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Entry version 160 (22 Apr 2020)
Sequence version 2 (14 Nov 2003)
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Protein

Double-stranded RNA-specific adenosine deaminase

Gene

Adar

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi859ZincPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei861Proton donorPROSITE-ProRule annotation1
Metal bindingi915ZincPROSITE-ProRule annotation1
Metal bindingi985ZincPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Hydrolase, RNA-binding
Biological processAntiviral defense, Immunity, Innate immunity, mRNA processing, RNA-mediated gene silencing, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.4.37 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-75102 C6 deamination of adenosine
R-MMU-77042 Formation of editosomes by ADAR proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Double-stranded RNA-specific adenosine deaminase (EC:3.5.4.37)
Short name:
DRADA
Alternative name(s):
RNA adenosine deaminase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adar
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1889575 Adar

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice do not survive past E11.0-E12.5 and embryos display widespread apoptosis, a rapidly disintegrating liver structure and severe defects in hematopoiesis.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001717751 – 1178Double-stranded RNA-specific adenosine deaminaseAdd BLAST1178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30Asymmetric dimethylarginineCombined sources1
Modified residuei42Asymmetric dimethylarginineCombined sources1
Modified residuei231PhosphoserineBy similarity1
Modified residuei238PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei434PhosphoserineBy similarity1
Modified residuei567PhosphoserineBy similarity1
Modified residuei582PhosphoserineCombined sources1
Modified residuei589PhosphoserineBy similarity1
Modified residuei757PhosphothreonineBy similarity1
Modified residuei763PhosphoserineBy similarity1
Modified residuei772PhosphoserineBy similarity1
Modified residuei774PhosphoserineBy similarity1
Cross-linki824Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylation reduces RNA-editing activity.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99MU3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99MU3

PeptideAtlas

More...
PeptideAtlasi
Q99MU3

PRoteomics IDEntifications database

More...
PRIDEi
Q99MU3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q99MU3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99MU3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99MU3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in brain and spleen. Lowest levels in liver.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By inflammation. Under normal conditions, long forms starting at Met-1 are dominant. Inflammation causes selective induction of short forms starting at Met-519.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027951 Expressed in dorsal tegmental nucleus and 302 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99MU3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Homodimerization is essential for its catalytic activity (PubMed:12618436). Isoform 5 can form heterodimers with ADARB1/ADAR2. Isoform 1 and isoform 5 (via DRBM 3 domain) interact with TNPO1. Isoform 5 (via DRBM domains) interacts with XPO5. Isoform 1 and isoform 5 can interact with UPF1 (By similarity).

Isoform 1 interacts with ILF2/NF45 and ILF3/NF90 (PubMed:16055709). Binding to ILF3/NF90 up-regulates ILF3-mediated gene expression. Isoform 1 and isoform 5 interact with EIF2AK2/PKR (PubMed:17079286).

By similarity3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
207963, 2 interactors

Protein interaction database and analysis system

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IntActi
Q99MU3, 1 interactor

Molecular INTeraction database

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MINTi
Q99MU3

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000103028

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99MU3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99MU3

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati135 – 204DRADA 1Add BLAST70
Repeati246 – 313DRADA 2Add BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini456 – 524DRBM 1PROSITE-ProRule annotationAdd BLAST69
Domaini567 – 635DRBM 2PROSITE-ProRule annotationAdd BLAST69
Domaini675 – 743DRBM 3PROSITE-ProRule annotationAdd BLAST69
Domaini835 – 1170A to I editasePROSITE-ProRule annotationAdd BLAST336

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni135 – 204Interaction with Z-DNABy similarityAdd BLAST70
Regioni665 – 674N-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signalBy similarity10
Regioni744 – 750C-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signalBy similarity7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first DRADA repeat binds Z-DNA.By similarity
The third dsRNA-binding domain (DRBM 3) contains an additional N-terminal alpha-helix that is part of a bi-partite nuclear localization signal, together with the sequence immediately C-terminal to DRBM 3. The presence of DRBM 3 is important to bring together the N-terminal and the C-terminal part of the bi-partite nuclear localization signal for import mediated by TNPO1. RNA binding interferes with nuclear import.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2777 Eukaryota
ENOG410XT0Z LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157243

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_005382_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99MU3

KEGG Orthology (KO)

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KOi
K12968

Database of Orthologous Groups

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OrthoDBi
947117at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99MU3

TreeFam database of animal gene trees

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TreeFami
TF315806

Family and domain databases

Conserved Domains Database

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CDDi
cd00048 DSRM, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002466 A_deamin
IPR014720 dsRBD_dom
IPR000607 dsRNA_A_deaminase_rpt
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR042371 Zalpha_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02137 A_deamin, 1 hit
PF00035 dsrm, 3 hits
PF02295 z-alpha, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00552 ADEAMc, 1 hit
SM00358 DSRM, 3 hits
SM00550 Zalpha, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46785 SSF46785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50141 A_DEAMIN_EDITASE, 1 hit
PS50139 DRADA_REPEAT, 2 hits
PS50137 DS_RBD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q99MU3-1) [UniParc]FASTAAdd to basket
Also known as: ADAR1Lb, p150

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQGFRGPTG VFPHQTQSYL DPSHEHSKWR YPQPQGPESY PRSFQLQQIE
60 70 80 90 100
FLKGRLPEAP LIGIQTQSLP PFLPGHWPRF PGPPAQDRQL EIWEFPRSVT
110 120 130 140 150
LRNQGFHIGP PLPPPHSRGT PWRGADGLCS HFRELSISQS PEQKVLNRLE
160 170 180 190 200
ELGEGKATTA HVLARELRIP KRDINRILYS LEKKGKLHRG RGKPPLWSLV
210 220 230 240 250
PLSQAWTQPP GVVNPDSCIQ EFPRGEPGLD SEDGDPASDL EGPSEPLDMA
260 270 280 290 300
EIKEKICDYL FNVSNSSALN LAKNIGLTKA RDVTSVLIDL ERQGDVYRQG
310 320 330 340 350
ATPPIWYLTD KKRERLQMKR STHSAPAPTP TAVPEATRSP SFPACHPPPA
360 370 380 390 400
GASSSVAASK RVENGQEPAI KHESRHEARP GPMRLRPHAY HNGPSRAGYV
410 420 430 440 450
ASENGQWATD DIPDNLNSIH TAPGEFRAIM EMPSFYSPTL PRCSPYKKLT
460 470 480 490 500
ECQLKNPVSG LLEYAQFTSQ TCDFNLIEQS GPSHEPRFKF QVVINGREFP
510 520 530 540 550
PAEAGSKKVA KQDAAVKAMA ILLREAKAKD SGQPEDLSHC PMEEDSEKPA
560 570 580 590 600
EAQAPSSSAT SLFSGKSPVT TLLECMHKLG NSCEFRLLSK EGPAHDPKFQ
610 620 630 640 650
YCVAVGAQTF PPVSAPSKKV AKQMAAEEAM KALQEEAASS ADDQSGGANT
660 670 680 690 700
DSLDESMAPN KIRRIGELVR YLNTNPVGGL LEYARSHGFA AEFKLIDQSG
710 720 730 740 750
PPHEPKFVYQ AKVGGRWFPA VCAHSKKQGK QDAADAALRV LIGESEKAEQ
760 770 780 790 800
LGFAEVTPVT GASLRRTMLL LSRSPDAHPK TLPLSGSTFH DQIAMLSHRC
810 820 830 840 850
FNALTNSFQP SLLGRKILAA IIMKRDPEDM GVVVSLGTGN RCVKGDSLSL
860 870 880 890 900
KGETVNDCHA EIISRRGFIR FLYSELMKYN HHTAKNSIFE LARGGEKLQI
910 920 930 940 950
KKTVSFHLYI STAPCGDGAL FDKSCSDRAV ESTESRHYPV FENPKQGKLR
960 970 980 990 1000
TKVENGEGTI PVESSDIVPT WDGIRLGERL RTMSCSDKIL RWNVLGLQGA
1010 1020 1030 1040 1050
LLTHFLQPVY LKSVTLGYLF SQGHLTRAIC CRVTRDGKAF EDGLRYPFIV
1060 1070 1080 1090 1100
NHPKVGRVSV YDSKRQSGKT KETSVNWCMA DGYDLEILDG TRGTVDGPGK
1110 1120 1130 1140 1150
ELSRVSKKNI FLQFKKLCSF RARRDLLQLS YGEAKKAARD YDLAKNYFKK
1160 1170
SLRDMGYGNW ISKPQEEKNF YLCPVPND
Length:1,178
Mass (Da):130,447
Last modified:November 14, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C28B71F00744724
GO
Isoform 2 (identifier: Q99MU3-2) [UniParc]FASTAAdd to basket
Also known as: ADAR1La

The sequence of this isoform differs from the canonical sequence as follows:
     756-781: Missing.

Show »
Length:1,152
Mass (Da):127,660
Checksum:i084406057050D3EB
GO
Isoform 3 (identifier: Q99MU3-3) [UniParc]FASTAAdd to basket
Also known as: ADAR1Sa

The sequence of this isoform differs from the canonical sequence as follows:
     1-518: Missing.
     756-781: Missing.

Show »
Length:634
Mass (Da):70,102
Checksum:iFF1AE77D36F08920
GO
Isoform 4 (identifier: Q99MU3-4) [UniParc]FASTAAdd to basket
Also known as: ADAR1Sb, p80

The sequence of this isoform differs from the canonical sequence as follows:
     1-518: Missing.

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Length:660
Mass (Da):72,889
Checksum:i4FEA49B89A5B9B75
GO
Isoform 5 (identifier: Q99MU3-5) [UniParc]FASTAAdd to basket
Also known as: p110

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.

Show »
Length:930
Mass (Da):102,580
Checksum:i94CDFC1E3EFBA538
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti415N → D in AAK16102 (PubMed:12954622).Curated1
Sequence conflicti644Q → K in AAC06233 (Ref. 3) Curated1
Sequence conflicti730K → R in AAC06233 (Ref. 3) Curated1
Sequence conflicti920L → H in AAC06233 (Ref. 3) Curated1
Sequence conflicti1003T → A in BAC40888 (PubMed:16141072).Curated1
Sequence conflicti1098P → S in AAK16102 (PubMed:12954622).Curated1
Sequence conflicti1149K → R in AAK16102 (PubMed:12954622).Curated1
Sequence conflicti1173C → R in BAC40888 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti20L → S in strain: Czech II. 1 Publication1
Natural varianti32P → L in strain: Czech II. 1 Publication1
Natural varianti120T → P in strain: Czech II. 1
Natural varianti330P → L in strain: Czech II. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0192361 – 518Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST518
Alternative sequenceiVSP_0192371 – 248Missing in isoform 5. 1 PublicationAdd BLAST248
Alternative sequenceiVSP_008875756 – 781Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF291875 mRNA Translation: AAK16101.1
AF291876 mRNA Translation: AAK16102.1
AF291877 mRNA Translation: AAK16103.1
AF291050 mRNA Translation: AAK17103.1
AF052506 mRNA Translation: AAC06233.1
BC042505 mRNA Translation: AAH42505.1
AK089451 mRNA Translation: BAC40888.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS17513.1 [Q99MU3-2]
CCDS17514.1 [Q99MU3-5]
CCDS50963.1 [Q99MU3-1]

NCBI Reference Sequences

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RefSeqi
NP_001139768.1, NM_001146296.1 [Q99MU3-1]
NP_062629.3, NM_019655.3 [Q99MU3-2]
XP_006501817.1, XM_006501754.2 [Q99MU3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000029563; ENSMUSP00000029563; ENSMUSG00000027951 [Q99MU3-2]
ENSMUST00000098924; ENSMUSP00000096525; ENSMUSG00000027951 [Q99MU3-5]
ENSMUST00000107405; ENSMUSP00000103028; ENSMUSG00000027951 [Q99MU3-1]
ENSMUST00000118341; ENSMUSP00000113453; ENSMUSG00000027951 [Q99MU3-4]
ENSMUST00000121094; ENSMUSP00000112969; ENSMUSG00000027951 [Q99MU3-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56417

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:56417

UCSC genome browser

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UCSCi
uc008pzv.2 mouse [Q99MU3-1]
uc008pzw.2 mouse [Q99MU3-2]
uc008pzy.2 mouse [Q99MU3-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291875 mRNA Translation: AAK16101.1
AF291876 mRNA Translation: AAK16102.1
AF291877 mRNA Translation: AAK16103.1
AF291050 mRNA Translation: AAK17103.1
AF052506 mRNA Translation: AAC06233.1
BC042505 mRNA Translation: AAH42505.1
AK089451 mRNA Translation: BAC40888.2
CCDSiCCDS17513.1 [Q99MU3-2]
CCDS17514.1 [Q99MU3-5]
CCDS50963.1 [Q99MU3-1]
RefSeqiNP_001139768.1, NM_001146296.1 [Q99MU3-1]
NP_062629.3, NM_019655.3 [Q99MU3-2]
XP_006501817.1, XM_006501754.2 [Q99MU3-5]

3D structure databases

SMRiQ99MU3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi207963, 2 interactors
IntActiQ99MU3, 1 interactor
MINTiQ99MU3
STRINGi10090.ENSMUSP00000103028

PTM databases

iPTMnetiQ99MU3
PhosphoSitePlusiQ99MU3
SwissPalmiQ99MU3

Proteomic databases

EPDiQ99MU3
PaxDbiQ99MU3
PeptideAtlasiQ99MU3
PRIDEiQ99MU3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1280 246 antibodies

Genome annotation databases

EnsembliENSMUST00000029563; ENSMUSP00000029563; ENSMUSG00000027951 [Q99MU3-2]
ENSMUST00000098924; ENSMUSP00000096525; ENSMUSG00000027951 [Q99MU3-5]
ENSMUST00000107405; ENSMUSP00000103028; ENSMUSG00000027951 [Q99MU3-1]
ENSMUST00000118341; ENSMUSP00000113453; ENSMUSG00000027951 [Q99MU3-4]
ENSMUST00000121094; ENSMUSP00000112969; ENSMUSG00000027951 [Q99MU3-3]
GeneIDi56417
KEGGimmu:56417
UCSCiuc008pzv.2 mouse [Q99MU3-1]
uc008pzw.2 mouse [Q99MU3-2]
uc008pzy.2 mouse [Q99MU3-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
103
MGIiMGI:1889575 Adar

Phylogenomic databases

eggNOGiKOG2777 Eukaryota
ENOG410XT0Z LUCA
GeneTreeiENSGT00940000157243
HOGENOMiCLU_005382_0_0_1
InParanoidiQ99MU3
KOiK12968
OrthoDBi947117at2759
PhylomeDBiQ99MU3
TreeFamiTF315806

Enzyme and pathway databases

BRENDAi3.5.4.37 3474
ReactomeiR-MMU-75102 C6 deamination of adenosine
R-MMU-77042 Formation of editosomes by ADAR proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Adar mouse

Protein Ontology

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PROi
PR:Q99MU3
RNActiQ99MU3 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027951 Expressed in dorsal tegmental nucleus and 302 other tissues
GenevisibleiQ99MU3 MM

Family and domain databases

CDDicd00048 DSRM, 3 hits
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR002466 A_deamin
IPR014720 dsRBD_dom
IPR000607 dsRNA_A_deaminase_rpt
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR042371 Zalpha_dom
PfamiView protein in Pfam
PF02137 A_deamin, 1 hit
PF00035 dsrm, 3 hits
PF02295 z-alpha, 2 hits
SMARTiView protein in SMART
SM00552 ADEAMc, 1 hit
SM00358 DSRM, 3 hits
SM00550 Zalpha, 2 hits
SUPFAMiSSF46785 SSF46785, 2 hits
PROSITEiView protein in PROSITE
PS50141 A_DEAMIN_EDITASE, 1 hit
PS50139 DRADA_REPEAT, 2 hits
PS50137 DS_RBD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSRAD_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MU3
Secondary accession number(s): O70375
, Q80UZ6, Q8C222, Q99MU2, Q99MU4, Q99MU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: April 22, 2020
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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