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Entry version 93 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Transmembrane protein 121B

Gene

Tmem121b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 121BBy similarity
Alternative name(s):
Cat eye syndrome critical region protein 6 homologBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmem121bImported
Synonyms:Cecr6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2136977, Tmem121b

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894671 – 572Transmembrane protein 121BAdd BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei162PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei548PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99MX7

PRoteomics IDEntifications database

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PRIDEi
Q99MX7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q99MX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99MX7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99MX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000094626, Expressed in visual cortex and 65 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99MX7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99MX7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000135924

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99MX7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 22Poly-Pro4
Compositional biasi34 – 305Gly-richAdd BLAST272
Compositional biasi62 – 66Poly-Gly5
Compositional biasi92 – 95Poly-Ala4
Compositional biasi163 – 171Poly-Cys9
Compositional biasi232 – 235Poly-Val4
Compositional biasi536 – 544Poly-Pro9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM121 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502R54H, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154822

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_539622_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99MX7

Identification of Orthologs from Complete Genome Data

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OMAi
SSAHNHH

Database of Orthologous Groups

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OrthoDBi
1029672at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99MX7

TreeFam database of animal gene trees

More...
TreeFami
TF336944

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026624, CECR6
IPR032776, CECR6/TMEM121

The PANTHER Classification System

More...
PANTHERi
PTHR47399, PTHR47399, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14997, CECR6_TMEM121, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99MX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPALGHPRA LSSAPASFPP PPAAARLQPL FLRGGSSRGR RGSGDSSTST
60 70 80 90 100
STSRGGCGGR RGGGGGSPSS STGAEREDDD ESISISKPLV PAAAALPGPP
110 120 130 140 150
AQGGVPVSAT APAAASSTST PTSSCSMTAA DFGAGAAAGT VGGPGSRSAV
160 170 180 190 200
GAGGTGTGGA ASCCSCCCCC CGRPTRSGRR GRRRGCSPSP GCRWGYQALS
210 220 230 240 250
VVLLLAQGGL LDLYLIAVTD LYWCSWIATD LVVVVGWAIF FAKNSRGRRG
260 270 280 290 300
GPANSMHNHH QLHHHSAPPL HLSAAASAGA GAKARGGRGG SGGSGAGPGT
310 320 330 340 350
TGAAGEFAFA YLAWLIYSIA FTPKVVLILG TSILDLIELR APFGTTGFRL
360 370 380 390 400
TMALSVPLLY SLVRAISEAG APPGSAGPLL LQPQQHRAAG CFLGTCLDLL
410 420 430 440 450
DSFTLVELML DGRVPLPAHL RYLLIAVYFL TLASPVLWLY ELNTATAAPS
460 470 480 490 500
WGQTSGPGSC SRLLRLLGGC LVDVPLLALR SLLVVSYQQP LSIFMLKNLF
510 520 530 540 550
FLGCRGLEAL EGCWDRGSWV SPSRARSSYG APPSAPPPPP PPPPQGGSQR
560 570
GHLENEGGPH GYVNTLAVAS QN
Length:572
Mass (Da):58,158
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AC65BBE56503A1C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF277399 mRNA Translation: AAK17095.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57446.1

NCBI Reference Sequences

More...
RefSeqi
NP_291045.1, NM_033567.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000178687; ENSMUSP00000135924; ENSMUSG00000094626

Database of genes from NCBI RefSeq genomes

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GeneIDi
94047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:94047

UCSC genome browser

More...
UCSCi
uc009dnk.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277399 mRNA Translation: AAK17095.1
CCDSiCCDS57446.1
RefSeqiNP_291045.1, NM_033567.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135924

PTM databases

iPTMnetiQ99MX7
PhosphoSitePlusiQ99MX7
SwissPalmiQ99MX7

Proteomic databases

PaxDbiQ99MX7
PRIDEiQ99MX7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22642, 115 antibodies

Genome annotation databases

EnsembliENSMUST00000178687; ENSMUSP00000135924; ENSMUSG00000094626
GeneIDi94047
KEGGimmu:94047
UCSCiuc009dnk.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27439
MGIiMGI:2136977, Tmem121b

Phylogenomic databases

eggNOGiENOG502R54H, Eukaryota
GeneTreeiENSGT00940000154822
HOGENOMiCLU_539622_0_0_1
InParanoidiQ99MX7
OMAiSSAHNHH
OrthoDBi1029672at2759
PhylomeDBiQ99MX7
TreeFamiTF336944

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
94047, 2 hits in 18 CRISPR screens

Protein Ontology

More...
PROi
PR:Q99MX7
RNActiQ99MX7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000094626, Expressed in visual cortex and 65 other tissues
ExpressionAtlasiQ99MX7, baseline and differential
GenevisibleiQ99MX7, MM

Family and domain databases

InterProiView protein in InterPro
IPR026624, CECR6
IPR032776, CECR6/TMEM121
PANTHERiPTHR47399, PTHR47399, 1 hit
PfamiView protein in Pfam
PF14997, CECR6_TMEM121, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT121B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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