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Entry version 111 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

EH domain-binding protein 1-like protein 1

Gene

Ehbp1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as Rab effector protein and play a role in vesicle trafficking (By similarity).

Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1 (PubMed:26833786).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EH domain-binding protein 1-like protein 1
Alternative name(s):
Tangerin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ehbp1l1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3612340, Ehbp1l1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002852051 – 1716EH domain-binding protein 1-like protein 1Add BLAST1716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei170PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei191PhosphoserineBy similarity1
Modified residuei278PhosphothreonineCombined sources1
Modified residuei310PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei448PhosphothreonineCombined sources1
Modified residuei1074PhosphoserineCombined sources1
Modified residuei1135PhosphoserineBy similarity1
Modified residuei1342PhosphoserineBy similarity1
Modified residuei1444PhosphoserineCombined sources1
Modified residuei1460PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99MS7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99MS7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99MS7

PeptideAtlas

More...
PeptideAtlasi
Q99MS7

PRoteomics IDEntifications database

More...
PRIDEi
Q99MS7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
277807 [Q99MS7-1]
277808 [Q99MS7-2]
277809 [Q99MS7-3]
277810 [Q99MS7-4]
277811 [Q99MS7-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99MS7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99MS7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB8A, RAB8B, RAB10, RAB13 and RAB15 (in their GTP-bound forms); at least in case of RAB8A can bind 2 molecules of RAB8A simultaneously.

Interacts with BIN1 and AMPH.

Interacts with DNM1.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
227759, 11 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000037656

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99MS7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99MS7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 157C2 NT-typePROSITE-ProRule annotationAdd BLAST150
Domaini1211 – 1316Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST106
Domaini1542 – 1694bMERBPROSITE-ProRule annotationAdd BLAST153

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni174 – 560DisorderedSequence analysisAdd BLAST387
Regioni598 – 617DisorderedSequence analysisAdd BLAST20
Regioni1173 – 1210DisorderedSequence analysisAdd BLAST38
Regioni1382 – 1543DisorderedSequence analysisAdd BLAST162
Regioni1399 – 1549Interaction with BIN1 and AMPH1 PublicationAdd BLAST151

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1005 – 1033Sequence analysisAdd BLAST29
Coiled coili1558 – 1707Sequence analysisAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1713 – 1716CAAX motifBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi209 – 231Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi320 – 351Polar residuesSequence analysisAdd BLAST32
Compositional biasi352 – 386Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi414 – 430Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi478 – 497Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi520 – 542Polar residuesSequence analysisAdd BLAST23
Compositional biasi543 – 559Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1461 – 1475Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1512 – 1534Pro residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CAAX motif is a signal for prenylation and required for endosomal colocalization with Rab8 and Rab10.By similarity
The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0035, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99MS7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99MS7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR029928, Ehbp1l1
IPR019448, NT-C2

The PANTHER Classification System

More...
PANTHERi
PTHR23167:SF42, PTHR23167:SF42, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF10358, NT-C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51848, BMERB, 1 hit
PS51840, C2_NT, 1 hit
PS50021, CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99MS7-1) [UniParc]FASTAAdd to basket
Also known as: Tangerin A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSVWKRLQR VGKRAAKFQF VACYHELVLE CTKKWQPDKL VVVWTRRNRR
60 70 80 90 100
ICSKAHSWQP GIQNPYRGTV VWMVPENVDI SVTLYRDPHV DQYETKEWTF
110 120 130 140 150
IIENESKGQR KVLATVDVNL AHHAGPVPAQ VPLRLRLKPK SVKVVHAELS
160 170 180 190 200
LTLSGVLLRE GRATDDDMQS LASLMSVKPS DVGNLDDFAE SDEEEANGPG
210 220 230 240 250
APEVRTRGPQ SDLSRELKTL CEEEDEGHIR PQQAAARPSS AEDTSPAPVS
260 270 280 290 300
APAPPVRAFR GQGSEPAAIT GGQVGPETPE PPPSPPETRS TGQPGQTMVP
310 320 330 340 350
TPAPRLRKGS DAPSSPVPCS GDEVPNTSED PPTGMGSSGE TQAQISSQEG
360 370 380 390 400
TEAHEARPEP DIEVRGSKDS LGGERSKVEE EERGDGPGAS GTGNREKNTK
410 420 430 440 450
KSDTTAGEAG ESSELHQVDA EHKSKVQHRA TEGPEAAGLT PKARLGDTPE
460 470 480 490 500
APPRSAQRRM GVRTQEEAPS DLNPPPAEPE EHLGDLRDAR PAGQEKGSAE
510 520 530 540 550
VRSKVPAIGR AGPEQGSSAR AASAGPQVSC VQTVPSDGQG VKSRDQRAQE
560 570 580 590 600
AEVGESRVLE TEAEWVPWEV IGTSKTDAGI PESLDTEAGT AESEILEAQE
610 620 630 640 650
SEAARSEGLE PEAAGTAESE VLRTQNNEIV VLGMPRTGPE IREPEEFGET
660 670 680 690 700
EVGGFTVPDT KTVIAETEIL ETQGVVDGEA AVLKTQAEIS ETQKTEAGEA
710 720 730 740 750
EAGTLESQKV AAEGLGAPEV GAEMAEAEKL GVQETEVEIW RIPRIETETA
760 770 780 790 800
GTETLGIHKI GPPQMQPRLV GDQETDVSVM ETAEDAILGT REITAGCGVL
810 820 830 840 850
LIEAKIPESK IDRSLETEEG DLGVLEVDTG IAEAKILGIP ERAPGVQKAL
860 870 880 890 900
GAGTEVARVL EAEAASSEVP ETDAEEAETL QAKERSESSV ALRVVANLPE
910 920 930 940 950
SELLGTQKTE VGGTGISQRE VREAETEIPK TQEISSEGSG VPDLEAKMEE
960 970 980 990 1000
SGRKMEIWET PEVEKVNSEL FGTQKGSEIP ELETKTIKSE ILDAQETEVR
1010 1020 1030 1040 1050
DLGLRRGEAE KAEAEMLETQ KMEAKTARDE EIELVDPGVS SPEAEALRVQ
1060 1070 1080 1090 1100
WAGTVVLESG EVKADILGVQ KPGSWGALKY EALDVPVTKQ RLSGAKEVVP
1110 1120 1130 1140 1150
EVPRAQEPET KVLGIVEAKS WTLGQQEAEM EGFESPENKS NIFEAQEADS
1160 1170 1180 1190 1200
GVLGTMKGKE AVESLEEAGL SKAQVASEAG AGVPRPSGAS SLEEPEEDRR
1210 1220 1230 1240 1250
LPGSQAPPTL VSSSQSLLEW CQEVTNGYRG VCITNFTTSW RNGLAFCAIL
1260 1270 1280 1290 1300
HRFYPDKIDY FSLDPLNIKQ NNKQAFDGFA ALGVSRLLEP ADMVLLSVPD
1310 1320 1330 1340 1350
KLIVMTYLCQ IRAFCTGQEL QLVQLEGGGG SGTYRVGNAQ PSLPDCLDAG
1360 1370 1380 1390 1400
DLAQRLREHG AEVPTEPKEA VNRGTGAIPK VASRDTDLSC SSKDGEAEVA
1410 1420 1430 1440 1450
QEAIPQEAPT DGPRARSSTT PVVPAEGLVN GVGASGGVRL RRSSVNGEAG
1460 1470 1480 1490 1500
PVPPPRAHGS FSHVRDADLL KKRRSRLRNS NSFSVDDQDS GAAVGAGPAG
1510 1520 1530 1540 1550
PGAVEGPNPA SSPDANPLPA PVPQQPPGGP PPTEESSPSL GEEAGLQRFQ
1560 1570 1580 1590 1600
DTSQYVCAEL QALEQEQGQI DGRAAEVEKQ LRSLMESGAN RLQEEVLIQE
1610 1620 1630 1640 1650
WFTLVNKKNA LIRRQDQLQL LIEEQDLERR FELLSRELRA MLAIEEWQKT
1660 1670 1680 1690 1700
VAQQHREQLL LEELVSLVNQ RDELVRDLDQ KERIALEEDE RLERGLEQRR
1710
RKVSRQLSRR ERCTLS
Length:1,716
Mass (Da):184,834
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE9587BAAD06CA00
GO
Isoform 2 (identifier: Q99MS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-1206: Missing.
     1438-1438: V → VSGV

Show »
Length:877
Mass (Da):95,832
Checksum:i65F16248BDE19C70
GO
Isoform 3 (identifier: Q99MS7-3) [UniParc]FASTAAdd to basket
Also known as: Tangerin B

The sequence of this isoform differs from the canonical sequence as follows:
     365-1206: Missing.

Show »
Length:874
Mass (Da):95,589
Checksum:iBD903958BCDF5DBB
GO
Isoform 4 (identifier: Q99MS7-4) [UniParc]FASTAAdd to basket
Also known as: Tangerin C

The sequence of this isoform differs from the canonical sequence as follows:
     249-1205: Missing.

Show »
Length:759
Mass (Da):83,948
Checksum:i8770323D25E707B4
GO
Isoform 5 (identifier: Q99MS7-5) [UniParc]FASTAAdd to basket
Also known as: Tangerin C'

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: S → SGRGCAPRLGRFP
     249-1205: Missing.

Show »
Length:771
Mass (Da):85,217
Checksum:i0B38BE6106C3EA0A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QP49E9QP49_MOUSE
EH domain-binding protein 1-like pr...
Ehbp1l1
1,718Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BBL8A0A494BBL8_MOUSE
EH domain-binding protein 1-like pr...
Ehbp1l1
744Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B921A0A494B921_MOUSE
EH domain-binding protein 1-like pr...
Ehbp1l1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E8Y6G5E8Y6_MOUSE
EH domain-binding protein 1-like pr...
Ehbp1l1
774Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BA91A0A494BA91_MOUSE
EH domain-binding protein 1-like pr...
Ehbp1l1
877Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B9G7A0A494B9G7_MOUSE
EH domain-binding protein 1-like pr...
Ehbp1l1
762Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155G → W in BAC40012 (PubMed:16141072).Curated1
Sequence conflicti364V → A in AAK32110 (Ref. 1) Curated1
Sequence conflicti364V → A in AAH04660 (PubMed:15489334).Curated1
Sequence conflicti364V → A in BAC40012 (PubMed:16141072).Curated1
Sequence conflicti1522V → A in BAC40012 (PubMed:16141072).Curated1
Sequence conflicti1544A → T in BAC40012 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024837211S → SGRGCAPRLGRFP in isoform 5. 1 Publication1
Alternative sequenceiVSP_024838249 – 1205Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST957
Alternative sequenceiVSP_024839365 – 1206Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST842
Alternative sequenceiVSP_0248401438V → VSGV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF305087 mRNA Translation: AAK32109.1
AF305088 mRNA Translation: AAK32110.1
AF305089 mRNA Translation: AAK32111.1
AF305090 mRNA Translation: AAK32112.1
BC004660 mRNA Translation: AAH04660.1
AK087817 mRNA Translation: BAC40012.1
AK013080 mRNA Translation: BAE43236.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS89316.1 [Q99MS7-2]

NCBI Reference Sequences

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RefSeqi
NP_444482.2, NM_053252.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
114601

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:114601

UCSC genome browser

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UCSCi
uc008gev.2, mouse [Q99MS7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305087 mRNA Translation: AAK32109.1
AF305088 mRNA Translation: AAK32110.1
AF305089 mRNA Translation: AAK32111.1
AF305090 mRNA Translation: AAK32112.1
BC004660 mRNA Translation: AAH04660.1
AK087817 mRNA Translation: BAC40012.1
AK013080 mRNA Translation: BAE43236.1
CCDSiCCDS89316.1 [Q99MS7-2]
RefSeqiNP_444482.2, NM_053252.3

3D structure databases

SMRiQ99MS7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi227759, 11 interactors
STRINGi10090.ENSMUSP00000037656

PTM databases

iPTMnetiQ99MS7
PhosphoSitePlusiQ99MS7

Proteomic databases

EPDiQ99MS7
jPOSTiQ99MS7
PaxDbiQ99MS7
PeptideAtlasiQ99MS7
PRIDEiQ99MS7
ProteomicsDBi277807 [Q99MS7-1]
277808 [Q99MS7-2]
277809 [Q99MS7-3]
277810 [Q99MS7-4]
277811 [Q99MS7-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
114601

Genome annotation databases

GeneIDi114601
KEGGimmu:114601
UCSCiuc008gev.2, mouse [Q99MS7-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
254102
MGIiMGI:3612340, Ehbp1l1

Phylogenomic databases

eggNOGiKOG0035, Eukaryota
InParanoidiQ99MS7
PhylomeDBiQ99MS7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
114601, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ehbp1l1, mouse

Protein Ontology

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PROi
PR:Q99MS7
RNActiQ99MS7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR029928, Ehbp1l1
IPR019448, NT-C2
PANTHERiPTHR23167:SF42, PTHR23167:SF42, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF10358, NT-C2, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS51848, BMERB, 1 hit
PS51840, C2_NT, 1 hit
PS50021, CH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEH1L1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MS7
Secondary accession number(s): Q3V443
, Q8C2W6, Q99J97, Q99MS5, Q99MS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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