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Entry version 147 (02 Jun 2021)
Sequence version 2 (29 Apr 2008)
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Protein

RING finger protein 17

Gene

Rnf17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis.

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri30 – 73RING-typePROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • spermatid development Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RING finger protein 17
Alternative name(s):
Mad member-interacting protein 2
Short name:
Mmip-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rnf17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1353419, Rnf17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Male mice are sterile, exhibit a complete arrest in round spermatids and fail to produce sperm.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000560601 – 1640RING finger protein 17Add BLAST1640

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei134PhosphoserineCombined sources1
Modified residuei229N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99MV7

PeptideAtlas

More...
PeptideAtlasi
Q99MV7

PRoteomics IDEntifications database

More...
PRIDEi
Q99MV7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
300495 [Q99MV7-1]
300496 [Q99MV7-2]
300497 [Q99MV7-3]
300498 [Q99MV7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99MV7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99MV7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in adult testis. Expressed in male germ cells (at protein level). Expressed at lower levels in adult thyroid, submaxillary gland, ovary and epididymis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000000365, Expressed in spermatocyte and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99MV7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99MV7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self-associates.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
205956, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q99MV7, 2 interactors

Molecular INTeraction database

More...
MINTi
Q99MV7

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000093469

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99MV7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99MV7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini751 – 809Tudor 1PROSITE-ProRule annotationAdd BLAST59
Domaini985 – 1044Tudor 2PROSITE-ProRule annotationAdd BLAST60
Domaini1246 – 1303Tudor 3PROSITE-ProRule annotationAdd BLAST58
Domaini1496 – 1556Tudor 4PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni348 – 376DisorderedSequence analysisAdd BLAST29
Regioni413 – 435DisorderedSequence analysisAdd BLAST23
Regioni1170 – 1191DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi356 – 373Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1170 – 1185Basic and acidic residuesSequence analysisAdd BLAST16

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 73RING-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2039, Eukaryota
KOG2279, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157559

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003202_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99MV7

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDMLWYR

Database of Orthologous Groups

More...
OrthoDBi
117171at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99MV7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04508, TUDOR, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039117, RNF17
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
IPR001841, Znf_RING
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR16442, PTHR16442, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00567, TUDOR, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333, TUDOR, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50304, TUDOR, 4 hits
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99MV7-1) [UniParc]FASTAAdd to basket
Also known as: RNF17L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEASSTGL ASCHLVESKS GAQGASGCQC TRCGRKVSVA SGDHHKFPCG
60 70 80 90 100
HAFCELCLLA PQEYTTSKCT DCEVHTTVSM NQGHYPVDGF IEEDSSLEAL
110 120 130 140 150
PPKMVNNCSS DLEKTVDQLI NDLEHSSSIH RNVSNPSAVM SETEEIDEAL
160 170 180 190 200
KIAGCNFEQL SNAIKMLDST QDQTRQETHS LTEAVEKQFD TLLASLDSRK
210 220 230 240 250
KSLCEELIRR TDDYLSKLVT VKSYIEEKKS DLDAAMKIAK ELRSAPSLRT
260 270 280 290 300
YCDLTQIIRT LKLTFESELS QVSSIIPRNT PRLDINCSEA ICMFSSMGKI
310 320 330 340 350
EFEDSTKCYP QENEDGQNVQ KKFNNRKELC CDVYSSLEKK KVDAAVLTDE
360 370 380 390 400
TPEPPLQAEA PDRHLEGKKK QPTKEMVVVT SPKTIAVLPQ LGSSPDVIIE
410 420 430 440 450
EIIEENLESC FTDDPIETSG YPKKPPQKEQ SAPVGSKAGC PELVFVSHVI
460 470 480 490 500
HPCHFYVRKY SQIKDATILE KKMKQVCNRS LHLDPSDILE LGARIFVNSI
510 520 530 540 550
KNRMWCRGII TEIIPSKTKN IRKPCSPTKF SVCEISLIQI FMVDFGNSEV
560 570 580 590 600
LIITGVGDTH EGPEHDGEQH ITLSDFCLLL MKSEPYSEEL LKDIPHLAHL
610 620 630 640 650
CSLKDIVPYN STEGWEKEAK VEFLKMVNKK AVLMKVFGEE DDVLIVDLQK
660 670 680 690 700
PPTNKISSDM PVSLRDALVF MELARFRSQS PRSHSEKNTT LCYHPPILPE
710 720 730 740 750
EMTEVSVMVC HINSPTDFYL QLMENLDFLS LLKTIEEFYK GEDGENLEIL
760 770 780 790 800
CPLQNQACVA KFEDGIWYRA KVIGLPGHRE VEVKYVDFGN TAKITLKDMR
810 820 830 840 850
KIKDEFLEPP EKAIKCKLAY VEPSKKSQWS KKAKEKFEEK TQDKFVTCSV
860 870 880 890 900
IKILENNVLL VELFDSRAPG KSAVSINDQL VKEGLASYEA GYTLKDNSKK
910 920 930 940 950
HLEVWDPSPE EIITSEINNL SPLSVKSLPN ENFQSLYNKE LPVNICNVIS
960 970 980 990 1000
PEKIYVQWLL TENLLNSLEE KMVAAYEHSE WKPVKWECDM HCAVKVPAKN
1010 1020 1030 1040 1050
QWRRGQILRM VTDKLVEVLL YDVGVELVVN IHCLRELQEN LKTMGRLSLE
1060 1070 1080 1090 1100
CSLVDIRPTG GSDKWTATAC DCLSLHLTGA IATIILQESN TTWPLPVKIF
1110 1120 1130 1140 1150
CRDEKGERVD VSKYLIKKGL ALRERRVSKS SNSHSPEKSL EIPLEQGDSV
1160 1170 1180 1190 1200
VTKCFKINFD TNKKIADKVN EHKVPDSKGK KSESRSTGCY RPPAVPNTSS
1210 1220 1230 1240 1250
FEAIVTCIGD DGTIFVVPKL SEFELIKMMD EIQSNLKCLG LLEPYSWKKG
1260 1270 1280 1290 1300
EPCAVRGSDT LWYRGKVMEV VGGTIRVQYL DHGFTEKIPQ CHLYPILLYP
1310 1320 1330 1340 1350
DTPQFCIPCQ LYQTLPVGNT WQPDAIELLQ ELLSKREVDI HIMELPNNSW
1360 1370 1380 1390 1400
GKLSVHLYFD GMSLSHFMAH HKYCIFEHTE EIFKEKPRGQ NKKYEDENWK
1410 1420 1430 1440 1450
IRFEDLLLPE MEAPVLPPYL SSLLPPPEEL FAVQVKHIVS PDEMYICLDS
1460 1470 1480 1490 1500
EDSYTQFNHH GDTDDSGVSW ESESENLEEA LQRFNKNVET FPPLTDFSSE
1510 1520 1530 1540 1550
MPCLAEYADG LWYRAKIISI KEFNPLSVLV LFVDYGCTEK LTINRLRQIP
1560 1570 1580 1590 1600
VQLMQYPAQA IKVLLAGFKP PLSDSGKTRI PYCPKWSMEA LWTMIDCLQG
1610 1620 1630 1640
KQLYASSVAQ APEQIVTLYE DEQYPVHMSL VEMGLADKDE
Length:1,640
Mass (Da):185,600
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6597E5750AE5ECC
GO
Isoform 2 (identifier: Q99MV7-2) [UniParc]FASTAAdd to basket
Also known as: RNF17S

The sequence of this isoform differs from the canonical sequence as follows:
     1127-1129: VSK → ASS
     1130-1640: Missing.

Note: Major.Curated
Show »
Length:1,129
Mass (Da):127,176
Checksum:iB7E1C7B5983E2CF0
GO
Isoform 3 (identifier: Q99MV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-580: Missing.

Show »
Length:1,060
Mass (Da):121,166
Checksum:i62038B1F91262AD1
GO
Isoform 4 (identifier: Q99MV7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-626: TEGWEKEAKVEFLKM → VSERESDSPSKAVEF
     627-1640: Missing.

Show »
Length:626
Mass (Da):69,653
Checksum:iAC8084E425727349
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDU5A0A286YDU5_MOUSE
RING finger protein 17
Rnf17
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF01336 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20S → SGAQ in AAF01336 (PubMed:10597267).Curated1
Sequence conflicti23Q → S in AAF01336 (PubMed:10597267).Curated1
Sequence conflicti282R → E in AAF01336 (PubMed:10597267).Curated1
Sequence conflicti307K → P in AAF01336 (PubMed:10597267).Curated1
Sequence conflicti311Q → L in AAF01336 (PubMed:10597267).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0330771 – 580Missing in isoform 3. 1 PublicationAdd BLAST580
Alternative sequenceiVSP_033078612 – 626TEGWE…EFLKM → VSERESDSPSKAVEF in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_033079627 – 1640Missing in isoform 4. 1 PublicationAdd BLAST1014
Alternative sequenceiVSP_0330801127 – 1129VSK → ASS in isoform 2. 2 Publications3
Alternative sequenceiVSP_0330811130 – 1640Missing in isoform 2. 2 PublicationsAdd BLAST511

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF285585 mRNA Translation: AAK31964.1
AY854010 mRNA Translation: AAX51690.1
AY854011 mRNA Translation: AAX51691.1
AF190166 mRNA Translation: AAF01336.1 Frameshift.
AK029693 mRNA Translation: BAC26567.1
BC099501 mRNA Translation: AAH99501.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27149.1 [Q99MV7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001028215.1, NM_001033043.1 [Q99MV7-1]
XP_006519173.1, XM_006519110.3
XP_006519175.1, XM_006519112.1 [Q99MV7-3]
XP_017171542.1, XM_017316053.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000095793; ENSMUSP00000093469; ENSMUSG00000000365 [Q99MV7-1]
ENSMUST00000223627; ENSMUSP00000153222; ENSMUSG00000000365 [Q99MV7-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
30054

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:30054

UCSC genome browser

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UCSCi
uc007ubx.1, mouse [Q99MV7-4]
uc007ubz.1, mouse [Q99MV7-2]
uc007uca.1, mouse [Q99MV7-1]
uc011zma.1, mouse [Q99MV7-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285585 mRNA Translation: AAK31964.1
AY854010 mRNA Translation: AAX51690.1
AY854011 mRNA Translation: AAX51691.1
AF190166 mRNA Translation: AAF01336.1 Frameshift.
AK029693 mRNA Translation: BAC26567.1
BC099501 mRNA Translation: AAH99501.1
CCDSiCCDS27149.1 [Q99MV7-1]
RefSeqiNP_001028215.1, NM_001033043.1 [Q99MV7-1]
XP_006519173.1, XM_006519110.3
XP_006519175.1, XM_006519112.1 [Q99MV7-3]
XP_017171542.1, XM_017316053.1

3D structure databases

SMRiQ99MV7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi205956, 3 interactors
IntActiQ99MV7, 2 interactors
MINTiQ99MV7
STRINGi10090.ENSMUSP00000093469

PTM databases

iPTMnetiQ99MV7
PhosphoSitePlusiQ99MV7

Proteomic databases

PaxDbiQ99MV7
PeptideAtlasiQ99MV7
PRIDEiQ99MV7
ProteomicsDBi300495 [Q99MV7-1]
300496 [Q99MV7-2]
300497 [Q99MV7-3]
300498 [Q99MV7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22496, 73 antibodies

Genome annotation databases

EnsembliENSMUST00000095793; ENSMUSP00000093469; ENSMUSG00000000365 [Q99MV7-1]
ENSMUST00000223627; ENSMUSP00000153222; ENSMUSG00000000365 [Q99MV7-4]
GeneIDi30054
KEGGimmu:30054
UCSCiuc007ubx.1, mouse [Q99MV7-4]
uc007ubz.1, mouse [Q99MV7-2]
uc007uca.1, mouse [Q99MV7-1]
uc011zma.1, mouse [Q99MV7-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56163
MGIiMGI:1353419, Rnf17

Phylogenomic databases

eggNOGiKOG2039, Eukaryota
KOG2279, Eukaryota
GeneTreeiENSGT00940000157559
HOGENOMiCLU_003202_1_0_1
InParanoidiQ99MV7
OMAiPDMLWYR
OrthoDBi117171at2759
PhylomeDBiQ99MV7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
30054, 4 hits in 57 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rnf17, mouse

Protein Ontology

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PROi
PR:Q99MV7
RNActiQ99MV7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000000365, Expressed in spermatocyte and 116 other tissues
ExpressionAtlasiQ99MV7, baseline and differential
GenevisibleiQ99MV7, MM

Family and domain databases

CDDicd04508, TUDOR, 4 hits
Gene3Di2.40.50.90, 3 hits
InterProiView protein in InterPro
IPR039117, RNF17
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
IPR001841, Znf_RING
IPR017907, Znf_RING_CS
PANTHERiPTHR16442, PTHR16442, 1 hit
PfamiView protein in Pfam
PF00567, TUDOR, 5 hits
SMARTiView protein in SMART
SM00333, TUDOR, 4 hits
PROSITEiView protein in PROSITE
PS50304, TUDOR, 4 hits
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNF17_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MV7
Secondary accession number(s): Q3T4H2
, Q3T4H3, Q4FZG6, Q8CDR4, Q9QXQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: April 29, 2008
Last modified: June 2, 2021
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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