UniProtKB - Q99MU1 (TPRA1_MOUSE)
Protein
Transmembrane protein adipocyte-associated 1
Gene
Tpra1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
- embryonic cleavage Source: MGI
- negative regulation of mitotic cell cycle phase transition Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein adipocyte-associated 1Alternative name(s): Integral membrane protein GPR175 TPRA40 Transmembrane domain protein of 40 kDa regulated in adipocytes |
Gene namesi | Name:Tpra1 Synonyms:Gpr175, Tpra40 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1345190, Tpra1 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 45 – 65 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 73 – 93 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 120 – 140 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 148 – 168 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 189 – 209 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 237 – 257 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Transmembranei | 262 – 282 | Helical; Name=7Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076100 | 1 – 369 | Transmembrane protein adipocyte-associated 1Add BLAST | 369 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 20 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 329 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q99MU1 |
PaxDbi | Q99MU1 |
PRIDEi | Q99MU1 |
PTM databases
GlyGeni | Q99MU1, 2 sites |
PhosphoSitePlusi | Q99MU1 |
Expressioni
Tissue specificityi
Ubiquitous, with higher levels in heart, brain, lung, liver and kidney.1 Publication
Inductioni
Induced during adipocytes differentiation and in white fat from aged and diabetics mice.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000002871, Expressed in lens of camera-type eye and 286 other tissues |
ExpressionAtlasi | Q99MU1, baseline and differential |
Genevisiblei | Q99MU1, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000063042 |
Miscellaneous databases
RNActi | Q99MU1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the UPF0359 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4536, Eukaryota |
GeneTreei | ENSGT00390000016807 |
HOGENOMi | CLU_056255_0_0_1 |
InParanoidi | Q99MU1 |
OMAi | SMPYHVG |
OrthoDBi | 948626at2759 |
PhylomeDBi | Q99MU1 |
TreeFami | TF314072 |
Family and domain databases
InterProi | View protein in InterPro IPR018781, TPRA1/CAND2/CAND8 |
PANTHERi | PTHR15876, PTHR15876, 1 hit |
Pfami | View protein in Pfam PF10160, Tmemb_40, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q99MU1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASLQEANGS TAWPPPTASN ISEPHQCLLL LYEDIGSSRV RYWDLLLLIP
60 70 80 90 100
NVLFFIFLLW KLPLARAKIR VTSSPIFITF YILVFVVALV GIARAVVSMT
110 120 130 140 150
VSASDAATVA DKILWEITRF FLLAIELSVI ILGLAFGHLE SKSSIKRVLA
160 170 180 190 200
ITTVLSLAYS VTQGTLEILY PDSHLSAEDF NIYGHGGRQF WLVSSCFFFL
210 220 230 240 250
VYSLVVILPK TPLKERVSLP SRRSFYVYAG ILATLNLLQG LGSALLCANI
260 270 280 290 300
IVGLCCVDAT TFLYFSFFAP LIYVAFLRGF FGSEPKILFS YKCQVDEAEE
310 320 330 340 350
PDMHLPQPYA VARREGIESA GPACASAANY SSTQFDSAGV AYLDDIASMP
360
CHTGSINSTD SERWKAINA
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z018 | D3Z018_MOUSE | Integral membrane protein GPR175 | Tpra1 | 188 | Annotation score: | ||
A0A0N4SUW2 | A0A0N4SUW2_MOUSE | Integral membrane protein GPR175 | Tpra1 | 192 | Annotation score: | ||
A0A0N4SVH0 | A0A0N4SVH0_MOUSE | Integral membrane protein GPR175 | Tpra1 | 222 | Annotation score: | ||
A0A0N4SVI2 | A0A0N4SVI2_MOUSE | Integral membrane protein GPR175 | Tpra1 | 210 | Annotation score: | ||
A0A0N4SW46 | A0A0N4SW46_MOUSE | Integral membrane protein GPR175 | Tpra1 | 230 | Annotation score: | ||
A0A0N4SW75 | A0A0N4SW75_MOUSE | Integral membrane protein GPR175 | Tpra1 | 222 | Annotation score: | ||
A0A0N4SUT1 | A0A0N4SUT1_MOUSE | Transmembrane protein adipocyte-ass... | Tpra1 | 41 | Annotation score: | ||
A0A0N4SV31 | A0A0N4SV31_MOUSE | Transmembrane protein adipocyte-ass... | Tpra1 | 42 | Annotation score: | ||
A0A0N4SVI3 | A0A0N4SVI3_MOUSE | Transmembrane protein adipocyte-ass... | Tpra1 | 71 | Annotation score: |
Sequence cautioni
The sequence AAD15788 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF051098 mRNA Translation: AAD15788.1 Frameshift. AK089317 mRNA Translation: BAC40839.1 AK164913 mRNA Translation: BAE37962.1 AK172045 mRNA Translation: BAE42796.1 BC010244 mRNA Translation: AAH10244.1 BC028977 mRNA Translation: AAH28977.1 AY255531 mRNA Translation: AAO85043.1 |
CCDSi | CCDS39555.1 |
RefSeqi | NP_036036.2, NM_011906.2 XP_006506124.1, XM_006506061.2 XP_006506125.1, XM_006506062.2 XP_006506126.1, XM_006506063.2 |
Genome annotation databases
Ensembli | ENSMUST00000055022; ENSMUSP00000063042; ENSMUSG00000002871 ENSMUST00000203185; ENSMUSP00000145168; ENSMUSG00000002871 ENSMUST00000204765; ENSMUSP00000145050; ENSMUSG00000002871 |
GeneIDi | 24100 |
KEGGi | mmu:24100 |
UCSCi | uc009cvy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF051098 mRNA Translation: AAD15788.1 Frameshift. AK089317 mRNA Translation: BAC40839.1 AK164913 mRNA Translation: BAE37962.1 AK172045 mRNA Translation: BAE42796.1 BC010244 mRNA Translation: AAH10244.1 BC028977 mRNA Translation: AAH28977.1 AY255531 mRNA Translation: AAO85043.1 |
CCDSi | CCDS39555.1 |
RefSeqi | NP_036036.2, NM_011906.2 XP_006506124.1, XM_006506061.2 XP_006506125.1, XM_006506062.2 XP_006506126.1, XM_006506063.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000063042 |
PTM databases
GlyGeni | Q99MU1, 2 sites |
PhosphoSitePlusi | Q99MU1 |
Proteomic databases
MaxQBi | Q99MU1 |
PaxDbi | Q99MU1 |
PRIDEi | Q99MU1 |
Protocols and materials databases
Antibodypediai | 17215, 281 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000055022; ENSMUSP00000063042; ENSMUSG00000002871 ENSMUST00000203185; ENSMUSP00000145168; ENSMUSG00000002871 ENSMUST00000204765; ENSMUSP00000145050; ENSMUSG00000002871 |
GeneIDi | 24100 |
KEGGi | mmu:24100 |
UCSCi | uc009cvy.1, mouse |
Organism-specific databases
CTDi | 131601 |
MGIi | MGI:1345190, Tpra1 |
Phylogenomic databases
eggNOGi | KOG4536, Eukaryota |
GeneTreei | ENSGT00390000016807 |
HOGENOMi | CLU_056255_0_0_1 |
InParanoidi | Q99MU1 |
OMAi | SMPYHVG |
OrthoDBi | 948626at2759 |
PhylomeDBi | Q99MU1 |
TreeFami | TF314072 |
Miscellaneous databases
BioGRID-ORCSi | 24100, 1 hit in 17 CRISPR screens |
ChiTaRSi | Tpra1, mouse |
PROi | PR:Q99MU1 |
RNActi | Q99MU1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000002871, Expressed in lens of camera-type eye and 286 other tissues |
ExpressionAtlasi | Q99MU1, baseline and differential |
Genevisiblei | Q99MU1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR018781, TPRA1/CAND2/CAND8 |
PANTHERi | PTHR15876, PTHR15876, 1 hit |
Pfami | View protein in Pfam PF10160, Tmemb_40, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPRA1_MOUSE | |
Accessioni | Q99MU1Primary (citable) accession number: Q99MU1 Secondary accession number(s): Q80UD9 Q9Z112 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families