKDSAT GKAFEKSVMR HSKESMLEKF SVRKEITNLE KEMFNEGTCI
510 520 530 540 550
QQDNFSSSER GAFETSKHEK QPPVYCTSPD FQIGGASDAS TAKSPFSAVG
560 570 580 590 600
ESNLPSSSPT VSVNPVTRSP PEASSQLVPN PLLLNSTAEQ MEEISESIGK
610 620 630 640 650
SQFTAESTHL NVGHRSLGHS LSIECKGIDK ELNESKNTHL DIPRISSSLG
660 670 680 690 700
KKPSLTSDSG IHAITPSVVN FTSLFSNKPF LKLGAVTAPD KHCQVAESLS
710 720 730 740 750
SSFQSKPLKK RKGRKPRWTK VVARSTCRSP KGLDLERSEL FKNVSCSSLS
760 770 780 790 800
NSSEPAKFMK TIGASSFVDH DFLKRRLPKL SKSSAPSLAL LTDSEKPSHK
810 820 830 840 850
SFITHKLSSS MCVTSDLLSD IYKPKRGRPK SKEMPQLEGP PKRTLKIPAS
860 870 880 890 900
KVFSLQSKEE QEPPILQPEI EIPSFKQSLS VSPFPKKRGR PKRQMRSPVK
910 920 930 940 950
MKPPVLSVAP FVATESPSKL ESESENHRSS SDFFESEDQL QDTDDLDDSH
960 970 980 990 1000
RQSVCSMSDL EMEPDKKISK RNNGQLMKTI IRKINKMKTL KRKKLLNQIL
1010 1020 1030 1040 1050
SSSVESSNKG KVQSKLHNTV SSLAATFGSK LGQQINVSKK GTIYIGKRRG
1060 1070 1080 1090 1100
RKPKTVLNGL LSGSPASLAV LEQTAQQAAG SALGQILPPL LPSPASSSEI
1110 1120 1130 1140 1150
LPSPICSQSS GTSGGQSPVS SDAGFVEPSS VPYLHVHSRQ GSMIQTLAMK
1160 1170 1180 1190 1200
KASKGRRRLS PPTLLPNSPS HLSELTSLKE ATPSPVSESH SDETIPSDSG
1210 1220 1230 1240 1250
IGTDNNSTSD RAEKFCGQKK RRHSFEHISL IPPETSTVLN SLKEKHKHKC
1260 1270 1280 1290 1300
KRRSHDYLSY DKMKRQKRKR KKKYPQLRNR QDPDFIAELE ELISRLSEIR
1310 1320 1330 1340 1350
ITHRSHHFIP RDLLPTIFRI NFNSFYTHPS FPLDPLHYIR KPDLKKKRGR
1360 1370 1380 1390 1400
PPKMREAMAE MPFMHSLSFP LSSTGFYPSY GMPYSPSPLT AAPIGLGYYG
1410 1420 1430 1440 1450
RYPPTLYPPP PSPSFTTPLP PPSYMHAGHL LLNPTKYHKK KHKLLRQEAF
1460 1470 1480 1490 1500
LTTSRTPLLS MSTYPSVPPE MAYGWMVEHK HRHRHKHREH RSEQPQVSMD
1510 1520 1530 1540 1550
SGSSRSVLES LKRYRFGKDT VGDRYKHKEK HRCHMSCPHL SPSKNLINRE
1560 1570 1580 1590 1600
EQWVSREPSE SSSLALGLQT PLQIDCSESS PSLSLGGFTP NSEPASSDEH
1610 1620 1630 1640 1650
MNLFTSAIGS CRVSNPNSSC RKKLTDSPGL FPVQDTALNR PHRKEPLPSS
1660 1670 1680 1690 1700
ERAIQSLAGS QSASDKPSQR SSESTNCSPT RKRSSSESTS STVNGVPSRS
1710 1720 1730 1740 1750
PRLVASMDDS VDSLLQRIVH HDEQESMEKN GDASITTVSA PPSSSPGHSY
1760 1770 1780 1790 1800
SKERALGKSD SLLVPAVPND SCSNIPLLSE KSASRCSPHH IKRSVVEAMQ
1810 1820 1830 1840 1850
RQARKMCNYD KILATKKNLD HVNKILKAKK LQRQARTGNN FVKRRPGRPR
1860 1870 1880 1890 1900
KCPLQAVVSM QAFQAAQFVS PELNEGEDMS LHLSPDTVTD VIEAVVQSVN
1910 1920 1930 1940 1950
LTSEHKKGVK RKNWLLEEQT RKKQKTVPEE EEQENNKSFI ETPVEIPSPL
1960 1970 1980 1990 2000
ETPAEPSEPE NTLQPVLALI PREKKAPRPP KKKYQRAGLY SDVYKTIDPK
2010 2020 2030 2040 2050
SRLIQLKKEK LEYTPGEHEY GLFPAPIHVG KYLRQKRIDF QLPYDILWQW
2060 2070 2080 2090 2100
KHNQLYKKPD VPLYKKIRSN VYVDVKPLSG YEATTCNCKK PDDDTRKGCG
2110 2120 2130 2140 2150
DDCLNRMIFA ECSPNTCPCG EQCCNQRIQR HEWVQCLERF RAEEKGWGIR
2160 2170 2180 2190 2200
TKEPLKAGQF IIEYLGEVVS EQEFRNRMIE QYHNHSDHYC LNLDSGMVID
2210 2220 2230 2240 2250
SYRMGNEARF INHSCDPNCE MQKWSVNGVY RIGLYALKDM PAGTELTYDY
2260 2270 2280 2290 2300
NFHSFNVEKQ QLCKCGFEKC RGIIGGKSQR MNGLPSHKGS QSSSTHRKSA
2310 2320 2330 2340 2350
RAKEKRKSKH KLKKRKGHPS EEPSENINTP TRLTPQLQMK PMSNRERNFV
2360 2370 2380 2390 2400
LKHHVFLVRN WEKIHQKQEE VKHTRDIHSA SLYTRWNGLC RDDGNIKSDV
2410 2420 2430 2440 2450
FMTQFSALQT ARSVRTRRLA AAEENLEVAR AARLAQIFKE ICDGIISYRD
2460 2470 2480 2490 2500
SSQQTLAAPL LNLPPKKKNA DYYEKISDPL DLSTIEKQIL IGYYKTVEAF
2510 2520 2530 2540 2550
DADMLKVFRN AEKYYGRKSP IGRDVCRLRK AYYSARHEAS AQIDEIVGET
2560 2570 2580 2590 2600
ASEADSSETS VSEKESGHEK DDDVIRCICG LYKDEGLMIQ CDKCMVWQHC
2610 2620 2630 2640 2650
DCMGVNTDVE HYLCEQCDPR PVDREVPMIP RPHYAQPGCV YFICLLRDDL
2660 2670 2680 2690 2700
LLRQGDCVYL MRDSRRTPDG HPVRQSYRLL SHINRDKLDI FRIEKLWKNE
2710 2720 2730 2740 2750
KEERFAFGHH YFRPHETHHS PSRRFYHNEL FRVPLYEIIP LEAVVGTCCV
2760 2770 2780 2790 2800
LDLYTYCKGR PKGIKEQDVY ICDYRLDKSA HLFYKIHRNR YPVCTKPYAF
2810 2820 2830 2840 2850
DHFPKKLTPK RDFSPHYVPD NYKRNGGRSS WKSERSKPPL KDLGQEDDAL
2860 2870 2880 2890 2900
PLIEEVLASQ EQAAREVPSP EEPDQERATG DIGDAEKKPE ESSQEAQLAS
2910 2920 2930 2940 2950
TPEERRHSQR ERLNQILLNL LEKIPGKNAI DVTYLLEEGS GRKLRRRTLF

IPENSFRK
Length:2,958
Mass (Da):331,333
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8CA3E7AB72BEF2B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK26242 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE32182 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti331L → M in BAC40390 (PubMed:16141072).Curated1
Sequence conflicti711 – 714RKGR → EKEE in AAK26242 (Ref. 4) Curated4
Sequence conflicti1073Q → K in AAK26242 (Ref. 4) Curated1
Sequence conflicti1095A → V in AAK26242 (Ref. 4) Curated1
Sequence conflicti1994Y → S in AAK26242 (Ref. 4) Curated1
Sequence conflicti2656D → H in AAK26242 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC127377 Genomic DNA No translation available.
AC140468 Genomic DNA No translation available.
AK033177 mRNA Translation: BAC28183.2
AK034679 mRNA Translation: BAC28795.2
AK088497 mRNA Translation: BAC40390.1
AK153783 mRNA Translation: BAE32182.1 Different initiation.
AF247132 mRNA Translation: AAK26242.1 Different initiation.
BC052194 mRNA Translation: AAH52194.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS17487.1

NCBI Reference Sequences

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RefSeqi
NP_619620.3, NM_138679.5
XP_006501204.1, XM_006501141.2
XP_006501205.1, XM_006501142.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.130752

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000090933; ENSMUSP00000088451; ENSMUSG00000028053
ENSMUST00000186583; ENSMUSP00000140251; ENSMUSG00000028053

Database of genes from NCBI RefSeq genomes

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GeneIDi
192195

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:192195

UCSC genome browser

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UCSCi
uc008pxi.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127377 Genomic DNA No translation available.
AC140468 Genomic DNA No translation available.
AK033177 mRNA Translation: BAC28183.2
AK034679 mRNA Translation: BAC28795.2
AK088497 mRNA Translation: BAC40390.1
AK153783 mRNA Translation: BAE32182.1 Different initiation.
AF247132 mRNA Translation: AAK26242.1 Different initiation.
BC052194 mRNA Translation: AAH52194.1
CCDSiCCDS17487.1
RefSeqiNP_619620.3, NM_138679.5
XP_006501204.1, XM_006501141.2
XP_006501205.1, XM_006501142.2
UniGeneiMm.130752

3D structure databases

ProteinModelPortaliQ99MY8
SMRiQ99MY8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228672, 2 interactors
STRINGi10090.ENSMUSP00000088451

PTM databases

iPTMnetiQ99MY8
PhosphoSitePlusiQ99MY8

Proteomic databases

MaxQBiQ99MY8
PaxDbiQ99MY8
PeptideAtlasiQ99MY8
PRIDEiQ99MY8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090933; ENSMUSP00000088451; ENSMUSG00000028053
ENSMUST00000186583; ENSMUSP00000140251; ENSMUSG00000028053
GeneIDi192195
KEGGimmu:192195
UCSCiuc008pxi.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55870
MGIiMGI:2183158 Ash1l

Phylogenomic databases

eggNOGiKOG1083 Eukaryota
COG2940 LUCA
COG5076 LUCA
GeneTreeiENSGT00940000156698
HOVERGENiHBG080871
InParanoidiQ99MY8
KOiK06101
OMAiHSEMTDY
OrthoDBi507784at2759
TreeFamiTF106416

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ash1l mouse

Protein Ontology

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PROi
PR:Q99MY8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028053 Expressed in 289 organ(s), highest expression level in ciliary body
GenevisibleiQ99MY8 MM

Family and domain databases

Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR006560 AWS_dom
IPR001025 BAH_dom
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01426 BAH, 1 hit
PF00439 Bromodomain, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00384 AT_hook, 4 hits
SM00570 AWS, 1 hit
SM00439 BAH, 1 hit
SM00297 BROMO, 1 hit
SM00249 PHD, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS51038 BAH, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASH1L_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MY8
Secondary accession number(s): E9QNM2
, Q3U598, Q80VY5, Q8BM69, Q8BTX0, Q8BZY6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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